LOCUS       NM_001013103            1081 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Rattus norvegicus cell division cycle 34, ubiquitin conjugating
            enzyme (Cdc34), mRNA.
ACCESSION   NM_001013103 XM_216827
VERSION     NM_001013103.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Rajsbaum,R., Versteeg,G.A., Schmid,S., Maestre,A.M.,
            Belicha-Villanueva,A., Martinez-Romero,C., Patel,J.R., Morrison,J.,
            Pisanelli,G., Miorin,L., Laurent-Rolle,M., Moulton,H.M.,
            Stein,D.A., Fernandez-Sesma,A., tenOever,B.R. and Garcia-Sastre,A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Wu,K., Kovacev,J. and Pan,Z.Q.
  TITLE     Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for
            polyubiquitination on a SCF substrate
  JOURNAL   Mol Cell 37 (6), 784-796 (2010)
   PUBMED   20347421
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   David,Y., Ziv,T., Admon,A. and Navon,A.
  TITLE     The E2 ubiquitin-conjugating enzymes direct polyubiquitination to
            preferred lysines
  JOURNAL   J Biol Chem 285 (12), 8595-8604 (2010)
   PUBMED   20061386
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Guo,W., Shang,F., Liu,Q., Urim,L., West-Mays,J. and Taylor,A.
  TITLE     Differential regulation of components of the ubiquitin-proteasome
            pathway during lens cell differentiation
  JOURNAL   Invest Ophthalmol Vis Sci 45 (4), 1194-1201 (2004)
   PUBMED   15037588
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Rideout,H.J. and Stefanis,L.
  TITLE     Proteasomal inhibition-induced inclusion formation and death in
            cortical neurons require transcription and ubiquitination
  JOURNAL   Mol Cell Neurosci 21 (2), 223-238 (2002)
   PUBMED   12401444
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   Pati,D., Meistrich,M.L. and Plon,S.E.
  TITLE     Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target
            repressors of cyclic AMP-induced transcription for proteolysis
  JOURNAL   Mol Cell Biol 19 (7), 5001-5013 (1999)
   PUBMED   10373550
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   9  (bases 1 to 1081)
  AUTHORS   Smyth,M.J., Hulett,M.D., Thia,K.Y., Young,H.A., Sayers,T.J.,
            Carter,C.R. and Trapani,J.A.
  TITLE     Cloning and characterization of a novel NK cell-specific serine
            protease gene and its functional 5'-flanking sequences
  JOURNAL   Immunogenetics 42 (2), 101-111 (1995)
   PUBMED   7607701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB611861.1 and BG375350.1.
            
            On Dec 12, 2007 this sequence version replaced NM_001013103.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB611861.1, SRR8487230.67620.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               CB611861.1         4-545
            543-1081            BG375350.1         1-539               c
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1081
                     /gene="Cdc34"
                     /note="cell division cycle 34, ubiquitin conjugating
                     enzyme"
                     /db_xref="GeneID:299602"
                     /db_xref="RGD:1305411"
     exon            1..195
                     /gene="Cdc34"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..726
                     /gene="Cdc34"
                     /EC_number="6.3.2.19"
                     /note="serine protease; cell division cycle 34, ubiqiutin
                     conjugating enzyme; ubiquitin-conjugating enzyme Cdc34;
                     cell division cycle 34 homolog"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 R1"
                     /protein_id="NP_001013121.2"
                     /db_xref="GeneID:299602"
                     /db_xref="RGD:1305411"
                     /translation="MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVA
                     IFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVD
                     DPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDRE
                     YTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEE
                     ADSCFGDEEDDSGTEES"
     exon            196..282
                     /gene="Cdc34"
                     /inference="alignment:Splign:2.1.0"
     exon            283..380
                     /gene="Cdc34"
                     /inference="alignment:Splign:2.1.0"
     exon            381..515
                     /gene="Cdc34"
                     /inference="alignment:Splign:2.1.0"
     exon            516..1064
                     /gene="Cdc34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgccgccg tcaccgccat ggcccggccg ctggtgccca gctcgcagaa ggcgctgctg
       61 ctggagctga aggggctgca ggaggagccg gtggagggct tccgggtgac gctggtggac
      121 gagggcgacc tgtacaactg ggaggtggcc atcttcggac cccccaacac ctactatgag
      181 ggcggctact tcaaggctcg cctcaagttc cccatcgact acccatattc cccaccagcc
      241 ttccggttcc tcaccaagat gtggcaccca aacatctatg agacagggga cgtatgcatc
      301 tccatcctcc atcccccagt tgatgaccca cagagtgggg agctaccctc agagcggtgg
      361 aaccccacgc agaatgtcag gaccatcctc ctgagtgtga tctccctgct gaatgagccc
      421 aacaccttct cgcctgccaa cgtggacgcc tcggtgatgt acagaaaatg gaaggagagc
      481 aaggggaagg accgcgagta cacggacatc atccggaagc aggtcctggg gaccaaggtg
      541 gacgcagagc gcgatggcgt gaaggtgccc accacgctgg ccgagtactg cgtgaagacc
      601 aaggcgccgg cgcccgacga gggctcagac ctcttctacg acgactacta tgaggacggt
      661 gaagtggagg aggccgacag ctgctttggg gatgaagagg atgactctgg caccgaggag
      721 tcctgaccca cgtccctgaa ataaacttac aaattttacc tcagcaggac ccgtgtgggc
      781 ctcaggcgac agactacctc accgaggttc aatgtgggct cccatcccat gatccttagg
      841 tcctcttacc ctgtattccc catgggtttt cctcggcttt ggagaagagc tgtggtgcag
      901 ggcagacacc ccactcagcc ttcagaggat gacaagcctg ggaggctggg aaccgactgc
      961 ccaggggagc cagagactcc agcccaaaga gggccagccc cacagtctcc tctctgcttt
     1021 tggtgtgtgt gaaatccaaa taaaatagct ttctgagaag ctgaaaaaaa aaaaaaaaaa
     1081 a
//
