LOCUS       NM_171993               1774 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cell division cycle 20 (Cdc20), mRNA.
ACCESSION   NM_171993
VERSION     NM_171993.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1774)
  AUTHORS   He,J., Xu,S., Jiang,M., Wang,T., Zhang,Y., Jia,Z., Bai,M. and
            Zhang,A.
  TITLE     CDC20 inhibition alleviates fibrotic response of renal tubular
            epithelial cells and fibroblasts by regulating nuclear
            translocation of beta-catenin
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (4), 166663 (2023)
   PUBMED   36764621
  REMARK    GeneRIF: CDC20 inhibition alleviates fibrotic response of renal
            tubular epithelial cells and fibroblasts by regulating nuclear
            translocation of beta-catenin.
REFERENCE   2  (bases 1 to 1774)
  AUTHORS   Wang,X., Li,F., Zhu,J., Feng,D., Shi,Y., Qu,L., Li,Y., Guo,K.,
            Zhang,Y., Wang,Q., Wang,N., Wang,X. and Ge,S.
  TITLE     Up-regulation of cell division cycle 20 expression alters the
            morphology of neuronal dendritic spines in the nucleus accumbens by
            promoting FMRP ubiquitination
  JOURNAL   J Neurochem 162 (2), 166-189 (2022)
   PUBMED   35621027
  REMARK    GeneRIF: Up-regulation of cell division cycle 20 expression alters
            the morphology of neuronal dendritic spines in the nucleus
            accumbens by promoting FMRP ubiquitination.
REFERENCE   3  (bases 1 to 1774)
  AUTHORS   Yamada,K., Tamamori-Adachi,M., Goto,I., Iizuka,M., Yasukawa,T.,
            Aso,T., Okazaki,T. and Kitajima,S.
  TITLE     Degradation of p21Cip1 through anaphase-promoting complex/cyclosome
            and its activator Cdc20 (APC/CCdc20) ubiquitin ligase
            complex-mediated ubiquitylation is inhibited by cyclin-dependent
            kinase 2 in cardiomyocytes
  JOURNAL   J Biol Chem 286 (51), 44057-44066 (2011)
   PUBMED   22045811
  REMARK    GeneRIF: CDK2 blocks APC/CCdc20-mediated ubiquitylation of p21 at
            the N terminus, causing G2 arrest in mitogen-stimulated
            cardiomyocytes
REFERENCE   4  (bases 1 to 1774)
  AUTHORS   Chen,Z., Yu,Y., Fu,D., Li,Z., Niu,X., Liao,M. and Lu,S.
  TITLE     Functional roles of PC-PLC and Cdc20 in the cell cycle,
            proliferation, and apoptosis
  JOURNAL   Cell Biochem Funct 28 (4), 249-257 (2010)
   PUBMED   20517887
  REMARK    GeneRIF: The functional roles of Cdc20 protein is involved in the
            cell cycle, mitosis, and apoptosis in CBRH-7919 cells.
REFERENCE   5  (bases 1 to 1774)
  AUTHORS   Yang,Y., Kim,A.H., Yamada,T., Wu,B., Bilimoria,P.M., Ikeuchi,Y., de
            la Iglesia,N., Shen,J. and Bonni,A.
  TITLE     A Cdc20-APC ubiquitin signaling pathway regulates presynaptic
            differentiation
  JOURNAL   Science 326 (5952), 575-578 (2009)
   PUBMED   19900895
  REMARK    GeneRIF: findings define a Cdc20-APC(anaphase promoting complex)
            ubiquitin signaling pathway that governs presynaptic development,
            which holds important implications for neuronal connectivity and
            plasticity in the brain
REFERENCE   6  (bases 1 to 1774)
  AUTHORS   Chen,J. and Fang,G.
  TITLE     MAD2B is an inhibitor of the anaphase-promoting complex
  JOURNAL   Genes Dev 15 (14), 1765-1770 (2001)
   PUBMED   11459826
REFERENCE   7  (bases 1 to 1774)
  AUTHORS   Pfleger,C.M., Salic,A., Lee,E. and Kirschner,M.W.
  TITLE     Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel
            mechanism for regulating Cdh1
  JOURNAL   Genes Dev 15 (14), 1759-1764 (2001)
   PUBMED   11459825
REFERENCE   8  (bases 1 to 1774)
  AUTHORS   Luo,X., Fang,G., Coldiron,M., Lin,Y., Yu,H., Kirschner,M.W. and
            Wagner,G.
  TITLE     Structure of the Mad2 spindle assembly checkpoint protein and its
            interaction with Cdc20
  JOURNAL   Nat Struct Biol 7 (3), 224-229 (2000)
   PUBMED   10700282
REFERENCE   9  (bases 1 to 1774)
  AUTHORS   Weinstein,J., Karim,J., Geschwind,D.H., Nelson,S.F., Krumm,J. and
            Sakamoto,K.M.
  TITLE     Genomic organization, 5' flanking enhancer region, and chromosomal
            assignment of the cell cycle gene, p55Cdc
  JOURNAL   Mol Genet Metab 64 (1), 52-57 (1998)
   PUBMED   9682218
  REMARK    Erratum:[Mol Genet Metab 2001 Apr;72(4):364]
REFERENCE   10 (bases 1 to 1774)
  AUTHORS   Weinstein,J., Jacobsen,F.W., Hsu-Chen,J., Wu,T. and Baum,L.G.
  TITLE     A novel mammalian protein, p55CDC, present in dividing cells is
            associated with protein kinase activity and has homology to the
            Saccharomyces cerevisiae cell division cycle proteins Cdc20 and
            Cdc4
  JOURNAL   Mol Cell Biol 14 (5), 3350-3363 (1994)
   PUBMED   7513050
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_171993.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U05341.1, BC085691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               JAXUCZ010000005.1  137255427-137255799 c
            374-522             JAXUCZ010000005.1  137255189-137255337 c
            523-619             JAXUCZ010000005.1  137255003-137255099 c
            620-748             JAXUCZ010000005.1  137254774-137254902 c
            749-945             JAXUCZ010000005.1  137254482-137254678 c
            946-1040            JAXUCZ010000005.1  137254269-137254363 c
            1041-1269           JAXUCZ010000005.1  137253960-137254188 c
            1270-1395           JAXUCZ010000005.1  137253263-137253388 c
            1396-1513           JAXUCZ010000005.1  137252234-137252351 c
            1514-1774           JAXUCZ010000005.1  137251596-137251856 c
FEATURES             Location/Qualifiers
     source          1..1774
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1774
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /note="cell division cycle 20"
                     /db_xref="GeneID:64515"
                     /db_xref="RGD:620477"
     exon            1..373
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1692
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /note="cell cycle protein p55CDC; cell division cycle 20
                     homolog"
                     /codon_start=1
                     /product="cell division cycle protein 20 homolog"
                     /protein_id="NP_741990.1"
                     /db_xref="GeneID:64515"
                     /db_xref="RGD:620477"
                     /translation="MAQFVFESDLHSLLQLDAPIPNAPIARWQRKAKEATGPAPSPMR
                     AANRSHSAGRTPGRTPGKSNSKVQTTPSKPGGDRYIPQRSASQMEVASFLLSKENQPE
                     DGGTPTKKEHQKAWARNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGS
                     SRKACRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQ
                     LLQMEQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKRLRNMTSHSARVSSLSW
                     NSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVN
                     VWPSGPGESGWVPLQTFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGAC
                     LSAVDVHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTARVLSLT
                     MSPDGATVASAAADETLRLWRCFELDPALRREREKASTSKSSLIHQGIR"
     exon            374..522
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            523..619
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            620..748
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            749..945
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1040
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1269
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1395
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1513
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1774
                     /gene="Cdc20"
                     /gene_synonym="p55cdc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtgcctt tagccggtca gaaaagaacg cattcggcac ttctacagac gcactgagga
       61 gtcagggatt tgtgtttggg agaggtttac gaagaggtgc tgggctggtg cgaactgtgg
      121 caggcagagc ccaggagtcc tgcgaggtcc tgagtttggt cgcctctcac ccccctcccc
      181 ggtagacggg ccatggcgca gttcgtgttc gagagcgatt tgcattcact gcttcaactg
      241 gacgcgccca tccccaatgc accgattgct cgctggcagc gcaaagcaaa agaagccaca
      301 ggcccagccc cctcgcctat gcgggccgcc aacagatcac acagcgccgg tcggaccccg
      361 ggccgaactc ctggcaaatc taattctaag gttcagacca cccctagcaa acctggaggt
      421 gaccgctata tcccccaacg tagtgcttcc caaatggagg tggccagctt cctcttgagc
      481 aaggagaacc agccggaaga cgggggtacg cccaccaaga aggagcatca gaaagcctgg
      541 gctcggaacc tgaacggttt tgatgtggag gaagccaaga tcctcaggct cagtggaaaa
      601 cctcagaatg ccccagaagg ctaccagaac agattgaaag tactctacag ccagaaagcc
      661 acgcctggct ccagtcggaa ggcttgcaga tacattcctt ccctgccaga caggattctt
      721 gatgcccctg aaatccggaa tgactactac ctgaatcttg tcgattggag ctctggaaat
      781 gtattagctg tggcactgga caacagtgtg tacttatgga acgctggttc cggtgacatc
      841 ctgcagctgt tgcaaatgga gcagcctggg gactacatat catccgtggc ctggatcaaa
      901 gagggcaact acctggctgt gggcaccagt aatgctgagg tgcagctatg ggatgtgcag
      961 cagcagaaac ggcttcgaaa catgaccagc cactctgctc gagtaagctc cctgagttgg
     1021 aacagctata tcctgtcaag tggttcacga tctggccaca tccaccacca cgatgttcga
     1081 gtagcagaac accatgtggc cacactgagt ggccatagcc aggaagtatg tgggctgcgc
     1141 tgggccccag atggacgaca tctggcaagc ggtggcaatg ataacattgt caacgtgtgg
     1201 cctagtggtc ctggagaaag tggctgggtt cccctgcaga cattcactca acatcaaggt
     1261 gctgtcaagg ctgttgcatg gtgtccctgg cagtccaata tcctggcaac aggaggaggt
     1321 accagtgacc gacacattcg catttggaac gtctgctctg gagcctgtct gagtgctgtg
     1381 gatgtgcatt cccaggtgtg ctccatcctc tggtctcccc actataagga gctcatctca
     1441 ggccatggct ttgcccagaa ccagctggtt atttggaagt acccaaccat ggccaaggtg
     1501 gcagagctca aaggtcacac agcccgggtc ctgagtctca ccatgagtcc agacggggcc
     1561 acagtggcat ctgcagcagc cgatgagact ctgcggctct ggcgctgctt tgagctggac
     1621 cctgcccttc ggcgggagcg ggaaaaagcc agcacatcta aaagtagcct catccaccaa
     1681 ggcatccggt gaaagacaac cctttctttt cccttcttga ttttgttgtt tatttttttc
     1741 taataaagtt catatcttcc tttcttgtgt tcca
//
