LOCUS       NM_012927               3639 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cadherin 6 (Cdh6), mRNA.
ACCESSION   NM_012927 XM_346617
VERSION     NM_012927.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3639)
  AUTHORS   Fouillade,C., Baron-Menguy,C., Domenga-Denier,V., Thibault,C.,
            Takamiya,K., Huganir,R. and Joutel,A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   2  (bases 1 to 3639)
  AUTHORS   Marthiens,V., Padilla,F., Lambert,M. and Mege,R.M.
  TITLE     Complementary expression and regulation of cadherins 6 and 11
            during specific steps of motoneuron differentiation
  JOURNAL   Mol Cell Neurosci 20 (3), 458-475 (2002)
   PUBMED   12139922
REFERENCE   3  (bases 1 to 3639)
  AUTHORS   Machell,N.H., Blaschuk,O.W. and Farookhi,R.
  TITLE     Expression and localization of P-, K-, and OB-cadherin in the
            prepubertal rat ovary
  JOURNAL   Mol Reprod Dev 61 (2), 142-154 (2002)
   PUBMED   11803548
  REMARK    GeneRIF: expressed throughout prepubertal ovarian development
REFERENCE   4  (bases 1 to 3639)
  AUTHORS   Hu,E., Chen,Z., Fredrickson,T.A., Spurr,N., Gentle,S., Sims,M.,
            Zhu,Y., Halsey,W., Van Horn,S., Mao,J., Sathe,G.M. and Brooks,D.P.
  TITLE     Rapid isolation of tissue-specific genes from rat kidney
  JOURNAL   Exp Nephrol 9 (2), 156-164 (2001)
   PUBMED   11150865
REFERENCE   5  (bases 1 to 3639)
  AUTHORS   Johnson,K.J., Patel,S.R. and Boekelheide,K.
  TITLE     Multiple cadherin superfamily members with unique expression
            profiles are produced in rat testis
  JOURNAL   Endocrinology 141 (2), 675-683 (2000)
   PUBMED   10650949
REFERENCE   6  (bases 1 to 3639)
  AUTHORS   Xiang,Y.Y., Tanaka,M., Suzuki,M., Igarashi,H., Kiyokawa,E.,
            Naito,Y., Ohtawara,Y., Shen,Q., Sugimura,H. and Kino,I.
  TITLE     Isolation of complementary DNA encoding K-cadherin, a novel rat
            cadherin preferentially expressed in fetal kidney and kidney
            carcinoma
  JOURNAL   Cancer Res 54 (11), 3034-3041 (1994)
   PUBMED   8187093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 5, 2021 this sequence version replaced NM_012927.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            37 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D25290.1, SRR26643287.4994.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               JAXUCZ010000002.1  63952171-63952287   c
            118-481             JAXUCZ010000002.1  63871806-63872169   c
            482-776             JAXUCZ010000002.1  63837054-63837348   c
            777-896             JAXUCZ010000002.1  63833101-63833220   c
            897-1064            JAXUCZ010000002.1  63830452-63830619   c
            1065-1252           JAXUCZ010000002.1  63827395-63827582   c
            1253-1506           JAXUCZ010000002.1  63824892-63825145   c
            1507-1643           JAXUCZ010000002.1  63817797-63817933   c
            1644-1765           JAXUCZ010000002.1  63815288-63815409   c
            1766-1883           JAXUCZ010000002.1  63814121-63814238   c
            1884-2135           JAXUCZ010000002.1  63813729-63813980   c
            2136-3639           JAXUCZ010000002.1  63806135-63807638   c
FEATURES             Location/Qualifiers
     source          1..3639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3639
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="cadherin 6"
                     /db_xref="GeneID:25409"
                     /db_xref="RGD:2322"
     exon            1..117
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            118..481
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..2626
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /note="K-cadherin; kidney cadherin; cadherin 6, type 2,
                     K-cadherin"
                     /codon_start=1
                     /product="cadherin-6 precursor"
                     /protein_id="NP_037059.2"
                     /db_xref="GeneID:25409"
                     /db_xref="RGD:2322"
                     /translation="MRTYRYFLLLFWVGQPYPTFSNPLSKRTSGFPAKRRALELSANS
                     RNELSRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFI
                     INENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFT
                     KDVYTATVPEMADVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIK
                     TALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFK
                     TPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGHDMFDVITDQETQEGIITVKKL
                     LDFEKKRVYTLKVEASNPHIEPRFLYLGPFKDSATVRIVVDDVDEPPVFSKLAYILQI
                     REDAQINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRET
                     LLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQT
                     LHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLL
                     PVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIV
                     ILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEA
                     MEDSKSRRDIVPEALFLPRRTPTARDNTDVRDFISQRLKENDTDPTAPPYDSLATYAY
                     EGTGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGGMDSDKDS"
     exon            482..776
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            777..896
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1064
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1252
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1506
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1643
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1765
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1883
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2135
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..3639
                     /gene="Cdh6"
                     /gene_synonym="KCAD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagagctg cagttccagg cacagcagca agaagcacag agccggcgac cgtggcggag
       61 gcaggagcat cctgggcgag tggcagggtg tccccaggag ccggaaggca aacagagata
      121 ccctctgaaa gccaagcaga gaacattaag gaagaaagga ggaatgagcc tgggtctggt
      181 gcggtgaaaa gagacgcatt aaggaaaggg gaactcacta cccagacgct ccactgccag
      241 ccttgccatc agcatgagaa cttaccggta cttcctgctg ctcttttggg tcggccagcc
      301 ctacccaact ttctcaaacc cgttatctaa aaggactagt ggcttcccag caaagaggag
      361 ggccctggag ctctctgcca acagcaggaa tgagctgagc cgttcaaaaa ggagttggat
      421 gtggaatcag ttcttcctcc tggaggaata cacgggatca gattatcagt acgtcggcaa
      481 gttacattca gaccaggata gaggagatgg atcacttaaa tatatccttt caggagatgg
      541 agcgggagat ctcttcatta tcaatgaaaa cacaggcgac atacaagcca ccaagaggct
      601 ggacagggaa gagaaacccg tttacatcct tcgagcccaa gctatcaaca gaaggacagg
      661 gagacccgtc gagcctgagt ctgaattcat catcaagatc catgacatca atgataatga
      721 gccaatattc accaaggatg tttacacagc cacagtcccc gagatggcag atgtcggaac
      781 atttgtagtc caagtcacag caactgatgc cgatgacccg acgtacggga acagtgctaa
      841 agtcgtgtac agcatcctgc agggacagcc ctacttttca gtggagtcgg aaacaggtat
      901 catcaagaca gcgttgctca acatggatcg agaaaacaga gagcagtacc aagtggtgat
      961 tcaggccaag gacatgggcg gccagatggg aggactgtcg gggaccacga ccgtgaacat
     1021 cacactgaca gatgtcaatg acaatcctcc tcgcttcccc cagagtacct atcagtttaa
     1081 gactcccgag tcttctccac caggaacacc aattggcagg atcaaagcca gtgatgctga
     1141 tgtgggagaa aatgcagaga tcgagtacag catcacagac ggtgagggac atgatatgtt
     1201 tgacgtcatc accgaccagg aaacccagga agggattata actgtcaaaa agctcttgga
     1261 ttttgaaaag aagagagtgt acaccctcaa ggtggaagcc tccaatcccc acatcgaacc
     1321 ccgatttctc tacctgggtc cgttcaaaga ctcggccaca gtgagaatcg tggtagatga
     1381 cgtagatgaa cctcctgtct tcagcaaact ggcctacatc ctacagatac gagaggatgc
     1441 tcagataaac acaaccatag gctctgtcgc agctcaggat cctgacgctg ccaggaatcc
     1501 tgtcaagtac tcggtggata gacacacaga tatggacagg atattcaaca ttgattctgg
     1561 aaatggctcc atttttacat caaaacttct cgaccgggaa acgctgttgt ggcataacat
     1621 cacagtgata gcaacggaga ttaataatcc aaagcaaagc agccgcgtgc ctctatatat
     1681 taaagttctc gacgtcaatg acaatgcccc agaatttgct gagttctatg aaacttttgt
     1741 ctgtgaaaaa gcaaaggcgg atcagctgat tcagaccctg cacgctgttg acaaggatga
     1801 tccttacagt ggacaccaat tctccttctc tttggcccca gaagcagcca gtggctctaa
     1861 ttttaccata caagacaaca aagacaacac tgcagggatc ctaactcgga aaaatggcta
     1921 taacagacac gagatgagca cttatctcct gccggtggtc atttcagaca acgactaccc
     1981 agtccaaagc agcactggga cagtgactgt ccgggtctgt gcatgtgacc accatggaaa
     2041 catgcagtcc tgccacgccg aggccctcat ccaccccaca gggctgagca caggggctct
     2101 ggtggccatc cttctgtgca tcgtgatcct actagtgaca gtggtgctgt tcgcagctct
     2161 gaggcggcag cgaaagaaag agcctttgat catttccaaa gaggacatca gagacaacat
     2221 tgtcagttac aacgacgaag gtggcggaga ggaagacacc caggcctttg atatcggaac
     2281 cctgaggaac cctgaagcca tggaggacag caaatcgcgc agggacattg tgcctgaagc
     2341 tctttttcta ccacggcgga ctccaacagc tcgtgacaac acggatgtca gagatttcat
     2401 tagccaaagg ttaaaggaaa atgacacgga cccaacagcc cctccctacg actccttggc
     2461 cacctatgcc tacgaaggca ctggctcggt ggccgactcc ctgagctcac tagaatcagt
     2521 gaccacagat ggagaccaag attatgacta tttgagtgac tggggccctc ggttcaaaaa
     2581 gctggcagat atgtacggag ggatggacag tgacaaagac tcctaatctg ttgccttttc
     2641 attttccaat atgacactgg aatatgtgac gtggctattc ctttctattt atccactatt
     2701 ccgtgagggg ttctccgttg tacccgttcc aaaagtcaat ggctgcagtc cgtgtggatc
     2761 caatgttaga gacttttttc tagtacactt ttatgagctt ctaagaggca aatttttatt
     2821 ttttagttca tgcagttaac caagttagcc cagcaggcac gctgcgggag gagaggaagg
     2881 aacggcgttt ttcccgtgtt ccccttagag caggttggcc acgcccctta ctgctggcct
     2941 agactctact ttggttcacg gcctccattc cgctgaatgc tccaaatgta catttcacat
     3001 gctacacatg ctaatggaag aagggatcat actttgatga ttaaaaatat agttttagta
     3061 tttaaaaggg gggaggaaac aattgggaaa ttgttcctgg tctatcagtt gtcaaggaga
     3121 taattaacta tgaaggggtt tgtaaggata tgcgtgtgtc aaggaatata aagtggggca
     3181 tcctgtctgt gctggaagag gtgtttctgg catcaacaaa tactcgtaat gctgaatcct
     3241 tccatgttct aagatggctt agaagcaaat caagtggtat catgttcaaa gacagtaacg
     3301 aaagacaggg ctgtgttccc tgacaagatt ttgttgcatg tgataaacag atgcttcacc
     3361 atcatgccaa acaaaggaaa aaagagaaat agctttacaa aaaaaaatta acaaaggaca
     3421 tatttaggga atttcaaggt tttgtactac caacagtatc ccgggtccct tcattctttc
     3481 aactatcagt aaactaatga gaagtaggtc taatcatata agcgtccttg agagaatttc
     3541 ctgaggcaaa tgttaactct ttgtctgtag ttgttgttac tattatccta ctatacctga
     3601 gtgtagcagt gtgaagtaca ataattcata ttcttcaaa
//
