LOCUS       NM_001107407            2550 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus cadherin 5 (Cdh5), mRNA.
ACCESSION   NM_001107407 XM_001057656 XM_226213
VERSION     NM_001107407.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2550)
  AUTHORS   Shuwen H, Xi Y, Miao D, Jiamin X, Jing Z and Weili G.
  TITLE     Nine Genes Mediate the Therapeutic Effects of Iodine-131
            Radiotherapy in Thyroid Carcinoma Patients
  JOURNAL   Dis Markers 2020, 9369341 (2020)
   PUBMED   32626543
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2550)
  AUTHORS   Cao S, Li L, Geng X, Ma Y, Huang X and Kang X.
  TITLE     The upregulation of miR-101 promotes vascular endothelial cell
            apoptosis and suppresses cell migration in acute coronary syndrome
            by targeting CDH5
  JOURNAL   Int J Clin Exp Pathol 12 (9), 3320-3328 (2019)
   PUBMED   31934175
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2550)
  AUTHORS   Xiao ZP, Zhao JL, Rong WL, Jiang JW and Li MH.
  TITLE     Role of Vascular Endothelial-Cadherin and p120-Catenin in the
            Formation of Experimental Intracranial Aneurysm in Animals
  JOURNAL   World Neurosurg 128, e177-e184 (2019)
   PUBMED   30995547
  REMARK    GeneRIF: Decreased expression of VE-cadherin was detected in
            intracranial aneurysm endothelium.
REFERENCE   4  (bases 1 to 2550)
  AUTHORS   Liu L, Meng L, Zhang P, Lin H, Chi J, Peng F and Guo H.
  TITLE     Angiotensin II inhibits the protein expression of ZO-1 in vascular
            endothelial cells by downregulating VE-cadherin
  JOURNAL   Mol Med Rep 18 (1), 429-434 (2018)
   PUBMED   29749551
  REMARK    GeneRIF: these results suggested that Ang II inhibited the protein
            expression of ZO1 in vascular endothelial cells by downregulating
            VEcadherin, thus destroying the tight junctions between endothelial
            cells, which may also be the mechanism by which Ang II is involved
            in the development of cardiovascular diseases.
REFERENCE   5  (bases 1 to 2550)
  AUTHORS   Dorofejeva O and Barr AJ.
  TITLE     Defining the molecular basis of interaction between R3
            receptor-type protein tyrosine phosphatases and VE-cadherin
  JOURNAL   PLoS One 12 (9), e0184574 (2017)
   PUBMED   28926625
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2550)
  AUTHORS   Bulla R, Villa A, Bossi F, Cassetti A, Radillo O, Spessotto P, De
            Seta F, Guaschino S and Tedesco F.
  TITLE     VE-cadherin is a critical molecule for trophoblast-endothelial cell
            interaction in decidual spiral arteries
  JOURNAL   Exp Cell Res 303 (1), 101-113 (2005)
   PUBMED   15572031
REFERENCE   7  (bases 1 to 2550)
  AUTHORS   Soeki T, Tamura Y, Shinohara H, Sakabe K, Onose Y and Fukuda N.
  TITLE     Elevated concentration of soluble vascular endothelial cadherin is
            associated with coronary atherosclerosis
  JOURNAL   Circ J 68 (1), 1-5 (2004)
   PUBMED   14695457
REFERENCE   8  (bases 1 to 2550)
  AUTHORS   Glass R, Loesch A, Bodin P and Burnstock G.
  TITLE     P2X4 and P2X6 receptors associate with VE-cadherin in human
            endothelial cells
  JOURNAL   Cell Mol Life Sci 59 (5), 870-881 (2002)
   PUBMED   12088286
REFERENCE   9  (bases 1 to 2550)
  AUTHORS   Zanetti A, Lampugnani MG, Balconi G, Breviario F, Corada M,
            Lanfrancone L and Dejana E.
  TITLE     Vascular endothelial growth factor induces SHC association with
            vascular endothelial cadherin: a potential feedback mechanism to
            control vascular endothelial growth factor receptor-2 signaling
  JOURNAL   Arterioscler Thromb Vasc Biol 22 (4), 617-622 (2002)
   PUBMED   11950700
REFERENCE   10 (bases 1 to 2550)
  AUTHORS   Morita K, Sasaki H, Furuse M and Tsukita S.
  TITLE     Endothelial claudin: claudin-5/TMVCF constitutes tight junction
            strands in endothelial cells
  JOURNAL   J Cell Biol 147 (1), 185-194 (1999)
   PUBMED   10508865
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474006.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057656.1, XM_226213.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676784,
                              SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2550
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p14"
     gene            1..2550
                     /gene="Cdh5"
                     /note="cadherin 5"
                     /db_xref="GeneID:307618"
                     /db_xref="RGD:1307370"
     exon            1..42
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            43..241
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2392
                     /gene="Cdh5"
                     /note="vascular endothelial cadherin; VE-cadherin"
                     /codon_start=1
                     /product="cadherin-5"
                     /protein_id="NP_001100877.1"
                     /db_xref="GeneID:307618"
                     /db_xref="RGD:1307370"
                     /translation="MQRLTELATALGTFLGLLAVAAMAGPNMLPVHQRQKRDWIWNQM
                     HIDEEKNESLPHYVGKIKSNVNRQNAKYVLQGEQAGKIFRVDADTGDVLAYERLDREK
                     VSEYFLTALIVDKKTNKNLEQPSSFTVKVHDVNDNWPVFTHQVFNASVPEMSAIGTSV
                     IRVTATDADDPTVAGHATVLYQMVKGNEYFAIDNSGLIFTKDKNLDRETRAEYKIVVE
                     AQDAQGLRGESGTATVLIRLEDINDNFPIFTQSTYTFSVPEDIRVGKPLGSLSVEDPD
                     EPQNRMTKYSIMQGEYRDTFTIETDPDRNEGIIKPTKPLDYELIQQYTFHIEATDPTI
                     RLGYLSSTAGKNKAKIIINVLDVDEPPVFQRRFYHFHLPENKKKPLIGTVVAKDPDKA
                     QRSIGYSIRKTSDRGQYFRITKQGNIYNEKELDRETHAWYNLTVEANELDSRGNPVGK
                     ESIVQIYIEVLDENDNAPEFAQPYEPKVCENAAQGKLVVQISATDKDVVPVNTKFKFA
                     LKNEDSNFTLINNHDNTANITVKYGQFNREHTKFHYLPVLISDNGMPSLTGTGTLTVA
                     VCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIFLRRRLRKQAHAHS
                     KSALEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRTGSNKPLRSTMDARPAVYTQVQK
                     PPRLAPSLHGGPREMATMIEVKKEEADNDGGGPPYDTLHIYGYEGTESIAESLSSLST
                     NSSDSDIDYDFLNDWGPRFKMLAELYGSDPQEELII"
     exon            242..530
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            531..647
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            648..812
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1000
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1251
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1394
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1519
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1628
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1874
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2550
                     /gene="Cdh5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcgacaga ctgaagagga gagtcttcag ctcacggaca agatcagctc ctccaagaag
       61 gatgcagagg ctcacagagc tggccactgc tttgggcacc ttcttgggcc tgctggcagt
      121 ggcagcgatg gcaggcccca acatgctgcc tgtccaccag cgccaaaaga gagactggat
      181 ttggaatcaa atgcacatag atgaagagaa aaatgagtcg ctgccccact atgtgggaaa
      241 gatcaagtcc aatgtgaacc gtcagaatgc taagtatgtg ctccaaggag aacaagctgg
      301 caagatcttc agggtcgatg ctgacacagg ggatgtgctt gcctatgaga ggttagaccg
      361 ggaaaaagtc tctgagtact tccttactgc cctcattgtg gacaagaaga ccaacaaaaa
      421 cctggaacaa ccttccagct tcactgtcaa ggtgcatgat gtaaatgaca actggcctgt
      481 gtttacgcac caggtattca acgcatctgt gcccgagatg tcagctatag ggacctctgt
      541 catccgtgtg acagcaacgg atgcagatga ccctacggtg gctggccacg ccactgtctt
      601 gtaccaaatg gtgaaaggaa atgagtactt cgccatcgac aattctggac tcattttcac
      661 aaaggacaaa aacttggaca gagagacacg ggctgaatac aagatcgtgg tggaagcaca
      721 agatgcccag ggtctgcggg gagagtcagg cacagccact gtgctgatca gattggaaga
      781 catcaatgac aacttcccca tctttactca gtccacatac acattttcgg tgcctgaaga
      841 tatccgtgtg ggcaagccct tgggctctct ctctgttgag gacccagatg agcctcagaa
      901 ccggatgacc aaatatagca tcatgcaggg cgagtacagg gacaccttca ccattgagac
      961 agaccccgac cgtaatgagg gtatcatcaa acccacaaag cccctggact atgaactcat
     1021 ccagcagtac acgttccaca tcgaggccac agaccccact atcagactcg gatacctgag
     1081 cagcactgcg ggcaaaaaca aagccaagat catcatcaat gtcctagatg tggatgagcc
     1141 ccctgtcttc cagcgacgct tctaccactt ccacctgccc gaaaacaaga agaaaccact
     1201 gattggcact gtggtggcca aagaccccga caaggctcaa cgcagcatag gatactccat
     1261 ccgcaagacc agtgacagag gccaatactt ccgaataacc aaacaaggga acatctataa
     1321 tgagaaagaa ctggacagag aaacccacgc ctggtataac ctgactgtgg aggccaacga
     1381 attggattct aggggtaacc ctgtaggtaa agaatccatt gtacagattt acattgaagt
     1441 tttggatgag aatgacaacg ccccagaatt tgcccagccc tacgaaccta aagtatgtga
     1501 gaatgctgcc cagggcaagc tggtagtaca gatctctgca acagacaagg acgtggtgcc
     1561 agtaaacaca aagttcaagt ttgccctgaa gaacgaggac agcaacttca ccctcatcaa
     1621 caaccacgac aataccgcca acatcacagt caagtatgga cagtttaatc gggagcatac
     1681 caagttccac tacctgcctg tgctcatctc cgacaatggg atgcccagcc tgactggaac
     1741 cggcacgcta acagtggctg tgtgcaaatg caacgaacag ggcgagttca ccttctgtga
     1801 ggagatggcc gcacaggcgg gtgtcagcat ccaggcactg gtagccatct ttctgtgcat
     1861 cctcaccatc acagtgatca ccttgctgat cttcctgcgg aggcggctcc ggaagcaggc
     1921 gcatgctcat agcaagagtg cgcttgagat tcatgagcag ttggtcacct acgacgagga
     1981 gggcggtggc gagatggaca ccacaagcta cgacgtgtct gtgcttaatt ctgtgcgcac
     2041 cggctccaac aagcctctgc ggtccacgat ggatgcccgg ccagcagtat acacacaggt
     2101 gcagaagcct ccacgactgg cgcctagcct gcacggaggg cccagagaga tggccaccat
     2161 gatcgaggtg aagaaagaag aggcagacaa tgatggcggt ggtcccccct acgatacact
     2221 gcacatctac ggctacgagg gcacagagtc catcgcagag tccctcagct ccctgagcac
     2281 caattcctcc gactctgaca tcgactatga cttcctcaat gactggggac ccaggttcaa
     2341 gatgctggca gagctgtatg gctcagatcc tcaggaagag ctcatcatct agggtttgtg
     2401 gtctttgggc ctggggaccc aatctcattg caacctggat cagacacccg acattgcctt
     2461 ccctgatttc caaggtgtga cacagactct ccaacccagt ggcccttgcc tgtgggtacc
     2521 aaagacactt ccatccccaa ggtagcaaat
//
