LOCUS       NM_001024769            2101 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cell division cycle 73 (Cdc73), mRNA.
ACCESSION   NM_001024769 XM_222685
VERSION     NM_001024769.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Hosny Mohammed,K., Siddiqui,M.T., Willis,B.C., Zaharieva
            Tsvetkova,D., Mohamed,A., Patel,S., Sharma,J., Weber,C. and
            Cohen,C.
  TITLE     Parafibromin, APC, and MIB-1 Are Useful Markers for Distinguishing
            Parathyroid Carcinomas From Adenomas
  JOURNAL   Appl Immunohistochem Mol Morphol 25 (10), 731-735 (2017)
   PUBMED   27490759
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Cho,I., Lee,M., Lim,S. and Hong,R.
  TITLE     Significance of Parafibromin Expression in Laryngeal Squamous Cell
            Carcinomas
  JOURNAL   J Pathol Transl Med 50 (4), 264-269 (2016)
   PUBMED   27334641
REFERENCE   3  (bases 1 to 2101)
  AUTHORS   Zhang,Z., Yang,X.F., Huang,K.Q., Ren,L., Gou,W.F., Shen,D.F.,
            Zhao,S., Sun,H.Z., Takano,Y. and Zheng,H.C.
  TITLE     The clinicopathological significances and biological functions of
            parafibromin expression in head and neck squamous cell carcinomas
  JOURNAL   Tumour Biol 36 (12), 9487-9497 (2015)
   PUBMED   26124004
REFERENCE   4  (bases 1 to 2101)
  AUTHORS   Rather,M.I., Swamy,S., Gopinath,K.S. and Kumar,A.
  TITLE     Transcriptional repression of tumor suppressor CDC73, encoding an
            RNA polymerase II interactor, by Wilms tumor 1 protein (WT1)
            promotes cell proliferation: implication for cancer therapeutics
  JOURNAL   J Biol Chem 289 (2), 968-976 (2014)
   PUBMED   24257751
REFERENCE   5  (bases 1 to 2101)
  AUTHORS   Xia,P., Wang,W., Xu,X.Y., Wang,J.P., Takano,Y. and Zheng,H.C.
  TITLE     Parafibromin expression in lung normal tissue and carcinoma: its
            comparison with clinicopathological parameters of carcinoma
  JOURNAL   Histol Histopathol 26 (8), 1039-1047 (2011)
   PUBMED   21692036
REFERENCE   6  (bases 1 to 2101)
  AUTHORS   Mosimann,C., Hausmann,G. and Basler,K.
  TITLE     Parafibromin/Hyrax activates Wnt/Wg target gene transcription by
            direct association with beta-catenin/Armadillo
  JOURNAL   Cell 125 (2), 327-341 (2006)
   PUBMED   16630820
REFERENCE   7  (bases 1 to 2101)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   8  (bases 1 to 2101)
  AUTHORS   Yart,A., Gstaiger,M., Wirbelauer,C., Pecnik,M., Anastasiou,D.,
            Hess,D. and Krek,W.
  TITLE     The HRPT2 tumor suppressor gene product parafibromin associates
            with human PAF1 and RNA polymerase II
  JOURNAL   Mol Cell Biol 25 (12), 5052-5060 (2005)
   PUBMED   15923622
REFERENCE   9  (bases 1 to 2101)
  AUTHORS   Shattuck,T.M., Valimaki,S., Obara,T., Gaz,R.D., Clark,O.H.,
            Shoback,D., Wierman,M.E., Tojo,K., Robbins,C.M., Carpten,J.D.,
            Farnebo,L.O., Larsson,C. and Arnold,A.
  TITLE     Somatic and germ-line mutations of the HRPT2 gene in sporadic
            parathyroid carcinoma
  JOURNAL   N Engl J Med 349 (18), 1722-1729 (2003)
   PUBMED   14585940
REFERENCE   10 (bases 1 to 2101)
  AUTHORS   Carpten,J.D., Robbins,C.M., Villablanca,A., Forsberg,L.,
            Presciuttini,S., Bailey-Wilson,J., Simonds,W.F., Gillanders,E.M.,
            Kennedy,A.M., Chen,J.D., Agarwal,S.K., Sood,R., Jones,M.P.,
            Moses,T.Y., Haven,C., Petillo,D., Leotlela,P.D., Harding,B.,
            Cameron,D., Pannett,A.A., Hoog,A., Heath,H. 3rd, James-Newton,L.A.,
            Robinson,B., Zarbo,R.J., Cavaco,B.M., Wassif,W., Perrier,N.D.,
            Rosen,I.B., Kristoffersson,U., Turnpenny,P.D., Farnebo,L.O.,
            Besser,G.M., Jackson,C.E., Morreau,H., Trent,J.M., Thakker,R.V.,
            Marx,S.J., Teh,B.T., Larsson,C. and Hobbs,M.R.
  TITLE     HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw
            tumor syndrome
  JOURNAL   Nat Genet 32 (4), 676-680 (2002)
   PUBMED   12434154
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097445.1.
            
            On Jun 10, 2005 this sequence version replaced XM_222685.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097445.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2101
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /note="cell division cycle 73"
                     /db_xref="GeneID:304832"
                     /db_xref="RGD:1311766"
     exon            1..265
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1730
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /note="hyperparathyroidism 2 protein homolog; cell
                     division cycle protein 73 homolog; hyperparathyroidism 2
                     (with jaw tumor); cell division cycle 73, Paf1/RNA
                     polymerase II complex component, homolog"
                     /codon_start=1
                     /product="parafibromin"
                     /protein_id="NP_001019940.1"
                     /db_xref="GeneID:304832"
                     /db_xref="RGD:1311766"
                     /translation="MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWG
                     TGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEA
                     STSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGH
                     KEGIVQTEQIRSLSEAMLVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEV
                     DVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPV
                     DPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQT
                     PAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEK
                     KKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGP
                     AWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDR
                     PVFLRFWETLDRYMVKHKSHLRF"
     exon            266..371
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..441
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            442..504
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..557
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            558..646
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..863
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..962
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1041
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1106
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1164
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1200
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1288
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1450
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1551
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1693
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..2069
                     /gene="Cdc73"
                     /gene_synonym="Hrpt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggctgtt ggttcgcggc ggcggcggcg ggggaagagg gcgaggcgac ggggaaagga
       61 ggcggcgggc gcggcggcga cggcggtgcc cggggcccgc ggcggcggcg gctgtagcag
      121 cgaggggggc gaagatggcg gacgtgctca gcgtcctgcg acagtacaac atccagaaga
      181 aggagattgt ggtcaagggg gatgaagtga tcttcgggga gttctcctgg cccaagaatg
      241 tgaagaccaa ctatgtagtt tgggggaccg gaaaggaagg ccaacccaga gaatactaca
      301 cattggattc tatcctattt ctccttaata atgtgcacct ttcgcatcct gtttatgtcc
      361 gacgtgcagc tactgaaaat attcctgtgg ttagaagacc tgacagaaag gatctccttg
      421 gatatctcaa tggggaagca tcaacatcag caagcataga caggagtgcc cccctggaaa
      481 taggtcttca gcggtctact caagtcaaaa gagctgcaga tgaagtttta gcagaagcaa
      541 agaaaccacg aattgaggat gaagagtgtg tgcgccttga taaagagaga ttggcagccc
      601 gtttggaagg ccataaagaa ggaatcgtgc agactgaaca gattaggtct ttatctgaag
      661 ccatgttagt ggaaaaaatt gctgcaatca aagccaaaat tatggctaag aaaagatcta
      721 ctatcaagac cgatctagat gatgatataa ctgcccttaa gcagaggagt tttgtggatg
      781 ctgaggtaga tgtgaccaga gatattgtca gcagagagag agtatggcgg acaagaacaa
      841 ctatcttaca gagcacagga aagaattttt caaagaatat tttcgcaatt cttcaatcag
      901 taaaagccag agaagaaggg cgtgcccccg aacaacggcc agctccaaat gcagcccctg
      961 tggatcctac attgcgtaca aaacagccta ttccagctgc ctacaacaga tatgaccaag
     1021 aaagattcaa aggcaaagaa gaaacggaag gttttaagat cgatactatg ggtacctacc
     1081 atggcatgac gctgaaatct gtcacggaag gtgcatctgc ccgtaagact caaactcctg
     1141 cagcccagcc tgtacctaga ccagtgtctc aagcaagacc tcccccaaat cagaagaaag
     1201 ggtctcgaac acccatcatt attattcctg cagctaccac ttctttaata accatgctta
     1261 atgcaaaaga ccttctacag gatctgaaat ttgtcccatc agatgaaaag aagaaacagg
     1321 gatgtcaacg agaaaatgaa acactaatac agagaagaaa agaccagatg caacctgggg
     1381 gcacagcaat tagtgtcaca gtcccttaca gagtagtaga ccagcctctg aagcttatgc
     1441 ctcaagactg ggatcgagtc gtagctgttt ttgtacaagg tcctgcttgg cagttcaaag
     1501 gttggccatg gcttctacct gatggatcac cagttgacat atttgcaaaa attaaagcct
     1561 tccatctcaa gtatgatgaa gttcgtctag atccaaatgt tcaaaaatgg gatgtaacag
     1621 tattagaact cagctatcat aaacgtcatt tggatagacc agttttctta cgtttctggg
     1681 aaacattgga tagatacatg gtaaagcaca aatcccactt gagattctga atcatttaat
     1741 tcctcctttt ctgaaaactt ggattaagaa gcatggatat agcttgatct acagactgaa
     1801 accaagcttt atgaattcat caagaacttg taaatgaaga aggacacaga gtagtctttt
     1861 ataagacctt gtttgatgct gtgtgcttca aaggggcaat gcctcccatc catacaagca
     1921 aacttttttg gcttacaact atttttttaa tattagcctt ctagtctgta atggaaattg
     1981 tatattttga tagaagtttt ttctctattg gttaaattag cattacttaa aatttgtttc
     2041 tttagaaata aatacaggtt ataaatgtga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2101 a
//
