LOCUS       NM_019296               1187 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Rattus norvegicus cyclin-dependent kinase 1 (Cdk1), mRNA.
ACCESSION   NM_019296
VERSION     NM_019296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1187)
  AUTHORS   Nie,B.X., Zhao,G., Yuan,X.F., Yu,L.X., Zhang,J., Yuan,Y., Liu,Y.,
            Hu,J., Song,E., Zhou,Y.C. and Shu,J.
  TITLE     Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and
            confers neuroprotection after chronic spinal cord injury in vivo
  JOURNAL   J Chem Neuroanat 119, 102053 (2022)
   PUBMED   34839004
  REMARK    GeneRIF: Inhibition of CDK1 attenuates neuronal apoptosis and
            autophagy and confers neuroprotection after chronic spinal cord
            injury in vivo.
REFERENCE   2  (bases 1 to 1187)
  AUTHORS   Gao,L., Wang,C., Qin,B., Li,T., Xu,W., Lenahan,C., Ying,G., Li,J.,
            Zhao,T., Zhu,Y. and Chen,G.
  TITLE     6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses
            Neuronal Apoptosis by Increasing Glycolysis and 'cyclin-dependent
            kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal
            Cord Injury in Rats
  JOURNAL   Cell Transplant 29, 963689720950226 (2020)
   PUBMED   32841050
  REMARK    GeneRIF: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
            Suppresses Neuronal Apoptosis by Increasing Glycolysis and
            ''cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After
            Traumatic Spinal Cord Injury in Rats.
REFERENCE   3  (bases 1 to 1187)
  AUTHORS   Gu,L., Wang,H., Wang,J., Guo,Y., Tang,Y., Mao,Y., Chen,L., Lou,H.
            and Ji,G.
  TITLE     Reconstitution of HuR-Inhibited CUGBP1 Expression Protects
            Cardiomyocytes from Acute Myocardial Infarction-Induced Injury
  JOURNAL   Antioxid Redox Signal 27 (14), 1013-1026 (2017)
   PUBMED   28350193
REFERENCE   4  (bases 1 to 1187)
  AUTHORS   Zhao,X., Hirota,T., Han,X., Cho,H., Chong,L.W., Lamia,K., Liu,S.,
            Atkins,A.R., Banayo,E., Liddle,C., Yu,R.T., Yates,J.R. 3rd,
            Kay,S.A., Downes,M. and Evans,R.M.
  TITLE     Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBalpha
            Degradation
  JOURNAL   Cell 165 (7), 1644-1657 (2016)
   PUBMED   27238018
REFERENCE   5  (bases 1 to 1187)
  AUTHORS   Iimori,M., Watanabe,S., Kiyonari,S., Matsuoka,K., Sakasai,R.,
            Saeki,H., Oki,E., Kitao,H. and Maehara,Y.
  TITLE     Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic
            progression and genome stability
  JOURNAL   Nat Commun 7, 11117 (2016)
   PUBMED   27030108
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1187)
  AUTHORS   Shimizu,M., Ichikawa,E., Inoue,U., Nakamura,T., Nakajima,T.,
            Nojima,H., Okayama,H. and Oda,K.
  TITLE     The G1/S boundary-specific enhancer of the rat cdc2 promoter
  JOURNAL   Mol Cell Biol 15 (5), 2882-2892 (1995)
   PUBMED   7739568
REFERENCE   7  (bases 1 to 1187)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   8  (bases 1 to 1187)
  AUTHORS   Leibovitch,S.A., Guillier,M., Lenormand,J.L. and Leibovitch,M.P.
  TITLE     p34cdc2 protein is complexed with the c-mos protein in rat skeletal
            muscle
  JOURNAL   Oncogene 8 (9), 2361-2369 (1993)
   PUBMED   8395677
REFERENCE   9  (bases 1 to 1187)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   10 (bases 1 to 1187)
  AUTHORS   Riabowol,K., Draetta,G., Brizuela,L., Vandre,D. and Beach,D.
  TITLE     The cdc2 kinase is a nuclear protein that is essential for mitosis
            in mammalian cells
  JOURNAL   Cell 57 (3), 393-401 (1989)
   PUBMED   2541912
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019296.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60767.1, FQ227059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000020.1  19265293-19265368
            77-139              JAXUCZ010000020.1  19268025-19268087
            140-296             JAXUCZ010000020.1  19271706-19271862
            297-420             JAXUCZ010000020.1  19272831-19272954
            421-591             JAXUCZ010000020.1  19275422-19275592
            592-755             JAXUCZ010000020.1  19277593-19277756
            756-897             JAXUCZ010000020.1  19277847-19277988
            898-1187            JAXUCZ010000020.1  19280166-19280455
FEATURES             Location/Qualifiers
     source          1..1187
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..1187
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /note="cyclin-dependent kinase 1"
                     /db_xref="GeneID:54237"
                     /db_xref="RGD:2319"
     exon            1..76
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            77..139
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..996
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="cell division control protein 2 homolog; cell
                     division protein kinase 1; p34 protein kinase; cell
                     division cycle 2 homolog A; cell division cycle 2, G1 to S
                     and G2 to M; Cell division cycle control protein 2"
                     /codon_start=1
                     /product="cyclin-dependent kinase 1"
                     /protein_id="NP_062169.1"
                     /db_xref="GeneID:54237"
                     /db_xref="RGD:2319"
                     /translation="MEDYIKIEKIGEGTYGVVYKGRHRTTGQIVAMKKIRLESEEEGV
                     PSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDS
                     SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY
                     THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR
                     ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRI
                     SGKMALKHPYFDDLDNQIKKM"
     exon            140..296
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            297..420
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            421..591
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            592..755
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            756..897
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1187
                     /gene="Cdk1"
                     /gene_synonym="Cdc2; Cdc2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggcctct aagctcccgg agtcgctgcg tccgcgcagt ccggaactgc ggtgtggcca
       61 ccgcgggaac agagagggtc cgttgtaacc tgttgagtaa ctatggagga ctatatcaaa
      121 atagagaaaa tcggagaagg gacttatggt gtggtatata aaggtagaca caggactact
      181 ggccagatcg tggccatgaa gaaaatcaga cttgaaagcg aggaagaagg agtgcccagt
      241 acggcaatcc gggaaatctc tctgttaaaa gaacttcgac atccaaatat agtcagcctg
      301 caggatgtac tcatgcagga ctccaggctg tatctcatct tcgagttcct gtccatggat
      361 ctcaagaagt acctggactc tatccctcct ggccagttca tggattcttc gctcgttaag
      421 agttacttgt accaaatcct ccaggggatt gtgttttgtc actcccgacg agttcttcac
      481 agagacttga aacctcaaaa tctattgatt gatgacaaag gaacaatcaa actggcagat
      541 ttcggccttg ccagagcgtt tggaataccg ataagagtgt acacacacga ggtagtgacg
      601 ctgtggtacc ggtcgccaga ggtgttgctg ggctcggctc gctactccac cccggttgac
      661 atctggagca tagggaccat atttgcagag ctggcgacca agaagccgct tttccacggc
      721 gactcagaga ttgaccagct cttcaggatc ttcagagctc tgggcacccc taacaacgaa
      781 gtgtggccag aagtagagtc cctgcaggac tacaagaaca ctttccccaa gtggaagccg
      841 gggagcctcg cgtcccacgt caagaacctg gatgaaaacg gcttggactt gctctcgaaa
      901 atgctggtct atgatccagc caaacgaatc tctggaaaaa tggcccttaa gcacccatac
      961 tttgacgact tggacaatca gatcaagaag atgtaaccct ctggaagtcc cgccctgctg
     1021 tggcagggga agatcgtggc gtttactgtt ggctcttcct gtcttgtata gttttctttt
     1081 ctttgtctgt aaaccatcat ctggactttt cctattttcc tacgtataac ttaattaaca
     1141 tgtaaatatt attccatatg aatttaaata taattctgta tatgtgt
//
