LOCUS       NP_446390                822 aa            linear   ROD 31-MAR-2024
DEFINITION  cadherin-3 precursor [Rattus norvegicus].
ACCESSION   NP_446390 XP_001076282 XP_226426
VERSION     NP_446390.2
DBSOURCE    REFSEQ: accession NM_053938.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 822)
  AUTHORS   Samuelov,L., Sprecher,E., Sugawara,K., Singh,S.K., Tobin,D.J.,
            Tsuruta,D., Biro,T., Kloepper,J.E. and Paus,R.
  TITLE     Topobiology of human pigmentation: P-cadherin selectively
            stimulates hair follicle melanogenesis
  JOURNAL   J Invest Dermatol 133 (6), 1591-1600 (2013)
   PUBMED   23334344
REFERENCE   2  (residues 1 to 822)
  AUTHORS   Halford,S., Holt,R., Nemeth,A.H. and Downes,S.M.
  TITLE     Homozygous deletion in CDH3 and hypotrichosis with juvenile macular
            dystrophy
  JOURNAL   Arch Ophthalmol 130 (11), 1490-1492 (2012)
   PUBMED   23143461
REFERENCE   3  (residues 1 to 822)
  AUTHORS   Samuelov,L., Sprecher,E., Tsuruta,D., Biro,T., Kloepper,J.E. and
            Paus,R.
  TITLE     P-cadherin regulates human hair growth and cycling via canonical
            Wnt signaling and transforming growth factor-beta2
  JOURNAL   J Invest Dermatol 132 (10), 2332-2341 (2012)
   PUBMED   22696062
REFERENCE   4  (residues 1 to 822)
  AUTHORS   Guo,Q.Y., Miao,L.N., Li,B., Ma,F.Z., Liu,N., Cai,L. and Xu,Z.G.
  TITLE     Role of 12-lipoxygenase in decreasing P-cadherin and increasing
            angiotensin II type 1 receptor expression according to glomerular
            size in type 2 diabetic rats
  JOURNAL   Am J Physiol Endocrinol Metab 300 (4), E708-E716 (2011)
   PUBMED   21285403
  REMARK    GeneRIF: Diabetic proteinuria is mediated by the activation of
            12-LO pathway that is partially attributed to the decreased
            glomerular P-cadherin expression.
REFERENCE   5  (residues 1 to 822)
  AUTHORS   Pospechova,K., Kopecky,M., Nachtigal,P., Pospisilova,N.,
            Jamborova,G. and Semecky,V.
  TITLE     Changes in the expression of P-cadherin in the normal, cryptorchid
            and busulphan-treated rat testis
  JOURNAL   Int J Androl 30 (5), 430-438 (2007)
   PUBMED   17298545
REFERENCE   6  (residues 1 to 822)
  AUTHORS   Tanoue,T. and Takeichi,M.
  TITLE     Mammalian Fat1 cadherin regulates actin dynamics and cell-cell
            contact
  JOURNAL   J Cell Biol 165 (4), 517-528 (2004)
   PUBMED   15148305
REFERENCE   7  (residues 1 to 822)
  AUTHORS   Zhou,S., Matsuyoshi,N., Liang,S.B., Takeuchi,T., Ohtsuki,Y. and
            Miyachi,Y.
  TITLE     Expression of T-cadherin in Basal keratinocytes of skin
  JOURNAL   J Invest Dermatol 118 (6), 1080-1084 (2002)
   PUBMED   12060406
REFERENCE   8  (residues 1 to 822)
  AUTHORS   Machell,N.H., Blaschuk,O.W. and Farookhi,R.
  TITLE     Expression and localization of P-, K-, and OB-cadherin in the
            prepubertal rat ovary
  JOURNAL   Mol Reprod Dev 61 (2), 142-154 (2002)
   PUBMED   11803548
  REMARK    GeneRIF: expressed throughout prepubertal ovarian development
REFERENCE   9  (residues 1 to 822)
  AUTHORS   Johnson,K.J., Patel,S.R. and Boekelheide,K.
  TITLE     Multiple cadherin superfamily members with unique expression
            profiles are produced in rat testis
  JOURNAL   Endocrinology 141 (2), 675-683 (2000)
   PUBMED   10650949
REFERENCE   10 (residues 1 to 822)
  AUTHORS   Smythe,W.R., Williams,J.P., Wheelock,M.J., Johnson,K.R.,
            Kaiser,L.R. and Albelda,S.M.
  TITLE     Cadherin and catenin expression in normal human bronchial
            epithelium and non-small cell lung cancer
  JOURNAL   Lung Cancer 24 (3), 157-168 (1999)
   PUBMED   10460003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 28, 2014 this sequence version replaced NP_446390.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1379584.1,
                                           SRR26643285.53614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..822
                     /product="cadherin-3 precursor"
                     /note="cadherin 3, type 1, P-cadherin (placental)"
                     /calculated_mol_wt=87604
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2830
     Region          103..203
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Site            order(110..111,166,168,199,201..202)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206635"
     Region          211..316
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(218..219,279,281,312,314..315)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          325..428
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(331..332,389,391,425,427..428)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          443..536
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(443..444,494,496,532,534..535)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          536..630
                     /region_name="CA_like"
                     /note="Cadherin repeat-like domain; cl46864"
                     /db_xref="CDD:481204"
     Region          758..817
                     /region_name="CADH_Y-type_LIR"
                     /note="Cadherin, Y-type LIR-motif; pfam01049"
                     /db_xref="CDD:460041"
     CDS             1..822
                     /gene="Cdh3"
                     /coded_by="NM_053938.2:346..2814"
                     /db_xref="GeneID:116777"
                     /db_xref="RGD:621089"
ORIGIN      
        1 mellsgplvf lllllqvcwl rsvvsesyre dfireagvtl evggtdleps qalekealag
       61 hevlgadsgg iitlnretvq ggkgvmnspp srilrrrkre wvmppisvpe ngkgpfpqrl
      121 nqlksnkdrg tklfysitgp gadsppegvf tieketgwll lnmpldreki vkyelfghav
      181 sengasveep mnisiivtdq ndnkpkftqd tfrgsvpegv mpgtsvmqvt atdeddaint
      241 yngvvaysih sqepkephdl mftihkstgt isvissgldr ekvpeytlti qatdmdgdgs
      301 tttaeavvqi ldtndnapef qpqkyeawvp enavghevqr ltvtdldspn spawratyhi
      361 vggddgdhft vathpetnqg ilttkkgldf eaqnqhtlyi evtneasfav klptatatvv
      421 vhvedvneap vfvppskvie aqegisigel vcvytaqdpd keeqkisysi lrdpaswlav
      481 dpdsgqitaa gildredeqf vkndiyevmv latdngnppt tgtgtllltl tdindhgpip
      541 eprqiiicnq spvpqvlnit dkdlspnssp fqaqlthdsd iywmaevsek gdtvalslkk
      601 flkqdtydlh lslsdhgnre qltmiratvc dchgqvlndc prpwkggfil pvlgavlall
      661 tlllallllv rkkrkvkepl llpeddtrdn vfyygeeggg eedqdyditq lhrglearpe
      721 vvlrndvapt fiptpmyrpr panpdeignf iienlkaant dptappydsl lvfdyegsgs
      781 daaslsslts stsdqdqdyn yltewgsrfk kladmyggge dd
//
