LOCUS       NM_031334               4396 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cadherin 1 (Cdh1), mRNA.
ACCESSION   NM_031334
VERSION     NM_031334.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4396)
  AUTHORS   Krimpenfort,R.A., van der Meulen,S.A., Verhagen,H., Driessen,M.,
            Filonova,G., Hoogenboezem,M., van den Akker,E., von Lindern,M. and
            Nethe,M.
  TITLE     E-cadherin/beta-catenin expression is conserved in human and rat
            erythropoiesis and marks stress erythropoiesis
  JOURNAL   Blood Adv 7 (23), 7169-7183 (2023)
   PUBMED   37792794
  REMARK    GeneRIF: E-cadherin/beta-catenin expression is conserved in human
            and rat erythropoiesis and marks stress erythropoiesis.
REFERENCE   2  (bases 1 to 4396)
  AUTHORS   Chang,J.H., Lee,Y.L., Laiman,V., Han,C.L., Jheng,Y.T., Lee,K.Y.,
            Yeh,C.T., Kuo,H.P., Chung,K.F., Heriyanto,D.S., Hsiao,T.C.,
            Wu,S.M., Ho,S.C., Chuang,K.J. and Chuang,H.C.
  TITLE     Air pollution-regulated E-cadherin mediates contact inhibition of
            proliferation via the hippo signaling pathways in emphysema
  JOURNAL   Chem Biol Interact 351, 109763 (2022)
   PUBMED   34852269
  REMARK    GeneRIF: Air pollution-regulated E-cadherin mediates contact
            inhibition of proliferation via the hippo signaling pathways in
            emphysema.
REFERENCE   3  (bases 1 to 4396)
  AUTHORS   Huang,X., Liang,X., Zhou,Y., Li,H., Du,H., Suo,Y., Liu,W., Jin,R.,
            Chai,B., Duan,R., Li,H. and Li,Q.
  TITLE     CDH1 is Identified as A Therapeutic Target for Skin Regeneration
            after Mechanical Loading
  JOURNAL   Int J Biol Sci 17 (1), 353-367 (2021)
   PUBMED   33390855
  REMARK    GeneRIF: CDH1 is Identified as A Therapeutic Target for Skin
            Regeneration after Mechanical Loading.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4396)
  AUTHORS   Sunnaghatta Nagaraja,S., Raviraj,R., Selvakumar,I.,
            Dharmalingam,D., Ramadas,N., Chellappan,D.R., Ponnachipudhur
            Chinnaswamy,P. and Nagarajan,D.
  TITLE     Radiation-induced H3K9 tri-methylation in E-cadherin promoter
            during lung EMT: in vitro and in vivo approaches using vanillin
  JOURNAL   Free Radic Res 54 (7), 540-555 (2020)
   PUBMED   32842802
  REMARK    GeneRIF: Radiation-induced H3K9 tri-methylation in E-cadherin
            promoter during lung EMT: in vitro and in vivo approaches using
            vanillin.
REFERENCE   5  (bases 1 to 4396)
  AUTHORS   Ikezaki,M., Nishioka,N., Nishikawa,T., Higashimoto,N. and Ihara,Y.
  TITLE     Hsc70 is required for E-cadherin expression in epithelial-like
            NRK-52E cells
  JOURNAL   Biochem Biophys Res Commun 527 (2), 481-488 (2020)
   PUBMED   32336545
  REMARK    GeneRIF: Hsc70 is required for E-cadherin expression in
            epithelial-like NRK-52E cells.
REFERENCE   6  (bases 1 to 4396)
  AUTHORS   Ohsugi,M., Hwang,S.Y., Butz,S., Knowles,B.B., Solter,D. and
            Kemler,R.
  TITLE     Expression and cell membrane localization of catenins during mouse
            preimplantation development
  JOURNAL   Dev Dyn 206 (4), 391-402 (1996)
   PUBMED   8853988
REFERENCE   7  (bases 1 to 4396)
  AUTHORS   Haegel,H., Larue,L., Ohsugi,M., Fedorov,L., Herrenknecht,K. and
            Kemler,R.
  TITLE     Lack of beta-catenin affects mouse development at gastrulation
  JOURNAL   Development 121 (11), 3529-3537 (1995)
   PUBMED   8582267
REFERENCE   8  (bases 1 to 4396)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
REFERENCE   9  (bases 1 to 4396)
  AUTHORS   Knudsen,K.A. and Wheelock,M.J.
  TITLE     Plakoglobin, or an 83-kD homologue distinct from beta-catenin,
            interacts with E-cadherin and N-cadherin
  JOURNAL   J Cell Biol 118 (3), 671-679 (1992)
   PUBMED   1639850
REFERENCE   10 (bases 1 to 4396)
  AUTHORS   Nagafuchi,A. and Takeichi,M.
  TITLE     Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa
            protein functionally associated with a specific region of the
            cytoplasmic domain of E-cadherin
  JOURNAL   Cell Regul 1 (1), 37-44 (1989)
   PUBMED   2519616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB017696.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4396
                     /gene="Cdh1"
                     /note="cadherin 1"
                     /db_xref="GeneID:83502"
                     /db_xref="RGD:69279"
     exon            1..174
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2787
                     /gene="Cdh1"
                     /note="uvomorulin; epithelial cadherin; E-cadherin"
                     /codon_start=1
                     /product="cadherin-1 precursor"
                     /protein_id="NP_112624.1"
                     /db_xref="GeneID:83502"
                     /db_xref="RGD:69279"
                     /translation="MGARCRSFSALLLLLQVSSWLCQQPESESDSCRPGFSSEVYTFL
                     VPERHLERGHILGRVKFEGCTGRPRTAFFSEDSRFKVSTDGVITVKRHLKLHKLETSF
                     LVHAWDSSYRKLSTKVTLKSLGHHHHRHHHRDPVSESNPELLTFPSFHQGLRRQKRDW
                     VIPPINCPENQKGEFPQRLVQIKSNRDKETTVFYSITGPGADKPPVGVFIIERETGWL
                     KVTQPLDREAIDKYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRPEFIQEVFEGSVA
                     EGALPGTSVMQVSATDADDDINTYNAAIAYTILSQDPELPHKNMFTVNRDTGVISVVT
                     SGLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPIFNPSTYQGQVLENE
                     VGARIATLKVTDDDAPNTPAWNAVYTVVNDPDHQFTVITDPKTNEGILKTAKGLDFEA
                     KQQYILHVTVENEEPFEGSLVPSTATVTVDVVDVNEAPIFVPAEKRVEVPEDFGVGLE
                     IASYTAREPDTFMEQKITYRIWRDTANWLEINPETGVISTRAEMDREDSEHVKNSTYT
                     ALIIATDDGSPIATGTGTLLLVLSDVNDNAPIPEPRNMQFCQRNPKPHVITILDPDLP
                     PNTSPFTAELTHGASVNWTIEYNDAEQESLILQPRKDLEIGEYKINLKLSDNQNKDQV
                     TTLEVHVCDCEGTVNNCMKAISLEAGLQVPAILGILGGILALLILILLLLLFLRRRTV
                     VKEPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVIRNDVAPTLMSM
                     PQYRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSE
                     SDQDQDYDYLNEWGNRFKKLADMYGGGEED"
     exon            175..301
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..525
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..669
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..825
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..970
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1146
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1275
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1458
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1703
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1849
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2074
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2302
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2433
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2577
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..4396
                     /gene="Cdh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtgtggg agccgcggcg cactactgag ttctcaagaa cttctgctag acttcagccc
       61 ggcctaaccc ggctctgccc gaccgcaccc gagctcagtg tttgctcggc gtttgcccgg
      121 ccagccatgg gagcccggtg ccgcagcttc tccgcgctcc tgctcctgct gcaggtctcc
      181 tcgtggcttt gtcagcagcc ggagtcggag tctgactcct gccgtcccgg cttcagttcc
      241 gaggtctaca ccttcctggt gccggagagg cacctggaga gaggccacat cctgggcaga
      301 gtgaaatttg aaggatgcac cggccgtcca aggacagcct tcttttctga agactcccga
      361 ttcaaagtgt ctacagatgg cgtcatcaca gtcaaacggc atctaaagct tcacaagctg
      421 gagaccagtt ttctcgtcca tgcctgggac tccagttaca ggaagctttc taccaaagtg
      481 acactgaagt ccctgggcca ccaccaccac cggcatcacc acagagaccc tgtctctgaa
      541 tccaacccag agctgctcac gtttcccagc tttcaccagg gtctgagaag acagaaacga
      601 gactgggtca tccctcccat caactgcccg gaaaatcaaa agggcgaatt cccccagcga
      661 ctggttcaga tcaaatccaa cagggacaaa gagacaacgg ttttctacag catcaccggc
      721 ccaggagctg acaaaccccc tgttggcgtt ttcatcattg agagggagac aggctggctg
      781 aaagtgacgc agcctctgga cagagaagcc attgacaagt accttctcta ctctcatgct
      841 gtgtcatcaa atggggaagc cgtggaggat cccatggaga tagtggtcac agtcacagat
      901 cagaatgaca acaggccaga gtttatccag gaggtctttg agggatctgt tgcagaaggc
      961 gctcttccag gaacctccgt gatgcaggtc tcagccactg atgcagacga tgacataaac
     1021 acctacaatg ctgccatcgc ctacaccatc ctcagccaag atcctgagct gcctcacaaa
     1081 aacatgttca ctgtcaaccg ggacactggg gtcatcagtg tggtcacctc cggactggac
     1141 cgagagagtt accctacata tactctggtg gttcaggctg ccgaccttca aggcgaaggc
     1201 ctaagcacaa cagcaaaagc tgtgatcact gtcaaggata ttaatgacaa cgctcccatc
     1261 ttcaacccaa gcacgtacca gggtcaagtg cttgagaatg aggtcggtgc ccgtattgcc
     1321 acactcaagg tgactgatga tgatgccccc aacactccag cgtggaatgc tgtgtacacc
     1381 gtagtcaatg atcctgatca tcagttcact gtcatcacag accccaagac caacgagggc
     1441 attctgaaaa cagccaaggg cttggatttt gaggccaagc agcagtacat tctgcacgtg
     1501 acagtggaaa atgaggagcc ctttgagggg tctcttgtcc cttccacagc cactgtcacc
     1561 gtggatgtgg tagacgtgaa tgaagccccc atttttgtgc ctgcggagaa gagagtcgag
     1621 gtgcctgagg actttggtgt gggtctggag atcgcatctt acactgcgcg agagccagac
     1681 acattcatgg aacagaagat cacgtatcgg atttggaggg acactgccaa ttggctggag
     1741 attaacccag agactggggt catttccact cgggctgaga tggacagaga agattcggag
     1801 catgtgaaga acagcacgta tacagctctc atcattgcca cagatgatgg ttcacccatt
     1861 gccactggca cagggactct tctcctggtc ctgtcagacg tcaacgacaa tgctcccatc
     1921 ccagaacctc gaaatatgca gttctgccag agaaacccga agccccatgt catcaccatc
     1981 ttggatccag accttccccc aaacacatcc cccttcactg cagagctcac ccatggggcc
     2041 agcgtcaact ggaccattga gtacaatgac gcagaacaag aatctctcat tttgcaacca
     2101 agaaaggact tagagattgg cgaatacaaa atcaatctca agctctcgga taaccagaat
     2161 aaagaccagg tgaccacgtt ggaggtccac gtgtgtgact gtgaagggac cgtcaacaac
     2221 tgcatgaagg cgatctccct ggaagcagga ttacaagttc ccgccatcct tggaatcctg
     2281 ggagggatcc tggccctcct gattctgatc ctcctgctcc tactgtttct acggaggaga
     2341 acggtggtca aagagccctt gctgccacca gatgacgata cccgggacaa tgtgtattac
     2401 tatgatgaag agggaggtgg agaagaagac caggactttg atttgagcca gctgcacagg
     2461 ggccttgatg ccagaccgga agtgattcga aatgatgtgg ctcccaccct catgagcatg
     2521 ccccagtatc gtccccgtcc agccaatcct gatgaaatcg ggaacttcat cgatgaaaac
     2581 ctgaaggcag cggacagtga ccccacagcg cccccttacg actctctgtt ggtgtttgac
     2641 tatgagggga gtggttctga agctgcctcc ctgagctcgc tgaactcctc tgagtcagat
     2701 caggaccagg actacgatta tctgaacgaa tggggcaacc ggttcaagaa gctggccgat
     2761 atgtatggtg gcggcgaaga agactagaga gtcgttcctg tgtggcacca tgggagatgc
     2821 agaatcatga tgtcagtggt ctttcagctc cttccctgac tttgtagaag agagactgat
     2881 ctgagaagta tgcagattgc atactggtcc cactctacct accagtctgt ctgtgttagg
     2941 agggttttca ctggttgttg gaatcttttt ctaaaatgtt tttgttttta cagtgctgtg
     3001 atgtgatgaa ctgtaccctc tttttgtttt tgttttgagc tatgttctgc tccggacaca
     3061 cagcccccaa gcccttcacc cctcactaat ttttttacat tgtatacttt cactcaatta
     3121 ccatgtttat gttctgtatt ctaatagcca ctaagttcct gaattctgtt gcctggccca
     3181 ggtgctattc tgtgacacag tagtgcctgg gcccttttat ggtaagagac aggtttcttg
     3241 gtgtgggtgc aactgagctg gatagtgtat gtttcaaaca cctttcctgt gttctctccc
     3301 cacctccaga gtgtctttac ttattcagct gtgtgtttgg ggcagaacaa aaaaataatg
     3361 ggaccactat gcaagctgcg aagattctaa ggtgcacacc tgattcttag gcagatgcca
     3421 tagtgagata tgttgctttg gttctctatc caatgctgtg accgggacct gcagcgaggt
     3481 tttcggacac cgtggtttct tgcgtttctt tcaaaccagc agtaaaaaat ggttttttct
     3541 gagagagact ggagtgccac caccaaagat agaggagaga agccaagctt ggggacagca
     3601 agcatgccag tgaacctgac cactgtcatg agtcatgtgg gtggccacat gtccgtgaac
     3661 ctggccagtt ggcacactga tggtgagggt acaaggaggc tagacctcgt cccacaaaat
     3721 ttctggaaga attagggttg tctcagccaa tgtttcctag ctggaatcct gtccatgtat
     3781 gtgttcctga agcccaggaa atacacccct ctagtgcctg cttttgatgg tagttataga
     3841 aaagaccggc tgatttggac ctgagttgcc caatcttaag tacaaataga aaactgagac
     3901 tatgctgggt gtgttggtgc acgcctttaa tcccggcact cgggaggcag agacagtctc
     3961 agatctctct gagttcaagg tcagcctggt atagtaagtg aattccagga cagccagggc
     4021 tacacagaaa ctctgtcttg gaaaaccaaa aaagaaaact gagaatatta gagattgtgc
     4081 attttctcag aaagcaggaa gaaaacacca ctctgatggg aaaagggagg caaggccctt
     4141 gagacttttc attgaaattg ctgtactcac ataattttgg aagcaaatga tgactgcaat
     4201 caactgtgag aactgttggt ttctctgtag tttaattgtc taatgttgat agcgtgccct
     4261 ttgtatgtag tttgagtgta tatgtgtgtg ggtgctgata attttgtatt ttgtggggag
     4321 tggaaaaggc aagcaatcgg aactgttctc taagatgcat ttttatgaat tttattaaag
     4381 agttttgtta aactgt
//
