LOCUS       NM_001401323            1884 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cell division cycle 25C (Cdc25c), mRNA.
ACCESSION   NM_001401323 XM_008772039
VERSION     NM_001401323.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1884)
  AUTHORS   Zhou,X., Lu,D., Yi,W. and Xu,D.
  TITLE     Downregulation of CDC25C in NPCs Disturbed Cortical Neurogenesis
  JOURNAL   Int J Mol Sci 24 (2), 1505 (2023)
   PUBMED   36675024
  REMARK    GeneRIF: Downregulation of CDC25C in NPCs Disturbed Cortical
            Neurogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1884)
  AUTHORS   Wang,Z., Trope,C.G., Florenes,V.A., Suo,Z., Nesland,J.M. and
            Holm,R.
  TITLE     Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in
            vulvar squamous cell carcinomas are associated with malignant
            features and aggressive cancer phenotypes
  JOURNAL   BMC Cancer 10, 233 (2010)
   PUBMED   20500813
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1884)
  AUTHORS   Vandyke,K., White,M.Y., Nguyen-Khuong,T., Ow,K., Luk,S.C.,
            Kingsley,E.A., Rowe,A., Pang,S.F., Walsh,B.J. and Russell,P.J.
  TITLE     Plant-derived MINA-05 inhibits human prostate cancer proliferation
            in vitro and lymph node spread in vivo
  JOURNAL   Neoplasia 9 (4), 322-331 (2007)
   PUBMED   17460776
REFERENCE   4  (bases 1 to 1884)
  AUTHORS   Su,C., Deaton,R.A., Iglewsky,M.A., Valencia,T.G. and Grant,S.R.
  TITLE     PKN activation via transforming growth factor-beta 1 (TGF-beta 1)
            receptor signaling delays G2/M phase transition in vascular smooth
            muscle cells
  JOURNAL   Cell Cycle 6 (6), 739-749 (2007)
   PUBMED   17374997
REFERENCE   5  (bases 1 to 1884)
  AUTHORS   Lokeshwar,V.B., Cerwinka,W.H., Isoyama,T. and Lokeshwar,B.L.
  TITLE     HYAL1 hyaluronidase in prostate cancer: a tumor promoter and
            suppressor
  JOURNAL   Cancer Res 65 (17), 7782-7789 (2005)
   PUBMED   16140946
REFERENCE   6  (bases 1 to 1884)
  AUTHORS   Vassileva,V., Millar,A., Briollais,L., Chapman,W. and Bapat,B.
  TITLE     Genes involved in DNA repair are mutational targets in endometrial
            cancers with microsatellite instability
  JOURNAL   Cancer Res 62 (14), 4095-4099 (2002)
   PUBMED   12124347
REFERENCE   7  (bases 1 to 1884)
  AUTHORS   Lu,P.J., Zhou,X.Z., Shen,M. and Lu,K.P.
  TITLE     Function of WW domains as phosphoserine- or
            phosphothreonine-binding modules
  JOURNAL   Science 283 (5406), 1325-1328 (1999)
   PUBMED   10037602
REFERENCE   8  (bases 1 to 1884)
  AUTHORS   Peng,C.Y., Graves,P.R., Ogg,S., Thoma,R.S., Byrnes,M.J. 3rd, Wu,Z.,
            Stephenson,M.T. and Piwnica-Worms,H.
  TITLE     C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and
            promotes 14-3-3 protein binding
  JOURNAL   Cell Growth Differ 9 (3), 197-208 (1998)
   PUBMED   9543386
REFERENCE   9  (bases 1 to 1884)
  AUTHORS   Mizoguchi,S. and Kim,K.H.
  TITLE     Expression of cdc25 phosphatases in the germ cells of the rat
            testis
  JOURNAL   Biol Reprod 56 (6), 1474-1481 (1997)
   PUBMED   9166700
REFERENCE   10 (bases 1 to 1884)
  AUTHORS   Sadhu,K., Reed,S.I., Richardson,H. and Russell,P.
  TITLE     Human homolog of fission yeast cdc25 mitotic inducer is
            predominantly expressed in G2
  JOURNAL   Proc Natl Acad Sci U S A 87 (13), 5139-5143 (1990)
   PUBMED   2195549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Feb 8, 2022 this sequence version replaced XM_008772039.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.59308.1,
                                           SRR26360181.1237955.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               JAXUCZ010000018.1  26630136-26630292   c
            158-255             JAXUCZ010000018.1  26629950-26630047   c
            256-481             JAXUCZ010000018.1  26629573-26629798   c
            482-576             JAXUCZ010000018.1  26628016-26628110   c
            577-622             JAXUCZ010000018.1  26626379-26626424   c
            623-656             JAXUCZ010000018.1  26624270-26624303   c
            657-746             JAXUCZ010000018.1  26623942-26624031   c
            747-845             JAXUCZ010000018.1  26621523-26621621   c
            846-995             JAXUCZ010000018.1  26620301-26620450   c
            996-1097            JAXUCZ010000018.1  26616348-26616449   c
            1098-1160           JAXUCZ010000018.1  26614770-26614832   c
            1161-1259           JAXUCZ010000018.1  26612028-26612126   c
            1260-1393           JAXUCZ010000018.1  26611254-26611387   c
            1394-1505           JAXUCZ010000018.1  26610503-26610614   c
            1506-1884           JAXUCZ010000018.1  26609945-26610323   c
FEATURES             Location/Qualifiers
     source          1..1884
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..1884
                     /gene="Cdc25c"
                     /note="cell division cycle 25C"
                     /db_xref="GeneID:307511"
                     /db_xref="RGD:1311875"
     exon            1..157
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            158..255
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            256..481
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1658
                     /gene="Cdc25c"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 3"
                     /protein_id="NP_001388252.1"
                     /db_xref="GeneID:307511"
                     /db_xref="RGD:1311875"
                     /translation="MSTVPFPAASEEGSYVSAPSFRFKQRKMLHLLLERHASFTVGSD
                     FPESPGDKLHDSANLSLLSGGTPKCCLDLSSLSNGEVSASHLSTSADIEENGSLDSSG
                     PQDIHLTGKDFHQDLMKGIPAQLLCSTPNALDHGHRRKDAKCSTSANKENINTSFKTL
                     EWEAPRTPRLQKKPGDPLASPLCELENGILLESEMKNLGSPITTVPKLSKNLKLEDQE
                     GISEDPMECSLEDQDAKGLSLKKTVPLCGMDAIELEEEDSDSEHLTGDFSKACVLPTV
                     PGKHQDLKYISPDTVAALLSGKFQSVIERFYIIDCRYPYEYLGGHILGALNLYSQKEL
                     YEFFLKKPVVPEDTQKRVIIVFLCEFSSERGPRMCRSLREKDRALNQYPALYYPELYI
                     LRGGYRDFFPEYMELCEPQGYCPMLHQDHQAELLSWRSQSKAQEGERQLREQIALLVK
                     NVSPQ"
     exon            482..576
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            577..622
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            623..656
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            657..746
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            747..845
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            846..995
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1097
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1160
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1259
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1393
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1505
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1884
                     /gene="Cdc25c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaagctga acctcaggct acgtggatgc agttttaacc cgaacagccg cgtctgttcc
       61 tcagattcct tgtcattcgg tggagtcttc gcttccatcc agtcctgcag gatttttttt
      121 ttctcacaca aaattcaagt cggcctttaa acttaagatc cgtttcttct ggtcaagaac
      181 gtgaaggtgg gtggtccgga tcaagccagt cttctctgca ttccaccttt gaagtcctga
      241 gcttgccgga agtctatagc tccacctcgc tcggtgaaga cgctgaggtc atgtctacag
      301 tacctttccc agctgcaagt gaagagggga gttatgtctc agcacccagt tttaggttca
      361 aacaaaggaa gatgttacac ctacttttgg agagacacgc ttcttttacc gttggttcag
      421 atttccccga atctccgggt gacaaactcc atgactcggc aaacctaagc cttctgtccg
      481 gaggaacccc aaaatgttgc cttgaccttt cgagtcttag caatggagag gtgtctgctt
      541 ctcacctttc tacttctgct gacattgagg aaaacggttc cttggactcc tcaggacctc
      601 aggatattca cttaactggc aaggattttc accaggacct tatgaaaggc atcccagcac
      661 agcttctctg tagtactcca aatgctttgg atcatggcca cagaaggaag gatgcaaagt
      721 gtagcacatc tgcaaataaa gaaaatataa acaccagttt taaaacattg gaatgggagg
      781 cacctaggac cccgaggctt caaaaaaagc ctggcgatcc tctggcttct cctctctgtg
      841 agctggaaaa tggaatcttg ctggaaagtg aaatgaagaa tctgggcagt cccattacta
      901 cagttccaaa actgagtaaa aatctcaagc tagaagacca agaagggatt tcagaagacc
      961 caatggagtg ttccctggaa gaccaagatg ccaagggctt aagtctgaag aagacggtcc
     1021 ctctctgtgg catggatgcc attgagttgg aggaggaaga ttctgactca gagcatctga
     1081 ctggtgattt ctcaaaggcg tgtgtactgc caacggtgcc agggaaacac caggatctga
     1141 agtatatcag cccagataca gtggctgcat tgctgtctgg gaagttccag agtgtgatcg
     1201 agaggtttta tatcattgat tgccgttatc cgtatgagta cctgggagga cacattctgg
     1261 gagccttaaa cctgtacagt cagaaggaac tatacgagtt ctttctgaag aagcctgttg
     1321 tccctgagga cacccagaag agagtcatca ttgtgttcct ctgtgaattc tcctcagaga
     1381 gaggcccacg aatgtgccgt tctctgagag aaaaagacag ggctctgaac cagtatccag
     1441 cattatacta ccctgagctg tatatcctca gagggggcta cagagatttc tttccagaat
     1501 atatggagct gtgtgaaccc cagggctact gtcctatgct tcaccaggac caccaggccg
     1561 agctgctgag ctggcgcagc cagagcaaag cccaggaagg ggagcggcag ctgcgagaac
     1621 agattgccct cctggtgaag aatgtgagcc ctcaatagtg actatgacgg tggcagtgaa
     1681 gacactacaa ccctgaacag gagtcatcgt ccatgttgct aagcctataa ttgtatctgc
     1741 aaacacacgc atagccgggc gagctgcaag ggcctttagt cccagcgcta cggaggcaaa
     1801 ggcaggagaa tcttttgagt ttgaggccag tccggtctac atgcaaaaca aagcaaacaa
     1861 caagcccatt aaacaaaaac ctct
//
