LOCUS       NM_171994                928 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cell division cycle 42 (Cdc42), mRNA.
ACCESSION   NM_171994
VERSION     NM_171994.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 928)
  AUTHORS   Ravichandran,Y., Hanisch,J., Murray,K., Roca,V., Dingli,F.,
            Loew,D., Sabatet,V., Boeda,B., Stradal,T.E. and
            Etienne-Manneville,S.
  TITLE     The distinct localization of CDC42 isoforms is responsible for
            their specific functions during migration
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38386112
  REMARK    GeneRIF: The distinct localization of CDC42 isoforms is responsible
            for their specific functions during migration.
REFERENCE   2  (bases 1 to 928)
  AUTHORS   Li,Y.T., Chen,F.Z., Chen,W., Zhu,H.M., Chen,Y., Li,Z.L., Yan,F.,
            Liu,Z.Y., Dong,W.R., Zhang,L. and Wang,H.H.
  TITLE     Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by
            Inhibiting Glycogen Synthase Kinase-3beta
  JOURNAL   J Integr Neurosci 21 (5), 133 (2022)
   PUBMED   36137969
  REMARK    GeneRIF: Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons
            by Inhibiting Glycogen Synthase Kinase-3beta.
REFERENCE   3  (bases 1 to 928)
  AUTHORS   Sasaki,S., Takahashi,R., Luo,Y., Chujo,K., Sera,T. and Kudo,S.
  TITLE     Spatiotemporal distribution of PKCalpha, Cdc42, and Rac1 before
            directed cell migration
  JOURNAL   Biochem Biophys Res Commun 584, 26-31 (2021)
   PUBMED   34753065
  REMARK    GeneRIF: Spatiotemporal distribution of PKCalpha, Cdc42, and Rac1
            before directed cell migration.
REFERENCE   4  (bases 1 to 928)
  AUTHORS   Okabayashi,K., Nakamura,M. and Narita,T.
  TITLE     Cdc42 activates paracellular transport in polarised submandibular
            gland cells
  JOURNAL   Arch Oral Biol 132, 105276 (2021)
   PUBMED   34634536
  REMARK    GeneRIF: Cdc42 activates paracellular transport in polarised
            submandibular gland cells.
REFERENCE   5  (bases 1 to 928)
  AUTHORS   Li,Z., Wu,J., Zhang,X., Ou,C., Zhong,X., Chen,Y., Lu,L., Liu,H.,
            Li,Y., Liu,X., Wu,B., Wang,Y., Yang,P., Yan,J. and Chen,M.
  TITLE     CDC42 promotes vascular calcification in chronic kidney disease
  JOURNAL   J Pathol 249 (4), 461-471 (2019)
   PUBMED   31397884
  REMARK    GeneRIF: CDC42 contributes to vascular calcification in chronic
            kidney disease through a mechanism involving AKT signaling.
REFERENCE   6  (bases 1 to 928)
  AUTHORS   Zhang,B. and Zheng,Y.
  TITLE     Negative regulation of Rho family GTPases Cdc42 and Rac2 by
            homodimer formation
  JOURNAL   J Biol Chem 273 (40), 25728-25733 (1998)
   PUBMED   9748241
REFERENCE   7  (bases 1 to 928)
  AUTHORS   Auer,K.L., Contessa,J., Brenz-Verca,S., Pirola,L., Rusconi,S.,
            Cooper,G., Abo,A., Wymann,M.P., Davis,R.J., Birrer,M. and Dent,P.
  TITLE     The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which
            agonists stimulate DNA synthesis in primary cultures of rat
            hepatocytes
  JOURNAL   Mol Biol Cell 9 (3), 561-573 (1998)
   PUBMED   9487126
REFERENCE   8  (bases 1 to 928)
  AUTHORS   Fanger,G.R., Johnson,N.L. and Johnson,G.L.
  TITLE     MEK kinases are regulated by EGF and selectively interact with
            Rac/Cdc42
  JOURNAL   EMBO J 16 (16), 4961-4972 (1997)
   PUBMED   9305638
REFERENCE   9  (bases 1 to 928)
  AUTHORS   Teramoto,H., Coso,O.A., Miyata,H., Igishi,T., Miki,T. and
            Gutkind,J.S.
  TITLE     Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the
            c-Jun N-terminal kinase/stress-activated protein kinase pathway. A
            role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel
            member of the mixed lineage kinase family
  JOURNAL   J Biol Chem 271 (44), 27225-27228 (1996)
   PUBMED   8910292
REFERENCE   10 (bases 1 to 928)
  AUTHORS   Symons,M., Derry,J.M., Karlak,B., Jiang,S., Lemahieu,V.,
            Mccormick,F., Francke,U. and Abo,A.
  TITLE     Wiskott-Aldrich syndrome protein, a novel effector for the GTPase
            CDC42Hs, is implicated in actin polymerization
  JOURNAL   Cell 84 (5), 723-734 (1996)
   PUBMED   8625410
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_171994.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060535.1, CF976511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840106, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                JAXUCZ010000005.1  154876492-154876511 c
            21-174              JAXUCZ010000005.1  154857322-154857475 c
            175-247             JAXUCZ010000005.1  154854083-154854155 c
            248-357             JAXUCZ010000005.1  154851240-154851349 c
            358-555             JAXUCZ010000005.1  154850939-154851136 c
            556-928             JAXUCZ010000005.1  154839596-154839968 c
FEATURES             Location/Qualifiers
     source          1..928
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..928
                     /gene="Cdc42"
                     /note="cell division cycle 42"
                     /db_xref="GeneID:64465"
                     /db_xref="RGD:71043"
     exon            1..20
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            21..174
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..645
                     /gene="Cdc42"
                     /EC_number="3.6.5.2"
                     /note="cell division cycle 42 homolog; cell division cycle
                     42 (GTP binding protein)"
                     /codon_start=1
                     /product="cell division control protein 42 homolog"
                     /protein_id="NP_741991.3"
                     /db_xref="GeneID:64465"
                     /db_xref="RGD:71043"
                     /translation="MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTV
                     MIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEIT
                     HHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL
                     TQKGLKNVFDEAILAALEPPEPKKSRRCVLL"
     exon            175..247
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            248..357
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            358..555
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            556..928
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccggcgg agaagctgag gtcaacatca gtttgagata ttaaaagtgg atacaaaact
       61 atttacgcca tgcagacaat taagtgtgtt gttgttggtg atggtgctgt tggtaaaaca
      121 tgtctcctga tatcctacac aacaaacaaa ttcccgtcgg agtatgtacc aactgttttt
      181 gacaactatg cagtcacagt tatgattggt ggagagccat acactcttgg actttttgat
      241 actgcagggc aagaggatta tgacagacta cgaccgttaa gttatccaca gacagatgtt
      301 tttctagtat gtttctcagt ggtctctcca tcctcatttg aaaatgtgaa agaaaagtgg
      361 gtgcctgaga taactcacca ctgtccaaag actcctttct tgcttgtcgg gacccaaatt
      421 gatctcagag atgacccttc tactattgag aaacttgcca agaacaaaca gaagcctatt
      481 actccagaga ctgctgaaaa gctggcgcgg gatctgaagg ctgtcaagta tgtggagtgt
      541 tccgccctca cacagaaagg cctaaagaat gtgtttgatg aagcaatatt ggctgccttg
      601 gagcctccag aaccgaagaa gagccgcagg tgtgtgctgc tatgaacgca tctccagagc
      661 cctttctgca cagctggtgt tgtcatcata ctaaaagcaa tgtttaaatc aaactaaaga
      721 ttaaaaatta aaattcgttt ctgcaataat gacagacgac ctgcacctac ccacatgcac
      781 tcatgtgaga caaggcccat tagtatggcc cccttgccct tccggtaata gttaattttg
      841 aataattatg tattgtctaa aaagcgatga gtgctagttt tgtttccttg tttaaaaaaa
      901 aaaaaaaaac aacgcaaatc cccacaaa
//
