LOCUS       NM_053743               1627 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cell division cycle 37, HSP90 cochaperone
            (Cdc37), mRNA.
ACCESSION   NM_053743 XM_001077364
VERSION     NM_053743.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Sun,W., Mao,X., Wu,W., Nan,Y., Xu,C., Wang,Y. and Xu,H.
  TITLE     Inhibition of Cdc37 Ameliorates Arthritis in Collagen-Induced
            Arthritis Rats by Inhibiting Synoviocyte Proliferation and
            Migration Through the ERK Pathway
  JOURNAL   Inflammation 46 (3), 1022-1035 (2023)
   PUBMED   36920636
  REMARK    GeneRIF: Inhibition of Cdc37 Ameliorates Arthritis in
            Collagen-Induced Arthritis Rats by Inhibiting Synoviocyte
            Proliferation and Migration Through the ERK Pathway.
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Liu,Y., Wang,S., Ding,D., Yu,Z., Sun,W. and Wang,Y.
  TITLE     Up-Regulation of Cdc37 Contributes to Schwann Cell Proliferation
            and Migration After Sciatic Nerve Crush
  JOURNAL   Neurochem Res 43 (6), 1182-1190 (2018)
   PUBMED   29687307
  REMARK    GeneRIF: The expression of Cdc37 increased and reached a peak at
            one week after sciatic nerve crush.
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Woodford,M.R., Sager,R.A., Marris,E., Dunn,D.M., Blanden,A.R.,
            Murphy,R.L., Rensing,N., Shapiro,O., Panaretou,B., Prodromou,C.,
            Loh,S.N., Gutmann,D.H., Bourboulia,D., Bratslavsky,G., Wong,M. and
            Mollapour,M.
  TITLE     Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates
            folding of kinase and non-kinase clients
  JOURNAL   EMBO J 36 (24), 3650-3665 (2017)
   PUBMED   29127155
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   Datta,R., Bansal,T., Rana,S., Datta,K., Chattopadhyay,S.,
            Chawla-Sarkar,M. and Sarkar,S.
  TITLE     Hsp90/Cdc37 assembly modulates TGFbeta receptor-II to act as a
            profibrotic regulator of TGFbeta signaling during cardiac
            hypertrophy
  JOURNAL   Cell Signal 27 (12), 2410-2424 (2015)
   PUBMED   26362850
  REMARK    GeneRIF: Blocking Hsp90-Cdc37 interactions during pressure overload
            hypertrophy results in ubiquitin-mediated proteasomal degradation
            of TGFBR2 leading to termination of TGF beta mediated signaling.
            Erratum:[Cell Signal. 2020 Jan;65:109437. doi:
            10.1016/j.cellsig.2019.109437.. PMID: 31668398]
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Erazo,T., Moreno,A., Ruiz-Babot,G., Rodriguez-Asiain,A.,
            Morrice,N.A., Espadamala,J., Bayascas,J.R., Gomez,N. and
            Lizcano,J.M.
  TITLE     Canonical and kinase activity-independent mechanisms for
            extracellular signal-regulated kinase 5 (ERK5) nuclear
            translocation require dissociation of Hsp90 from the ERK5-Cdc37
            complex
  JOURNAL   Mol Cell Biol 33 (8), 1671-1686 (2013)
   PUBMED   23428871
REFERENCE   6  (bases 1 to 1627)
  AUTHORS   Miyata,Y. and Nishida,E.
  TITLE     CK2 controls multiple protein kinases by phosphorylating a
            kinase-targeting molecular chaperone, Cdc37
  JOURNAL   Mol Cell Biol 24 (9), 4065-4074 (2004)
   PUBMED   15082798
  REMARK    GeneRIF: Results unveil a regulatory mechanism of Cdc37, identify a
            molecular link between casein kinase 2 (CK2) and many crucial
            protein kinases via Cdc37, and reveal the molecular basis for the
            ability of CK2 to regulate pleiotropic cellular functions.
REFERENCE   7  (bases 1 to 1627)
  AUTHORS   Stewart,S., Sundaram,M., Zhang,Y., Lee,J., Han,M. and Guan,K.L.
  TITLE     Kinase suppressor of Ras forms a multiprotein signaling complex and
            modulates MEK localization
  JOURNAL   Mol Cell Biol 19 (8), 5523-5534 (1999)
   PUBMED   10409742
REFERENCE   8  (bases 1 to 1627)
  AUTHORS   Young,J.C., Obermann,W.M. and Hartl,F.U.
  TITLE     Specific binding of tetratricopeptide repeat proteins to the
            C-terminal 12-kDa domain of hsp90
  JOURNAL   J Biol Chem 273 (29), 18007-18010 (1998)
   PUBMED   9660753
REFERENCE   9  (bases 1 to 1627)
  AUTHORS   Ozaki,T. and Sakiyama,S.
  TITLE     Interaction of rat Cdc37-related protein with retinoblastoma gene
            product
  JOURNAL   DNA Cell Biol 15 (11), 975-979 (1996)
   PUBMED   8945638
REFERENCE   10 (bases 1 to 1627)
  AUTHORS   Ozaki,T., Irie,K. and Sakiyama,S.
  TITLE     Molecular cloning and cell cycle-dependent expression of a novel
            gene that is homologous to cdc37
  JOURNAL   DNA Cell Biol 14 (12), 1017-1023 (1995)
   PUBMED   8534368
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053743.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26564.1, BC061720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000008.1  27966719-27966930   c
            213-491             JAXUCZ010000008.1  27958949-27959227   c
            492-600             JAXUCZ010000008.1  27958414-27958522   c
            601-716             JAXUCZ010000008.1  27958206-27958321   c
            717-839             JAXUCZ010000008.1  27958003-27958125   c
            840-1022            JAXUCZ010000008.1  27956626-27956808   c
            1023-1094           JAXUCZ010000008.1  27956428-27956499   c
            1095-1627           JAXUCZ010000008.1  27954294-27954826   c
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..1627
                     /gene="Cdc37"
                     /note="cell division cycle 37, HSP90 cochaperone"
                     /db_xref="GeneID:114562"
                     /db_xref="RGD:71006"
     exon            1..212
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1250
                     /gene="Cdc37"
                     /note="p50Cdc37; hsp90 chaperone protein kinase-targeting
                     subunit; CDC37 (cell division cycle 37 S. cerevisiae
                     homolog); cell division cycle 37 homolog"
                     /codon_start=1
                     /product="hsp90 co-chaperone Cdc37"
                     /protein_id="NP_446195.2"
                     /db_xref="GeneID:114562"
                     /db_xref="RGD:71006"
                     /translation="MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQ
                     KEKEELDRGCRECKRKVAECQRKLKELEVAEGGGQVELERLRAEAQQLRKEERSWEQK
                     LEDMRKKEKNMPWNVDTLSKDGFSKSMVNTKPEKAEEDSEEAREQKHKTFVEKYEKQI
                     KHFGMLHRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTMVMQ
                     FILELAKSLKVDPRACFRQFFTKIKTADQQYMEGFKYELEAFKERVRGRAKLRIEKAM
                     KEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHM
                     QRCIDSGLWVPNSKSGEAKEGEEAGPGDPLLEAVPKAGNEKDISA"
     exon            213..491
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            492..600
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            601..716
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            717..839
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1022
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1094
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1627
                     /gene="Cdc37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcggaag gggcggggcg gggcgagcgg actctctagc ccttgtgggt ccctgttcag
       61 cgcccggccg tgtggagacc cgggagccag tccgggcctc cgaggcgaag atggtggact
      121 acagcgtttg ggatcacatc gaggtgtcgg acgatgagga cgagacgcac cccaacatag
      181 acacggccag cctgttccgc tggcggcacc aggcccgggt ggaacgcatg gaacagtttc
      241 agaaggagaa agaagaactg gaccggggct gccgggaatg caagcgcaag gtagccgagt
      301 gccagcgcaa gctgaaggaa ctggaagtgg ctgagggtgg tggccaggtg gagcttgagc
      361 ggcttcgagc ggaggcacag cagctgcgca aggaggagcg aagctgggag cagaagctgg
      421 aggacatgcg caaaaaggag aagaacatgc cctggaatgt ggacacactc agcaaagatg
      481 gcttcagcaa gagcatggtc aataccaagc ctgagaaggc agaggaagac tcagaggagg
      541 caagggagca gaaacacaag accttcgttg aaaaatacga gaaacagatc aaacatttcg
      601 gcatgctcca ccgctgggat gacagccaga agtacctgtc agacaatgtc cacctggtgt
      661 gcgaggagac agccaactac ctggttatct ggtgcattga cctggaagtc gaggagaagt
      721 gtgccctgat ggagcaggtg gctcaccaga ccatggtcat gcagttcatc ctggagttgg
      781 ccaagagtct gaaggtcgac ccccgggcct gcttccggca gtttttcacc aagatcaaga
      841 ctgctgacca gcagtacatg gagggcttca agtatgaact ggaggccttt aaggagcgtg
      901 tgcggggccg cgccaagctg cgaatagaga aggccatgaa ggagtacgag gaggaggagc
      961 gcaagaagag gctaggccct ggtggcctgg accctgtgga ggtctacgaa tctctgcctg
     1021 aggagctgca gaagtgcttt gatgtgaagg atgtacagat gctgcaagac gccatcagca
     1081 agatggatcc tactgatgcc aagtatcaca tgcagcgttg catcgattct ggcctctggg
     1141 tccccaactc caagtctggt gaggccaagg agggggagga ggcgggcccc ggggacccat
     1201 tgctggaagc cgtccccaaa gcgggcaacg agaaagacat cagtgcgtga cccttctcca
     1261 gaaaaggaaa cccagccacc atgtccctag ctcccgactt cttcacttct gctgctcctc
     1321 acgtcctggc ccatggcctg ccccatgtcc cctctcctcc ggcctgtccc cagcactcat
     1381 cagattctct gcttcgggtt gaggggctct gctgtctgca gcccccccac ccccatcagc
     1441 gttatgccaa agtcctgggg gtctggggag gggcagcagc tgccaggttg gtccaccggg
     1501 ttggggatac acatgtcccc atctgggcag ggtctgtccc tatgggtcta tggtcactgt
     1561 ttctcttctg tctagctttc tgtcctgcaa ctggcaacaa tgtccaataa acagttccag
     1621 gtgctgg
//
