LOCUS       NM_053393               3123 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus cadherin 8 (Cdh8), mRNA.
ACCESSION   NM_053393
VERSION     NM_053393.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Friedman,L.G., Riemslagh,F.W., Sullivan,J.M., Mesias,R.,
            Williams,F.M., Huntley,G.W. and Benson,D.L.
  TITLE     Cadherin-8 expression, synaptic localization, and molecular control
            of neuronal form in prefrontal corticostriatal circuits
  JOURNAL   J Comp Neurol 523 (1), 75-92 (2015)
   PUBMED   25158904
  REMARK    GeneRIF: Results indicate that Cdh8 delineates developing
            corticostriatal circuits where it is a strong candidate for
            regulating the generation of normal cortical projections, neuronal
            morphology, and corticostriatal synapses
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Duan,X., Krishnaswamy,A., De la Huerta,I. and Sanes,J.R.
  TITLE     Type II cadherins guide assembly of a direction-selective retinal
            circuit
  JOURNAL   Cell 158 (4), 793-807 (2014)
   PUBMED   25126785
REFERENCE   3  (bases 1 to 3123)
  AUTHORS   Huntley,G.W., Elste,A.M., Patil,S.B., Bozdagi,O., Benson,D.L. and
            Steward,O.
  TITLE     Synaptic loss and retention of different classic cadherins with
            LTP-associated synaptic structural remodeling in vivo
  JOURNAL   Hippocampus 22 (1), 17-28 (2012)
   PUBMED   20848607
  REMARK    GeneRIF: Loss of cadherin-8 probably represents selective removal
            from synapses rather than overall loss of synaptic junctions.
REFERENCE   4  (bases 1 to 3123)
  AUTHORS   Miloushev,V.Z., Bahna,F., Ciatto,C., Ahlsen,G., Honig,B.,
            Shapiro,L. and Palmer,A.G. 3rd.
  TITLE     Dynamic properties of a type II cadherin adhesive domain:
            implications for the mechanism of strand-swapping of classical
            cadherins
  JOURNAL   Structure 16 (8), 1195-1205 (2008)
   PUBMED   18682221
REFERENCE   5  (bases 1 to 3123)
  AUTHORS   Bekirov,I.H., Nagy,V., Svoronos,A., Huntley,G.W. and Benson,D.L.
  TITLE     Cadherin-8 and N-cadherin differentially regulate pre- and
            postsynaptic development of the hippocampal mossy fiber pathway
  JOURNAL   Hippocampus 18 (4), 349-363 (2008)
   PUBMED   18064706
  REMARK    GeneRIF: Cadherin-8 and N-cadherin are critical for generating the
            mossy fiber pathway, but each contributes uniquely to afferent and
            target differentiation, thereby complementing one another in the
            assembly of a synaptic circuit.
REFERENCE   6  (bases 1 to 3123)
  AUTHORS   Suzuki,S.C., Furue,H., Koga,K., Jiang,N., Nohmi,M., Shimazaki,Y.,
            Katoh-Fukui,Y., Yokoyama,M., Yoshimura,M. and Takeichi,M.
  TITLE     Cadherin-8 is required for the first relay synapses to receive
            functional inputs from primary sensory afferents for cold sensation
  JOURNAL   J Neurosci 27 (13), 3466-3476 (2007)
   PUBMED   17392463
  REMARK    Erratum:[J Neurosci. 2014 Aug 20;34(34):11514]
REFERENCE   7  (bases 1 to 3123)
  AUTHORS   Johnson,K.J., Patel,S.R. and Boekelheide,K.
  TITLE     Multiple cadherin superfamily members with unique expression
            profiles are produced in rat testis
  JOURNAL   Endocrinology 141 (2), 675-683 (2000)
   PUBMED   10650949
REFERENCE   8  (bases 1 to 3123)
  AUTHORS   Kido,M., Obata,S., Tanihara,H., Rochelle,J.M., Seldin,M.F.,
            Taketani,S. and Suzuki,S.T.
  TITLE     Molecular properties and chromosomal location of cadherin-8
  JOURNAL   Genomics 48 (2), 186-194 (1998)
   PUBMED   9521872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AAHX01096923.1, AAHX01096927.1, AAHX01096928.1, AAHX01096929.1,
            AAHX01096931.1, AAHX01096933.1, AAHX01096934.1 and AAHX01096939.1.
            
            On Apr 24, 2008 this sequence version replaced NM_053393.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence from the Celera alternate assembly to make the
            sequence consistent with orthologs. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AAHX01096923.1     113857-114190
            335-785             AAHX01096923.1     128451-128901
            786-1080            AAHX01096927.1     35527-35821         c
            1081-1200           AAHX01096928.1     14518-14637
            1201-1368           AAHX01096929.1     17998-18165
            1369-1556           AAHX01096929.1     21792-21979
            1557-1810           AAHX01096929.1     27656-27909
            1811-1947           AAHX01096931.1     5707-5843
            1948-2069           AAHX01096933.1     9234-9355
            2070-2187           AAHX01096934.1     12271-12388
            2188-2439           AAHX01096939.1     31496-31747
            2440-3123           AAHX01096939.1     33876-34559
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p13"
     gene            1..3123
                     /gene="Cdh8"
                     /note="cadherin 8"
                     /db_xref="GeneID:84408"
                     /db_xref="RGD:69286"
     exon            1..334
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            335..785
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..2933
                     /gene="Cdh8"
                     /codon_start=1
                     /product="cadherin-8 precursor"
                     /protein_id="NP_445845.2"
                     /db_xref="GeneID:84408"
                     /db_xref="RGD:69286"
                     /translation="MPERLAETLLDLWTPLIILWITLPSFVYMAPMNQAHVLTTGSPL
                     ELSRQSEEMRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSG
                     DGAGTIFQINDITGDIHAIKRLDREEKAEYTLTAQAVDWETNKPLEPPSEFIIKVQDI
                     NDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSI
                     EPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKF
                     AQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQD
                     GVIRLRKPLDFETKKSYTLKVEAANIHIDPRFSGRGPFKDTATVKIVVEDADEPPVFS
                     SPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITL
                     ATPLDRELSVWHNISIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENG
                     KPGQVIQTVSAMDKDDPKNGHFFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNR
                     QKQEVYLLPIVISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGAL
                     IAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDI
                     ATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPP
                     YDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESDKE
                     T"
     exon            786..1080
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1200
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1368
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1556
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1810
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1947
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2069
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2187
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2439
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..3123
                     /gene="Cdh8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaagccgg ggagcgctcg gcccagaatt agtggatgga tttggaatct ccctgcctcc
       61 tccaagctcc gccactgcca ctttaggcag agacctgagc gtcaacacgc gagccgtact
      121 tttaggctgc ggacactgag cccagcgcgc cagcttcgca tctccgcacc aggctccaca
      181 gctcggagag gcatgaacgc gatccggagg agactaccct gcgcgcgggg atccgtggac
      241 attagccgct ctcgggaact gacccccagc tccttcagcc atttatgaat ccagaggctt
      301 gagatttttt tccgcatccc ggagcccgac ctgagaaatt tcaatgaaaa ggaaagtcaa
      361 tggatcgtgg tcttggaaaa gctgcttaga catgtctgtt tcccggctct ctgaacccgt
      421 ggcagagctg taagtaagcg cttcacagtg cgtgatgaat tggatggctt cggacccgag
      481 gcaaaaaaaa taattgtctc attttcgtgc tgatttgctt aactggtggg accatgccag
      541 aaaggctagc tgagacgctt ttggacctct ggactccatt aataatatta tggattactc
      601 ttccctcttt tgtgtacatg gctccgatga atcaggctca cgttttaact actggatccc
      661 ctttggaact aagcaggcag agtgaagaaa tgcggatttt gaaccgctcc aaaagaggtt
      721 gggtttggaa tcaaatgttt gttctggaag aattttctgg acctgaaccg attctcgttg
      781 gccggttaca cacagatctg gatcctggga gcaaaaaaat caagtatatc ctatcgggtg
      841 atggagccgg cacaatcttt caaataaacg atataactgg agacatccat gctatcaaaa
      901 gacttgaccg agaggaaaag gctgagtata cgttaacagc tcaggcagtg gactgggaga
      961 caaacaaacc tctcgagcct ccttctgaat ttattattaa ggttcaagac atcaacgaca
     1021 atgcccccga gtttctcaat ggaccttacc atgctactgt tccagagatg tccatcttgg
     1081 gtacatctgt cactaatgta acggccactg atgctgacga tccagtttat ggaaacagtg
     1141 caaagttggt ttacagtatc ttggagggac agccgtattt ttccattgag cctgaaacag
     1201 ctattataaa aactgccctt cctaacatgg acagagaggc caaggaggaa tacctggttg
     1261 taattcaagc caaagatatg ggtgggcatt ccggtggtct gtctggaacc acgacactca
     1321 cagtgacgct taccgatgtg aatgacaatc ctccaaaatt tgctcaaagt ttgtatcact
     1381 tctcagtacc agaagatgtg gtccttggca ctgcaatagg aagggttaaa gccaatgacc
     1441 aggatattgg tgaaaatgca caatcttcct atgacatcat tgatggagat gggacagcac
     1501 tatttgaaat cacttctgat gcccaggcac aggatggtgt tataagacta agaaagcctc
     1561 tggactttga gaccaaaaaa tcctatactc tgaaggtgga ggcagccaat atccacatcg
     1621 acccacgttt cagtggcagg ggacccttta aagatacagc aacagtcaaa attgttgtag
     1681 aggatgctga tgagcctccg gtcttctctt caccgactta cctccttgaa gttcatgaaa
     1741 atgctgcctt gaactctgtg attggccaag tgacagctcg tgaccctgat atcacttcca
     1801 gcccaataag gttttccatt gaccgccaca ctgacttgga gagacagttc aacatcaatg
     1861 cagatgatgg gaagataaca ctggcgaccc cactggacag agaactaagt gtgtggcaca
     1921 acatctccat cattgctact gagatcagga accacagtca gatatcgcga gtgcctgttg
     1981 ctattaaagt gctggatgtc aatgacaacg cccctgaatt cgcgtccgaa tatgaggcat
     2041 ttttatgtga aaatggaaaa cccggccaag tcattcaaac agtaagcgcc atggacaaag
     2101 acgatcccaa aaatggacat tttttcttgt acagtcttct tccagaaatg gtcaacaacc
     2161 caaatttcac catcaagaaa aacgaagata attccctgag cattctggca aaacataatg
     2221 gattcaaccg ccagaagcaa gaagtctacc ttctgcctat cgtgatcagt gacagtggga
     2281 acccccctct gagtagcacc agtaccctga ccatccgcgt ctgtggctgt agcaatgacg
     2341 gcgtggttca gtcgtgcaat gtcgaagctt atgtccttcc tattgggctc agtatgggcg
     2401 cgttaattgc tatattagcc tgcatcattt tgctgctcgt cattgtggtt ctgttcgtta
     2461 ccctgaggcg gcataaaaat gaaccactaa taatcaaaga tgatgaagac gttcgagaaa
     2521 acatcattcg ctacgacgac gaaggaggcg gggaggagga cacagaggct tttgacattg
     2581 caactttgca aaacccagat ggaattaatg gatttttacc ccgtaaggat attaaaccag
     2641 atttgcagtt tatgccaagg caagggcttg ctccagttcc aaatggtgtt gatgtcgatg
     2701 aatttataaa tgtaaggctt catgaggcag ataatgaccc cacggcccca ccatatgact
     2761 ccattcagat ttatggctat gaaggccgag ggtctgtggc tggctctctc agctcgttgg
     2821 agtccaccac atcagactca gaccagaatt ttgactacct cagtgactgg ggtccccgct
     2881 ttaagagact gggcgaactc tactctgttg gtgaaagtga caaagaaact tgacagtgga
     2941 ttacataaat aatcaatgga actgagcatt ctgtaatatt ctagggtcac tccccttaga
     3001 tgcaacaaat gtggctattt gttttagagg caagtttagc accaatcatc tataaactca
     3061 accacatttt aatgttgaac caaaaaaaat aataaaaaat aaaaagtata tgttaggagg
     3121 tga
//
