LOCUS       NM_053527               2831 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cell division cycle 5-like (Cdc5l), mRNA.
ACCESSION   NM_053527
VERSION     NM_053527.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Marechal,A., Li,J.M., Ji,X.Y., Wu,C.S., Yazinski,S.A., Nguyen,H.D.,
            Liu,S., Jimenez,A.E., Jin,J. and Zou,L.
  TITLE     PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and
            drives ATR activation via a ubiquitin-mediated circuitry
  JOURNAL   Mol Cell 53 (2), 235-246 (2014)
   PUBMED   24332808
REFERENCE   3  (bases 1 to 2831)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   4  (bases 1 to 2831)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2831)
  AUTHORS   Urano-Tashiro,Y., Sasaki,H., Sugawara-Kawasaki,M., Yamada,T.,
            Sugiyama,A., Akiyama,H., Kawasaki,Y. and Tashiro,F.
  TITLE     Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex
            formation in neuronal differentiation
  JOURNAL   J Neurosci Res 88 (13), 2787-2797 (2010)
   PUBMED   20629186
REFERENCE   6  (bases 1 to 2831)
  AUTHORS   Johnson,L.M. and Too,C.K.
  TITLE     Prolactin, interleukin-2 and FGF-2 stimulate expression, nuclear
            distribution and DNA-binding of rat homolog of pombe Cdc5 in Nb2 T
            lymphoma cells
  JOURNAL   Mol Cell Endocrinol 184 (1-2), 151-161 (2001)
   PUBMED   11694351
REFERENCE   7  (bases 1 to 2831)
  AUTHORS   Lei,X.H., Shen,X., Xu,X.Q. and Bernstein,H.S.
  TITLE     Human Cdc5, a regulator of mitotic entry, can act as a
            site-specific DNA binding protein
  JOURNAL   J Cell Sci 113 Pt 24, 4523-4531 (2000)
   PUBMED   11082045
REFERENCE   8  (bases 1 to 2831)
  AUTHORS   Boudrez,A., Beullens,M., Groenen,P., Van Eynde,A., Vulsteke,V.,
            Jagiello,I., Murray,M., Krainer,A.R., Stalmans,W. and Bollen,M.
  TITLE     NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a
            regulator of pre-mRNA splicing and mitotic entry
  JOURNAL   J Biol Chem 275 (33), 25411-25417 (2000)
   PUBMED   10827081
REFERENCE   9  (bases 1 to 2831)
  AUTHORS   Too,C.K.
  TITLE     Differential expression of elongation factor-2, alpha4
            phosphoprotein and Cdc5-like protein in
            prolactin-dependent/independent rat lymphoid cells
  JOURNAL   Mol Cell Endocrinol 131 (2), 221-232 (1997)
   PUBMED   9296381
REFERENCE   10 (bases 1 to 2831)
  AUTHORS   Bernstein,H.S. and Coughlin,S.R.
  TITLE     Pombe Cdc5-related protein. A putative human transcription factor
            implicated in mitogen-activated signaling
  JOURNAL   J Biol Chem 272 (9), 5833-5837 (1997)
   PUBMED   9038199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053527.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111403.1, AF000578.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JAXUCZ010000009.1  23062397-23062546
            151-254             JAXUCZ010000009.1  23064912-23065015
            255-416             JAXUCZ010000009.1  23066753-23066914
            417-544             JAXUCZ010000009.1  23067477-23067604
            545-644             JAXUCZ010000009.1  23068823-23068922
            645-863             JAXUCZ010000009.1  23073044-23073262
            864-1008            JAXUCZ010000009.1  23075834-23075978
            1009-1197           JAXUCZ010000009.1  23076860-23077048
            1198-1346           JAXUCZ010000009.1  23079508-23079656
            1347-1509           JAXUCZ010000009.1  23080728-23080890
            1510-1674           JAXUCZ010000009.1  23081829-23081993
            1675-1755           JAXUCZ010000009.1  23084660-23084740
            1756-1998           JAXUCZ010000009.1  23085028-23085270
            1999-2196           JAXUCZ010000009.1  23088128-23088325
            2197-2409           JAXUCZ010000009.1  23099615-23099827
            2410-2831           JAXUCZ010000009.1  23100478-23100899
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..2831
                     /gene="Cdc5l"
                     /note="cell division cycle 5-like"
                     /db_xref="GeneID:85434"
                     /db_xref="RGD:70892"
     exon            1..150
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2514
                     /gene="Cdc5l"
                     /note="cell division cycle 5-related protein; cdc5-like
                     protein; pombe Cdc5-related protein; CDC5 cell division
                     cycle 5-like"
                     /codon_start=1
                     /product="cell division cycle 5-like protein"
                     /protein_id="NP_445979.1"
                     /db_xref="GeneID:85434"
                     /db_xref="RGD:70892"
                     /translation="MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAK
                     QCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEF
                     LLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLA
                     NTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRGVDYNAEIPFEK
                     KPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLP
                     SAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSAS
                     STLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDF
                     SGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNI
                     NPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREMD
                     DTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLT
                     DLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKF
                     SKEDLKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANL
                     ASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLLKQLNDLWD
                     QIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQQRYADLLMEKETL
                     QAKF"
     exon            151..254
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            255..416
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            417..544
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            545..644
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            645..863
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1008
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1197
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1346
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1509
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1674
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1755
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1998
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2196
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2409
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2831
                     /gene="Cdc5l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcgctctt ggaggaagtg gcctctttgc gtcccgtgac cgaagcgccg ttactacttt
       61 ctcgaagctc cactcggccg cttgccggga cactccgccg ccaagatgcc ccggattatg
      121 atcaaagggg gcgtgtggag gaatacggag gatgaaattc ttaaagcagc ggtaatgaaa
      181 tatgggaaaa accagtggtc taggattgcc tcattgctgc ataggaaatc ggcaaagcag
      241 tgcaaagcca gatggtacga atggctggac ccaagtatta agaaaactga atggtccaga
      301 gaagaggaag aaaagctctt gcacttggcc aagctgatgc caacgcagtg gaggaccatt
      361 gctccaatca taggaaggac agcagcccag tgcttggagc actatgaatt cctcctggac
      421 aaaactgccc aaagggacaa tgaagaggaa acaacagatg acccccgaaa acttaagcct
      481 ggagagatag atccaaatcc agaaaccaaa ccagcccggc ctgatccaat tgacatggat
      541 gaggatgaac ttgagatgct ttctgaggct cgagcccgtt tggccaatac tcaaggaaag
      601 aaggctaaga ggaaagcaag agaaaagcag ttggaagaag caaggcgcct tgctgccctc
      661 cagaaaagac gggaacttcg agcagctggc atagagattc agaagaaaag gaaaaagaag
      721 agaggagttg attataatgc tgaaatccca tttgaaaaaa agcctgctct tggtttttat
      781 gatacttctg aggagaatta ccaggccctt gatgctgatt tcaggaaatt acgacagcag
      841 gatcttgacg gggagctaag atctgaaaaa gaaggaagag atagaaaaaa agacaaacag
      901 catttaaaaa ggaaaaaaga atctgattta ccatctgcta tccttcaaac tagtggtgtc
      961 tctgagttta ctaaaaagag aagcaaactt gtgctgcctg cccctcagat ttcagatgct
     1021 gaactccagg aagttgtcaa ggtaggccag gccagtgaag ttgcacggca gactgcggag
     1081 gagtctggga tcacaaactc tgcttctagc actctcctgt ctgagtacaa tgtcacaaac
     1141 aacagcattg ctctgagaac accacggact ccagcctccc aagacaggat tctacaggaa
     1201 gctcagaacc tcatggcctt gaccaatgtg gacactccac tgaaaggtgg gcttaacacc
     1261 ccactgcacg agagtgactt ctctggtgtg acgccacagc ggcaggttgt gcagactcca
     1321 aatacggttc tgtctacccc tttcaggact ccttctaatg gagctgaagg gctgactccc
     1381 cggagtggaa caaccccgaa accagtcact aacgccaccc caggtagaac accacttaga
     1441 gacaaattaa acattaatcc agaggatgga atggcagact acagtgaccc ctcttacgtg
     1501 aagcagatgg aaagagaatc tcgtgaacat ctccgtctag ggttgttagg cctccctgca
     1561 ccgaagaatg attttgaaat tgttctgcca gaaaatgcgg agaaggaact ggaagaacgt
     1621 gaaatggatg acacgtacat cgaggatgct gctgatgtgg atgctcgcaa gcaggccata
     1681 cgagatgctg agcgtgtaaa ggaaatgaaa cgaatgcaca aagctgttca gaaggatcta
     1741 cccagaccgt ctgaagtaaa tgaaactatt ttaagacctt taaatgtaga accacctcta
     1801 acagatttgc agaaaagtga ggaactgatc aaaaaagaga tgattacgat gcttcattat
     1861 gacctgctgc atcaccccta cgagccgtct gggaataaga aagggaaaaa cgtcgggttt
     1921 gctaccaaca attcagagca cattacctat cttgagcata gcccttatga gaagttctcc
     1981 aaagaggatc taaaaaaggc ccaggatgtt ctggtgcaag agatggaagt ggtaaaacaa
     2041 ggaatgagcc acggagaact ctccagtgaa gcttacaacc aggtgtggga ggaatgctac
     2101 agtcaagtcc tctatcttcc tgctcagagc cgctacacac gggctaatct tgctagcaaa
     2161 aaggacagaa ttgaatcact tgaaaagaga cttgagataa acaggggtca catgacaaca
     2221 gaagccaaga gagctgcaaa gatggaaaaa aagatgaaga ttttgctggg tggttaccag
     2281 tcccgcgcca tggggctcct gaagcagctg aacgacctgt gggaccaaat cgagcaggcg
     2341 cacctggagc tgcgcacctt tgaggaactc aagaaacacg aagactctgc tattccccgt
     2401 aggctagagt gtctaaagga agatgtgcag cggcaacagg aaagagagaa agagcttcag
     2461 caaagatatg cggatttgct gatggagaaa gagactttac aggcaaagtt ctgaagcaca
     2521 gaggacgctc tgcctcagaa gaactagttg ctggtttcgt actcagcaag gccgagactg
     2581 acctttctcc tcattgacaa agtcacccag cacctgtggg ctctcggttg cttgttttga
     2641 atgatactga tcttgcgtgt tctgtgttac aaacttggac tccaggataa tgagggttta
     2701 aattatccag atgctcattc tttgccagtg tcatatttac aaaatttcgt agtttaggcc
     2761 tttaatttaa aaagcctgat tttaaatact gcctgcaagt aaacccttga ataaaaagaa
     2821 catgtgaaga a
//
