LOCUS       NM_001108352            2917 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus cell division cycle 7 (Cdc7), mRNA.
ACCESSION   NM_001108352 XM_001062185 XM_341183
VERSION     NM_001108352.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2917)
  AUTHORS   Ito S, Goto H, Kuniyasu K, Shindo M, Yamada M, Tanaka K, Toh GT,
            Sawa M, Inagaki M, Bartek J and Masai H.
  TITLE     Cdc7 kinase stimulates Aurora B kinase in M-phase
  JOURNAL   Sci Rep 9 (1), 18622 (2019)
   PUBMED   31819079
  REMARK    GeneRIF: Cdc7 kinase stimulates Aurora B kinase in M-phase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2917)
  AUTHORS   Yoshizawa-Sugata N and Masai H.
  TITLE     Human Tim/Timeless-interacting protein, Tipin, is required for
            efficient progression of S phase and DNA replication checkpoint
  JOURNAL   J Biol Chem 282 (4), 2729-2740 (2007)
   PUBMED   17102137
REFERENCE   3  (bases 1 to 2917)
  AUTHORS   Yoshizawa-Sugata N, Ishii A, Taniyama C, Matsui E, Arai K and Masai
            H.
  TITLE     A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required
            for efficient progression of S and M phases
  JOURNAL   J Biol Chem 280 (13), 13062-13070 (2005)
   PUBMED   15668232
REFERENCE   4  (bases 1 to 2917)
  AUTHORS   Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D,
            Mercurio C, Berthelsen J and Santocanale C.
  TITLE     Drf1, a novel regulatory subunit for human Cdc7 kinase
  JOURNAL   EMBO J 21 (12), 3171-3181 (2002)
   PUBMED   12065429
REFERENCE   5  (bases 1 to 2917)
  AUTHORS   Sato N, Arai K and Masai H.
  TITLE     Human and Xenopus cDNAs encoding budding yeast Cdc7-related
            kinases: in vitro phosphorylation of MCM subunits by a putative
            human homologue of Cdc7
  JOURNAL   EMBO J 16 (14), 4340-4351 (1997)
   PUBMED   9250678
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474079.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341183.3, XM_001062185.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2917
                     /gene="Cdc7"
                     /note="cell division cycle 7"
                     /db_xref="GeneID:360908"
                     /db_xref="RGD:1308351"
     exon            1..104
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            105..289
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1890
                     /gene="Cdc7"
                     /EC_number="2.7.11.1"
                     /note="cell division cycle 7 homolog"
                     /codon_start=1
                     /product="cell division cycle 7-related protein kinase"
                     /protein_id="NP_001101822.1"
                     /db_xref="GeneID:360908"
                     /db_xref="RGD:1308351"
                     /translation="MEEPMAFSPLRGCDRCPADDSLKKYEQSVKLSGIKRDIEELCEA
                     VPQLVSVFKIKDKIGEGTFSSVYLATAQLQEGREEKIALKHLIPTSHPVRIAAELQCL
                     TVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFVALK
                     RIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCS
                     RNKCHGVIGHKGPLSRPAPKNVDQHITTKTSVKRSYANAQIHIKQGKDGKEGSVGLSV
                     QRSVFGERNFNIHSSISHESPAEKLIKQSKTVDIMSRKLATKKMAVSTKAVNSSMRDS
                     ARSCPAALTCDCYGTDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWS
                     AGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSILCSKEVPAQD
                     LRTLCERLRGPDSANPKSAVDPPGNTGHHPAASESTDHKAPHAPASPAQHSEDSLYKR
                     GSGGGRRHPRDRTANPEGWDSVPDDAYDLLDKLLDLNPASRITAEAALVHPFFKDVC"
     exon            290..373
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            374..509
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            510..603
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            604..746
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            747..996
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1092
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1268
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1351
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1501
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..2917
                     /gene="Cdc7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattcaaagc agcgcgggaa gaatcgcgcc tgcgcgtttg gcgggccggc tcagtgggac
       61 gctccgggag gcagcgaccg cggacgtcca aacttccgtg aaccctgctg ctctcgcttg
      121 tgcgcatgac tcggtagccc actgctctct gcatcccagt cgtgcgtggt ggaagcctct
      181 ttggggactc agatggagga gccaatggcg ttttctcccc tgcgtggctg tgacaggtgt
      241 ccggctgatg actctttaaa aaaatatgag cagagtgtta aactttcagg tattaaaaga
      301 gatattgagg agctttgcga agccgtacca cagcttgtca gtgtgttcaa aattaaggac
      361 aaaatcggag aaggcacctt cagctctgtt tatttggcca cagcgcagct gcaagaagga
      421 cgtgaagaga agattgcgct gaaacactta attcccacaa gccatcctgt gaggattgcg
      481 gccgagcttc agtgtctgac cgtcgcaggg gggcaggaca atgtcatggg agtgaagtac
      541 tgcttcagga agaacgacca tgtggtgatt gctatgccct acctggaaca tgagtctttt
      601 ctggacattt tgaattctct ttcctttcaa gaagttcgag aatatatgtt caaccttttc
      661 gtagctctga agcggattca ccagtttggc attgttcacc gtgatgtgaa gcccagtaac
      721 tttttataca atagacgcct gaaaaagtat gccttggtgg acttcggttt ggcccaagga
      781 acccgtgaca caaagataga gctgctcaag tttgtccagt ctgaagctca gcaggaagat
      841 tgttcacgaa acaaatgtca tggagtcatt ggacacaagg gcccactgag tcgcccagca
      901 cctaaaaatg tggatcagca catcaccaca aaaacttctg tcaaaagatc ctatgcaaac
      961 gcacagattc acattaagca aggaaaagac ggaaaggagg ggtctgtagg cctttctgtc
     1021 cagcgctctg tttttggaga aagaaatttc aatatacaca gctccatttc acatgagagc
     1081 cctgcagaga aactcatcaa gcaatcgaag actgtggaca taatgtcaag aaagctagca
     1141 acaaaaaaga tggccgtttc tacaaaggct gtgaatagct cgatgaggga ctctgccagg
     1201 tcctgcccag ctgccctcac gtgcgactgc tatggaacag atagagtgtg cagcgtttgc
     1261 ctgtcgaggc ggcagcaggt tgcccctagg gcaggcacac caggattcag agcgccagag
     1321 gtcctgacaa agtgtcctga ccagactaca gcgattgaca tgtggtctgc aggtgtcata
     1381 ttcctttcct tgctcagtgg gcggtacccg ttttacaagg ccagcgatga cttaactgct
     1441 ttggcccaaa tcatgacaat tcgaggatcc agggaaacta tccaggctgc taaagctttt
     1501 ggcaaatcaa ttttgtgtag caaagaagtc ccagcacaag acttgaggac gctctgtgag
     1561 agactacggg gtccggactc tgccaatccc aagtctgctg ttgatcctcc agggaatact
     1621 ggccaccacc ctgctgcttc ggagagcact gaccataaag cgccccatgc accggcctct
     1681 ccggcacagc actcggagga ttccctgtat aaaaggggca gcggcggtgg tcggagacat
     1741 cccagagatc gaactgccaa cccagagggc tgggactcgg tgcctgatga cgcctatgac
     1801 ctgctcgata aacttctgga cttaaaccca gcctccagga taacagcaga agcggccttg
     1861 gtccatccgt tctttaaaga tgtgtgctga tgtggcttcc cactcactgt tgtcgccgtg
     1921 cggtgtgatg tggggtagat aaccacgggt tgtttgtgtc ggagtccagg gtagaaagag
     1981 taagttgtca gattgtaaac agattaagaa ttctgaagat cctgggggat ccttagcaag
     2041 atcttggagt gaaaccacca agttgactct gtggcttagt gtcctggttt tccctgcctc
     2101 aggagtaacc cacttagcct gatatagggg tccaggtcag acagctaaca atgtgacagg
     2161 gagaagtgag tgaaaacagt ttccaaggca gtgtgtgctc tacaccgtgt gcacgtggga
     2221 attggctgtt ggtggcggac aggtgtgcaa gtgaacaatt attgcagaaa tgtttgtcac
     2281 tgcctaacat agtcattgta aattacacgg tgcttactac agagtttctg gatgcttcac
     2341 taagtgctac aagtatttat atttggagcc taataatgtg tgtatggttg ataagacaga
     2401 aatgcttctt tttctcatag tatttttttt cctcacacca ccttcatttg cttaattagg
     2461 taatggacac aaagaaaagt gagtgtagaa ctggaacatt actggtgtgt gtgtgtgtat
     2521 gtgtgtgtgt gtgtctgtct gtcttgtctg tctgtctgtc tgccaggagc atctgcattt
     2581 ctgtttaagt tgatttggtc aggaggaatg ggtcttaggt agttgagaaa aagacactaa
     2641 gtgacaaagc acaaaaggct tggtacagcg atttgtgctt tacttatgtt ctaaactctg
     2701 tgtcaaggat agcgtaccag gcttcccagg ggtcacagac tatagggagc ggtctctgag
     2761 tgttcacgtt actgctgtga atgtgggtag ataaatgtgt ctcatggatc tatttgacgt
     2821 gtatatttgt gtgtatacat gctttgtctt atgctgtaat tttttaaaac ttcagtgttt
     2881 caggatatgt atttaataat aaaactttta gactctt
//
