LOCUS       NM_019161               3479 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cadherin 22 (Cdh22), mRNA.
ACCESSION   NM_019161 XM_001053016
VERSION     NM_019161.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3479)
  AUTHORS   Yovchev,M.I., Grozdanov,P.N., Joseph,B., Gupta,S. and Dabeva,M.D.
  TITLE     Novel hepatic progenitor cell surface markers in the adult rat
            liver
  JOURNAL   Hepatology 45 (1), 139-149 (2007)
   PUBMED   17187413
  REMARK    GeneRIF: We identified novel cell surface markers specific for
            hepatic progenitor/oval cells. Six are unique for the adult
            progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
REFERENCE   2  (bases 1 to 3479)
  AUTHORS   Wu,J., Jester,W.F. Jr. and Orth,J.M.
  TITLE     Short-type PB-cadherin promotes survival of gonocytes and activates
            JAK-STAT signalling
  JOURNAL   Dev Biol 284 (2), 437-450 (2005)
   PUBMED   16038895
  REMARK    GeneRIF: PB-cadherin promotes survival of spermatocytes and
            activates Jak2 and Stat3 signalling.
REFERENCE   3  (bases 1 to 3479)
  AUTHORS   Sugimoto,K., Honda,S., Yamamoto,T., Ueki,T., Monden,M., Kaji,A.,
            Matsumoto,K. and Nakamura,T.
  TITLE     Molecular cloning and characterization of a newly identified member
            of the cadherin family, PB-cadherin
  JOURNAL   J Biol Chem 271 (19), 11548-11556 (1996)
   PUBMED   8626716
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019161.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83348.1, SRR26643289.11692.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000003.1  174389801-174389892 c
            93-648              JAXUCZ010000003.1  174333587-174334142 c
            649-943             JAXUCZ010000003.1  174323575-174323869 c
            944-1063            JAXUCZ010000003.1  174310181-174310300 c
            1064-1231           JAXUCZ010000003.1  174299447-174299614 c
            1232-1425           JAXUCZ010000003.1  174296613-174296806 c
            1426-1679           JAXUCZ010000003.1  174295004-174295257 c
            1680-1816           JAXUCZ010000003.1  174289388-174289524 c
            1817-1938           JAXUCZ010000003.1  174277336-174277457 c
            1939-2056           JAXUCZ010000003.1  174277130-174277247 c
            2057-2308           JAXUCZ010000003.1  174269584-174269835 c
            2309-3479           JAXUCZ010000003.1  174264869-174266039 c
FEATURES             Location/Qualifiers
     source          1..3479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3479
                     /gene="Cdh22"
                     /note="cadherin 22"
                     /db_xref="GeneID:29182"
                     /db_xref="RGD:2321"
     exon            1..92
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            93..648
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..2844
                     /gene="Cdh22"
                     /note="pituitary and brain cadherin; PB-cadherin"
                     /codon_start=1
                     /product="cadherin-22 precursor"
                     /protein_id="NP_062034.2"
                     /db_xref="GeneID:29182"
                     /db_xref="RGD:2321"
                     /translation="MRPRPAGALRAGAALSPVLLLLLLLQLLGHLWAASTPAPSSLSP
                     GTQQDNQLGAGRVKRGWVWNQFFVVEEYTGTEPLYVGKIHSDSDEGDGTIKYTISGEG
                     AGTIFLIDELTGDIHATERLDREQKTFYTLRAQARDRATNRLLEPESEFIIKVQDIND
                     SEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDPTYGSSARLVYSVLDGEHHFTVDP
                     KTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLSGSTTVTIVVTDVNDNPPRFPQ
                     KMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLREESGSGGDAFKVTTDSDTQE
                     AIIVVQKHLDFESQQVHTVVLEALNKFVDPRFADLGTFRDQAIVRVAVTDVDEPPEFR
                     PPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRDSDLEQIFDIDADTGAIVT
                     GKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNPPELATPYEAAVCEDA
                     KPGQLIQTISVVDRDEPQGGHRFYFRLVPEEPSNPHFSLLDIEDNTAAVHTQHVGFNR
                     QEQDVFLLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAFVMAASLSPGAL
                     IALLVCVLILVVLALLILTLRRHHKSHLSSDVDEDMRDNVIKYNDEGGGEQDTEAYDM
                     SALRSLYDFGELKGGDPGGGAASPPQAASSSERHSLPRGPSSPEPDFSVFRDFISRKV
                     ALADADLSVPPYDAFQTYAFEGAGSPAASLSSLHSGSTGSEQDFAFLRAWGPRFRPLA
                     ALYAGHRGDDEAPAS"
     exon            649..943
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1063
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1231
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1425
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1679
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1816
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1938
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2056
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2308
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..3479
                     /gene="Cdh22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgagcggacg ccggagccgg acctggcccg gatcctgccg ctcgctggcg tcccaaggtg
       61 cggaccaggg tgcagcccgg ccgctccccg aggttcccaa tggatctgga tgacccctaa
      121 tcccagaaag acttcaagat ccttttgctc ccactgacca caccatctgg gtacagggac
      181 catggcacaa gccctactca ggagcagcta ctgggctgcc tagtgactgg acctggggct
      241 tcagcgaggg gggcgcgggc caggaccggg tgtccatgcc cgggtgcggc cgcgccccct
      301 cccagtccag cccggcatcc ctgaggctga ggtcaccatg tgacgcagta ccgctgcggt
      361 gcctctggtc catgctccgg ggcttggccc gcgccgccaa gcatgaggcc acggccagca
      421 ggggcgctcc gggccggggc tgcgctgtcg cctgtgctgc tgcttctgct actgctacag
      481 ctgctggggc atctgtgggc cgcaagcaca cctgccccat cctccttgtc acctgggact
      541 cagcaggaca accagctggg tgcaggccga gtgaagcgcg gttgggtgtg gaaccaattc
      601 ttcgtggtgg aggagtacac ggggacagaa cccctgtacg tgggcaagat ccactcggat
      661 tctgacgaag gcgacgggac catcaagtac accatctcgg gcgagggtgc agggaccatc
      721 ttcctgatcg acgagctgac aggtgacatc cacgccacgg agcgcctgga ccgggagcag
      781 aaaaccttct acacactccg ggcccaagcc agggatcgag ccaccaaccg tctgctggag
      841 ccggagtcag agttcatcat caaagtgcag gacatcaacg acagtgaacc acgctttctc
      901 cacggcccct acatcggcag tgtggccgag ctgtcaccta caggcacgtc cgtgatgcag
      961 gtgatggcct ctgatgcaga tgaccccact tacggcagca gtgcccggct ggtgtacagc
     1021 gtcctggatg gcgagcacca cttcacagtg gaccccaaga caggtgtgat ccggacagca
     1081 gtgcctgacc tcgaccgtga gagccaggaa cgctacgagg tggtaatcca agccacggac
     1141 atggcaggcc agctgggcgg cctctcaggc tccactacag tgaccatcgt ggttactgat
     1201 gtcaacgaca acccaccccg ctttccacaa aagatgtacc agttcagcat acaggagtca
     1261 gcgcccatcg gcacagccgt aggccgagtg aaggcggagg actcagatgt gggcgagaac
     1321 acagacatga cttatcacct gagagaagag agtggcagtg gaggagacgc attcaaggtc
     1381 accacggaca gcgacactca ggaggccatc atagtggtgc agaagcacct ggacttcgag
     1441 tcgcagcagg tccacacagt ggtactggaa gccctcaaca agtttgtgga cccccgcttc
     1501 gccgacctgg gcacattccg agaccaggca atcgtgcgcg tggccgtgac cgatgtggat
     1561 gagccccccg agttccggcc accctccggc ctactggagg tgcaggagga cgcgcaggtg
     1621 ggctccctgg tcggcgtggt gacggcgcgg gaccccgacg ccgccaaccg gcccgtccgg
     1681 tacgccattg accgagactc ggatttggag cagatcttcg acatcgatgc ggacactggc
     1741 gccatcgtga ctggcaaggg gctggaccgt gaaaccgccg gctggcacaa cattactgtg
     1801 ttggccatgg aagcagacaa tcatgctcag ctgtctcggg catccctacg gatccgaatc
     1861 ctggatgtga atgacaatcc cccagagctg gccacaccct acgaggccgc tgtgtgtgaa
     1921 gacgccaagc caggccagct cattcaaacc atcagtgtgg tggacagaga cgaaccacag
     1981 ggcggccacc gcttctattt ccgcctggta ccagaggaac ccagcaaccc tcacttctct
     2041 ctgctggaca tcgaagataa cacggctgcg gtgcacaccc agcatgtggg cttcaaccgg
     2101 caagagcagg atgtgttcct cctgcccatc cttgttgtgg acagcgggcc acccaccctg
     2161 agcagcacag gcaccctcac catccgtatc tgcggctgtg acagttccgg taccatccag
     2221 tcctgcaaca ccactgcctt tgtcatggct gcctccctca gcccgggagc actcatcgct
     2281 ctcttggtct gtgtcctcat cctggtcgtg ctggctttgc tgattctcac cctcaggcgg
     2341 caccacaaga gccacctgag ctcagatgtg gatgaagaca tgcgggacaa cgtgatcaaa
     2401 tacaacgacg aaggcggcgg cgagcaggac accgaggctt atgacatgtc agcgctgcgg
     2461 agcctctacg atttcgggga gctcaagggt ggcgacccag gcgggggcgc ggccagtccc
     2521 ccgcaggctg cttcctcctc tgagcgccac tcgctgcctc gggggccgtc gagccccgag
     2581 ccggacttct cggtgttcag ggacttcatc agccgcaagg tggcgctggc ggacgcggac
     2641 ctgtcggtgc ctccctacga cgccttccag acctacgcgt tcgagggcgc gggctcgccg
     2701 gcagcctcgc tcagctcgct gcacagcggc tcgaccggct cggagcagga cttcgccttt
     2761 cttcgcgcct ggggcccgcg cttccgaccg ctggccgctc tctacgccgg ccaccgcggg
     2821 gacgacgagg ccccggcctc ctagccccag cccgcccagt ccgacgggag gggatccgca
     2881 gggcccccgc tccgcgacac gtttccaggg gtgcagcttg cggaggactc aggggtgcgg
     2941 gggtgacgag caatgtcagg agaaaggagg gaaacccggc ctgcacggat ctgggttgga
     3001 caggaccgcg gagggggaac ccggctctgg gaaaggacaa tgagaggaga aagcagagga
     3061 tggcgctgct gcggtgccca ccccaaggct ttctggcatc caattaaaga tgaaggaagg
     3121 gctgttcatt tactaagcac ctactgtgtg ctgagagcta cccggtaccg actgcattgt
     3181 tggagaaact atgaggtgga gtcctgaagg tgtcagatgg gaaagcctcc cagagaagtg
     3241 gttctgactt gtgcagggac acccagacag caagtggtgg agcctctggc actggccggc
     3301 tgcctggcct tgagcacgtc acctcacttc tctgggcctc agtttcctca tctgtcaaat
     3361 gaggttaata acagcaccta cctcgaagat ttgagaggat aaaaatggtt catgtgtcaa
     3421 gttgttgggc agtgcctggc acagagtagg tgtttaataa atgctcgcct ttgatacta
//
