LOCUS       NM_001108404            5553 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus cell division cycle 14B (Cdc14b), transcript
            variant 1, mRNA.
ACCESSION   NM_001108404 XM_001059579 XM_341478
VERSION     NM_001108404.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5553)
  AUTHORS   Kim Y, Choi JW, Lee JH and Kim YS.
  TITLE     Loss of CDC14B expression in clear cell renal cell carcinoma:
            meta-analysis of microarray data sets
  JOURNAL   Am J Clin Pathol 141 (4), 551-558 (2014)
   PUBMED   24619757
REFERENCE   2  (bases 1 to 5553)
  AUTHORS   Jeronimo C, Bataille AR and Robert F.
  TITLE     The writers, readers, and functions of the RNA polymerase II
            C-terminal domain code
  JOURNAL   Chem Rev 113 (11), 8491-8522 (2013)
   PUBMED   23837720
  REMARK    Review article
REFERENCE   3  (bases 1 to 5553)
  AUTHORS   Egloff S, Dienstbier M and Murphy S.
  TITLE     Updating the RNA polymerase CTD code: adding gene-specific layers
  JOURNAL   Trends Genet 28 (7), 333-341 (2012)
   PUBMED   22622228
  REMARK    Review article
REFERENCE   4  (bases 1 to 5553)
  AUTHORS   Wei Z, Peddibhotla S, Lin H, Fang X, Li M, Rosen JM and Zhang P.
  TITLE     Early-onset aging and defective DNA damage response in
            Cdc14b-deficient mice
  JOURNAL   Mol Cell Biol 31 (7), 1470-1477 (2011)
   PUBMED   21262768
REFERENCE   5  (bases 1 to 5553)
  AUTHORS   Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A
            and Pagano M.
  TITLE     The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response
            checkpoint
  JOURNAL   Cell 134 (2), 256-267 (2008)
   PUBMED   18662541
REFERENCE   6  (bases 1 to 5553)
  AUTHORS   Li L, Ernsting BR, Wishart MJ, Lohse DL and Dixon JE.
  TITLE     A family of putative tumor suppressors is structurally and
            functionally conserved in humans and yeast
  JOURNAL   J Biol Chem 272 (47), 29403-29406 (1997)
   PUBMED   9367992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000284.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001108404.4.
            
            On Dec 22, 2022 this sequence version replaced NM_001108404.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               JACYVU010000284.1  844686-845070
            386-476             JACYVU010000284.1  872372-872462
            477-552             JACYVU010000284.1  873065-873140
            553-645             JACYVU010000284.1  876275-876367
            646-722             JACYVU010000284.1  898438-898514
            723-789             JACYVU010000284.1  902979-903045
            790-852             JACYVU010000284.1  903810-903872
            853-940             JACYVU010000284.1  906998-907085
            941-1171            JACYVU010000284.1  907561-907791
            1172-1310           JACYVU010000284.1  912515-912653
            1311-1470           JACYVU010000284.1  912760-912919
            1471-1568           JACYVU010000284.1  913694-913791
            1569-1685           JACYVU010000284.1  921496-921612
            1686-1751           JACYVU010000284.1  925706-925771
            1752-5553           JACYVU010000284.1  926060-929861
FEATURES             Location/Qualifiers
     source          1..5553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..5553
                     /gene="Cdc14b"
                     /note="cell division cycle 14B"
                     /db_xref="GeneID:361195"
                     /db_xref="RGD:1311163"
     exon            1..385
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1788
                     /gene="Cdc14b"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein phosphatase CDC14B; CDC14 cell
                     division cycle 14 homolog B"
                     /codon_start=1
                     /product="dual specificity protein phosphatase CDC14B
                     isoform 1"
                     /protein_id="NP_001101874.1"
                     /db_xref="GeneID:361195"
                     /db_xref="RGD:1311163"
                     /translation="MKRKSERRSAWATAPPCSRRSSSSSPGVKKSRSSTPQELHRLEQ
                     QDDLYLDITDRLCFAILYSRPKSASNEHYFSIDNELEYENFYADFGPLNLAMVYRYCC
                     KINKKLKSITMLRKKIIHFTGTDQRKQANAAFLIGCYMVIYLGRAPEDAYRTLIFGDT
                     AYIPFRDAAYGSCSFYITLLDCFHAVKKAIQYGFLNFNSFNLDEYEHYEKAENGDFNW
                     IIPERFLAFCGPHSRSRLESGYHQHSPETYIPYFKNHNVTTIIRLNKRMYDAKRFTDA
                     GFDHHDLFFPDGSTPAEAIVQEFLDICENVEGAIAVHCKAGLGRTGTLIGCYLMKHYR
                     MTAAESIAWLRICRPGSVIGPQQQFLVMKQSSLWLEGDYFRQKLRGQENGALREAFSK
                     HLSDVDDISINGLENQDSQEPEPYSDDDEVSGVTQGDRLRALKSRRQPKTNAIPLTVI
                     LQSSVQSSKTPEPNLSGSAGITKRTTRSASGKSSLKSLAPWRERRRRSALQHMPMLAL
                     CPAISRTKTVLR"
     exon            386..476
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            477..552
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            553..645
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            646..722
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            723..789
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            790..852
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            853..940
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1171
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1310
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1470
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1568
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1685
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1751
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..5553
                     /gene="Cdc14b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaatgaag ctccacggaa catccctcct gggggtcccc gggagccgcg gcccgctgag
       61 ctcggacgcc ccggcagcag cgtcccaggg agcgcgcgct ttgctccagc caccggccag
      121 cgctgtgggg cccctgggac gcgggcagcg ggagacgcag cgcgaggacc cgggccgggt
      181 tgccgggcca tggtcgcggt cccctgacgg gccgcggccg cctccatgaa gcgtaagagc
      241 gagcggcgct cggcttgggc caccgcgccc ccctgctcac gccgcagctc gtcctcctct
      301 cccggtgtga agaagagccg cagctccacg ccgcaggagc tgcaccgcct ggagcagcag
      361 gacgacctgt acctggacat cacggatcgc ctttgttttg ccattctcta cagcagacca
      421 aagagtgcat caaacgagca ttatttcagc atagataacg agctagagta tgagaacttc
      481 tatgcggatt ttggaccact caatctggcc atggtttaca gatattgttg caagataaat
      541 aagaagctca agtccattac aatgctgagg aagaaaatta tccattttac cggcactgat
      601 cagagaaagc aagcgaatgc cgccttcctt atcgggtgtt atatggttat atatttgggg
      661 agggcaccag aagacgcgta tagaacatta atcttcgggg atacagccta tattcctttc
      721 agagatgctg cctatggaag ctgcagtttc tacattacac ttctcgactg ttttcatgca
      781 gtaaaaaagg caatccagta tggcttcctt aatttcaact catttaacct cgatgaatat
      841 gaacactatg aaaaagcaga aaatggagat ttcaactgga taataccaga gcggtttctt
      901 gccttctgtg ggccacactc aagatccagg ctggaaagtg gttaccacca acattctcct
      961 gagacttata ttccatattt taagaatcac aatgtaacta ccattatccg tctgaataaa
     1021 aggatgtatg atgctaagcg ctttacggat gctggattcg atcaccatga tcttttcttt
     1081 ccggatggca gcacccctgc tgaggcaatt gtccaagaat ttctggatat ttgtgaaaat
     1141 gtcgagggtg ccattgcggt gcattgcaaa gctggccttg gtcgaacagg cacactgata
     1201 ggctgctacc tcatgaaaca ttacaggatg acagcagccg agagcattgc ctggctcagg
     1261 atctgtaggc ccggctcagt gattgggccc cagcaacagt ttctggtcat gaagcaatcg
     1321 agcctctggc tggaaggcga ctatttccgt caaaagttga gagggcagga gaacggagcc
     1381 ctcagagaag ccttctccaa acacctttca gatgttgatg acatttcgat aaatgggctt
     1441 gagaatcaag acagtcaaga gcctgagccg tatagtgatg atgatgaagt cagtggagtg
     1501 acacaaggag acagacttcg ggccctgaaa agccggagac agccgaaaac caacgctatc
     1561 cccctcacag taattcttca gtccagtgtt cagagctcta aaacccctga acctaacctt
     1621 tctggcagtg caggcattac taaacgaacc accagatctg cttcgggaaa aagcagtctt
     1681 aaaagcctgg ctccttggag ggagaggagg aggaggagtg ctttgcagca catgcccatg
     1741 ctggccttat gtccagccat ttcaaggact aagacagtct tacgttaaag taaaaaaccg
     1801 gtgaacagca ctccagggaa gactaggaac agaaaacccc aaaggattta gccaatcgat
     1861 ctgagaacaa agcagactgt gcaatggcct tagcttcttt ccacataaga agttcattca
     1921 aggaggaaaa tgtcactggc ctgtcatcca ctcactgact ctggggtgtg gttgaaccat
     1981 ttgaaggcct gactctccct ttcataatct caagtcggac aaaagctgct gttgtgaatt
     2041 tagtctcagg tgtcgatacc ctgtcctctg ccaccagaga gctgtctggt gagtgtggta
     2101 catgtgtgtc cctgtgatgg caatcatgtt tgctgctggc ctccagaaga gtgggggatc
     2161 tggtggagat ctcttgggta tttatttctg ttcggcctgt ggccccgact tacagtttat
     2221 aaagatgtaa gagatgaacc ccccagtggt accctccgtc ttaaggtgtg atttggtacg
     2281 gtcagcttca ctttactctc gttaacgctg ttgtgatgtt cgttcactgc gtgaagtacc
     2341 caagctgctt gtctttcacc aaagagtgct ttattaacaa tctgtgaata ctgcatttaa
     2401 acactgttgt atgttgtcgt ggttaccaaa aacctgctag aaaatgttga tgagagcatt
     2461 ggaacccttt ctcagtcaaa tggttcctac aaatccttcc ttgtgtcatt tagaagattt
     2521 cagagctgag atgttgttgg gttgctcagt cacatgtttt ttgtggtttt ttttttcatt
     2581 tttttttttt tttttcggag ctggggatcg aacccagggc cttgcgcttg ctaggcaagc
     2641 gctctaccac tgagccaaat ccccaacccc gctcagtcac atgttataat tgtgtttact
     2701 ccattacatt aaaaccaaac atcaacccta gcattttttc tggaaaagca tcgtaaataa
     2761 tgttgacttt aaaaacaaaa ttgtgagcct tgaggtagtg gtgcttgcct ttaatcccag
     2821 cattgggagg cagaggcagg tgcatgtctg agttcaaggc cagccaatga tacataagga
     2881 agtctcagag acaacaaaac aaaaaccaac ccccacatcc caaaactgtt aagtccttgt
     2941 agagtctttc tctgtaatgc tgcggaattt ctttccttgt gattcacagt ttgattttag
     3001 tgacaatcac ttgcttctgg agttaggctg tttatgtaag agaactcact gttgcctttg
     3061 gttagggaat atgactagaa actgtagcgt gccttttctc ttcatcctgc tggaacccag
     3121 cagcacccgt gccatgaagc aattgcaaaa ccagaattta tctgttgcca aaaaacaaca
     3181 acaaaaagac caaaaaaggc agagaccata attagaaaat actttatagt tgtcttggtt
     3241 acttccacaa ttgaggctag tggtttttga ctctcccagt ttagaaactg gagaaatgca
     3301 atattgaaag ccattgacag ccattgcctt cctcagacag atgaatgtgt caggtgagca
     3361 ggctatctca cttgaaaagc tgcctttctt gtagttggta tcgacaggtt taaagtttag
     3421 ttattgtaaa aatatttaaa ggccatgggt tccccctttc agtgtttcta tcctcaaact
     3481 gcattggctg gccttgggtc ggagacctga ggattcaatg taaacccaca caaagagccc
     3541 ctccctagat agcacatagc tttcaaacag tggagaaaga cagttaaggt agggtttgtt
     3601 attcctggat atgaatgagt ttaagctcta gctaggagga caaacatttc atttaccaat
     3661 aatgctaaat caaactgccc aagtctaaaa taaaagcttc tcaggtggtt cttccttccc
     3721 tgaacaagct aggccaggta ctgagcagac agaaggagac ttccttccat ctgaactaat
     3781 ctggatttgt tctcatggat caggatgagt gaacagggcc tgcccatgat ggccttgtag
     3841 ccagcaaatt tgggaggaaa ccacctgggc ttcagagatg gccacagtgc tttttaaaag
     3901 gcacggtacc tttttgtgtt ggcaggtcca ttcagctaga actcctgcca ctgtggctct
     3961 tccctgtatt taactccctt gctgaagtta cttaggaaac atgagttggt aaggacattc
     4021 ccaggaaaac tacttaatgt tgtctgggga ggacggcata gcaactgact ggtgacatcc
     4081 aggacccaga aagtctttga tcaaacaaat gaaaagtcct tcctgttggg aattagtgga
     4141 ctacctctgc ccaaactaca actacccaga aacttaaggg tagaagaaga ccctattgct
     4201 atagagcatg gatctataga gtgggtattg gaggggcccc tttaacttaa gaacgttaaa
     4261 tacctttgta agtacatcaa gttagaaagt atatttatag gtgaccttga tgcttgttgg
     4321 gagcccacac catccggagc ccaagagagg aatgtctgcc aagctgggct tcaggacttt
     4381 agacagatta atacagttct gaggcccagc tacaactctt gccttgaggc aagaaggatg
     4441 gagcctcagc agccacattc aaggttgtag tatttgtcta aactctcatg gccacacgct
     4501 gttcttcctc attaactccc cagctttaac tcaaccccct aaacctagcc ctatccattg
     4561 tcctgccctg ccccactgcc cacctctcag gggtggcttc tacctcttgg cttgggccct
     4621 gacaggtcat agaggctccc caagtgttct catgaggctc tgtgagcata atcaggtctg
     4681 gtagaccttc ccagctttct gggtagtttg tgcctggaat tcctcaggcc ttcccttagc
     4741 ttgaatagct gtctgtgaca agtgcgtatg tgttctagaa acatcagctg cttttcctca
     4801 tattttttta aaaattcttt cttgcatttt ggaaagcagt tggtcagaaa ccttaaaacc
     4861 tattttttta gggcggttgt aggaggtggt tctctgtgag tttaaggcct acctggtctt
     4921 cagagtgagt tccagtgtag ttagggctac acagagaagc cctgtctcaa aacagacaat
     4981 aagaactatt ttaagatttc atgatttctc tcccgctgaa gtggcctagt gaggatagcc
     5041 actgctcttg tatttctccg taaatcagag tgttccccat gtcgctgagt ggaaatacta
     5101 caggtagtgt aaaggattgc ctatactgtg taagaaatta cctccttgct gatcagtaga
     5161 actcactgtg catagacatg tctatcagtt acagtactgc agtcctacat ccattgtttg
     5221 aagactctat tatacactca cgtacagatg aagtgaagtt ttaaaatgtt actgatgact
     5281 cagtatttga tcagccattg tcttggtatt ttattaaatt gtatatttct aatcatattt
     5341 tttaaagctg aaagaactgg ttggatgttt atctctgaag gtgtttttaa gataaaagcg
     5401 tcactgtagc ctgtaaactt ggcacacatg tagtttttga tactttttgt tgcatttgaa
     5461 aaatcttgtg tattgtaaaa tggttttata caaaatacta aatagtagaa attgtataat
     5521 ttacaatcat ataattaaaa atattaaaca gtc
//
