LOCUS       NM_145766               2556 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 11B (Cdk11b), mRNA.
ACCESSION   NM_145766
VERSION     NM_145766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Liu,X., Cheng,C., Shao,B., Wu,X., Ji,Y., Lu,X. and Shen,A.
  TITLE     LPS-stimulating astrocyte-conditioned medium causes neuronal
            apoptosis via increasing CDK11(p58) expression in PC12 cells
            through downregulating AKT pathway
  JOURNAL   Cell Mol Neurobiol 33 (6), 779-787 (2013)
   PUBMED   23703121
  REMARK    GeneRIF: AKT signaling pathway is involved in CDK11(p58)-induced
            neuronal apoptosis process.
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Liu,X., Cheng,C., Shao,B., Wu,X., Ji,Y., Lu,X. and Shen,A.
  TITLE     The functional interaction between CDK11p58 and
            beta-1,4-galactosyltransferase I involved in astrocyte activation
            caused by lipopolysaccharide
  JOURNAL   Inflammation 35 (4), 1365-1377 (2012)
   PUBMED   22527143
  REMARK    GeneRIF: These findings indicated that the functional interaction
            between CDK11(p58) and beta-1,4-GalT-I may play an important role
            during astrocyte activation after LPS administration.
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Niu,Z., Shen,A., Shen,H., Jiang,J., Zong,H. and Gu,J.
  TITLE     Protein expression pattern of CDK11(p58) during testicular
            development in the mouse
  JOURNAL   Mol Cell Biochem 270 (1-2), 99-106 (2005)
   PUBMED   15792358
REFERENCE   5  (bases 1 to 2556)
  AUTHORS   Li,T., Inoue,A., Lahti,J.M. and Kidd,V.J.
  TITLE     Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null
            mutant mice at the blastocyst stage of embryonic cell development
  JOURNAL   Mol Cell Biol 24 (8), 3188-3197 (2004)
   PUBMED   15060143
REFERENCE   6  (bases 1 to 2556)
  AUTHORS   Hu,D., Mayeda,A., Trembley,J.H., Lahti,J.M. and Kidd,V.J.
  TITLE     CDK11 complexes promote pre-mRNA splicing
  JOURNAL   J Biol Chem 278 (10), 8623-8629 (2003)
   PUBMED   12501247
REFERENCE   7  (bases 1 to 2556)
  AUTHORS   Cornelis,S., Bruynooghe,Y., Denecker,G., Van Huffel,S., Tinton,S.
            and Beyaert,R.
  TITLE     Identification and characterization of a novel cell cycle-regulated
            internal ribosome entry site
  JOURNAL   Mol Cell 5 (4), 597-605 (2000)
   PUBMED   10882096
REFERENCE   8  (bases 1 to 2556)
  AUTHORS   Kerr,M., Fischer,J.E., Purushotham,K.R., Gao,D., Nakagawa,Y.,
            Maeda,N., Ghanta,V., Hiramoto,R., Chegini,N. and
            Humphreys-Beher,M.G.
  TITLE     Characterization of the synthesis and expression of the GTA-kinase
            from transformed and normal rodent cells
  JOURNAL   Biochim Biophys Acta 1218 (3), 375-387 (1994)
   PUBMED   8049264
REFERENCE   9  (bases 1 to 2556)
  AUTHORS   Xiang,J., Lahti,J.M., Grenet,J., Easton,J. and Kidd,V.J.
  TITLE     Molecular cloning and expression of alternatively spliced PITSLRE
            protein kinase isoforms
  JOURNAL   J Biol Chem 269 (22), 15786-15794 (1994)
   PUBMED   8195233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM031851.1, FM044847.1, DY556124.1, EX490221.1, DY544650.1 and
            AA817907.1.
            
            On May 9, 2012 this sequence version replaced NM_145766.1.
            
            Sequence Note: This RefSeq record was created from transcripts of
            different strains because no single transcript from the same strain
            was available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments and orthologous
            data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-597               FM031851.1         1-597
            598-698             FM044847.1         569-669
            699-940             DY556124.1         119-360
            941-1629            EX490221.1         31-719
            1630-2116           DY544650.1         226-712
            2117-2556           AA817907.1         1-440               c
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2556
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /note="cyclin-dependent kinase 11B"
                     /db_xref="GeneID:252879"
                     /db_xref="RGD:628604"
     exon            1..31
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            32..155
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..2399
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /EC_number="2.7.11.22"
                     /note="PITSLRE serine/threonine-protein kinase CDC2L1;
                     cell division protein kinase 11; cyclin-dependent kinase
                     11; cell division cycle 2-like protein kinase 1;
                     galactosyltransferase-associated protein kinase p58/GTA;
                     cell division cycle 2 homolog-like 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 11B"
                     /protein_id="NP_665709.2"
                     /db_xref="GeneID:252879"
                     /db_xref="RGD:628604"
                     /translation="MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSK
                     RDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKD
                     EKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREH
                     SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM
                     REDYSDKGKVGHWSRSPLRPPRERFELGDNRKPVREEKVEERDLLSDLQDISDSERKT
                     SSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEEETGSNSEEAS
                     EQSAEEVSDEEMSEDEDRENENHILVVPESRFDRDSGDSDEGEEEVGEGTPQSSAPTE
                     GDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTD
                     EIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYV
                     EHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDLKTSNLLLSHAGILK
                     VGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQK
                     PLFPGKSEIDQINKVFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGALLS
                     DQGFDLMNKFLTYFPGRRVSAEDGLKHEYFRETPLPIDSSMFPTWPAKSEQQRVKRGT
                     SPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF"
     exon            156..271
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            272..399
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            400..538
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            539..675
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            676..798
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            799..894
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1059
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1125
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1301
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1392
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1514
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1620
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1742
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1850
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1967
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2116
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2306
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2542
                     /gene="Cdk11b"
                     /gene_synonym="Cdc2l1; Cdk11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccggctgc ggcggctgta gcggcgcagg gtgttttaac tcaaatgggt gatgaaaagg
       61 actcttggaa agtgaaaacg ttagatgaaa ttctccagga aaagaaacga aggaaagaac
      121 aagaggagaa agcagagata aaacgcttaa aaaattctga tgaccgggat tccaaaaggg
      181 attcccttga ggagggggag ctgagagatc atcgaatgga aatcacaatc aggaactcac
      241 catacagaag agaggattct atggaagaca gaggagagga ggatgattct ctggccatca
      301 aaccacccca gcaaatgtct cgaaaagaaa aggctcatca cagaaaagat gagaaaagaa
      361 aagagaagcg tcgacatcgt agtcactcag cagagggagg gaaacatgcc cgagtaaaag
      421 agaaagaaag agaacacgag cggcggaaac ggcatcgaga ggaacaggat aaagcacgaa
      481 gagaatggga aagacagaag aggagggaga tggcaagaga gcattccagg agagagaggg
      541 accgcctgga gcagttagaa aggaagaggg agcgggagcg caagatgagg gagcaacaga
      601 aggaacagcg ggaacaaaag gaacgggaac ggagggcaga ggagcgccgc aaagagagag
      661 aagctcgtag ggaagtctct gcacatcacc gtaccatgag ggaggactac agtgataagg
      721 gaaaggttgg ccactggagc cgcagccctt tgaggccacc aagagagcgc tttgagctgg
      781 gagacaaccg gaagccagtg agagaagaga aggtggaaga aagagacctg ctgtcggacc
      841 tccaggacat cagtgacagt gagaggaaga ccagctcagc tgagtcctca tcagcagaat
      901 caggctcagg ttctgaggag gaggaggagg aggaggagga agaagaggag gaggaaggga
      961 gcaccagtga agagtcagag gaagaggaag aagaggaaga ggaggaagag gaggaggaaa
     1021 ctgggagcaa ctctgaggaa gcctcagaac agtctgctga agaagtcagt gacgaagaaa
     1081 tgagtgaaga tgaagacaga gaaaatgaga accacatctt ggttgttcca gagtcgcgat
     1141 ttgaccgaga ttctggggac agtgatgaag gagaagaaga agttggtgag gggacaccgc
     1201 agagcagcgc ccctaccgag ggagactatg tgcccgactc tccagctctg tcacctattg
     1261 agctaaaaca agagctgccc aagtacctgc cagccctgca gggatgccgg agtgtagagg
     1321 agtttcagtg tctgaacagg attgaagaag gcacctatgg ggtggtctac agagcaaagg
     1381 acaagaaaac agatgagatt gtggctctga agcggttaaa gatggagaag gagaaggaag
     1441 gcttcccaat cacatcactg agggaaatca acaccatcct caaggcccag caccccaata
     1501 tcgtcactgt cagagaaatt gttgtgggaa gcaacatgga caagatctac attgtgatga
     1561 actatgtgga acacgacctc aagagcctaa tggagacaat gaaacagccc ttcctgccag
     1621 gggaggtgaa gaccctgatg attcagctgt tgagtggggt gaagcacctc catgacaatt
     1681 ggatcctaca tcgtgacctt aagacctcta accttctgct gagccatgct ggcattctca
     1741 aggtgggcga ctttgggctg gctcgggagt atggttcacc cctaaaggcc tacactccag
     1801 ttgttgtaac cctgtggtat cgtgccccag aactgctcct tggtgctaag gaatactcca
     1861 cagctgtgga catgtggtca gtgggctgca tatttggaga actgctgaca cagaaacctc
     1921 tgttccctgg gaagtcagag attgatcaga ttaacaaggt tttcaaggac ctggggaccc
     1981 ccagtgagaa aatctggcct ggctataatg acctcccagc cgtcaagaag atgaccttca
     2041 gcgagtatcc ctataacaac ctccgcaagc gattcggagc tttgttatca gatcaaggat
     2101 tcgatctcat gaacaagttt ctgacttact tccctgggag gagggtcagc gcagaagatg
     2161 gcctcaagca cgagtatttc cgagagactc ccctccccat cgactcatcc atgttcccca
     2221 cgtggcctgc caagagtgag cagcagaggg tgaagagagg cacgagtccg aggccccctg
     2281 agggcggcct gggctacagc cagctgggag acgacgacct gaaggagacg ggcttccacc
     2341 tcaccaccac caaccaggga gcctcagctg ctggccctgg cttcagcctc aagttctgag
     2401 gtcagcttga tggacttggc ccgactgggt ggtgacagcc agatctgctg agtcggcagc
     2461 atcattgtcg ttgttactgt tgttctgtgt tgtttggggc aagttgtaaa tttgtagaat
     2521 taaatgaaat tttcttctga aaaaaaaaaa aaaaaa
//
