LOCUS       NM_053644              10920 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cadherin-related 23 (Cdh23), mRNA.
ACCESSION   NM_053644 XM_346602
VERSION     NM_053644.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10920)
  AUTHORS   Kamiya,K., Michel,V., Giraudet,F., Riederer,B., Foucher,I.,
            Papal,S., Perfettini,I., Le Gal,S., Verpy,E., Xia,W., Seidler,U.,
            Georgescu,M.M., Avan,P., El-Amraoui,A. and Petit,C.
  TITLE     An unusually powerful mode of low-frequency sound interference due
            to defective hair bundles of the auditory outer hair cells
  JOURNAL   Proc Natl Acad Sci U S A 111 (25), 9307-9312 (2014)
   PUBMED   24920589
REFERENCE   2  (bases 1 to 10920)
  AUTHORS   Selvakumar,D., Drescher,M.J. and Drescher,D.G.
  TITLE     Cyclic nucleotide-gated channel alpha-3 (CNGA3) interacts with
            stereocilia tip-link cadherin 23 + exon 68 or alternatively with
            myosin VIIa, two proteins required for hair cell
            mechanotransduction
  JOURNAL   J Biol Chem 288 (10), 7215-7229 (2013)
   PUBMED   23329832
  REMARK    GeneRIF: Data indicate that CNGA3 interacts with cadherin 23 and
            with cadherin 23 binding partner, myosin VIIa.
REFERENCE   3  (bases 1 to 10920)
  AUTHORS   Xiong,W., Grillet,N., Elledge,H.M., Wagner,T.F., Zhao,B.,
            Johnson,K.R., Kazmierczak,P. and Muller,U.
  TITLE     TMHS is an integral component of the mechanotransduction machinery
            of cochlear hair cells
  JOURNAL   Cell 151 (6), 1283-1295 (2012)
   PUBMED   23217710
REFERENCE   4  (bases 1 to 10920)
  AUTHORS   Hwang,J.H., Liu,K.S., Wu,C.C. and Liu,T.C.
  TITLE     Association of cadherin23 single nucleotide polymorphism with
            age-related hearing impairment in Han Chinese
  JOURNAL   Otolaryngol Head Neck Surg 147 (3), 531-534 (2012)
   PUBMED   22581638
REFERENCE   5  (bases 1 to 10920)
  AUTHORS   Kazmierczak,P. and Muller,U.
  TITLE     Sensing sound: molecules that orchestrate mechanotransduction by
            hair cells
  JOURNAL   Trends Neurosci 35 (4), 220-229 (2012)
   PUBMED   22177415
  REMARK    Review article
REFERENCE   6  (bases 1 to 10920)
  AUTHORS   Johnson,K.R., Erway,L.C., Cook,S.A., Willott,J.F. and Zheng,Q.Y.
  TITLE     A major gene affecting age-related hearing loss in C57BL/6J mice
  JOURNAL   Hear Res 114 (1-2), 83-92 (1997)
   PUBMED   9447922
REFERENCE   7  (bases 1 to 10920)
  AUTHORS   Noben-Trauth,K., Zheng,Q.Y., Johnson,K.R. and Nishina,P.M.
  TITLE     mdfw: a deafness susceptibility locus that interacts with deaf
            waddler (dfw)
  JOURNAL   Genomics 44 (3), 266-272 (1997)
   PUBMED   9325047
REFERENCE   8  (bases 1 to 10920)
  AUTHORS   Moriyama,K., Hashimoto,R., Hanai,A., Yoshizaki,N., Yonezawa,S. and
            Otani,H.
  TITLE     Degenerative hairlets on the vestibular sensory cells in mutant
            bustling (BUS/Idr) mice
  JOURNAL   Acta Otolaryngol 117 (1), 20-24 (1997)
   PUBMED   9039475
REFERENCE   9  (bases 1 to 10920)
  AUTHORS   Yonezawa,S., Nodasaka,Y., Kamada,T., Fujita,S.C., Kato,K.,
            Yamada,Y., Ogasawara,N. and Shoji,R.
  TITLE     Cochlear histopathology of the mutant bustling mouse, BUS/Idr
  JOURNAL   Acta Otolaryngol 116 (3), 409-416 (1996)
   PUBMED   8790740
REFERENCE   10 (bases 1 to 10920)
  AUTHORS   Otani,H., Moriyama,K., Yonezawa,S., Shoji,R. and Tanaka,O.
  TITLE     Vestibulocochlear defects and effects of deuterium oxide in mutant
            bustling (BUS) mice
  JOURNAL   Acta Otolaryngol Suppl 519, 286-293 (1995)
   PUBMED   7610888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053644.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB053447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               JAXUCZ010000020.1  29164991-29165332   c
            343-414             JAXUCZ010000020.1  29129624-29129695   c
            415-492             JAXUCZ010000020.1  29123117-29123194   c
            493-635             JAXUCZ010000020.1  29069286-29069428   c
            636-683             JAXUCZ010000020.1  29068649-29068696   c
            684-776             JAXUCZ010000020.1  29068425-29068517   c
            777-971             JAXUCZ010000020.1  29014066-29014260   c
            972-1100            JAXUCZ010000020.1  29010452-29010580   c
            1101-1179           JAXUCZ010000020.1  29003081-29003159   c
            1180-1292           JAXUCZ010000020.1  28965766-28965878   c
            1293-1481           JAXUCZ010000020.1  28964279-28964467   c
            1482-1631           JAXUCZ010000020.1  28944008-28944157   c
            1632-1790           JAXUCZ010000020.1  28943451-28943609   c
            1791-1855           JAXUCZ010000020.1  28917424-28917488   c
            1856-2093           JAXUCZ010000020.1  28915296-28915533   c
            2094-2199           JAXUCZ010000020.1  28912965-28913070   c
            2200-2327           JAXUCZ010000020.1  28912208-28912335   c
            2328-2400           JAXUCZ010000020.1  28906834-28906906   c
            2401-2517           JAXUCZ010000020.1  28905118-28905234   c
            2518-2630           JAXUCZ010000020.1  28899091-28899203   c
            2631-2738           JAXUCZ010000020.1  28897456-28897563   c
            2739-2928           JAXUCZ010000020.1  28892769-28892958   c
            2929-3074           JAXUCZ010000020.1  28892303-28892448   c
            3075-3294           JAXUCZ010000020.1  28888985-28889204   c
            3295-3447           JAXUCZ010000020.1  28887402-28887554   c
            3448-3561           JAXUCZ010000020.1  28885710-28885823   c
            3562-3710           JAXUCZ010000020.1  28882253-28882401   c
            3711-3771           JAXUCZ010000020.1  28869754-28869814   c
            3772-3920           JAXUCZ010000020.1  28868049-28868197   c
            3921-4056           JAXUCZ010000020.1  28863848-28863983   c
            4057-4445           JAXUCZ010000020.1  28861782-28862170   c
            4446-4547           JAXUCZ010000020.1  28859554-28859655   c
            4548-4550           JAXUCZ010000020.1  28859335-28859337   c
            4551-4700           JAXUCZ010000020.1  28856147-28856296   c
            4701-4829           JAXUCZ010000020.1  28855840-28855968   c
            4830-4958           JAXUCZ010000020.1  28854636-28854764   c
            4959-5186           JAXUCZ010000020.1  28853811-28854038   c
            5187-5408           JAXUCZ010000020.1  28816225-28816446   c
            5409-5528           JAXUCZ010000020.1  28815799-28815918   c
            5529-5709           JAXUCZ010000020.1  28814632-28814812   c
            5710-5843           JAXUCZ010000020.1  28810309-28810442   c
            5844-6053           JAXUCZ010000020.1  28809784-28809993   c
            6054-6161           JAXUCZ010000020.1  28808625-28808732   c
            6162-6264           JAXUCZ010000020.1  28806827-28806929   c
            6265-6390           JAXUCZ010000020.1  28805500-28805625   c
            6391-6594           JAXUCZ010000020.1  28804437-28804640   c
            6595-7053           JAXUCZ010000020.1  28802752-28803210   c
            7054-7170           JAXUCZ010000020.1  28799070-28799186   c
            7171-7395           JAXUCZ010000020.1  28797363-28797587   c
            7396-7565           JAXUCZ010000020.1  28796725-28796894   c
            7566-7703           JAXUCZ010000020.1  28796352-28796489   c
            7704-7823           JAXUCZ010000020.1  28795344-28795463   c
            7824-8001           JAXUCZ010000020.1  28794627-28794804   c
            8002-8213           JAXUCZ010000020.1  28794269-28794480   c
            8214-8405           JAXUCZ010000020.1  28792747-28792938   c
            8406-8519           JAXUCZ010000020.1  28792491-28792604   c
            8520-8649           JAXUCZ010000020.1  28791554-28791683   c
            8650-8901           JAXUCZ010000020.1  28791210-28791461   c
            8902-9063           JAXUCZ010000020.1  28790972-28791133   c
            9064-9320           JAXUCZ010000020.1  28788198-28788454   c
            9321-9418           JAXUCZ010000020.1  28787805-28787902   c
            9419-9539           JAXUCZ010000020.1  28786954-28787074   c
            9540-9619           JAXUCZ010000020.1  28786793-28786872   c
            9620-9660           JAXUCZ010000020.1  28786584-28786624   c
            9661-9721           JAXUCZ010000020.1  28786431-28786491   c
            9722-9851           JAXUCZ010000020.1  28785913-28786042   c
            9852-9974           JAXUCZ010000020.1  28785672-28785794   c
            9975-10920          JAXUCZ010000020.1  28783564-28784509   c
FEATURES             Location/Qualifiers
     source          1..10920
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..10920
                     /gene="Cdh23"
                     /note="cadherin-related 23"
                     /db_xref="GeneID:114102"
                     /db_xref="RGD:619760"
     exon            1..342
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            343..414
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..10301
                     /gene="Cdh23"
                     /note="Waltzing; cadherin-23; otocadherin;
                     cadherin-23-like; cadherin 23 (otocadherin)"
                     /codon_start=1
                     /product="cadherin-23 precursor"
                     /protein_id="NP_446096.2"
                     /db_xref="GeneID:114102"
                     /db_xref="RGD:619760"
                     /translation="MRHPPVTWCAMLWLLMLVSGSWGQVNRLPFFTNHFFDTYLLISE
                     DTPVGSSVTQLLARDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFT
                     VEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPD
                     LGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYEVTQAYQLTVNATDQDKTRPLST
                     LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRVITAVDQDKGRPRGIGYTIV
                     SGNTNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRSPSDATVTTTF
                     NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEGLNSMFEVYLVGNN
                     SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLIN
                     ENDNRPIFSQPLYNVSLYENITVGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSLDK
                     DTGLIMLIARLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVG
                     ALRENEPSVTQLVRLRATDEDSPPNNLITYSIVNASAFGSYFDISVYEGYGVISVSRP
                     LDYEQIPNGLIYLTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI
                     MAGATVLFLNATDLDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKAEY
                     ILIVRAVDGGVGHNQKTGIATVNVTLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV
                     VAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHVMLDRENPDPVEAELMRKIIV
                     SVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGTPAGVSVYQVVAID
                     LDEGLNGLVSYRMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPT
                     KSSTSTLTIRVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY
                     FITAGNVDGKFSVGYRDAVVRTVVGLDRETTAAYTLVLEAIDNGPVGKRRTGTATVFV
                     TVLDVNDNRPIFLQSSYEASVPEDIPEGHSIVQLKATDADEGEFGRVWYRILHGNHGN
                     NFRLHVSSGLLVRGPRPLDRERNSSHVLMAEAYNHDLGPMRSSVRVIVYVEDVNDEAP
                     VFTQQQYNRLGLRETAGIGTSVIVVRATDRDTGDGGLVNYRILSGAEGKFEIDESTGL
                     IVTVDYLDYETKTSYLMNVSATDGAPPFNQGFCSVYVTLLNELDEAVQFSNASYEAVI
                     MENLALGTEIVRVQAYSIDNLNQITYRFDAYTSAQAKALFKIDAITGVITVKGLVDRE
                     KGDFYTLTVVADDGGPKVDSTVKVYVTVLDENDNSPRFDFTSDSAISVPEDCPVGQRV
                     ATVKARDPDAGSNGQVVFSLASGNIAGAFEIITSNDSIGEVFVAKPLDREELDHYILK
                     IVASDRGTPPRKKDHILQVTILDVNDNPPVIESPFGYNVSVNENVGGGTSVVQVRATD
                     RDIGINSVLSYYITEGNEDMTFRMDRISGEIATRPAPPDRERQNFYHLVVTVEDEGTP
                     TLSATTHVYVTIVDENDNAPVFQQPHYEVVLDEGPDTVNTSLITVQALDLDEGPNGTV
                     TYAIVAGNIINTFRINRRTGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTT
                     TVLVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTFLAHDRDSGPNGQVEYSVVDG
                     DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGVPPLSSTMLVGIRVLDI
                     NDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNALLTFNITAGNRERAFFIN
                     ATTGIVTVNRPLDRERIPEYRLTVSVKDNPENPRIARKDFDLLLVSLADENDNHPLFT
                     EGTYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGTHSDLFVIDNSTGV
                     VTVRSGVIIDREAFSPPFLELLLLAEDVGQLNGTAYLFITILDDNDNWPTFSPPAYTV
                     HLLENCPPGFSVLQITATDEDSGLNGELVYRIEAGAQDRFLIHPVTGVIRVGNATIDR
                     EEQESYRLTVVATDRGTVPLSGTATVTILIDDINDSRPEFLNPIQTVSVLESTEPGTV
                     IANVTAIDLDLNPKLEYHILSIVAKDDTDRLVPDQEDAFAVNINTGSVIVKSPLNREL
                     VATYEVTLSVIDNASDLPERSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERVLEG
                     ATPGTTLIAVAAVDPDKGLNGLITYTLLDLIPPGYVQLEDSSAGKVIANRTVDYEEVH
                     WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQLSYQEAVFEDVAVGTVILRV
                     TATDADSGNFALIEYSLVDGEGKFAINPNTGDIYVLSSLDREKKDHYILTALAKDNPG
                     DVASNRRENSVQVVIRVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMLATDQDEGS
                     NGQLTYSLEGPGMEAFSVDMDSGLVTTQRPLQSYERFNLTVVATDGGEPPLWGTTMLL
                     VEVIDVNDNRPVFVRPPNGTILHIKEEIPLRSNVYEVYATDKDEGLNGAVRYSFLKST
                     GNRDWEYFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQPLQVALED
                     IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN
                     EDKNFHLQPDGRLLVLRDLDRETEAIFSFIVKASSNRSWTPPRGPSPALDLLTDLTLQ
                     EVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILAI
                     HYFRALANDSEDVGQVFTMGSVDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAII
                     GIYILRDDQRVKIVINEIPDRVRGFEEEFIRLLSNITGAIVNTDDVQFHVDMKGRVNF
                     AQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVQLPDDM
                     SALQMAIIVLAILLFLAAMLFVLMNWYYRTIHKRKLKAIVAGSAGNRGFIDIMDMPNT
                     NKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPA
                     AVKPEDDRYLRAAIQEYDNIAKLGQIIREGPIKLIHTDLEEEPGDHSPGQGSLRFRHK
                     PPTELKGPDGIHIVHGSTGTLLATDLNSLPEDDQKGLDRSLETLTASEATAFERNART
                     ESAKSTPLHKLRDVIMESPLEITEL"
     exon            415..492
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            493..635
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            636..683
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            684..776
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            777..971
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1100
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1179
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1292
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1481
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1631
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1790
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1855
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2093
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2199
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2327
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2400
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2517
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2630
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2738
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2928
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3074
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3294
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3447
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3561
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3710
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            3711..3771
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..3920
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            3921..4056
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4445
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            4446..4547
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            4548..4550
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            4551..4700
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..4829
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            4830..4958
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            4959..5186
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5408
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            5409..5528
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            5529..5709
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            5710..5843
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            5844..6053
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            6054..6161
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            6162..6264
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            6265..6390
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            6391..6594
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            6595..7053
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            7054..7170
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            7171..7395
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            7396..7565
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            7566..7703
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            7704..7823
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            7824..8001
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            8002..8213
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            8214..8405
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            8406..8519
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            8520..8649
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            8650..8901
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            8902..9063
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9064..9320
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9321..9418
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9419..9539
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9540..9619
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9620..9660
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9661..9721
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9722..9851
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9852..9974
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
     exon            9975..10920
                     /gene="Cdh23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggctcgga gcaagacacg atgcacggcc agggaacacg tcccacagca gccgagcgct
       61 gagctgcgca acagagagcg ggccccgggg atggagcacg ctagtccgga ctccccgtgt
      121 gccccacacg gggcaagcct tttctgatct ggctgcgcgt ctgaagttgc agccagcgag
      181 cagctcgcgg ggatcgggcc gcccgagtgg ctcccagaga gaccttcgcg ccggcgacga
      241 gaagcggcgg tggccaagac tggagtaggt ggcccgtggg ggcagagtcg gttgcgagca
      301 gatcccgagg cgcggcgcaa cgctgctcca cctgcgcaca cggagccatg aggcaccccc
      361 ctgtcacttg gtgtgccatg ctctggcttc tcatgctggt gtccggatcc tggggccagg
      421 tgaaccgact accttttttc accaatcact tctttgacac gtacctgctc atcagcgaag
      481 acactcctgt gggttcttct gtgacccagt tgctggcccg agacatggac aatgacccct
      541 tggtgttcgg cgtgtctggg gaggaggcct cccgcttctt tgccgtggag cctgacacgg
      601 gtgtggtgtg gctccggcag ccactggaca gagagactaa gtctgagttc acagtggagt
      661 tctccgtcag tgaccaccaa ggggtgatca caaggaaggt gaatatccaa gttggagacg
      721 tgaacgacaa tgcacccaca ttccacaacc agccctacag cgtgcgcatc cctgaaaaca
      781 caccagtggg gacacccatc ttcatcgtca acgccactga tcctgacctg ggcgcagggg
      841 gcagtgtcct ctactccttc cagcccccct ctcagttctt cgccatcgac agtgcccgag
      901 gcatagtcac cgtgatccgg gagctggact atgaggtcac gcaggcgtac cagctcacag
      961 tcaatgccac ggatcaagac aagaccagac ctctgtctac attagccaac ctggccatca
     1021 tcatcacgga cgtacaagac atggacccca tcttcatcaa tctgccctac agtaccaaca
     1081 tctatgagca ctctcccccg ggcacgactg tgcgggtgat cactgctgtg gatcaggata
     1141 agggacggcc ccgggggatt ggctacacta ttgtctcagg gaatacgaac agcatctttg
     1201 ccctggacta catcagcggg gctctcaccc tgaatggcct gctggaccgg gagaaccccc
     1261 tgtacagcca cggcttcatc ctgacggtga agggcactga gctgaatgat gatcgtagtc
     1321 cgtctgacgc caccgtcacc acgaccttca acatcctggt tatcgacatc aatgacaatg
     1381 ccccggagtt caacagctct gagtacagcg tggccattac tgagctggcg caggtcggct
     1441 ttgccctccc tctcttcatc caggtggtgg acaaggatga gggtctaaac agcatgttcg
     1501 aggtgtacct ggtgggcaac aactcccacc acttcatcat ctccccaacc tccgtccagg
     1561 ggaaagcaga catccgcatc cgagtggcaa tcccactgga ctacgagacc gtggacagat
     1621 acgactttga cctctttgcc aacgagagcg tacccgacca cgtgggctac gccaaggtga
     1681 agattacgct cattaatgaa aatgacaacc ggcccatctt cagccagccc ctctacaatg
     1741 tcagcctgta tgaaaacatc accgtgggga cctccgtgct gacagtcctg gcaacagaca
     1801 atgacgtggg cacttttggg gaagtcaact acttcttcag tgatgacccc gacaggttct
     1861 cactggacaa ggacacaggc ctcatcatgc ttatagcccg gctggactat gagcttatcc
     1921 agcgtttcac cttgactgtc attgcccggg atggtggcgg tgaggagacc acaggccggg
     1981 tccggatcaa tgtgctggat gtcaacgaca atgtgcccac cttccagaag gatgcctacg
     2041 tgggtgctct gagggagaat gagccatctg tcacacagct ggtgcggctc agggcaacag
     2101 atgaagactc ccctcccaac aacctgatca cctacagcat cgtcaacgcg tccgccttcg
     2161 gcagctactt tgacatcagt gtgtatgaag gctatggagt gatcagtgtg agccgcccac
     2221 tggattatga acagataccc aatgggctga tatacctaac cgtcatggcc aaggatgcag
     2281 gcaaccctcc gctctacagc accgtccctg tcaccattga ggtgtttgat gagaacgaca
     2341 accctcccac cttcagcaag cctgcctact tcgtgtctgt ggtggagaac atcatggcag
     2401 gagccacagt gttgttccta aatgccacgg acctggaccg ctcccgggag tatgggcagg
     2461 agtctatcat ctattcgctg gagggctcct cacagttccg catcaatgcc cgctctggag
     2521 aaatcaccac cacgtctctg ctggaccgag agaccaaagc tgaatacata ctcattgtgc
     2581 gtgctgtgga tgggggtgtg ggccacaacc agaaaactgg cattgccaca gtgaatgtca
     2641 ccctcctaga catcaatgac aaccacccca cctggaagga tgctccctac tacatcaacc
     2701 tggtggagat gacgcctcca gactctgatg tgaccacggt ggtagctgtg gacccagatc
     2761 tgggggagaa tggcaccctg gtgtacagca tccagccccc caacaagttc tatagtctga
     2821 acagcaccac aggcaagatc cgcaccaccc acgtcatgct ggaccgagag aaccctgacc
     2881 ccgtggaggc ggagctcatg cgcaagatca ttgtctctgt cacggactgt ggtagacccc
     2941 ccctgaaggc caccagcagt gccacagtct ttgtgaacct cttggatctc aatgacaacg
     3001 accccacctt ccagaacctg ccttttgtgg ctgaggttct tgagggcacc cctgcagggg
     3061 tctctgtcta ccaagtggtg gccatcgatc tggatgaggg cctgaatgga ctggtgtcct
     3121 atcgcatgca agtgggcatg ccccgcatgg actttgtcat caacagcacc agtggtgtgg
     3181 tcacgaccac agccgagttg gaccgggagc gcatcgccga gtaccagctg cgggtggtgg
     3241 ccagcgatgc gggcacacct accaagagct ccaccagcac cctcaccatc cgcgtgttgg
     3301 atgtgaacga tgagacgccc accttcttcc ctgccgtgta caacgtgtct gtgtctgagg
     3361 atgttccccg tgagttccgt gtggtctggc tgaactgcac agacaatgac gtcggtctca
     3421 atgcggaact cagctacttc atcacagcgg gaaatgtgga cgggaagttt agtgtgggct
     3481 accgtgatgc cgtggtgaga accgtggtcg gcctggaccg tgagaccaca gctgcgtaca
     3541 cactggtgct ggaggctatc gacaatggcc ctgtaggcaa gcggcgcaca ggtacggcca
     3601 ccgtgtttgt cacagttctg gatgtgaacg acaaccggcc catcttcctg caaagcagct
     3661 atgaggccag tgtcccagaa gacatccccg agggccacag cattgtgcag ctgaaagcca
     3721 cagatgcaga cgagggcgag tttggacgtg tctggtaccg catcctccat ggtaaccatg
     3781 gcaacaactt ccggctccac gtcagcagcg ggctcctggt gcgaggccca aggcccctgg
     3841 acagggagcg aaactcgtcc catgtgctga tggcagaagc ctacaaccac gacctggggc
     3901 ccatgcggag ctcggtcagg gtgatcgtgt atgtggaaga tgtcaacgat gaggcccctg
     3961 tgttcacaca gcagcagtac aatcgcctgg gccttcgaga gacagcaggc atcggcacct
     4021 cagtcatcgt tgtccgagcc accgacagag acactgggga cggtggcctg gtgaactacc
     4081 gcatcctgtc gggcgcagag ggcaagtttg agattgacga gagcacaggg ctcatcgtga
     4141 cggttgacta tctggactac gagaccaaga ccagctatct gatgaacgtg tcagccacag
     4201 acggtgcacc ccccttcaac cagggcttct gcagcgtcta cgtgacactt ctcaacgagc
     4261 tggatgaggc tgttcagttc tccaatgcct cctatgaggc agtcatcatg gagaatctgg
     4321 ctctggggac cgagatcgtg cgggtgcaag cctattccat tgataacctc aatcaaatca
     4381 cctaccgctt tgacgcctat accagcgccc aggccaaagc cctcttcaag atagatgcca
     4441 tcacgggcgt gatcacagtc aaaggcttgg tcgacaggga gaagggcgac ttctacacat
     4501 tgacggtcgt ggcagatgat ggtggcccca aggtggactc tactgtgaag gtctacgtca
     4561 ctgttctgga tgaaaatgat aacagcccac gctttgactt cacctctgat tcggccatca
     4621 gtgtgcctga ggactgccct gtaggccaac gagtagccac tgtcaaggcc cgggaccctg
     4681 atgctggcag caacggtcag gtggtcttct ccctggcctc cggtaacatt gctggggcct
     4741 ttgagattat caccagcaat gactccattg gtgaagtgtt tgtggctaag cccctggaca
     4801 gggaggaact ggaccactac atcctcaaga ttgtagcttc tgaccgtggc actcctccac
     4861 ggaagaaaga ccacatctta caggtgacca ttctggatgt caatgacaac cctccagtga
     4921 ttgagagccc ctttgggtac aacgtcagtg tgaatgagaa tgtgggtgga ggcacctcag
     4981 tagtccaggt gagagccacc gaccgtgaca tcgggatcaa cagcgtcctg tcctattata
     5041 tcacggaggg caatgaggac atgactttcc gtatggaccg catcagcggt gagattgcta
     5101 cacggcctgc tccacccgac cgtgagcgcc agaacttcta ccacctggtg gtcactgtgg
     5161 aagacgaggg cacccccaca ctatcggcta ccacccatgt gtacgtgact atcgtggacg
     5221 agaatgacaa tgctcctgtg ttccagcagc cacattatga ggtggtgctg gacgagggcc
     5281 cggacacagt caacaccagc ctcatcaccg tccaggcgct ggacctggat gagggcccga
     5341 atggcactgt tacctatgcc attgtggcag gcaatatcat caataccttc cgaatcaaca
     5401 ggcgcacggg tgtcattact gctgccaagg agctagacta tgagatcagt catggccgct
     5461 ataccctgat tgtcactgcc acagaccagt gtcccatctt gtcccaccgc ctcacctcta
     5521 ctaccacagt gctcgtgaac gtgaatgaca tcaatgacaa tgtgcccact ttccctcggg
     5581 actatgaagg accattcgat gtcactgagg gccaaccagg gcccagagtg tggacattcc
     5641 tggcccatga ccgggactcc ggtcccaatg ggcaggtgga gtacagtgtt gtggatggag
     5701 acccactggg ggagtttgtg atctctcctg tggagggtgt gctgagggtc cggaaggatg
     5761 tagaactgga tcgggagacc atcgccttct acaatctgac catctgtgcc cgagacaggg
     5821 gggtgccgcc actcagctcc acgatgctgg tgggaatccg agtgctggac atcaatgaca
     5881 atgacccggt gctgttgaat cttcccatga acatcaccat cagtgagaac agcccggtct
     5941 ccagcttcgt cgcccacgtc ctggccagcg acgctgacag tggctgcaat gccctgctca
     6001 ccttcaacat caccgctggc aaccgggagc gggccttctt catcaatgcc acgacaggga
     6061 tcgtcactgt caaccggccc ctggaccgag agcgcatccc agaatacagg ctgaccgttt
     6121 ctgtaaagga caacccagag aacccacgca tagccaggaa ggattttgac ttactgctgg
     6181 tctctctggc tgatgaaaat gacaaccacc ccctcttcac tgagggcacg taccaggccg
     6241 aggtgatgga gaactctcct gctgggacac ctctcaccgt gctcaatgga cctatcctgg
     6301 ccctggatgc tgatgaagat gtgtacgctg tagtcacgta tcaactcctg ggcactcaca
     6361 gcgacctgtt tgttattgac aatagcacgg gcgtggtgac tgtgaggtcc ggggtcatca
     6421 tcgaccggga ggccttctca cccccattcc tggagttgct gctgttggct gaggacgtgg
     6481 gacaactcaa tggcacggcc tacctgttca tcactatcct agatgacaat gacaactggc
     6541 ccaccttcag tcctcctgct tacactgtcc acctgctgga gaactgccca ccaggattct
     6601 cagtccttca gatcacagcc acagatgagg acagcggcct caatggggag ctggtctacc
     6661 gaatagaagc cggggctcag gaccgcttcc tcatccatcc agtcacagga gtcatccgtg
     6721 ttggcaatgc caccatcgac agagaagagc aggagtccta caggctgacg gtggtggcca
     6781 ccgaccgggg cactgttccc ttgtcgggca cagccaccgt caccatcctg atcgatgaca
     6841 tcaatgactc ccgccctgag ttcctcaacc ctatccagac agtgagcgtg ctggaatcca
     6901 cagagccagg cactgtcatt gctaacgtca ctgccatcga cctcgacctc aaccccaaac
     6961 tggagtatca catccttagc atcgtggcca aggacgacac tgaccgcctg gtgcctgacc
     7021 aggaagatgc ctttgctgtg aatatcaata cagggtccgt gatagtgaag tcccctctga
     7081 accgcgagct ggttgctacc tatgaggtca cgctctcagt aatcgacaat gccagcgacc
     7141 tcccagagcg ttctgtcagt gtgccaaacg ccaagctcac ggtcaacatc ctggatgtca
     7201 atgacaatac accgcagttc aagccctttg gaatcaccta ctacacagag cgggtcctgg
     7261 agggggccac cccaggcaca acgctcattg ctgtggccgc cgttgatccc gacaagggcc
     7321 ttaacgggct gatcacctac accctgctag acctcatacc cccaggctat gtccagctcg
     7381 aagactcttc agcagggaag gtcatcgcca accgtacggt ggactacgag gaggttcact
     7441 ggcttaactt caccgtgagg gcctcagaca atgggtcccc accccgggca gctgagatcc
     7501 ctgtctacct ggaaattgta gacattaatg acaacaaccc catctttgat cagctctcct
     7561 accaggaggc tgtttttgag gatgtagctg tgggcacggt catcctgagg gttacagcta
     7621 cggatgctga ctcaggcaac tttgctctca tcgagtacag cctggtggat ggagagggca
     7681 aatttgccat caaccccaac actggtgaca tctatgtgct gtcctctctg gaccgagaga
     7741 agaaggacca ctacatccta actgctttgg ccaaagacaa ccctggcgat gtggccagta
     7801 accgtcgcga gaactcggtg caggtggtga tccgagtact tgatgtcaat gactgtcggc
     7861 ctcagttctc caagccacag ttcagcacaa gtgtgtacga gaatgagcca gcaggtactt
     7921 cagtcatcac catgctggcc actgaccagg acgagggctc taatggccag ctgacctact
     7981 ctcttgaggg tcccggaatg gaggctttct ctgtggacat ggactcgggc ctggtgacca
     8041 cgcagcggcc actacagtcc tatgagaggt tcaacctgac cgtagtggct acagatggtg
     8101 gggagccccc actctggggc accacaatgc tcctagtgga agtcatcgat gtcaatgaca
     8161 accgccccgt cttcgtgcgc ccacccaatg gcaccattct gcacatcaaa gaggagatcc
     8221 cgctacgttc caatgtgtat gaagtctatg ctacagacaa ggatgaaggc ctcaacgggg
     8281 cagtacgcta cagcttcctg aagtcaacag gcaaccgtga ctgggagtac ttcaccatcg
     8341 acccaattag tggcctcatc cagacagcgc agcgcctgga ccgtgagaag caggcagtgt
     8401 acagtctcat cttggtggcc agcgacctgg gccagccagt gccatacgag acgatgcagc
     8461 cattgcaggt ggccctggag gacatcgatg acaatgagcc cctctttgtg aggcctccta
     8521 agggaagccc tcagtaccaa ctgctaacag tgcctgaaca ctccccccgt ggcacccttg
     8581 tgggcaacgt gacaggcgcg gtggacgcag atgaaggtcc caatgccatt gtgtactact
     8641 tcattgcagc tggtaacgag gacaagaatt tccacctaca acctgacgga cgcctgctag
     8701 tgcttagaga cctggatcgg gagacggaag ccatcttctc cttcattgtc aaggcgtcca
     8761 gcaatcgcag ttggacccct ccccgaggac cctccccagc cctcgatctg ctgaccgatc
     8821 tcaccctgca ggaggtgcgc gttgtgctgg aggacatcaa tgaccaaccg ccacgcttca
     8881 ccaaggctga gtataccgca ggagtggcca ccgacgccaa ggtaggctcg gagttgatcc
     8941 aggtgctggc cctggatgca gacatcggca acaacagcct ggtcttctat ggcattctgg
     9001 ctatccacta cttccgggcc ctggccaatg actccgagga tgtgggtcag gtcttcacca
     9061 tggggagtgt ggacggcatc ctgcgtacct ttgacctctt catggcctac agccctggct
     9121 actttgtggt agacatcgtg gcccgagacc tggccggtca caacgataca gccatcattg
     9181 gcatctacat cctgagggat gaccagcgcg ttaagatagt catcaacgag atcccagacc
     9241 gtgtgcgtgg ctttgaggag gagttcattc gcctgctgtc caacatcaca ggcgccatcg
     9301 tcaacactga tgacgtgcag ttccatgtgg atatgaaagg aagagtgaat tttgcacaga
     9361 cagagctgct catccacgtg gtcaaccgcg acacgaaccg catcctggat gtggacaggg
     9421 tcatccagat gattgatgag aacaaggaac aacttcgaaa cctcttccgg aactacaatg
     9481 tactggacgt gcagcctgcc atctctgtcc agctgccgga cgacatgtct gccctgcaga
     9541 tggccatcat tgtcctggcc atccttctct tcttggctgc catgctcttt gtcctcatga
     9601 actggtacta caggaccata cacaagagaa agctaaaggc cattgtggct ggttctgctg
     9661 ggaaccgtgg cttcattgac atcatggaca tgcccaatac caacaaatac tccttcgatg
     9721 gagccaaccc tgtgtggctg gaccccttct gccggaacct ggagctggct gcacaggctg
     9781 aacatgagga tgacctccct gagaacctga gtgagatcgc agacctgtgg aacagcccca
     9841 cccgcaccca tggaactttt ggacgtgagc ccgcggcagt caaacctgaa gatgacagat
     9901 acctgcgggc agccatccag gagtatgaca acatagccaa gctgggtcag atcattcgag
     9961 aaggacctat taagctgatc cacactgacc tggaggagga gcctggcgac cacagcccag
    10021 gccagggcag cctccgtttc cgacacaagc cacccacgga actcaagggg ccagatggaa
    10081 tccacatagt tcacggtagc acgggcacac tgctggccac tgatctcaac agcttgcctg
    10141 aggatgacca gaaggggcta gaccgctcac tggagactct gacagcctct gaagccactg
    10201 cctttgaacg caatgcccgc accgagtcgg ccaagtccac ccctctgcat aagcttcgag
    10261 acgtcatcat ggagagcccc ctggaaatca cggaactgtg acggacagca aggcttgctg
    10321 ctgaagcagg gccatggccg gcccttcgcc cagggcagca gcctttgtga gtgaccctgg
    10381 gctggccctg gcagcctgca cagttgctca gatttgcatc ctgccagaaa ctgattcagc
    10441 atctgatctc taccttcata aaattggtta tttttttaag aaaactttaa aaatgctaag
    10501 tgtctaagga caaggcaagg acgagtgctg gggaagcccc agagacttaa gactagctcg
    10561 gctcttcctg atgcctccaa ggaacagggg tccagcacag aactgacaac ccagctgacc
    10621 caccccgcct cagttcaagc cccactgtac ttctgcctct ggacatccgg gcggctccct
    10681 ggccctgcac acacacgtgg atgaggcaac caagcgtcca ccccatctcc cctcatcgtc
    10741 ttgaggtgcc cagttgacat gactgatgtc ccctgggttt tgaatgtaga gtgtttgtgt
    10801 gtatcccttt tctaaattaa gttatcccct caagatttcc tccaggttct gtttaactga
    10861 tactcagtca aagtttctgg aatgctctgt ttaaaaaagc aactcacctg gaaccagcaa
//
