LOCUS       NM_031333               4856 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus cadherin 2 (Cdh2), mRNA.
ACCESSION   NM_031333 XM_346508
VERSION     NM_031333.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4856)
  AUTHORS   Wang,L., Tsakiroglou,P., Gonzales,R., Cho,S., Li,A., Dos
            Remedios,C., Wright,N. and Kontrogianni-Konstantopoulos,A.
  TITLE     Essential role of obscurin kinase-1 in cardiomyocyte coupling via
            N-cadherin phosphorylation
  JOURNAL   JCI Insight 9 (3), e162178 (2024)
   PUBMED   38127465
  REMARK    GeneRIF: Essential role of obscurin kinase-1 in cardiomyocyte
            coupling via N-cadherin phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4856)
  AUTHORS   Zou,L., Wang,Y., Hu,Y., Liu,L., Luo,L., Chen,Z., Zhuo,Y., Li,P. and
            Zhou,Q.
  TITLE     N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus
            Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity
            Microenvironment
  JOURNAL   Int J Med Sci 21 (2), 341-356 (2024)
   PUBMED   38169592
  REMARK    GeneRIF: N-cadherin Alleviates Apoptosis and Senescence of Nucleus
            Pulposus Cells via Suppressing ROS-dependent ERS in the
            Hyper-osmolarity Microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4856)
  AUTHORS   Abdel-Ghani,M., Lee,Y., Akli,L.A., Moran,M., Schneeweis,A.,
            Djemil,S., El Choueiry,R., Murtadha,R. and Pak,D.T.S.
  TITLE     Plk2 promotes synaptic destabilization through disruption of
            N-cadherin adhesion complexes during homeostatic adaptation to
            hyperexcitation
  JOURNAL   J Neurochem 167 (3), 362-375 (2023)
   PUBMED   37654026
  REMARK    GeneRIF: Plk2 promotes synaptic destabilization through disruption
            of N-cadherin adhesion complexes during homeostatic adaptation to
            hyperexcitation.
REFERENCE   4  (bases 1 to 4856)
  AUTHORS   Liang,J.R. and Yang,H.
  TITLE     Ginkgolic acid (GA) suppresses gastric cancer growth by inducing
            apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS
  JOURNAL   Biomed Pharmacother 125, 109585 (2020)
   PUBMED   32106377
REFERENCE   5  (bases 1 to 4856)
  AUTHORS   Zhu,W.B., Zhao,Z.F. and Zhou,X.
  TITLE     AMD3100 inhibits epithelial-mesenchymal transition, cell invasion,
            and metastasis in the liver and the lung through blocking the
            SDF-1alpha/CXCR4 signaling pathway in prostate cancer
  JOURNAL   J Cell Physiol 234 (7), 11746-11759 (2019)
   PUBMED   30537000
REFERENCE   6  (bases 1 to 4856)
  AUTHORS   Chung,S.S., Mo,M.Y., Silvestrini,B., Lee,W.M. and Cheng,C.Y.
  TITLE     Rat testicular N-cadherin: its complementary deoxyribonucleic acid
            cloning and regulation
  JOURNAL   Endocrinology 139 (4), 1853-1862 (1998)
   PUBMED   9528971
REFERENCE   7  (bases 1 to 4856)
  AUTHORS   Hertig,C.M., Butz,S., Koch,S., Eppenberger-Eberhardt,M., Kemler,R.
            and Eppenberger,H.M.
  TITLE     N-cadherin in adult rat cardiomyocytes in culture. II.
            Spatio-temporal appearance of proteins involved in cell-cell
            contact and communication. Formation of two distinct
            N-cadherin/catenin complexes
  JOURNAL   J Cell Sci 109 (Pt 1), 11-20 (1996)
   PUBMED   8834786
REFERENCE   8  (bases 1 to 4856)
  AUTHORS   Hermiston,M.L. and Gordon,J.I.
  TITLE     Inflammatory bowel disease and adenomas in mice expressing a
            dominant negative N-cadherin
  JOURNAL   Science 270 (5239), 1203-1207 (1995)
   PUBMED   7502046
REFERENCE   9  (bases 1 to 4856)
  AUTHORS   Sacco,P.A., McGranahan,T.M., Wheelock,M.J. and Johnson,K.R.
  TITLE     Identification of plakoglobin domains required for association with
            N-cadherin and alpha-catenin
  JOURNAL   J Biol Chem 270 (34), 20201-20206 (1995)
   PUBMED   7650039
REFERENCE   10 (bases 1 to 4856)
  AUTHORS   Matsunami,H., Miyatani,S., Inoue,T., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Takeichi,M.
  TITLE     Cell binding specificity of mouse R-cadherin and chromosomal
            mapping of the gene
  JOURNAL   J Cell Sci 106 (Pt 1), 401-409 (1993)
   PUBMED   8270638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 5, 2020 this sequence version replaced NM_031333.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.53395.1, AF097593.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-901               JAXUCZ010000018.1  8264388-8265288     c
            902-1013            JAXUCZ010000018.1  8231387-8231498     c
            1014-1240           JAXUCZ010000018.1  8110987-8111213     c
            1241-1387           JAXUCZ010000018.1  8109179-8109325     c
            1388-1543           JAXUCZ010000018.1  8107194-8107349     c
            1544-1688           JAXUCZ010000018.1  8104933-8105077     c
            1689-1861           JAXUCZ010000018.1  8101513-8101685     c
            1862-1999           JAXUCZ010000018.1  8094371-8094508     c
            2000-2185           JAXUCZ010000018.1  8093480-8093665     c
            2186-2439           JAXUCZ010000018.1  8090982-8091235     c
            2440-2582           JAXUCZ010000018.1  8088365-8088507     c
            2583-2816           JAXUCZ010000018.1  8086195-8086428     c
            2817-3050           JAXUCZ010000018.1  8085652-8085885     c
            3051-3190           JAXUCZ010000018.1  8083693-8083832     c
            3191-3355           JAXUCZ010000018.1  8065262-8065426     c
            3356-4856           JAXUCZ010000018.1  8051097-8052597     c
FEATURES             Location/Qualifiers
     source          1..4856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..4856
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /note="cadherin 2"
                     /db_xref="GeneID:83501"
                     /db_xref="RGD:69280"
     exon            1..901
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     CDS             842..3562
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /note="cadherin 2, type 1, N-cadherin (neuronal); neural
                     cadherin"
                     /codon_start=1
                     /product="cadherin-2 precursor"
                     /protein_id="NP_112623.2"
                     /db_xref="GeneID:83501"
                     /db_xref="RGD:69280"
                     /translation="MCRIAGAPRTLLPLLAALLQASLEASGELALCKTGFPEAVYSAV
                     LPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLSAEQAKF
                     LIYAQDKETQEKWQVAVNLSLEPSLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRD
                     WVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQ
                     LSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGSV
                     PEGSKPGTYVMTVTAIDADDPNALNGMLRYRILSQAPSTPSPNMFTINNETGDIITVA
                     AGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP
                     ENRVDVIVANLTVTDKDQPHTPAWNAAYRISGGDPTGRFAILTDPNSNDGLVTVVKPI
                     DFETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEE
                     GLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVNGQITTIAVLDRESPNV
                     KNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNSINIT
                     ALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLEAGIYEVPIVI
                     TDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVL
                     MFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEP
                     DAIKPVGIRRLDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADNDPTAPPYDSLL
                     VFDYEGSGSTAGSLSSLNSSSSGGDQDYDYLNDWGPRFKKLADMYGGGDD"
     exon            902..1013
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1240
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1387
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1543
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1688
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1861
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1999
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2185
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2439
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2582
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2816
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..3050
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3190
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3355
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..4856
                     /gene="Cdh2"
                     /gene_synonym="N-cadherin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggagacc cttcgcggtg cacgcgagtg gcgaggagca ggcgtctggg gccgacgcgc
       61 gcgggcggcg aggggcacgg ccaccgcagc tctcccccca ccacaccgcc ccccgcttcg
      121 tgacaccccc cacgcggccg cagccggaga acagtctcca agtggcctgg gaacagggaa
      181 agggacgccg cggaggcctg gccagcggga ccgtcgccct ttgtgggcgc aacgcgcacg
      241 gccgcgagcg cccttcccgg aggcgctcta cccccggaag ctttgtcgca ccactcggcc
      301 ccggcgagga cgtccaggga aagggaaaag cgggggctcg aaagctcgcg tgggggagct
      361 gctgagagcg ccacccgccc agccgccacc tccgtatcct ccatccgccg catctctagg
      421 gctgcctccg cactcccggc cggagcccag ccgcctgcgc tgcggcccgc acacacgcac
      481 acgcgtgcac tcacttactc acacacacat acacacacac tcgcgcacac acacacactt
      541 ctcggcgcgc acgcacgccc gcccttctcc ccgccccctc cccagctcct tgatctcccg
      601 tctcttttat tactcctggt gcgagtccgg cggactccga ggcccgctat ttgttaccag
      661 ctcgctctca ttggcgggga gcgcagagca gcggagaagg gggtggggag gggaggggaa
      721 gggaaggggt ggccactgcc cggagccgtc tccgcgctgc tgttggtgcc gctgccgccg
      781 ctgctgctgc ctctgctgcc gccgccgcct ccggctcctc gctcggcccc tctccgcctc
      841 catgtgccgg atagcgggag cgccgcggac cctgctgccg cttctggcgg ccttgcttca
      901 ggcatctctg gaggcttctg gtgaacttgc attatgcaag actggatttc ctgaagctgt
      961 ttacagcgcg gtcttaccga aggacgtgca cgaaggccag cctcttctca atgtgaaatt
     1021 cagcaactgc aatagaaaaa ggaaagttca gtatgaaagc agtgaaccag cagatttcaa
     1081 ggtggatgag gacggcacag tgtacgctgt gagaagcttc cctctctctg cagagcaggc
     1141 aaagttcctg atatatgccc aagacaaaga aacccaggaa aagtggcagg tagctgttaa
     1201 cctgagcctg gagcccagcc tgactgagga gccgatgaag gaaccacatg aaattgaaga
     1261 aatagtattc cctagacaac tcgccaagca cagcggagct ctacaaaggc agaagagaga
     1321 ctgggtcatc cctccgatca acttgccaga aaactccaga ggaccctttc cgcaagagct
     1381 tgtcagaatc aggtctgata gagataagaa cctatctctg agatacagtg tcactgggcc
     1441 aggagctgac cagcctccaa cgggcatctt catcatcaac cccatctctg gacaactgtc
     1501 agtcacaaag cctctggaca gagaactgat agcccggttt cacctgaggg cacatgcagt
     1561 tgacatcaat ggcaatcaag tggagaaccc cattgacatc gtcatcaatg tcatcgacat
     1621 gaatgataac agacctgagt ttctgcacca ggtttggaat gggtctgttc cagagggatc
     1681 aaagcctggg acgtatgtga tgactgtcac tgccattgat gcagatgacc caaatgccct
     1741 gaatgggatg ctgaggtaca ggatcctctc ccaggcaccc agcacccctt ctcccaacat
     1801 gtttacaatc aacaacgaga ccggggacat catcactgtg gcagctggtc tggaccgaga
     1861 gaaagtgcaa cagtatacgt taataattca agccactgac atggaaggca atcccactta
     1921 tggcctttca aacacagcca cagccgtcat cacagtgaca gatgtcaatg acaatcctcc
     1981 agagtttact gccatgacct tctacggaga agtccctgag aacagagtgg atgtcattgt
     2041 agccaacctg actgtcaccg acaaggacca gccccacaca ccagcctgga atgcggcata
     2101 cagaatcagt ggtggagacc ccacgggaag gtttgccatc ctgacagacc ccaacagcaa
     2161 tgatgggcta gtcacagtgg taaaaccaat tgactttgaa acgaatagga tgtttgtcct
     2221 cactgttgct gcagaaaacc aagtgccatt agctaagggg atccagcacc cacctcagtc
     2281 gacagccacg gtgtctgtga cagttattga tgtcaatgaa aatccttatt ttgccccaaa
     2341 tcctaaaatc attcgccaag aggaaggcct ccacgcaggt accatgctga ccactctcac
     2401 tgctcaggac cccgatcgat atatgcaaca gaatatcaga tacacaaagt tatctgaccc
     2461 tgccaactgg ctgaaaatag accctgtgaa cgggcagatc accactatcg ctgttctgga
     2521 cagagagtcg ccaaatgtca aaaacaacat ctataatgct accttccttg cttctgacaa
     2581 tggaatccct cctatgagtg gaacaggaac gctgcaaatc tatttacttg atatcaatga
     2641 caacgcccct caggtgttac ctcaagaggc cgagacttgt gaaactccag aacccaattc
     2701 aattaacatc acagcgcttg attatgacat agaccccaat gcagggccct ttgcatttga
     2761 ccttccctta tccccagtga ctattaaaag aaactggacc atcacccggc ttaatggtga
     2821 ttttgctcag ctcaatttaa agatcaagtt tttggaagct ggcatctatg aagttcccat
     2881 cgttatcaca gattcaggga atccccccaa gtccaatatt tccatcctgc gtgtgaaagt
     2941 ttgccaatgt gactccaatg gagactgcac cgacgtagac aggatcgtgg gtgcagggct
     3001 tggcacgggc gccatcatcg cgatacttct gtgtatcatc atcctgctga tccttgtcct
     3061 catgttcgtg gtatggatga aacgccggga taaagagcgc caggccaagc agcttttaat
     3121 agacccagaa gatgatgtaa gagataacat attgaaatat gatgaagaag gtggaggaga
     3181 ggaagaccag gactatgact tgagccagct ccagcaacca gataccgtgg agcctgatgc
     3241 catcaaacct gtgggaatca gacggctaga cgagaggcct atccacgctg agccacagta
     3301 tccagtccga tccgcagccc cacaccctgg ggatattggg gacttcatta atgagggcct
     3361 taaagctgct gacaatgacc ccacggcgcc accatatgac tcccttttag tcttcgacta
     3421 tgagggcagc ggctccacgg ctggctcctt gagctctctc aactcctcca gcagcggcgg
     3481 ggaccaggac tatgactacc tgaatgactg gggaccccgc ttcaagaagc tggccgacat
     3541 gtatggtggt ggtgatgact gaacggcagg acggacttgg cttttggaca cgtatgaaca
     3601 gtttcacctg atattcccaa aaagcataca gaagctaggc tttaactctg tagtccacta
     3661 gcaccgtgct tgctggaggc tttggcgtag gctgcgaacc agtttgggct cccagggaat
     3721 atcagtgatc cgatactgtc tggaaaacac cgagctcagc tacacttgaa ttttacagta
     3781 cagaagcact gggattttat gtgccttttt gtaccttttt cagattggaa ttagttttct
     3841 gtttaaggct ttaatggtac tgatttctga aactataagg aaaagacaaa atattttgtg
     3901 gcgggagcag aaagttaaat gtgatacgct tcaacccact tttgttacaa tgcatttgct
     3961 tttgttaaga tacagaatga aacaacaaga ttaaaaaaaa ttaactcatg gagtgatttt
     4021 gttaccttgg ggtggggggt gggggatgag accacgagat aggaaaatgt acattacttc
     4081 tagttttaga ctttagattt tgtttttcac taaaatctta aaacttacgc agctggttgc
     4141 agataaaggg agttttcata tcaccaattt gtagcaaaat tgaatttttt cataaactag
     4201 aatgttagac acattttggt cttaatccat gtacactttt tttattttct gtattttttc
     4261 cacctcgctg taaaaatggt gtgtgtacat aatgtttcat cagcatagac tgtggaggag
     4321 tgcagagaac tcggaacatg tgtatgtatt atttggactt tggattcagg ttttttgcat
     4381 gttaatatct ttcgttatgg gtaaagtatt tacaaaacaa agtgacattt gattcaaccg
     4441 ttgagctgta gttagaatac tcaattttta attttttaat tttttaaatt ttttttaatt
     4501 ttctttttgt ttgttttgtt ttggggaggg ataaaagttc ttagcacaaa tgttttacat
     4561 aatttgtacc aaaaaaaatt acacacacac acacacacac acacacacac acacacacac
     4621 aaataaaagg aaagaaaagt aaaaggggtg gcctggtact ggcagcacta gcaagtgtgt
     4681 gtttttaaaa aacaaaacaa acaaacaaaa aaaattaata aagagaaaaa aaagaaaaaa
     4741 aagcttttaa actggagaga cttctgaaac agctttgcct ctgtgttgtg taccagaata
     4801 caaacaatac acccctgacc ccagcgttct gaataaaaag ctaattttgg atctgg
//
