LOCUS       NM_001419540            6318 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cadherin 4 (Cdh4), mRNA.
ACCESSION   NM_001419540 XM_039106753
VERSION     NM_001419540.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6318)
  AUTHORS   Niitsuma,K., Hatoko,M., Kuwahara,M., Tanaka,A., Yurugi,S. and
            Iioka,H.
  TITLE     Localization and expression of R-cadherin in skeletal muscle
            following nerve injury
  JOURNAL   Eur Surg Res 37 (2), 79-84 (2005)
   PUBMED   15905612
  REMARK    GeneRIF: R-cadherin plays some role in cells of normal and
            regenerating muscles
REFERENCE   2  (bases 1 to 6318)
  AUTHORS   Slater,S.C., Koutsouki,E., Jackson,C.L., Bush,R.C., Angelini,G.D.,
            Newby,A.C. and George,S.J.
  TITLE     R-cadherin:beta-catenin complex and its association with vascular
            smooth muscle cell proliferation
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (7), 1204-1210 (2004)
   PUBMED   15117735
  REMARK    GeneRIF: R-cadherin expression may be associated with increased
            cyclin D1 expression and VSMC proliferation and may therefore play
            an important role in vascular disease.
REFERENCE   3  (bases 1 to 6318)
  AUTHORS   Dorrell,M.I., Otani,A., Aguilar,E., Moreno,S.K. and Friedlander,M.
  TITLE     Adult bone marrow-derived stem cells use R-cadherin to target sites
            of neovascularization in the developing retina
  JOURNAL   Blood 103 (9), 3420-3427 (2004)
   PUBMED   14726407
REFERENCE   4  (bases 1 to 6318)
  AUTHORS   Andrews,G.L. and Mastick,G.S.
  TITLE     R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer
            axons
  JOURNAL   J Neurosci 23 (30), 9873-9880 (2003)
   PUBMED   14586016
REFERENCE   5  (bases 1 to 6318)
  AUTHORS   Matsunami,H., Miyatani,S., Inoue,T., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Takeichi,M.
  TITLE     Cell binding specificity of mouse R-cadherin and chromosomal
            mapping of the gene
  JOURNAL   J Cell Sci 106 (Pt 1), 401-409 (1993)
   PUBMED   8270638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 7, 2023 this sequence version replaced XM_039106753.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.20684.1,
                                           SRR26360190.2403637.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JAXUCZ010000003.1  186902763-186903006
            245-356             JAXUCZ010000003.1  186905094-186905205
            357-589             JAXUCZ010000003.1  187255890-187256122
            590-763             JAXUCZ010000003.1  187276591-187276764
            764-919             JAXUCZ010000003.1  187321490-187321645
            920-1064            JAXUCZ010000003.1  187326320-187326464
            1065-1237           JAXUCZ010000003.1  187339879-187340051
            1238-1375           JAXUCZ010000003.1  187355313-187355450
            1376-1561           JAXUCZ010000003.1  187362928-187363113
            1562-1815           JAXUCZ010000003.1  187367080-187367333
            1816-1958           JAXUCZ010000003.1  187367919-187368061
            1959-2192           JAXUCZ010000003.1  187370402-187370635
            2193-2426           JAXUCZ010000003.1  187372492-187372725
            2427-2566           JAXUCZ010000003.1  187374739-187374878
            2567-2731           JAXUCZ010000003.1  187375593-187375757
            2732-6318           JAXUCZ010000003.1  187377434-187381020
FEATURES             Location/Qualifiers
     source          1..6318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..6318
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /note="cadherin 4"
                     /db_xref="GeneID:114588"
                     /db_xref="RGD:621091"
     exon            1..244
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2938
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /note="R-CAD; R-cadherin; retinal cadherin; cadherin 4,
                     type 1, R-cadherin (retinal)"
                     /codon_start=1
                     /product="cadherin-4 precursor"
                     /protein_id="NP_001406469.1"
                     /db_xref="GeneID:114588"
                     /db_xref="RGD:621091"
                     /translation="MTRGSVLPLLLLGLSGALRAHHEDLTVREACKAGFSEEGYTALI
                     SPNVVEGEKLLKVKFSSCVDTKGTQYETNSLDFKVRADGTVFATRELKIPSEQVAFTV
                     TARERQSAEQWDAMVRLLVAQTSSSSAHSEHKKGKTVALDPSQLPKDTLLPWPQQHQS
                     SGGLRRQKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPME
                     VFNIDSMSGRMYVTRPMDREERASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPE
                     FINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTIN
                     SETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEF
                     TTSTFAGEVPENRIETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTN
                     EGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISVTDVNEAPYFP
                     SNHKLIRLEEGVPAGTALTTFSAVDPDRFMQQAVRYSKLSDPANWLHINTSNGQITTA
                     AVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQLYLIDINDNAPQLLPKEAQICE
                     RPGLNAINITAADADMDPNIGPYVFELPFIPTTVRKNWTITRLNGDYAQLSLRILYLE
                     AGVYDVPIIVTDSGNPPLSNTSVIKVKVCPCDENGDCTTVGAVAAAGLGTGAIVAILI
                     CIVILLTMVLLFVVWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLS
                     QLQQPEAMEHVLSKAPGVRRVDERPVGAEPQYPVRPVVPHPGDIGDFINEGLRAADND
                     PTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGE
                     ED"
     exon            245..356
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            357..589
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            590..763
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            764..919
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1064
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1237
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1375
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1561
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1815
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1958
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2192
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2426
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2566
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2731
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..6318
                     /gene="Cdh4"
                     /gene_synonym="Cdh4l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcgcgg gcggctgcga ggccggcgga cgcaccggcc ggagggagcg cgccgccggc
       61 ccacttggcc tggctcccgg agcccgggcg gcgagcgcgg ggagcagcag ggcgggcgcg
      121 ggcggagcat cgccgcggcg agggaagccg ggcaccgggc gagcgccggg gcggcgcggc
      181 ggggacgatg accaggggct cggtgctgcc gctgcttctg ctcgggctct cgggcgcgct
      241 ccgggcccac catgaggatc ttacagtcag agaggcctgc aaggctggct tctccgaaga
      301 aggctacact gcgttgatct ccccgaatgt cgtggaagga gagaaactac tcaaagttaa
      361 gttcagcagc tgcgtggaca ccaaagggac gcagtatgag accaacagct tggacttcaa
      421 agtcagggct gatgggacag tcttcgccac tcgggagttg aagatcccct cagagcaggt
      481 ggcctttacc gtaactgcac gggaacgcca gagcgctgag caatgggacg ccatggtacg
      541 gctgctggta gcccagacat catcgtcatc ggcacactct gaacacaaga aagggaagac
      601 agtggccctg gacccctctc agctcccgaa ggacacactg ctgccatggc ctcaacaaca
      661 ccagagctcc ggagggctga ggaggcagaa gcgtgactgg gtcatcccac ccatcaacgt
      721 tcccgagaac tcccgtgggc ccttccccca gcagctcgtc aggatcaggt cggacaaaga
      781 caatgacatc cccatccgct acagcatcac gggggtaggc gccgaccagc cccccatgga
      841 ggtcttcaac atcgactcca tgtctggccg gatgtatgtt actcggccca tggacagaga
      901 ggaaagagcc tcttaccacc tccgagccca cgcagtggat atgaacggta acaaggtgga
      961 gaatccgatt gatctgtata tctacgtcat cgacatgaat gacaaccgtc ccgagttcat
     1021 caaccaggtc tacaacggct ctgtggatga gggctccaag ccaggtacat acgtaatgac
     1081 ggtcaccgcc aacgatgcag atgacagcac cacagccaac ggcatggtga gataccggat
     1141 tgtcacccag acgccccaga gcccatccca gaacatgttc accatcaaca gtgagacagg
     1201 ggacatcgtg actgtggcag cgggcctgga ccgagagaaa gtccagcagt acacggtcat
     1261 cgtccaggcc actgacatgg aaggaaacct taattatggt ctctcgaaca cggccacggc
     1321 catcatcacg gtgacagacg taaatgacaa ccctccagaa ttcaccacca gcacatttgc
     1381 aggagaggtc cccgaaaacc gtatagagac agtagtggcc aacctcacag tgatggaccg
     1441 agaccagccc cactcaccca actggaatgc tgtctaccga atcataagtg gagacccctc
     1501 cgggcacttc agtgtccgca cagaccctgt gaccaatgag ggcatggtca ccgtggtgaa
     1561 ggcagtggac tatgagctga accgtgcctt catgctgacc gtaatggtat ccaaccaggc
     1621 gcccctggcc agcgggatcc agatgtcctt ccagtccaca gcgggggtaa ccatctctgt
     1681 caccgatgtc aacgaagccc cctacttccc ctccaaccat aaactgatcc gcctggaaga
     1741 gggtgtgcct gccgggacgg ctctcaccac tttttctgca gtggaccctg accggttcat
     1801 gcagcaagcc gtgaggtact cgaaactgtc tgatcccgcc aactggctgc acatcaacac
     1861 atccaatggg cagatcacca cggccgcagt cctggaccga gagtccctct ataccaagaa
     1921 caatgtatat gaggccacct tcctggctgc tgacaatggg atccccccag ccagtggcac
     1981 tgggaccctg cagctctacc tcatcgatat caatgacaac gcaccacagc tgctgcccaa
     2041 ggaggcacag atctgcgaga ggcctggcct caacgccatc aacatcaccg cagccgacgc
     2101 cgatatggac cccaacatcg gcccttacgt ctttgagttg cccttcatcc ccactacggt
     2161 gaggaagaat tggaccatca cccgcctaaa tggtgactat gcccagctca gtttgcgcat
     2221 tctgtacctg gaagcagggg tgtatgacgt ccccatcatt gtcacggact ctggcaaccc
     2281 tcccctgtcc aacacatccg tcataaaggt caaggtgtgc ccgtgcgatg agaatggcga
     2341 ctgtaccacg gtcggtgcag tggctgcagc tggcctgggc acgggcgcca tcgtggcgat
     2401 cctcatctgc atcgtgatcc tgctaaccat ggtcctgctg ttcgttgtgt ggatgaagcg
     2461 gagggaaaag gagagacaca cgaagcagct gctcatcgac cctgaggacg acgtgaggga
     2521 caacatcctg aagtacgacg aggaaggcgg cggcgaggag gaccaggact acgacctcag
     2581 ccagctacaa cagccagaag ccatggagca tgtgctgagc aaggcccctg gtgtgcggcg
     2641 agtggatgaa cggccagtag gtgccgaacc ccagtaccca gtcaggcctg tggtgccaca
     2701 cccaggagac attggagact tcatcaatga gggactccga gctgctgaca atgaccctac
     2761 cgcacccccc tatgactccc tgctggtctt cgactacgaa ggcagcggtt ctactgcagg
     2821 ctctgtcagc tccctgaact cctccagctc cggggatcaa gattacgact acttgaatga
     2881 ctgggggccc cggttcaaga agttggcgga catgtatggg ggtggcgagg aggactaacc
     2941 gacctcacca ccgtcgtgag aagggcacta gaggctgagc agcagaactg agccaaggtg
     3001 ccagagccgt ctggtgtcga gagatccctc cccgctgccg tccccgcgcg gagctctgca
     3061 gtatggacgg acacaggcca ccgggcaccc accatcgctg cggcatctcg gtagtcacag
     3121 ccacgtaccg tgaagggaga gccagaggca cagccctaac ttgaatttct taccacaaaa
     3181 gcactgttaa aacaaaacaa acaaacaaaa aaacaaaaca aaacaaaagt gccttttggt
     3241 acatgacaga ttccctaact caggagtgac tgaaagagga gagacagccc gagaccccca
     3301 cttctgtcca ccccgcccca cagccacagc cccattaggt accttctgaa ggtggtgagc
     3361 aatgggagac aatgtccttt tttattttta aagcctttta ttaagaaaca gaaagtaggt
     3421 aacttatttg caaaaacaga tctcaacagc ttctgttagg catagccagc gtctcctggg
     3481 ccctttggcc tccccgaggc tgttaggtga ggatcaggct ttccagcacc aaaaaagcac
     3541 tgggccagcc caaccccatc agcagagcca cttctgtgtg gactaggcct tcacctgaat
     3601 gtttgctctg cccctacaca ctgtaagtag ctggggcagg tgtgacgcct gaagaccttc
     3661 ccgggagtcc tcacctctcc acttggccac tgccacaccc tcaagtccac cataaagcct
     3721 ctctctggac cagctgtcgc ccccaatccc accgaagtcc cctttttgct ttggtctggg
     3781 acagtccatt gtctaagaag ctgcagcatc ctgcagaacc ctagtccagc catccactct
     3841 tcaggatgag accccgaggg atcccgttga aggcatagca atcacaaacc ctccactcag
     3901 cggacccctg aacgctctca acaccctccc caggctgtgc agacgcagac gcaaaaggca
     3961 gagcctggcc ggactccggc agctgcttgg cctccttggg ctcggctaac ctgagctccc
     4021 acctggtccc atgaactgct atggatgtga ggacctacca agaggccggc gagattacct
     4081 tgctgtgccc ctgtgaccac agagggaccc atgtttctgt tgttctctgg agctggtggg
     4141 gcacttaacc acggcagctt gagcgtgggg cgaactgggc agggtgaccg cttctgcagg
     4201 acagcaaaga ggccatgtac aagaacctac gggagatggc aaagcttacc ttttcactag
     4261 aggggaaaac agacctagga cgttcacatg tctgggccca aaagagccct gggatggggc
     4321 agaaaggcag gcaccaatga agcatcctgt gctgagtctt cctggcttac cccatgctat
     4381 aagatactcc caaggaaggg gttgaagagt gctgattgct tgggagacct tggtgtcaga
     4441 gtcttcttgg ggagacaaca gaagtcccgg cattgaggag aaataagttt cttccagatc
     4501 tctaacccat acctacaact ggggggtcag ggagatctca aaagggctgg gggtccccag
     4561 gagatcgcat gctcccttgc caggggtctc taatccatgg ctccccttgg cttctttact
     4621 ccgttgctag atcccctttc ccagactgct ttggcctcaa agatgcacct gagtgaactc
     4681 acaggtgccc aactcgtggg tatgacccat tggatgtcag ggttctttcc caaatcaaac
     4741 ccatgcccac ctctgaactc ctggacttga gctgggtttc tagctcacct gtgtctcctc
     4801 actcctcata ccgctgtcct aggagggggg atgaacaggg gcctctgtcc cttcctgggt
     4861 gtccccctgc ctacagccag cagtgctcgt gaagggggat gggagggctg tcctatgcaa
     4921 attgctcaaa tcgggtggtg ctgagcttgg catggccact ggtgggatgg actgttgagg
     4981 gttagggctg gggagttgaa aatgattttt ctgggtttga ttttagaaaa cccaagaagg
     5041 ttcttggaag tgtgcatatg tttggtaggc acgggaggca agaactctcc tgaaatccca
     5101 aggctttctt agaagcctag gacgggaggt accaaaccca tcagttacct ggaggcatgt
     5161 ctcacctgcc tccacctcct tctccctacc ctccaaggcc tctgtcactg ccaggcccct
     5221 gcaggagctt gtccctttca ccctacaccc cagtgagccc ctagggctag aggaagatag
     5281 ggttctacac acacccccag acccatcttg gaactccgtt cccaggccaa caagttagca
     5341 ttagccaagc atacagtcag tgtcaaatgt ttctcttctg tagcttgtag atacaatgcg
     5401 tctatggtca gggcccagcc aacctaggct ggtggccagc tccgtgcagt gtgaggatgt
     5461 ggtttggttc ctttaaggag aaacctatac cactgagtgg cttggaagaa caacacctgg
     5521 ccacggtcag cctcggtcac acctgactcc ccggccggca gcttttctct ctcatgtctt
     5581 tcagcacatc caaaatgctg ggtctcctgc caccaaaatg tcagagtaat ggccaacatc
     5641 aggccctcag agatgcctca gtttccccat agtgagtatg tggtccattg agacgacacc
     5701 tctgtgctct ctaaggtaaa caggagggga agtctctatt tccacccaca ccgaaaggca
     5761 aaaccaaaaa cccacagcag aatctccctg cacagagcac cgggtgtggt agtgcataga
     5821 ccacatacct agcaggctct accacaccag tcagccggtg gaaaccacct ccgtgtacac
     5881 cggggacgca tcttgctttt ccttcctctc ctgttttcca ttgatttatt ttctgcatgt
     5941 ttatttttga aaatggacaa atgtgtagca gcccgcatga ccgtggttgt ttcgggaaag
     6001 ataccggagt atgatgtgct cacactgcag ctctgagcgc catgcggtga gacagacgtt
     6061 ccgacttttt ttgtaatcgt caacagcaca aatattttgt attgtcgttt gtatcatttt
     6121 gtaccgaaaa agaaaaaaga aaaaaaaaaa caaaacaaga acaaaaaggg aagagagttg
     6181 atgtttttcg atgtgttttt agtgccaggc agtcttggtt ccggagggaa cgcagctttg
     6241 cggaattgtc gtgtccagga gtggagtcgg gcgttagcac gctgctccaa aggaggaaat
     6301 aaagtcccct ttgaagta
//
