LOCUS       NM_053977               3411 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cadherin 17 (Cdh17), mRNA.
ACCESSION   NM_053977
VERSION     NM_053977.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Bartolome,R.A., Pelaez-Garcia,A., Gomez,I., Torres,S.,
            Fernandez-Acenero,M.J., Escudero-Paniagua,B., Imbaud,J.I. and
            Casal,J.I.
  TITLE     An RGD motif present in cadherin 17 induces integrin activation and
            tumor growth
  JOURNAL   J Biol Chem 289 (50), 34801-34814 (2014)
   PUBMED   25336636
REFERENCE   2  (bases 1 to 3411)
  AUTHORS   Ohnishi,K., Melchers,F. and Shimizu,T.
  TITLE     Lymphocyte-expressed BILL-cadherin/cadherin-17 contributes to the
            development of B cells at two stages
  JOURNAL   Eur J Immunol 35 (3), 957-963 (2005)
   PUBMED   15688343
REFERENCE   3  (bases 1 to 3411)
  AUTHORS   Takamura,M., Ichida,T., Matsuda,Y., Kobayashi,M., Yamagiwa,S.,
            Genda,T., Shioji,K., Hashimoto,S., Nomoto,M., Hatakeyama,K.,
            Ajioka,Y., Sakamoto,M., Hirohashi,S. and Aoyagi,Y.
  TITLE     Reduced expression of liver-intestine cadherin is associated with
            progression and lymph node metastasis of human colorectal carcinoma
  JOURNAL   Cancer Lett 212 (2), 253-259 (2004)
   PUBMED   15279905
REFERENCE   4  (bases 1 to 3411)
  AUTHORS   Wendeler,M.W., Praus,M., Jung,R., Hecking,M., Metzig,C. and
            Gessner,R.
  TITLE     Ksp-cadherin is a functional cell-cell adhesion molecule related to
            LI-cadherin
  JOURNAL   Exp Cell Res 294 (2), 345-355 (2004)
   PUBMED   15023525
REFERENCE   5  (bases 1 to 3411)
  AUTHORS   Ohnishi,K., Shimizu,T., Karasuyama,H. and Melchers,F.
  TITLE     The identification of a nonclassical cadherin expressed during B
            cell development and its interaction with surrogate light chain
  JOURNAL   J Biol Chem 275 (40), 31134-31144 (2000)
   PUBMED   10906147
REFERENCE   6  (bases 1 to 3411)
  AUTHORS   Erickson,R.H., Gum,J.R. Jr., Lindstrom,M.M., McKean,D. and Kim,Y.S.
  TITLE     Regional expression and dietary regulation of rat small intestinal
            peptide and amino acid transporter mRNAs
  JOURNAL   Biochem Biophys Res Commun 216 (1), 249-257 (1995)
   PUBMED   7488096
REFERENCE   7  (bases 1 to 3411)
  AUTHORS   Berndorff,D., Gessner,R., Kreft,B., Schnoy,N., Lajous-Petter,A.M.,
            Loch,N., Reutter,W., Hortsch,M. and Tauber,R.
  TITLE     Liver-intestine cadherin: molecular cloning and characterization of
            a novel Ca(2+)-dependent cell adhesion molecule expressed in liver
            and intestine
  JOURNAL   J Cell Biol 125 (6), 1353-1369 (1994)
   PUBMED   8207063
REFERENCE   8  (bases 1 to 3411)
  AUTHORS   Dantzig,A.H., Hoskins,J.A., Tabas,L.B., Bright,S., Shepard,R.L.,
            Jenkins,I.L., Duckworth,D.C., Sportsman,J.R., Mackensen,D.,
            Rosteck,P.R. Jr. et al.
  TITLE     Association of intestinal peptide transport with a protein related
            to the cadherin superfamily
  JOURNAL   Science 264 (5157), 430-433 (1994)
   PUBMED   8153632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X78997.1 and JAXUCZ010000005.1.
            
            On Oct 11, 2007 this sequence version replaced NM_053977.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.21495.1,
                                           SRR26643286.15827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1061              X78997.1           223-1283
            1062-1699           JAXUCZ010000005.1  30111589-30112226
            1700-1740           X78997.1           1285-1325
            1741-2378           JAXUCZ010000005.1  30111589-30112226
            2379-4047           X78997.1           1327-2995
            4048-4685           JAXUCZ010000005.1  30111589-30112226
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3411
                     /gene="Cdh17"
                     /note="cadherin 17"
                     /db_xref="GeneID:117048"
                     /db_xref="RGD:619748"
     exon            1..83
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            84..153
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2589
                     /gene="Cdh17"
                     /note="LI-cadherin; liver-intestine cadherin"
                     /codon_start=1
                     /product="cadherin-17 precursor"
                     /protein_id="NP_446429.1"
                     /db_xref="GeneID:117048"
                     /db_xref="RGD:619748"
                     /translation="MVSAQLHFLCLLTLYLTGAYGQEGKFSGPLKPMTFSIFEGQEPS
                     QIIFQFKANPPAVTFELTGETDGIFKIEKDGLLYHTRVLDRETRAVHHLQLAALDSQG
                     AIVDGPVPIIIEVKDINDNRPTFLQTKYEGSVRQNSRPGKPFMYVNATDLDDPATPNG
                     QLFYQIVIQLPKINNVMYFQIDNKTGAISLTPEGSQVLDPIKNPYYNLVVSVKDMGGQ
                     NENSFSDTTSVDITVRENIWKAPEPVEIRENLTDPHPIKITQVQWNDPGAHYSLINKE
                     KLPQFPFSIDQEGNIYVTQPLDREEKDSHVFFATAKDENGKPLAYPLEIRVKVIDIND
                     NPPTCLSQVTVFEVQENEVLGSSIGIFAAHDMDEANNINSILKYRLVDQTPKVPSDEL
                     FLIDEYGGKVQLGKRSLKKQDSPQYNLTVEVSDIDFKTLCSLQVNVIDINDQIPIFER
                     SDYGSKTLSEDTAIGSTILIIQATDDDEPFTGSSKILYKIVQGDTEGRLEVVTDPMTN
                     TGYVKIRKPLDFETEPVTSIVFKAENPEPLVNGIEYNASSFASFELTVTDVNEVPVFP
                     QQIFQANVSEDTAIGTKVGTVTARDPEGLTVSYSLKDNKRGWLKIDSVTGDIFSTAPL
                     DRETESVYRVQVVATEVGGSSLSSTAYFHLVLMDVNDNPPRLAKDYTGLFFCHPLSAP
                     GSLIFEATDDDQQSVRRPKFTFALGRESLQSDWEVSKINGTHARLSTKHTRFEEQVYD
                     IPILINDGGQPPMEGIVSLSVTFCQCVDGSCFRPAGNQVGIPTVGMAVGILLTTFLVI
                     GIILAVVFIRMRKDKVEDPQSPENKPLRS"
     exon            154..252
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            253..387
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            388..526
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            527..685
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            686..885
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1017
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1168
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1384
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1461
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1653
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1898
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2029
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2269
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2386
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2500
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..3411
                     /gene="Cdh17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggttcttc agccacagca agtatctcca cggctgaatg gacgacaacg acttttaagc
       61 agtattttct tacttacaga aaggagtcca agtgaagaga gcaacatggt ctctgcccag
      121 cttcacttcc tgtgtcttct cacgctttat ttgactggcg catatggcca agaagggaag
      181 ttcagcggcc ccctgaaacc catgacattc tctatttttg aaggccaaga accgagtcaa
      241 atcatattcc agtttaaggc caaccctcca gctgtgactt ttgagctaac aggagagacg
      301 gatggtatat ttaagataga aaaggatgga cttctttatc acacaagagt cctggacaga
      361 gaaacaaggg cggttcatca tctgcagctt gcagccttgg attctcaggg agctatagtg
      421 gatggcccag tccccatcat catagaagtc aaggacatca atgacaaccg acctacattt
      481 ctccagacaa aatatgaagg ctcagtgagg cagaactctc gcccaggaaa gcctttcatg
      541 tatgtcaatg ctacagacct ggatgacccg gctactccca atggccagct tttttatcaa
      601 attgtcatcc agcttcccaa aatcaacaat gttatgtact tccagatcga caacaaaaca
      661 ggggcaatct cgcttacccc agaaggttct caggtattgg atccaataaa gaatccgtac
      721 tacaacctgg tggtctctgt gaaggacatg gggggccaga atgagaattc cttcagcgat
      781 accacatctg tggatattac tgtcagagag aacatctgga aagcaccaga gcctgtggag
      841 attcgagaaa acttaactga tcctcacccc atcaaaatca ctcaggtgca gtggaatgac
      901 ccaggggccc actattcctt aatcaacaag gagaagctgc cacagtttcc attctcgatc
      961 gaccaagaag gaaatattta cgtgactcag cctttggacc gtgaggaaaa ggactctcat
     1021 gttttctttg ccactgccaa ggatgagaat ggaaaacccc tcgcatatcc actggaaatt
     1081 cgtgtgaaag ttattgacat taatgacaac ccaccgacat gtctctctca agtgactgta
     1141 tttgaagtcc aggagaatga agtcttgggt agtagcattg ggatctttgc tgcccacgat
     1201 atggatgaag ctaacaatat caacagtatt ttgaagtaca gacttgtaga ccaaacaccc
     1261 aaagttccct cagatgaact ctttctcatt gacgaatatg gaggaaaggt ccagttgggt
     1321 aaacggtcct tgaagaagca agacagtcct cagtacaact taacagtaga ggtgtctgac
     1381 atagatttca agactctctg ttctcttcaa gtcaacgtta ttgatatcaa cgatcagatt
     1441 cccatctttg aaagatcaga ctatggaagc aagactcttt ctgaagacac agccatcgga
     1501 tccaccatct taatcatcca agctactgat gatgatgagc cctttaccgg gagctctaaa
     1561 attctgtaca agattgtaca gggagacact gagggaagac tggaagttgt cacagatccc
     1621 atgaccaata caggatacgt caagatcaga aagcctcttg attttgaaac cgaaccagtt
     1681 actagcattg tgttcaaagc agaaaaccct gagccgctgg tgaatggcat agagtacaat
     1741 gctagttctt ttgcctcctt cgagctgacc gtgacggatg tgaatgaagt gcctgtattt
     1801 ccccagcaaa tattccaagc caacgttagc gaggatactg ctataggcac taaagtgggc
     1861 actgtgactg ccagggatcc ggaaggcctg actgtgagtt attcactgaa agacaataag
     1921 agaggttggc ttaaaatcga ctccgtcacc ggcgacatat ttagcactgc tccgctggac
     1981 agggaaacag aaagtgtgta tcgagtacaa gtggtggcca ctgaagtagg tgggtcctct
     2041 ctgagttcta cagcatattt ccacctggtc ctcatggatg tgaatgacaa cccccctcgc
     2101 ctagctaagg actacacagg cttgttcttc tgccatcccc taagtgcccc tgggagcctc
     2161 atctttgaag ccactgatga tgaccagcag tcagttcgga ggcccaagtt tacgtttgcc
     2221 cttggcagag aaagcttaca aagtgactgg gaagtgtcca aaatcaatgg cacacatgct
     2281 agactctcca ccaagcacac acgctttgag gaacaagttt atgacatccc aatcctcatc
     2341 aatgatgggg ggcagccacc catggaaggc attgtctcct tatcagttac tttctgccag
     2401 tgtgtggacg gaagttgttt ccggccagca ggcaaccagg ttgggatacc caccgtgggc
     2461 atggcagttg gtatacttct gaccacattt ctggtcattg gtataatttt agcggttgta
     2521 ttcatccgta tgaggaaaga taaagttgaa gatccacagt cccctgagaa taagcctctg
     2581 aggagctgaa tttgaacaga aatgttcaag gttgtacacc aagcactgta tcaatgcctc
     2641 agctgtttaa tttcatccaa aatgtgaact ataattggta gagtttatgc atcatgtgct
     2701 atatctggtc cccagctgtt taatctcata atttcatcca aaatgtgaac tataatttct
     2761 ttgatggcat gcccttcttg tcctgcaaca cttaacgcta cttagatatt ttatctctgt
     2821 agacattaga gttactctcc attcccccat aacattttgc tcctttacaa aagcctacat
     2881 aacatgaact ttcccttctg ggaaagaaga tgaactaggt ataaaccctg tgtgctgttg
     2941 tttcagagac aagtctgttt tctcccaact gacttttcta ggctccactt atccctttct
     3001 gtttccacct gcgccccctg atctcagcat tacattaaat ttaaaatgtg tcacacaaaa
     3061 gaacaaagtg aagtccttgg ggggggtgtt gctaagtgga cagccttatt ctttagcaca
     3121 aacaacagct tctctgtgtt gtcatcttta atagaggtcc tccagcttgg ctatggtgta
     3181 gaccctgggg aggtatcaaa tacaactgcc gtgtttcaag aaagacctac ttcatgaggc
     3241 acaggaactg acgagctgtc tgggtttact cactactccg tgcttacata catgctgtac
     3301 atgttttatt tgtatattga agttttgtta tatatttatc atgtggagga aagacgaaag
     3361 catgtacgtg gtgaagaaat ccaaaataaa tgttggtttc agttgttttt a
//
