LOCUS       NM_133571               3419 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus cell division cycle 25A (Cdc25a), mRNA.
ACCESSION   NM_133571
VERSION     NM_133571.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3419)
  AUTHORS   Das,A.K. and Biswas,S.C.
  TITLE     Cdc25A phosphatase is activated and mediates neuronal cell death by
            PUMA via pRb/E2F1 pathway in a model of Parkinson's disease
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119848 (2024)
   PUBMED   39305937
  REMARK    GeneRIF: Cdc25A phosphatase is activated and mediates neuronal cell
            death by PUMA via pRb/E2F1 pathway in a model of Parkinson's
            disease.
REFERENCE   2  (bases 1 to 3419)
  AUTHORS   Masyuk,T.V., Lee,S.O., Radtke,B.N., Stroope,A.J., Huang,B.,
            Banales,J.M., Masyuk,A.I., Splinter,P.L., Gradilone,S.A.,
            Gajdos,G.B. and LaRusso,N.F.
  TITLE     Centrosomal abnormalities characterize human and rodent cystic
            cholangiocytes and are associated with Cdc25A overexpression
  JOURNAL   Am J Pathol 184 (1), 110-121 (2014)
   PUBMED   24211536
  REMARK    GeneRIF: accelerated cholangiocyte cystogenesis is likely due to
            overexpression of Cdc25A
REFERENCE   3  (bases 1 to 3419)
  AUTHORS   Giessrigl,B., Krieger,S., Rosner,M., Huttary,N., Saiko,P.,
            Alami,M., Messaoudi,S., Peyrat,J.F., Maciuk,A., Gollinger,M.,
            Kopf,S., Kazlauskas,E., Mazal,P., Szekeres,T., Hengstschlager,M.,
            Matulis,D., Jager,W. and Krupitza,G.
  TITLE     Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A
            degradation and cell-cycle attenuation in pancreatic carcinoma
            cells
  JOURNAL   Hum Mol Genet 21 (21), 4615-4627 (2012)
   PUBMED   22843495
REFERENCE   4  (bases 1 to 3419)
  AUTHORS   Masyuk,T.V., Radtke,B.N., Stroope,A.J., Banales,J.M., Masyuk,A.I.,
            Gradilone,S.A., Gajdos,G.B., Chandok,N., Bakeberg,J.L., Ward,C.J.,
            Ritman,E.L., Kiyokawa,H. and LaRusso,N.F.
  TITLE     Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent
            models of polycystic kidney and liver disease
  JOURNAL   Gastroenterology 142 (3), 622-633 (2012)
   PUBMED   22155366
  REMARK    GeneRIF: Cdc25A inhibitors block cell-cycle progression and
            proliferation, reduce liver and kidney weights and cyst growth in
            animal models of polycystic kidney/liver disease.
REFERENCE   5  (bases 1 to 3419)
  AUTHORS   Myer,D.L., Robbins,S.B., Yin,M., Boivin,G.P., Liu,Y., Greis,K.D.,
            Bahassi el,M. and Stambrook,P.J.
  TITLE     Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA
            damage but is not sufficient to produce tumors
  JOURNAL   Mutat Res 714 (1-2), 1-10 (2011)
   PUBMED   21376736
REFERENCE   6  (bases 1 to 3419)
  AUTHORS   Strazza,M., Luddi,A., Brogi,A., Carbone,M., Riccio,M., Santi,S.,
            Melli,M. and Costantino-Ceccarini,E.
  TITLE     Activation of cell cycle regulatory proteins in the apoptosis of
            terminally differentiated oligodendrocytes
  JOURNAL   Neurochem Res 29 (5), 923-931 (2004)
   PUBMED   15139290
REFERENCE   7  (bases 1 to 3419)
  AUTHORS   Chen,S. and Gardner,D.G.
  TITLE     Suppression of WEE1 and stimulation of CDC25A correlates with
            endothelin-dependent proliferation of rat aortic smooth muscle
            cells
  JOURNAL   J Biol Chem 279 (14), 13755-13763 (2004)
   PUBMED   14742443
  REMARK    GeneRIF: endothelin increases expression and activity of CDC25A,
            the regulatory phosphatase responsible for dephosphorylating
            Tyr(15).
REFERENCE   8  (bases 1 to 3419)
  AUTHORS   Jaime,M., Pujol,M.J., Serratosa,J., Pantoja,C., Canela,N.,
            Casanovas,O., Serrano,M., Agell,N. and Bachs,O.
  TITLE     The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and
            the intracellular localization of CDC25A in mice regenerating
            livers
  JOURNAL   Hepatology 35 (5), 1063-1071 (2002)
   PUBMED   11981756
REFERENCE   9  (bases 1 to 3419)
  AUTHORS   Mochizuki,T., Kitanaka,C., Noguchi,K., Muramatsu,T., Asai,A. and
            Kuchino,Y.
  TITLE     Physical and functional interactions between Pim-1 kinase and
            Cdc25A phosphatase. Implications for the Pim-1-mediated activation
            of the c-Myc signaling pathway
  JOURNAL   J Biol Chem 274 (26), 18659-18666 (1999)
   PUBMED   10373478
REFERENCE   10 (bases 1 to 3419)
  AUTHORS   Jinno,S., Suto,K., Nagata,A., Igarashi,M., Kanaoka,Y., Nojima,H.
            and Okayama,H.
  TITLE     Cdc25A is a novel phosphatase functioning early in the cell cycle
  JOURNAL   EMBO J 13 (7), 1549-1556 (1994)
   PUBMED   8156993
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133571.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16236.1, SRR26643293.47700.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-413               JAXUCZ010000008.1  118743048-118743460
            414-490             JAXUCZ010000008.1  118744440-118744516
            491-533             JAXUCZ010000008.1  118745515-118745557
            534-570             JAXUCZ010000008.1  118746459-118746495
            571-672             JAXUCZ010000008.1  118747092-118747193
            673-792             JAXUCZ010000008.1  118748975-118749094
            793-927             JAXUCZ010000008.1  118750687-118750821
            928-1002            JAXUCZ010000008.1  118751366-118751440
            1003-1176           JAXUCZ010000008.1  118751593-118751766
            1177-1275           JAXUCZ010000008.1  118754627-118754725
            1276-1338           JAXUCZ010000008.1  118756549-118756611
            1339-1437           JAXUCZ010000008.1  118756710-118756808
            1438-1568           JAXUCZ010000008.1  118757032-118757162
            1569-1680           JAXUCZ010000008.1  118759109-118759220
            1681-3419           JAXUCZ010000008.1  118759419-118761157
FEATURES             Location/Qualifiers
     source          1..3419
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3419
                     /gene="Cdc25a"
                     /note="cell division cycle 25A"
                     /db_xref="GeneID:171102"
                     /db_xref="RGD:621498"
     exon            1..413
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1821
                     /gene="Cdc25a"
                     /EC_number="3.1.3.48"
                     /note="dual specificity phosphatase Cdc25A"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 1"
                     /protein_id="NP_598255.2"
                     /db_xref="GeneID:171102"
                     /db_xref="RGD:621498"
                     /translation="MELGPEPPHRRRLLFTCSPTPAPQPTGKVLFGASAAGGLSPVTN
                     LTVTMDQLEGLGSDYEKPMDVRNSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISL
                     RRINCLPQKLLGCSPALKRSHSDSLDHDIFQLIDQDENKENEAFEFKKPIRPASRGCL
                     NAHVHEESKDPFTHRQNSAPARMLSSNESDISESGNFSPLFTPQSPVKATLSDEDDGF
                     IDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLADRCGLFDSPSPCSSTSSCSTRA
                     VKRADRSHEESPRGTKRRKSSEASPVKADVPEPTQLPHQSLSLTSFPKGTIENILDSD
                     PRDLIGDFSKGYLFHTVSGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEY
                     EGGHIKGAVNLHMEEEVEEFLLKKPIVPADGKRVIVVFHCEFSSERGPRMCRYVRERD
                     RLGNEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRT
                     WAGEKSKREMYSRLKKL"
     exon            414..490
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            491..533
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            534..570
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            571..672
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            673..792
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            793..927
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1002
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1176
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1275
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1338
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1437
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1568
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1680
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..3419
                     /gene="Cdc25a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcgggac acagagagag aagcaccggt gcttgtgcct ggcgcctgcc gagtccccga
       61 cgctcgcccg tccgcgccgc tgcccgtggc ggccgcgtct ctgaaccgcg gggtcgtgtt
      121 tgtgtttgac ccgcgggcgc tggcggcgtg gcacgcggct gaagccggtg ccagcggggc
      181 ggggcccggc gcagcggagg cggaggaaga cggagcggga gtccgggcag gcccggcggc
      241 gccatggaac tgggcccgga gcccccccac cgccgccgcc tgctcttcac ttgcagcccc
      301 actcctgcgc cgcagcccac ggggaaggtg ctgtttggcg cgtcagctgc tggcggactg
      361 tcccctgtca ccaacctgac ggtcaccatg gaccagctgg aagggctggg cagtgactat
      421 gagaaaccaa tggacgtgag aaatagcagc agtctacaga gaatgggctc ctctgaatcg
      481 actgattcag gtttctgtct agattctcct gggcccttgg acagtaaaga aaaccttgaa
      541 atttccctga ggagaataaa ttgcctacct cagaagctct tggggtgtag cccagcgcta
      601 aagaggagcc attctgattc tctagaccac gacatctttc aactcattga ccaggatgaa
      661 aataaagaaa atgaagcatt tgaatttaaa aagccaataa gacctgcatc tcgtggctgc
      721 ctgaatgctc acgttcacga ggaaagtaag gaccccttta cacacaggca gaattcagcc
      781 ccagctcgga tgctgtcttc aaatgaaagt gacattagtg aatcaggaaa tttcagtcct
      841 ctttttacac cccagtcacc tgtgaaagcc actttgtctg atgaggatga tggcttcata
      901 gaccttctgg atggagagaa tctgaagaat gatgaggaga ccccgtcgtg catgtcaagc
      961 ctctggaccg ctccccttgt catgagaaga cctacaaacc ttgccgatcg atgtggactg
     1021 tttgactccc cttccccgtg cagctccacc agcagctgca gcactcgggc agtgaagaga
     1081 gcagaccgat ctcatgagga gtctcctcga ggtacaaagc ggaggaagag cagtgaggcc
     1141 agtccagtga aggcagatgt tccggagcca acgcagcttc cacaccagtc tctctccctg
     1201 acatctttcc ccaaaggaac cattgagaac attttggaca gtgacccaag agaccttata
     1261 ggggatttct ccaagggtta cctctttcat acggtctctg ggaagcatca ggatttgaaa
     1321 tatatttctc cagaaattat ggcatctgtt ttgaatggca agtttgccaa tctcattaaa
     1381 gagtttgtta tcattgactg ccgataccca tatgaatatg aaggagggca catcaagggt
     1441 gccgtgaact tgcacatgga agaagaggtt gaggagttct tactcaagaa acctatcgtg
     1501 cccgctgacg gcaagcgtgt cattgtcgtg ttccactgtg agttctcctc tgagagaggc
     1561 cctcggatgt gccgatatgt acgggaacga gataggcttg gcaatgaata ccccaaactc
     1621 cattaccctg agctgtatgt cctgaagggg ggatacaagg agttcttttt gaaatgccag
     1681 tctcactgtg aaccccccag ctaccgaccg atgcaccatg aagactttaa agaagaccta
     1741 aagaagttcc gcaccaagag ccggacctgg gcaggggaga agagcaaaag ggagatgtac
     1801 agtcgcctga agaagctttg aggccaaatg gcagtgacct gagcttccct ccgccctgtc
     1861 cctttgtccc tttgctgtag agcagtaagc aaaggggcca gctatacggc acctggaccc
     1921 tggagaaaaa cctgggcctt ccatgccttg aacctcctac actcccaggt tggagcccag
     1981 ggcatcctgc cgtcacactc ttctgtgaga gtccttccct gtcaggactg tctgccaaag
     2041 ctggacaagc tcggcacagg ctggcacagg ctcgagtcta gtctggaacg ccacgtcagg
     2101 ctactccgac taagcatccc ctgaagaagt gcccaggcct ctcatgaggg gagagaagcc
     2161 actgaagtgc tgctggccaa ataccaaaga taggctggaa gggagaggtc ctcatggatg
     2221 actctttaat ttattcagcc tcatcaatta ttttattatt gttttaattc cttttacttt
     2281 tactttactg cttcaaagtc aaaatactgc cattctaggt agagttttat catcctagga
     2341 actacctcta cttttaattt aaaaaaaaaa aaatggggca gggataagaa aaaaggcaaa
     2401 cctgttaagt gtgggcagcg caaggaactc agtcacccct aggaggcgct gtagactggt
     2461 attgctgcta ttcaaagtca aggactgaga tgctggtcag agcctgcacc aaccagatcc
     2521 aggcttggct acaggacata agctaacctt cccagaccta cttctgccct ttgtgatgtc
     2581 ctttggggag agtcttgtct gtactcctgg tcccaggtcc ccgtgacagt gactggtgtg
     2641 ggagttgcag gaaggcacat caagccaccc ccaggccagt actggaatgt tgaagtgtac
     2701 cccaaggtgg gagtggggag gcatggaaaa gtggagtcca cagagtaagg gaggagcatg
     2761 cccactgaat gtcctttaga aaaaaaaaag tcattttatg agtcagagta tccaatcagt
     2821 gttgggtggg cacctaagcg tgagcagggg gcgggaagcc cgggctgtta cagacgactg
     2881 tagaatttct caggagggcg tagtaaattt tgaagtcaaa agttctgggt ttatcatgtt
     2941 ttaattgagg gacagagtgg tgaaacacat cagttacccc ctaatctaac cccgtggaag
     3001 tgaggctctg gggaatgcct cccatctaag gagctggccc gttttgattc tgtcagtgtc
     3061 ctcgggcacc agcctccctg ccatctgtgc tccattgggg tctagccagg tttttcttag
     3121 gaagagtctc ccctcttaac ctctgctttc tattctgggg gtggggaggg aatcaatgat
     3181 attgaagatg gctagttgct ttgttaaggg tttgagtttg catttggcta taaaacaaat
     3241 cttgttaaaa atatgtggag agcaagggaa tgagcagcct cttccctggt gtgttgaagt
     3301 atgtcctagt tggcccctgg tctggtttgt agagattctg ttagttgaat gccttcaagg
     3361 agaatgaatg gctttcagat tgtaccagct tagctagcat tgttaaccag ctgctgcag
//
