LOCUS       NM_001115042            1508 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus cell division cycle associated 5 (Cdca5), mRNA.
ACCESSION   NM_001115042 XM_001075312 XM_001075342
VERSION     NM_001115042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Remeseiro S, Cuadrado A, Kawauchi S, Calof AL, Lander AD and Losada
            A.
  TITLE     Reduction of Nipbl impairs cohesin loading locally and affects
            transcription but not cohesion-dependent functions in a mouse model
            of Cornelia de Lange Syndrome
  JOURNAL   Biochim Biophys Acta 1832 (12), 2097-2102 (2013)
   PUBMED   23920377
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Equilibrina I, Matsunaga S, Morimoto A, Hashimoto T, Uchiyama S and
            Fukui K.
  TITLE     ASURA (PHB2) interacts with Scc1 through chromatin
  JOURNAL   Cytogenet Genome Res 139 (4), 225-233 (2013)
   PUBMED   23548868
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Modi PK, Komaravelli N, Singh N and Sharma P.
  TITLE     Interplay between MEK-ERK signaling, cyclin D1, and
            cyclin-dependent kinase 5 regulates cell cycle reentry and
            apoptosis of neurons
  JOURNAL   Mol Biol Cell 23 (18), 3722-3730 (2012)
   PUBMED   22833568
  REMARK    GeneRIF: Data show that the MEK-ERK pathway regulates cell
            cycle-related neuronal apoptosis (CRNA) by elevating the levels of
            cyclin D1, and the increase in cyclin D1 attenuates the activation
            of cyclin-dependent kinase 5 (cdk5) by its neuronal activator p35.
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Nishiyama T, Ladurner R, Schmitz J, Kreidl E, Schleiffer A,
            Bhaskara V, Bando M, Shirahige K, Hyman AA, Mechtler K and Peters
            JM.
  TITLE     Sororin mediates sister chromatid cohesion by antagonizing Wapl
  JOURNAL   Cell 143 (5), 737-749 (2010)
   PUBMED   21111234
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Schmitz J, Watrin E, Lenart P, Mechtler K and Peters JM.
  TITLE     Sororin is required for stable binding of cohesin to chromatin and
            for sister chromatid cohesion in interphase
  JOURNAL   Curr Biol 17 (7), 630-636 (2007)
   PUBMED   17349791
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Rankin S, Ayad NG and Kirschner MW.
  TITLE     Sororin, a substrate of the anaphase-promoting complex, is required
            for sister chromatid cohesion in vertebrates
  JOURNAL   Mol Cell 18 (2), 185-200 (2005)
   PUBMED   15837422
  REMARK    Erratum:[Mol Cell. 2005 May 27;18(5):609]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158663.1.
            
            On Mar 12, 2008 this sequence version replaced NM_001115042.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132306
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1508
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /note="cell division cycle associated 5"
                     /db_xref="GeneID:684771"
                     /db_xref="RGD:1560863"
     exon            1..154
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1476
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /codon_start=1
                     /product="sororin"
                     /protein_id="NP_001108514.2"
                     /db_xref="GeneID:684771"
                     /db_xref="RGD:1560863"
                     /translation="MSERRTRSGGAVQRSGPRTSLTKPSKSSKRKSGSDLPNTFPEVW
                     PKTTPAAPVRKAIILKKIVPRAVEVPDVHTPVRRSPRISFILEKENNPPLKVPTKEDL
                     FKTCSVPGTPSSTPVLCAQNVKSNSREVEPDTRDLEMSQKVRRSYSRLQSLHCASTST
                     PGRRSFFGFERPEDLPGVSPVIRSKLMETPKVPVKHLVPDRTLPGISPPIVKEKRKKK
                     VPEITSSTAKKIALYKQILKTAMQPTEPQLEEPKDSDVEPSSEQMLNEQPEPTVTFLF
                     TLLNTPEPRDEETDTEILENQFVDQDDWGPRRTSEEIQLLQMDCNRLQEALYANQREN
                     LILEEKLENLPTLLYGDLENILISPEESRVTQDTDKNTQGQAEDIYEEAEDIHEEAED
                     IQEEAGVTQEEVQPLAQPKSVSGPRYSFDVSIPLPASSVFPEDSYRNAPPVSPSLSPS
                     NKDPH"
     exon            155..246
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            247..312
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            313..351
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            352..777
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            778..879
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            880..974
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1073
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1140
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1484
                     /gene="Cdca5"
                     /gene_synonym="RGD1560863"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttctcgc tagccgggcg ggtaatttga acgtttgaag ccgcaaacct ccgggttggc
       61 gcgagcctaa gtaggcgacc gcggcggaaa ctgagcccga ccatagacat gtcggagcgg
      121 cgaacacgat ccggaggggc cgtccagcgg tctgggccca gaacttcact tactaagcct
      181 tcaaagtcgt ccaagcggaa atctggctca gatctcccga acacgttccc tgaagtttgg
      241 ccgaagacaa ctccagcagc tccagtcaga aaagccatca tcttgaagaa gattgtacct
      301 cgtgcagtag aggtcccaga tgtccacaca ccagttcgca ggagtcctag gatctctttt
      361 atcttggaaa aagagaacaa ccctccactc aaggtgccca ctaaggagga cctcttcaag
      421 acgtgtagcg tccctggcac tccctccagc acccccgtgc tgtgcgctca gaatgttaag
      481 tctaactcta gagaagtgga gccggacacc agagatttgg aaatgtctca gaaagtcagg
      541 cggtcctaca gtcggctaca gagcctccat tgtgcctcaa cctccacccc cggccgccga
      601 tccttctttg gctttgagag acctgaagac ttgcctggag tctcacctgt cattcgttca
      661 aagttaatgg agaccccaaa ggtgcctgtg aaacacttgg ttccagatag aacgctccct
      721 ggaatctctc ccccaattgt gaaagagaaa cgaaagaaga aggttcctga gatcacgtct
      781 tccacagcca agaagatcgc cctctacaag cagattttga aaacagccat gcagcctact
      841 gagccacaac tagaagaacc taaggactcc gacgtggagc catcttcaga gcaaatgttg
      901 aacgagcagc cggaacccac tgtcacattc ctgttcacac tcctgaacac tcctgagccc
      961 agagatgaag aaacggacac agagatattg gagaatcagt tcgtggatca ggatgactgg
     1021 ggccctaggc ggacctcaga agaaatacag cttttgcaga tggactgcaa taggcttcag
     1081 gaagctctgt acgctaacca gagggaaaac ctgatccttg aagagaagct agaaaacctg
     1141 cctaccttgt tgtacgggga cctggagaac attttgatca gtccagagga atctagggtc
     1201 acccaggaca cagataaaaa cacccaaggc caagcagagg acatctatga ggaagcagag
     1261 gacatccatg aggaagcaga ggacatccag gaggaagcag gggttaccca ggaggaagtc
     1321 caacctcttg cacaaccaaa gagtgtttct ggcccgcgct actcctttga tgtttccata
     1381 cctttgccag catccagcgt attcccagaa gattcataca ggaatgcccc accagtcagc
     1441 ccctctttaa gccccagcaa taaagatccc cactgattgc agaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaa
//
