LOCUS       NM_133572               3112 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cell division cycle 25B (Cdc25b), transcript
            variant 1, mRNA.
ACCESSION   NM_133572
VERSION     NM_133572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Meng,J., Cui,C., Liu,Y., Jin,M., Wu,D., Liu,C., Wang,E. and Yu,B.
  TITLE     The role of 14-3-3epsilon interaction with phosphorylated Cdc25B at
            its Ser321 in the release of the mouse oocyte from prophase I
            arrest
  JOURNAL   PLoS One 8 (1), e53633 (2013)
   PUBMED   23326474
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Wang,Z., Trope,C.G., Florenes,V.A., Suo,Z., Nesland,J.M. and
            Holm,R.
  TITLE     Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in
            vulvar squamous cell carcinomas are associated with malignant
            features and aggressive cancer phenotypes
  JOURNAL   BMC Cancer 10, 233 (2010)
   PUBMED   20500813
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3112)
  AUTHORS   Oh,J.S., Han,S.J. and Conti,M.
  TITLE     Wee1B, Myt1, and Cdc25 function in distinct compartments of the
            mouse oocyte to control meiotic resumption
  JOURNAL   J Cell Biol 188 (2), 199-207 (2010)
   PUBMED   20083600
REFERENCE   4  (bases 1 to 3112)
  AUTHORS   Wang,R., Morris,D.S., Tomlins,S.A., Lonigro,R.J., Tsodikov,A.,
            Mehra,R., Giordano,T.J., Kunju,L.P., Lee,C.T., Weizer,A.Z. and
            Chinnaiyan,A.M.
  TITLE     Development of a multiplex quantitative PCR signature to predict
            progression in non-muscle-invasive bladder cancer
  JOURNAL   Cancer Res 69 (9), 3810-3818 (2009)
   PUBMED   19383904
REFERENCE   5  (bases 1 to 3112)
  AUTHORS   Schmidt,A., Durgan,J., Magalhaes,A. and Hall,A.
  TITLE     Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and
            exit from cytokinesis
  JOURNAL   EMBO J 26 (6), 1624-1636 (2007)
   PUBMED   17332740
REFERENCE   6  (bases 1 to 3112)
  AUTHORS   Wu,W., Slomovitz,B.M., Celestino,J., Chung,L., Thornton,A. and
            Lu,K.H.
  TITLE     Coordinate expression of Cdc25B and ER-alpha is frequent in
            low-grade endometrioid endometrial carcinoma but uncommon in
            high-grade endometrioid and nonendometrioid carcinomas
  JOURNAL   Cancer Res 63 (19), 6195-6199 (2003)
   PUBMED   14559803
REFERENCE   7  (bases 1 to 3112)
  AUTHORS   Ngan,E.S., Hashimoto,Y., Ma,Z.Q., Tsai,M.J. and Tsai,S.Y.
  TITLE     Overexpression of Cdc25B, an androgen receptor coactivator, in
            prostate cancer
  JOURNAL   Oncogene 22 (5), 734-739 (2003)
   PUBMED   12569365
REFERENCE   8  (bases 1 to 3112)
  AUTHORS   Davezac,N., Baldin,V., Blot,J., Ducommun,B. and Tassan,J.P.
  TITLE     Human pEg3 kinase associates with and phosphorylates CDC25B
            phosphatase: a potential role for pEg3 in cell cycle regulation
  JOURNAL   Oncogene 21 (50), 7630-7641 (2002)
   PUBMED   12400006
REFERENCE   9  (bases 1 to 3112)
  AUTHORS   Lincoln,A.J., Wickramasinghe,D., Stein,P., Schultz,R.M.,
            Palko,M.E., De Miguel,M.P., Tessarollo,L. and Donovan,P.J.
  TITLE     Cdc25b phosphatase is required for resumption of meiosis during
            oocyte maturation
  JOURNAL   Nat Genet 30 (4), 446-449 (2002)
   PUBMED   11912493
REFERENCE   10 (bases 1 to 3112)
  AUTHORS   Jinno,S., Suto,K., Nagata,A., Igarashi,M., Kanaoka,Y., Nojima,H.
            and Okayama,H.
  TITLE     Cdc25A is a novel phosphatase functioning early in the cell cycle
  JOURNAL   EMBO J 13 (7), 1549-1556 (1994)
   PUBMED   8156993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133572.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16237.1, SRR22582416.862367.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               JAXUCZ010000003.1  138860173-138860562
            391-512             JAXUCZ010000003.1  138861306-138861427
            513-564             JAXUCZ010000003.1  138862056-138862107
            565-606             JAXUCZ010000003.1  138864235-138864276
            607-643             JAXUCZ010000003.1  138864443-138864479
            644-766             JAXUCZ010000003.1  138864694-138864816
            767-889             JAXUCZ010000003.1  138864908-138865030
            890-1021            JAXUCZ010000003.1  138865661-138865792
            1022-1102           JAXUCZ010000003.1  138866181-138866261
            1103-1276           JAXUCZ010000003.1  138866348-138866521
            1277-1369           JAXUCZ010000003.1  138866728-138866820
            1370-1432           JAXUCZ010000003.1  138867252-138867314
            1433-1531           JAXUCZ010000003.1  138867476-138867574
            1532-1665           JAXUCZ010000003.1  138867761-138867894
            1666-1777           JAXUCZ010000003.1  138868687-138868798
            1778-3112           JAXUCZ010000003.1  138868953-138870287
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3112
                     /gene="Cdc25b"
                     /note="cell division cycle 25B"
                     /db_xref="GeneID:171103"
                     /db_xref="RGD:621500"
     exon            1..390
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1918
                     /gene="Cdc25b"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     M-phase inducer phosphatase 2; dual specificity
                     phosphatase Cdc25B"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 2 isoform 1"
                     /protein_id="NP_598256.2"
                     /db_xref="GeneID:171103"
                     /db_xref="RGD:621500"
                     /translation="MEVPPQKSAPGSALSTARVLGGIQRPRHLSGFGFGSDGLLGSPE
                     RAASSSPVTTLTQTMYNLAGLGSETPKTQVGSLSFQNRLTDLSLSRRTSECSLSSESS
                     ESSDAGLCMDSPSPMDPQTAERTFEQAIQAASRVIQNEQFTIKRFRSLPVRLLGHSPV
                     LQNITNSQALDSWEKDEAGYRAASSPGEDKENDGYIFKMPQKLPHSSSARALAEWASR
                     REAFTQRPSSAPDLMCLTTDGKMDVEEASPVAQSSSLTPVERACEEDDGFVDILESDL
                     KDDDMVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLE
                     RPHDRDVPVLSKRRKSGTPLEEQQLEEPKARVFRSKSLCHEIESILDSDHRGLIGDYS
                     KAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAV
                     NLPLEPDAETFLLKHPITPCNLDKRIILIFHCEFSSERGPRMCRFIRERDRAANDYPS
                     LYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHAAFRDELRNFRLKTRSWAGERSRR
                     ELCSRLQDQ"
     exon            391..512
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            513..564
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            565..606
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            607..643
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            644..766
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            767..889
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1021
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1102
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1276
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1369
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1432
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1531
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1665
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1777
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..3112
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcgcgtc ttcccctccc ttcctcccca catccctctc ctcactccca ggcccactgc
       61 tcttcctccc tccctcccct ccctccttcc ccttacccca ggctcactct cggagcctag
      121 ccatctgggt cggcgtctgc tggccgctgt acttgtggcc ctctagctag cctttgcccg
      181 ccccgccacc atggaggtac ccccgcagaa gtctgcgccg ggctcagctc tcagtactgc
      241 ccgcgtgctg ggtggcattc agcggccgcg ccacctctca ggctttgggt ttgggtctga
      301 tggcttgctg gggtctccag agcgtgcggc ttcctcctct ccggttacca ctcttaccca
      361 gaccatgtac aacctcgcag ggctcggcag cgagacccca aaaactcaag taggaagcct
      421 gtcgttccag aacaggctga cagacctgtc cctgtccaga cgtacctctg agtgctccct
      481 gtcatctgag tcctcagaat cttctgatgc aggtctctgc atggactccc ctagccctat
      541 ggacccacag acagcagagc gcacgtttga acaggccatt caggcagcca gtcgggtcat
      601 tcaaaatgag caatttacca taaaacgctt ccggtctttg ccagtgaggc tgctgggaca
      661 tagtcctgtg ctacagaaca tcaccaactc ccaagcactg gacagctggg agaaagatga
      721 agcaggctac agagctgcca gtagtcctgg ggaggacaaa gagaacgatg gatatatctt
      781 caagatgcca cagaagctcc ctcattccag ctctgcccga gctttggcag agtgggccag
      841 ccgcagagag gcctttaccc agaggcccag ctcagcccct gacttgatgt gtcttaccac
      901 tgacgggaag atggacgtgg aggaggcgag ccctgtggca cagtcttcct ccttgactcc
      961 tgtcgaaagg gcttgtgaag aagatgacgg atttgtggac atcctagaga gtgatttaaa
     1021 ggatgatgat atggtccccg caggcatgga gaacctcatt agtgctccac tggtcaaaaa
     1081 gctggataag gaagaggaac aggatctcat catgttcagc aagtgccagc ggcttttccg
     1141 ctctccatcc atgccgtgca gtgtgatccg gcccatcctc aagaggctag agcggcccca
     1201 cgacagggac gtgcctgtcc tgagcaagcg caggaagagt gggacacccc tggaagagca
     1261 gcagcttgaa gaacccaagg cccgggtctt ccgctcaaag tccctgtgtc acgagattga
     1321 gagcatcctg gacagtgacc accgtggcct gattggagat tactctaagg ccttcctcct
     1381 gcagactgtg gatggcaaac accaagacct caagtacatc tcaccagaaa ctatggtggc
     1441 cctgttgaca ggcaagttca gcaacatcgt ggagaagttt gtaattgtgg actgcagata
     1501 cccctatgag tatgaaggcg ggcatatcaa gaatgctgtg aacttgcccc tggaaccgga
     1561 tgccgagacc tttctgctga agcatcccat cacgccttgt aacctggaca agagaatcat
     1621 cctcattttc cactgtgaat tctcatctga gcgtggacca cggatgtgcc gcttcatcag
     1681 ggaacgggac cgtgcagcta acgactatcc cagcctgtac taccctgaga tgtacatcct
     1741 caaaggcggc tacaaggagt tcttcccgca gcatccgaac ttttgtgagc cccaggacta
     1801 ccgacccatg aaccatgcag ctttccggga tgagctgagg aacttccgcc tcaagacacg
     1861 cagctgggct ggggaacgga gcaggaggga actctgtagc aggctgcaag accagtgacg
     1921 agccagcctc agtcctgcca ccatccttac ctcaggaggc ttgcgagcca gtgggtccca
     1981 tgggcctatg cggccaccta cttgctagag gcctcaggtg ctataggggg ttggggggat
     2041 ggtgtggtgt cacatctgtc tgtccctgtc ctcaattttc ctgtctcact ccactaattt
     2101 tctgtatctt ggtactgatc ccatcttaaa gagctgaacc aatgggtgaa taccagctaa
     2161 gaggaagtcc tttgtgttca atgagagccc ttttacaatc tcctttttcc ttgtttgtgt
     2221 tgactccttg tcttacccct tcgcagggag agcctcagcc ctttaagatg agcacagtag
     2281 cttcttgggt agcctggatg caggacgcta cactgctgca cagggctgtg tctgctctcc
     2341 tctcctggcc tctgcacaga ttcctccatt ggaagcataa gtgcttactt ttcctgttgt
     2401 cgtcttaccc atagctttca ttttcgtctg tctcacttag cgtgtcccag gacacactga
     2461 cagctgggga ggctcccttg tacagctggg gactagagat tcaaatatca tgtactcatt
     2521 aggcttggct tttgttagcc cacaaaggga tcttttcctt taagaccccc agagctagag
     2581 caaaggcctg attcaggagc ctctgggagc cccatcctca ctgctgtgaa ccctagagcc
     2641 tcgctggtca gcacttgttg ctgggcaatg aaccagtcac tgagcttcac tttttggtcc
     2701 ttctctgtcc ctccctgtcc ctctctgtcc ttctttccat atctggtcct gagtatgcat
     2761 ggtttttccg tgttgctgta ctagtgacag agtctaggcc ctttgttgga tggtcatgga
     2821 tgcacagtgc cttgtacaca tgtatgcaca caaatcgagt gaagtatttt ggtaagcatg
     2881 atggcctatg gcaggagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2941 gtacaaagtc tttacactta gcatttggaa atattaaaga aatattgtca taggggaggg
     3001 aggaagaagc aacttttggg ttcagaatct acatatgaaa aggtcatgct ggaaggcccc
     3061 caatgcatcc tctgttgggg ccttggttca ataaagcact gagcaagttg aa
//
