LOCUS       NM_053938               3458 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cadherin 3 (Cdh3), mRNA.
ACCESSION   NM_053938 XM_001076282 XM_226426
VERSION     NM_053938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3458)
  AUTHORS   Samuelov,L., Sprecher,E., Sugawara,K., Singh,S.K., Tobin,D.J.,
            Tsuruta,D., Biro,T., Kloepper,J.E. and Paus,R.
  TITLE     Topobiology of human pigmentation: P-cadherin selectively
            stimulates hair follicle melanogenesis
  JOURNAL   J Invest Dermatol 133 (6), 1591-1600 (2013)
   PUBMED   23334344
REFERENCE   2  (bases 1 to 3458)
  AUTHORS   Halford,S., Holt,R., Nemeth,A.H. and Downes,S.M.
  TITLE     Homozygous deletion in CDH3 and hypotrichosis with juvenile macular
            dystrophy
  JOURNAL   Arch Ophthalmol 130 (11), 1490-1492 (2012)
   PUBMED   23143461
REFERENCE   3  (bases 1 to 3458)
  AUTHORS   Samuelov,L., Sprecher,E., Tsuruta,D., Biro,T., Kloepper,J.E. and
            Paus,R.
  TITLE     P-cadherin regulates human hair growth and cycling via canonical
            Wnt signaling and transforming growth factor-beta2
  JOURNAL   J Invest Dermatol 132 (10), 2332-2341 (2012)
   PUBMED   22696062
REFERENCE   4  (bases 1 to 3458)
  AUTHORS   Guo,Q.Y., Miao,L.N., Li,B., Ma,F.Z., Liu,N., Cai,L. and Xu,Z.G.
  TITLE     Role of 12-lipoxygenase in decreasing P-cadherin and increasing
            angiotensin II type 1 receptor expression according to glomerular
            size in type 2 diabetic rats
  JOURNAL   Am J Physiol Endocrinol Metab 300 (4), E708-E716 (2011)
   PUBMED   21285403
  REMARK    GeneRIF: Diabetic proteinuria is mediated by the activation of
            12-LO pathway that is partially attributed to the decreased
            glomerular P-cadherin expression.
REFERENCE   5  (bases 1 to 3458)
  AUTHORS   Pospechova,K., Kopecky,M., Nachtigal,P., Pospisilova,N.,
            Jamborova,G. and Semecky,V.
  TITLE     Changes in the expression of P-cadherin in the normal, cryptorchid
            and busulphan-treated rat testis
  JOURNAL   Int J Androl 30 (5), 430-438 (2007)
   PUBMED   17298545
REFERENCE   6  (bases 1 to 3458)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
REFERENCE   7  (bases 1 to 3458)
  AUTHORS   Zhou,S., Matsuyoshi,N., Liang,S.B., Takeuchi,T., Ohtsuki,Y. and
            Miyachi,Y.
  TITLE     Expression of T-cadherin in Basal keratinocytes of skin
  JOURNAL   J Invest Dermatol 118 (6), 1080-1084 (2002)
   PUBMED   12060406
REFERENCE   8  (bases 1 to 3458)
  AUTHORS   Machell,N.H., Blaschuk,O.W. and Farookhi,R.
  TITLE     Expression and localization of P-, K-, and OB-cadherin in the
            prepubertal rat ovary
  JOURNAL   Mol Reprod Dev 61 (2), 142-154 (2002)
   PUBMED   11803548
  REMARK    GeneRIF: expressed throughout prepubertal ovarian development
REFERENCE   9  (bases 1 to 3458)
  AUTHORS   Johnson,K.J., Patel,S.R. and Boekelheide,K.
  TITLE     Multiple cadherin superfamily members with unique expression
            profiles are produced in rat testis
  JOURNAL   Endocrinology 141 (2), 675-683 (2000)
   PUBMED   10650949
REFERENCE   10 (bases 1 to 3458)
  AUTHORS   Smythe,W.R., Williams,J.P., Wheelock,M.J., Johnson,K.R.,
            Kaiser,L.R. and Albelda,S.M.
  TITLE     Cadherin and catenin expression in normal human bronchial
            epithelium and non-small cell lung cancer
  JOURNAL   Lung Cancer 24 (3), 157-168 (1999)
   PUBMED   10460003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 28, 2014 this sequence version replaced NM_053938.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1379584.1,
                                           SRR26643285.53614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               JAXUCZ010000019.1  51303556-51303948
            394-511             JAXUCZ010000019.1  51304163-51304280
            512-585             JAXUCZ010000019.1  51330032-51330105
            586-711             JAXUCZ010000019.1  51331188-51331313
            712-867             JAXUCZ010000019.1  51331465-51331620
            868-1012            JAXUCZ010000019.1  51331722-51331866
            1013-1188           JAXUCZ010000019.1  51334362-51334537
            1189-1317           JAXUCZ010000019.1  51335170-51335298
            1318-1503           JAXUCZ010000019.1  51336851-51337036
            1504-1745           JAXUCZ010000019.1  51339348-51339589
            1746-1891           JAXUCZ010000019.1  51339811-51339956
            1892-2116           JAXUCZ010000019.1  51340876-51341100
            2117-2326           JAXUCZ010000019.1  51343631-51343840
            2327-2457           JAXUCZ010000019.1  51350232-51350362
            2458-2604           JAXUCZ010000019.1  51350658-51350804
            2605-3458           JAXUCZ010000019.1  51353047-51353900
FEATURES             Location/Qualifiers
     source          1..3458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3458
                     /gene="Cdh3"
                     /note="cadherin 3"
                     /db_xref="GeneID:116777"
                     /db_xref="RGD:621089"
     exon            1..393
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2814
                     /gene="Cdh3"
                     /note="cadherin 3, type 1, P-cadherin (placental)"
                     /codon_start=1
                     /product="cadherin-3 precursor"
                     /protein_id="NP_446390.2"
                     /db_xref="GeneID:116777"
                     /db_xref="RGD:621089"
                     /translation="MELLSGPLVFLLLLLQVCWLRSVVSESYREDFIREAGVTLEVGG
                     TDLEPSQALEKEALAGHEVLGADSGGIITLNRETVQGGKGVMNSPPSRILRRRKREWV
                     MPPISVPENGKGPFPQRLNQLKSNKDRGTKLFYSITGPGADSPPEGVFTIEKETGWLL
                     LNMPLDREKIVKYELFGHAVSENGASVEEPMNISIIVTDQNDNKPKFTQDTFRGSVPE
                     GVMPGTSVMQVTATDEDDAINTYNGVVAYSIHSQEPKEPHDLMFTIHKSTGTISVISS
                     GLDREKVPEYTLTIQATDMDGDGSTTTAEAVVQILDTNDNAPEFQPQKYEAWVPENAV
                     GHEVQRLTVTDLDSPNSPAWRATYHIVGGDDGDHFTVATHPETNQGILTTKKGLDFEA
                     QNQHTLYIEVTNEASFAVKLPTATATVVVHVEDVNEAPVFVPPSKVIEAQEGISIGEL
                     VCVYTAQDPDKEEQKISYSILRDPASWLAVDPDSGQITAAGILDREDEQFVKNDIYEV
                     MVLATDNGNPPTTGTGTLLLTLTDINDHGPIPEPRQIIICNQSPVPQVLNITDKDLSP
                     NSSPFQAQLTHDSDIYWMAEVSEKGDTVALSLKKFLKQDTYDLHLSLSDHGNREQLTM
                     IRATVCDCHGQVLNDCPRPWKGGFILPVLGAVLALLTLLLALLLLVRKKRKVKEPLLL
                     PEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTFIPTPMYRPR
                     PANPDEIGNFIIENLKAANTDPTAPPYDSLLVFDYEGSGSDAASLSSLTSSTSDQDQD
                     YNYLTEWGSRFKKLADMYGGGEDD"
     exon            394..511
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            512..585
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            586..711
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            712..867
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1012
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1188
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1317
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1503
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1745
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1891
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2116
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2326
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2457
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2604
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..3458
                     /gene="Cdh3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggtgaag tggattgggg gttttgtttt gttacatttg ttccattgaa gccagaaact
       61 gcgagagcca cggggtacct ttcagaagta gttccagaag agcagggagg acggaggagg
      121 gtaccgggga ggacctttag gagcttcggg agcgacttcg gcaagctggt ctggactcca
      181 cctgcgaggg ggcgggaccc tgtgacgttt gaccaatcag cagctacctg agcgcacctg
      241 gcctcctccc gcgggctcta gcgagccgcg ttgctcaaag ctgcaccggg agcttagcgg
      301 aacgcttggc taccgtcgcg gcagcctcct cacctccctt cagtcatgga gctgcttagt
      361 gggcccctgg tcttcctgct cctcctgctc caggtttgct ggctacgcag cgtggtctcc
      421 gagtcctacc gggaggactt catccgggag gctggagtga ccttggaggt gggaggaact
      481 gacctggagc cgagccaagc gctagagaaa gaggcattgg ctggacacga ggtgctcggt
      541 gcagacagtg gaggaatcat tacactgaat agggagacag tccagggagg gaagggtgtg
      601 atgaactccc caccctcacg catcttacgg agacgaaaga gagagtgggt gatgccacca
      661 atatcggtcc ctgagaatgg caaaggtcct tttcctcaga ggctgaatca gcttaaatct
      721 aataaggaca gaggcaccaa gcttttctac agcatcacgg ggcctggagc tgacagtccc
      781 cctgagggag tcttcaccat agagaaggag acgggctggc tgctgttgaa tatgccactg
      841 gacagggaga aaattgtcaa gtatgagctt tttggccacg ctgtatctga gaatggtgcg
      901 tctgtagagg agcccatgaa catatccatc attgtgacag atcagaatga caacaagccc
      961 aagttcactc aagacacctt cagagggagt gttccggagg gggtaatgcc tggcacttct
     1021 gtgatgcagg tgacagccac agatgaggac gacgccatca atacttacaa tggggtggtg
     1081 gcttactcca tccatagcca agagccgaag gagccacacg acctcatgtt caccatccat
     1141 aaaagcactg ggactattag cgtcatctcc agtggcctgg atagagagaa agtccctgag
     1201 tacacactga ccatccaggc cacagacatg gacggagacg gctctaccac aacagccgag
     1261 gccgtagtgc agatccttga taccaatgat aacgctccag agttccagcc gcaaaagtat
     1321 gaggcttggg tgcctgagaa tgcagtgggc cacgaggtac agaggctgac agtgaccgat
     1381 ctggattccc ccaactcacc ggcatggcgt gccacctacc acattgtggg aggtgacgat
     1441 ggggatcatt tcaccgtggc cactcaccca gagaccaacc aaggcatcct gacaaccaag
     1501 aagggtttgg attttgaggc tcagaaccaa cacaccctgt acatagaagt gaccaacgag
     1561 gcttcctttg cagtgaagct cccgactgcc accgccaccg tggtggtcca tgtggaagat
     1621 gtcaacgagg cccctgtgtt tgttccacct tccaaggtca ttgaggccca ggaaggcatc
     1681 tctattgggg aactggtctg tgtctatact gcacaggacc ctgacaagga ggaacagaag
     1741 atcagctaca gcatcttgag agacccagcc agctggcttg ctgtggaccc ggacagtggt
     1801 cagataacgg ctgcaggcat cttagatcgt gaggacgagc agtttgtgaa aaacgacatc
     1861 tacgaagtca tggtgttggc cacagacaat ggaaaccctc ccaccaccgg cactgggacc
     1921 ctcctgctaa cacttactga catcaatgac catggcccaa tccctgaacc tcgtcagatc
     1981 atcatctgta accaaagccc cgtgcctcaa gtgctgaaca tcacagacaa ggacctgtcc
     2041 cccaactcct cccctttcca ggcccagctc acacatgatt cagatatcta ctggatggca
     2101 gaagtcagcg agaaaggaga caccgtggcc ttgtccctga agaagttcct gaagcaagac
     2161 acatatgact tgcacctttc tttgtctgac catggcaacc gggaacagct aaccatgatc
     2221 agggccactg tgtgtgactg ccacggccag gtgttgaatg actgccccag accctggaaa
     2281 ggtggcttca tcctccccgt cctgggtgct gtcctggctc tactgaccct tcttctggcg
     2341 ctccttctgt tggtgagaaa gaagaggaag gtcaaagagc cccttctgct cccagaggat
     2401 gacactcgtg acaatgtctt ctattatgga gaagagggtg gtggcgaaga ggaccaggac
     2461 tatgacatca ctcaactcca ccggggacta gaggccaggc ctgaggtggt tctccgcaac
     2521 gacgtggcac caaccttcat ccccaccccc atgtaccgcc cccggcccgc caacccagat
     2581 gaaatcggca acttcatcat cgagaacctg aaagctgcca acacagaccc cactgctcct
     2641 ccctacgact ccctgctggt gtttgactac gagggcagtg gctctgatgc tgcctccctg
     2701 agctccctca cctcctccac ctctgatcag gaccaggact acaactacct taccgagtgg
     2761 ggaagtcgat tcaagaaact ggctgacatg tatggtggcg gtgaggatga ctagactggc
     2821 cggccatgct gtccaggcaa gaactacaga caggtcacag cagcatctca ggggagctct
     2881 cactcctgct cctgaggact ctgaagctcg ccaggaagtc gcccgcaaag caggctgcat
     2941 ctgacatgaa ggctagactg tgagcctttc aaatgggagg atgtgactct gacttcaaca
     3001 ctgatccccc tcagccgatg ctgagccctc agaatggact gtctagaggt ctcccgcctg
     3061 ccacacaggg ctcagggcag aacttgctct gatgcccttg gtgactttct ccacttgaat
     3121 ggctctctct ttagaaagag acctctcact aaggcccctt tttcctttaa tgcagttttc
     3181 ataaagaggc tcagggtggg gcagggtgca gacatcagtc tcccttcagg ccctccagaa
     3241 gagaagccta cagggcactg gccctggtac atttctctga tctccaggtc ttgaggcctc
     3301 acattgggag ggataaatgc tttttttttt ttttttaatg agtatatcta agttgtcttg
     3361 tattttttta ttttccctga tgtgtgctgt agatggagag tgatgacaat cgtgtaaatg
     3421 tactagaatt tttttattaa aatgaacttt ttcccaga
//
