LOCUS       NM_001108298            2672 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cell division cycle 6 (Cdc6), mRNA.
ACCESSION   NM_001108298 XM_001081412 XM_340896
VERSION     NM_001108298.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Chen,C., Lu,J., Yu,Q., Xiao,J.R., Wei,H.F., Song,X.J., Ge,J.B.,
            Tao,W.D., Qian,R., Yu,X.W. and Zhao,J.
  TITLE     Expression of CDc6 after acute spinal cord injury in adult rats
  JOURNAL   Neuropeptides 56, 59-67 (2016)
   PUBMED   26899166
  REMARK    GeneRIF: Cell division cycle 6 might play crucial roles in central
            nervous system pathophysiology after spinal cord injury.
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Varma,D., Chandrasekaran,S., Sundin,L.J., Reidy,K.T., Wan,X.,
            Chasse,D.A., Nevis,K.R., DeLuca,J.G., Salmon,E.D. and Cook,J.G.
  TITLE     Recruitment of the human Cdt1 replication licensing protein by the
            loop domain of Hec1 is required for stable kinetochore-microtubule
            attachment
  JOURNAL   Nat Cell Biol 14 (6), 593-603 (2012)
   PUBMED   22581055
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Uranbileg,B., Yamamoto,H., Park,J.H., Mohanty,A.R.,
            Arakawa-Takeuchi,S., Jinno,S. and Okayama,H.
  TITLE     Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the
            bound p27 protein undergoes C-terminal phosphorylation
  JOURNAL   J Biol Chem 287 (9), 6275-6283 (2012)
   PUBMED   22223646
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Bronze-da-Rocha,E., Lin,C.M., Shimura,T. and Aladjem,M.I.
  TITLE     Interactions of MCP1 with components of the replication machinery
            in mammalian cells
  JOURNAL   Int J Biol Sci 7 (2), 193-208 (2011)
   PUBMED   21383955
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Yim,H. and Erikson,R.L.
  TITLE     Cell division cycle 6, a mitotic substrate of polo-like kinase 1,
            regulates chromosomal segregation mediated by cyclin-dependent
            kinase 1 and separase
  JOURNAL   Proc Natl Acad Sci U S A 107 (46), 19742-19747 (2010)
   PUBMED   21041660
REFERENCE   6  (bases 1 to 2672)
  AUTHORS   Arakawa-Takeuchi,S., Kobayashi,K., Park,J.H., Uranbileg,B.,
            Yamamoto,H., Jinno,S. and Okayama,H.
  TITLE     Mammalian target of rapamycin complex 1 signaling opposes the
            effects of anchorage loss, leading to activation of Cdk4 and Cdc6
            stabilization
  JOURNAL   FEBS Lett 584 (13), 2779-2785 (2010)
   PUBMED   20466002
  REMARK    GeneRIF: Activation of mTORC1 overrides the absence of the
            anchorage and stabilizes Cdc6 at least partly via activating Cdk4/6
            that induces Emi1, an APC/C(Cdh1) ubiquitin ligase inhibitor.
REFERENCE   7  (bases 1 to 2672)
  AUTHORS   Kan,Q., Jinno,S., Yamamoto,H., Kobayashi,K. and Okayama,H.
  TITLE     ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6
  JOURNAL   Proc Natl Acad Sci U S A 105 (12), 4757-4762 (2008)
   PUBMED   18356301
  REMARK    GeneRIF: Cdc6 protein can activate p21-associated Cdk2 in an
            ATP-dependent manner in vitro.
REFERENCE   8  (bases 1 to 2672)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   9  (bases 1 to 2672)
  AUTHORS   Fujita,N., Furukawa,Y., Itabashi,N., Okada,K., Saito,T. and
            Ishibashi,S.
  TITLE     Differences in E2F subunit expression in quiescent and
            proliferating vascular smooth muscle cells
  JOURNAL   Am J Physiol Heart Circ Physiol 283 (1), H204-H212 (2002)
   PUBMED   12063292
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_340896.3, XM_001081412.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132300,
                              SAMD00155325 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2672
                     /gene="Cdc6"
                     /note="cell division cycle 6"
                     /db_xref="GeneID:360621"
                     /db_xref="RGD:1309157"
     exon            1..173
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            174..367
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1872
                     /gene="Cdc6"
                     /note="cell division cycle 6 homolog"
                     /codon_start=1
                     /product="cell division control protein 6 homolog"
                     /protein_id="NP_001101768.1"
                     /db_xref="GeneID:360621"
                     /db_xref="RGD:1309157"
                     /translation="MPQTRSQTQATIDFPKKKQSKTLSKTNSRDSEVKLRNVQPVPTT
                     PCADIKILPLSPRKRLGDDNLCNTPHLSPCSPPKLGRKENGPPRSHTRKGCRLIFDDE
                     LAVKASAPKEQDRVPQHQILSSAQRGQESETNPEQKCPPEKESACMRLFKQEGTCYQQ
                     AKLVLNTAVPDRLPAREQEMGVIRDFLKEHICGKKAGSLYLSGAPGTGKTACLSRILQ
                     DFKKEVKGFKTIVLNCMSLRNAQAVFPAIAQEIGREELCRPTGKDLMRKLEKHLTAER
                     GPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEAR
                     EGCKPKLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKAL
                     DVCRRAIEIVESDVRSQTVLKPLSECKSPCESLVPKRVGLAHISQVISGVDGNRVTLS
                     QENTQDSLPLQQKILVCSLLLLTKRLKIKEVTLGKLYEAYSSVCRKQQVAAVDQSECL
                     SLSGLLESRGIVGLKKNKESRLTKVSLKIEEKEIEHVLKGKAFIGNILAAGLP"
     exon            368..649
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            650..849
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1025
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1132
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1272
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1373
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1438
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1641
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1782
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2672
                     /gene="Cdc6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtggagtgc tggctagttc tgtgcagggg aggacggagc tgcactgcct ggacttggga
       61 gagcctaaat gtctggaact aaactagtgc taaagacgtc tcgcatgtct ggagtgaagg
      121 aactagaagt attatagaaa ttactggaga taaacttctg gcatcgctca agtttgtgtg
      181 gccatcatgc ctcaaacccg atcccagaca caagctacca tcgactttcc gaaaaagaag
      241 caatctaaga ccctgagcaa gacaaactcc cgtgacagtg aagtaaaact tagaaacgtc
      301 cagcctgtac ccaccactcc gtgtgcggac ataaaaattc tgcctctcag tccccgaaaa
      361 cgtttgggtg atgacaatct gtgcaacact ccccatttat ctccatgttc tccgcccaag
      421 ctgggcagga aggaaaacgg cccccctcgc tcacatacac ggaagggatg cagattaata
      481 ttcgatgatg agctggcagt taaggcttcc gccccaaaag aacaagacag agttccccag
      541 caccaaatac tttcctccgc tcaaagaggt caagagagcg aaacaaatcc tgagcagaaa
      601 tgcccaccag agaaggaatc cgcgtgtatg cgactgttca agcaggaagg cacttgctat
      661 caacaggcaa agcttgtcct gaatacagct gtcccggacc ggctgcctgc cagagaacag
      721 gagatgggtg tcatcaggga tttcctgaag gagcacatct gtgggaaaaa agctgggagt
      781 ctctaccttt ctggcgctcc tggaactggg aaaactgcct gtttaagccg gattctgcag
      841 gacttcaaga aggaagtgaa aggctttaaa actatcgtgc tgaattgcat gtccctgagg
      901 aacgctcagg ccgtgttccc agccattgct caggagattg gtcgggagga actctgcaga
      961 cccaccggga aggacttgat gagaaagctg gaaaagcact tgacagccga gaggggcccc
     1021 atgattgtgt tggtgttgga cgagatggat cagctggaca gcaaagggca ggatgtgtta
     1081 tacaccctgt ttgagtggcc gtggttaagc aattcccgat tggtgctcat tggtattgct
     1141 aataccctgg atctcacgga cagaattctg ccgagacttg aagctagaga aggctgtaag
     1201 ccgaagctac tgaacttccc accttacacc aggaatcaga tagctgcgat cttgcaggat
     1261 aggcttagtc aggtatcaaa agaccaggtt ctggacagtg ctgcgattca gttctgtgcc
     1321 cgcaaagtat ctgctgtctc aggggacatc cggaaagcgc tggatgtttg caggcgagct
     1381 attgaaattg tggagtcgga tgtcaggagc cagacagtcc tcaaaccact ctccgaatgt
     1441 aaatcaccct gcgagtcgct ggttcccaag cgtgtcggtc tcgctcacat atcccaagtc
     1501 atttcgggag ttgatggtaa cagggtgact ttgagccaag aaaacacaca ggattccctt
     1561 cctctccagc agaagatctt ggtttgctct ttgctgctct tgaccaagcg gctaaaaatc
     1621 aaagaggtca ccctggggaa gttatatgaa gcctacagta gtgtctgtcg taaacagcag
     1681 gtggcagccg tagaccagtc tgagtgtttg tccctttctg gactcctgga atccaggggc
     1741 attgtgggac tgaagaaaaa caaggagagc cgcctcacca aggtgtctct gaagattgaa
     1801 gaaaaggaga tagagcatgt cctaaaaggc aaagctttca ttgggaacat cctcgctgcc
     1861 gggctgccct gaacggttct cttccttagg gcacctgcaa gcgtcctgct ggcgtttgca
     1921 gctcggggga gtcttcgttt tagtaaggtc gttcggaaac agttaacggc cttttttact
     1981 ccgcaccagt aaattttagt gtatgaattc ctgagtgtta gcactggcta atgtccttgg
     2041 ctcttactgt ttttacccat aaaaatgacc gagtgctggg tgtgatggcg gatgcctgtg
     2101 ctcccagcac ttgggaaaca gagtcaggag ttcaaggcca tcctttgcta cacagtgagt
     2161 ttgagctagc ccggactaca caagactgta aaaagtaaaa gcagggctgg ggatttagct
     2221 cagtggtaga gcgcttacct aggaagcgca aggccctggg ttcggtcccc agctccgaaa
     2281 aaaaaagaac caaaaaaaaa aaaaaaaagt aaaagcaatg acccctttta aagcaacatt
     2341 cagtactttt cccttcctga ccacggtacc tgcaagtgtg tacagacttg tgttgaagaa
     2401 ttcgtatgta tattacctct gtctacaaag ggtgtgtttt gtaaagaact ttgaggttta
     2461 gaaagatgaa acggaatgat ccagaaaaat acacaagcct acatgggaaa cacaaaggac
     2521 attttgtgca gaggacgctc catacatgtg acaggtgctg ccgcaccgga ctttctaaag
     2581 acgggtggac gattctccag cgctccccac cagtatgggg gtgacaagga gagtgtaact
     2641 acagattgtg aatatattta ttttcaagtt tg
//
