LOCUS       NM_138899               1890 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus CDP-diacylglycerol--inositol
            3-phosphatidyltransferase (Cdipt), mRNA.
ACCESSION   NM_138899
VERSION     NM_138899.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1890)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 1890)
  AUTHORS   Lykidis,A., Jackson,P.D., Rock,C.O. and Jackowski,S.
  TITLE     The role of CDP-diacylglycerol synthetase and phosphatidylinositol
            synthase activity levels in the regulation of cellular
            phosphatidylinositol content
  JOURNAL   J Biol Chem 272 (52), 33402-33409 (1997)
   PUBMED   9407135
REFERENCE   3  (bases 1 to 1890)
  AUTHORS   Tanaka,S., Nikawa,J., Imai,H., Yamashita,S. and Hosaka,K.
  TITLE     Molecular cloning of rat phosphatidylinositol synthase cDNA by
            functional complementation of the yeast Saccharomyces cerevisiae
            pis mutation
  JOURNAL   FEBS Lett 393 (1), 89-92 (1996)
   PUBMED   8804431
REFERENCE   4  (bases 1 to 1890)
  AUTHORS   Monaco,M.E., Feldman,M. and Kleinberg,D.L.
  TITLE     Identification of rat liver phosphatidylinositol synthase as a 21
            kDa protein
  JOURNAL   Biochem J 304 (Pt 1) (Pt 1), 301-305 (1994)
   PUBMED   7998949
REFERENCE   5  (bases 1 to 1890)
  AUTHORS   Antonsson,B.E.
  TITLE     Purification and characterization of phosphatidylinositol synthase
            from human placenta
  JOURNAL   Biochem J 297 (Pt 3) (Pt 3), 517-522 (1994)
   PUBMED   8110188
REFERENCE   6  (bases 1 to 1890)
  AUTHORS   Imai,A. and Gershengorn,M.C.
  TITLE     Regulation by phosphatidylinositol of rat pituitary plasma membrane
            and endoplasmic reticulum phosphatidylinositol synthase activities.
            A mechanism for activation of phosphoinositide resynthesis during
            cell stimulation
  JOURNAL   J Biol Chem 262 (14), 6457-6459 (1987)
   PUBMED   3032971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070876.1.
            
            On May 24, 2004 this sequence version replaced NM_138899.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070876.1, EV774338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1890
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1890
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /note="CDP-diacylglycerol--inositol
                     3-phosphatidyltransferase"
                     /db_xref="GeneID:192260"
                     /db_xref="RGD:620576"
     exon            1..437
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1036
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /EC_number="2.7.8.11"
                     /note="PI synthase; ptdIns synthase; phosphatidylinositol
                     synthase"
                     /codon_start=1
                     /product="CDP-diacylglycerol--inositol
                     3-phosphatidyltransferase"
                     /protein_id="NP_620254.1"
                     /db_xref="GeneID:192260"
                     /db_xref="RGD:620576"
                     /translation="MPEENIFLFVPNLIGYARIVFAIISFYFMPCCPFTASSFYLLSG
                     LLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLALLYPRATLLFQLSMSLDV
                     ASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFNF
                     SEGPLVGSVGLFRMGLWITAPIALLKSIISVIHLVTAARNMAALDAADRAKKK"
     exon            438..572
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..726
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..808
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..890
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1863
                     /gene="Cdipt"
                     /gene_synonym="Pis; Pis1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaagcaggc cggccttaaa gggacctcag ccattattta tttaatttat ttatttatat
       61 ttaaaagccg ctctctcctt cctccgatgt tcttaacgtc cccgacggaa gaataggatc
      121 cgggagccag gcgcagccgg agctgcggga cccgttgctg gagacagcag ctcttgccca
      181 tcggaaggcc aggtgtgcgt gagctgtgcc caggggtgtc ccgcgccccg gtgccctgcg
      241 ggctctaaca gctgggatcg cccgggagaa ctgggcccag ggctcaggtg gagctgccga
      301 tgccccgggc tgaaaggtga gaccacgctg gtgaggctgg gacaagacct tgcacctcca
      361 gacctgggcc gagaccacaa ggggagccgc caagatgcca gaggaaaata tcttcctgtt
      421 cgtgcctaat cttattggtt atgcccggat tgttttcgcc atcatttcct tctactttat
      481 gccctgctgc cccttcacgg cctcctcctt ctatctactc agcggacttc tagacgcttt
      541 cgatggacac gcagctcgag cccttaatca aggaacccga tttggggcca tgctcgacat
      601 gctgacggac cgttgcgcca ccatgtgtct cttggtcaac ctggccctgc tctaccctcg
      661 ggccactctt ctgttccagc tcagcatgag cctggacgtg gccagtcact ggctgcatct
      721 gcacagttct gtggtgcgag gcagtgagag ccacaagatg attgacctgt ctgggaaccc
      781 tgtgcttcga atctactata cttccaggcc tgctctgttc accctgtgtg ctggaaatga
      841 actcttctac tgcctcctgt acctgttcaa tttctccgag ggaccactag tcggctctgt
      901 ggggcttttc cgaatgggcc tctggatcac agctcccatt gccctgctca agtccatcat
      961 tagtgtcatc cacctcgtca cggctgcaag gaacatggct gccctcgatg cagcagaccg
     1021 cgccaagaag aaatgatcct ctcccatccc cagctgccca cctgccctgg gtatctactg
     1081 tgccacatgg ctcctctcct cctaagaggt cccagtgtca tgtctttctc atgtgttctc
     1141 taacctgctg ggattggggg tcaccctctg tttggtgttg tcactgtctt tttactcctg
     1201 ataactagac ccaacccgtg accccaagga cctggcactg caaagcagga agggtgctca
     1261 ggaggcccac tcatccagcc ggtgctccag gaggcctgtc tgaagactgg gtgttgccac
     1321 atatcctgct ggatcagcct ggggtctggc ctgagacttt gggaacttat acgggcaaag
     1381 gagtcaggct gatgggccaa gaaggctggg gtaccaggcc agggagggaa ggggccaagg
     1441 gccaactaga tccttccctt aggcaagctc ctctatcctg tcctgctctg gaaacctcca
     1501 taataaaggg gggcaccttc actctttttg gatttgttta ctttgggaca ctcttagatg
     1561 atggcctagg gttcaaagga gctgggtaaa aaaaaaagaa atccacctgg atgcttttcc
     1621 cacaaaggtg gttggctcct ccctgtcatt ccagtgacct cagagaggcc tcgaggttca
     1681 caagcgttgt cctgcccacc tgctctatgt cctggctggc cactttcact gtaaccttga
     1741 tgtttttgac cctcatgaga atgtaagctt cacaagagca gatttagatc tttctcgtct
     1801 ctgcctggag tgaaaagtag cctggcatgt ggtaactgct taataaatat tcatggaaag
     1861 atgaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
