LOCUS       NM_001107718            2613 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus cell division cycle 14A (Cdc14a), transcript
            variant 2, mRNA.
ACCESSION   NM_001107718 XM_001073006 XM_001073037 XM_001073065 XM_227618
VERSION     NM_001107718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Imtiaz A, Belyantseva IA, Beirl AJ, Fenollar-Ferrer C, Bashir R,
            Bukhari I, Bouzid A, Shaukat U, Azaiez H, Booth KT, Kahrizi K,
            Najmabadi H, Maqsood A, Wilson EA, Fitzgerald TS, Tlili A,
            Olszewski R, Lund M, Chaudhry T, Rehman AU, Starost MF, Waryah AM,
            Hoa M, Dong L, Morell RJ, Smith RJH, Riazuddin S, Masmoudi S, Kindt
            KS, Naz S and Friedman TB.
  TITLE     CDC14A phosphatase is essential for hearing and male fertility in
            mouse and human
  JOURNAL   Hum Mol Genet 27 (5), 780-798 (2018)
   PUBMED   29293958
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Egloff S, Dienstbier M and Murphy S.
  TITLE     Updating the RNA polymerase CTD code: adding gene-specific layers
  JOURNAL   Trends Genet 28 (7), 333-341 (2012)
   PUBMED   22622228
  REMARK    Review article
REFERENCE   3  (bases 1 to 2613)
  AUTHORS   Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I,
            Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA
            and Andersen JS.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 2613)
  AUTHORS   Schindler K and Schultz RM.
  TITLE     The CDC14A phosphatase regulates oocyte maturation in mouse
  JOURNAL   Cell Cycle 8 (7), 1090-1098 (2009)
   PUBMED   19270517
REFERENCE   5  (bases 1 to 2613)
  AUTHORS   Sanchez M, Galy B, Dandekar T, Bengert P, Vainshtein Y, Stolte J,
            Muckenthaler MU and Hentze MW.
  TITLE     Iron regulation and the cell cycle: identification of an
            iron-responsive element in the 3'-untranslated region of human cell
            division cycle 14A mRNA by a refined microarray-based screening
            strategy
  JOURNAL   J Biol Chem 281 (32), 22865-22874 (2006)
   PUBMED   16760464
REFERENCE   6  (bases 1 to 2613)
  AUTHORS   Mailand N, Lukas C, Kaiser BK, Jackson PK, Bartek J and Lukas J.
  TITLE     Deregulated human Cdc14A phosphatase disrupts centrosome separation
            and chromosome segregation
  JOURNAL   Nat Cell Biol 4 (4), 317-322 (2002)
   PUBMED   11901424
  REMARK    Erratum:[Nat Cell Biol. 2006 Aug;8(8):897]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC161876.1.
            
            On Sep 10, 2008 this sequence version replaced NM_001107718.1.
            
            Summary: The protein encoded by this gene is a dual-specificity
            phosphatase that preferentially dephosphorylates cyclin dependent
            kinase substrates to regulate the cell cycle. In human cell lines,
            this protein localizes to interphase chromosomes, and depletion of
            the transcript results in centrosome separation and cytokinesis
            defects. In mouse, the protein localizes to the nucleus of prophase
            I arrested oocytes and then becomes dispersed in meiotically
            competent oocytes. Knockdown of the protein delays exit from
            metaphase I and results in eggs with chromosomal abnormalities and
            elevated aneuploidy, demonstrating a function in regulation of
            meiosis. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region and an alternate 3' terminal exon,
            resulting in a novel 3' coding region and 3' UTR compared to
            variant 1. It encodes isoform 2, which has a shorter and distinct
            C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..2613
                     /gene="Cdc14a"
                     /note="cell division cycle 14A"
                     /db_xref="GeneID:310806"
                     /db_xref="RGD:1304649"
     exon            1..670
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..2502
                     /gene="Cdc14a"
                     /note="isoform 2 is encoded by transcript variant 2; CDC14
                     cell division cycle 14 homolog A; dual specificity protein
                     phosphatase CDC14A"
                     /codon_start=1
                     /product="dual specificity protein phosphatase CDC14A
                     isoform 2"
                     /protein_id="NP_001101188.2"
                     /db_xref="GeneID:310806"
                     /db_xref="RGD:1304649"
                     /translation="MAAESGELIGACEFMKDRLYFATLRNRPKSTINIHYFSIDEELV
                     YENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTSFDQRKRANAAFLIGAY
                     AVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTVLDCLQGIRKGLQHGFFD
                     FETFDADEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKK
                     NNVTTIVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAV
                     HCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQ
                     GDIFRSKLKNRPSSEGSITKIISSLDDMSIAGNLSKLQSTERIGENNFEDEDMEIKNN
                     VTQGDKLRALKSQRQPRSSPSCAFRSDDMKGHQRAVAQTFRLSSSPQPTVPTVKTPKV
                     CLSPSVTAKRISRGSLSSGANIRSFSINSRLASSLGNLNSGTEETENKKTTSPIKAAF
                     IASPFTSFLNGSTQTPGRNYPELNNNQYTRSSNSSSGGSLGGNLNSSPSAKPEEHNTI
                     LRPSFSGALSSSSVRFLSRSIPVSSQTPPLSPQNPECNFCTLPSQPRLPPKKFNSAKE
                     TL"
     exon            671..761
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            762..837
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            838..930
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1010
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1077
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1140
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1228
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1459
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1598
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1758
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1871
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1919
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2042
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2583
                     /gene="Cdc14a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2583
                     /gene="Cdc14a"
ORIGIN      
        1 ccgcggagcc gtgaaagtgg agggggacga gggagggcgg ggaggcaggt ctgggggcgg
       61 acctaagagg aggaggagga gaggagggag gaagagttgc tgctgaaagg aggtggcgaa
      121 ggaggagtct gagcagctgc tactagcccc gcggacacct ccggagtcct gcccgctgcc
      181 gcacgagtgg ccacgggcgc gatccgggcc aaacgtcttg tcctccatga tcactttggg
      241 agccggggga agactttgcc cggctttgag agctggtgtg cgctatccag gtttggcgga
      301 gacggtgctg cgggagcaga aggagctgca gctcgagcag cagcagcagc cgccgccgcc
      361 gcagagtccg gatcacagcg gttacagtcc ggggcgtgtg cgtcccgcgc ccagcgggtt
      421 cggttcccca cggaatgtcc ccggggcgcc ccacgcgctg accctgcagc tgcctccgcc
      481 ttgggcgccc gccgcctccc tcaggcaggc tcggtgattg ggaccgcgag ctcccagctc
      541 ctgggcagtg gggaagcccc cgggggcggg tgacctcagc tggccacgac ccagccctcc
      601 ccggtgcgga tctcgcttaa gatggcagcg gagtcagggg aactaatcgg ggcttgcgag
      661 ttcatgaaag atcgattata ttttgctact ttaaggaata gaccaaaaag cacaataaat
      721 atccactatt tctccatcga cgaggagctg gtctatgaaa atttctatgc agattttgga
      781 cctctgaact tggcaatggt gtacagatac tgctgtaagc taaacaagaa actaaaatca
      841 tacagtttat caagaaagaa aatagtgcac tacacctctt tcgaccagcg gaaaagagca
      901 aacgcagcat tcttgatagg tgcttatgcc gtcatctact taaagaagac accagaagaa
      961 gcgtacagag ctctcctgtc tggctcaaac cctccttatc ttccattcag ggatgcgtcc
     1021 tttggaaatt gcacttacaa cctcaccgtc cttgactgtt tacaaggaat cagaaaggga
     1081 ttacagcatg gattttttga ctttgagaca tttgatgcgg atgaatatga acactatgag
     1141 cgagttgaaa atggggactt caactggatc gttccaggaa aatttttagc atttagtgga
     1201 ccacatccta aaagcaaaat tgaaaatggt taccctctcc acgctcctga agcctacttt
     1261 ccgtatttca aaaagaacaa cgtgacaaca atcgtgagat tgaataaaaa gatttatgag
     1321 gcgaagcgct tcacagacgc tggcttcgag cactacgacc tgttcttcat agatggcagc
     1381 acccccagcg acaacatcgt gcgaagattc ctgaacatct gtgagaacac ggagggggcc
     1441 attgcggtcc actgcaaagc tggtctgggg agaactggga ctttgatagc ctgttacgtc
     1501 atgaaacact acaggttcac acacgctgaa atcatcgctt ggatcagaat ttgtcgacca
     1561 ggctccatca ttggacccca gcagcatttc ctggaagaga aacaagcatc attgtgggtc
     1621 caaggagaca tttttcgatc caaactgaaa aatagaccgt ccagtgaagg aagtattact
     1681 aaaattattt ctagcttgga tgatatgtct attgctggga acttatctaa attacaaagc
     1741 acagaaagga ttggagagaa taattttgaa gacgaagata tggaaattaa aaacaacgta
     1801 acgcagggag acaaactacg tgccttaaaa agccagaggc agccccgctc ctcgccatcc
     1861 tgtgcattta ggtcagatga tatgaaagga caccaaaggg cagtggccca gactttcaga
     1921 ttaagttctt caccacaacc aacagtgccg actgtgaaga cccccaaagt gtgtttgtcc
     1981 ccttcagtga cagccaaaag gataagcaga ggttctctgt cttcaggagc aaacataaga
     2041 agcttctcca taaattcccg gctagccagt tccctgggga acttgaattc tgggacagaa
     2101 gaaactgaga acaaaaagac cacatcaccc atcaaggctg ctttcatagc cagcccgttc
     2161 accagcttct tgaatggcag cacccagaca cctggcagaa actaccctga gctcaacaac
     2221 aatcagtaca ccagaagcag caacagcagc agcggcggca gtcttggggg caacctgaac
     2281 agctctccaa gcgccaagcc cgaggagcat aacaccatcc ttagaccttc cttctcgggg
     2341 gcgctctctt cctcctcagt gagattcctg agccgttcta tacctgtaag ttcacagaca
     2401 ccacctctca gtcctcagaa ccctgaatgc aacttctgta ccttgccttc ccagcccagg
     2461 ctgccaccaa agaaatttaa tagtgccaag gaaaccttat gatcgacact ttccctctgt
     2521 gttgtgcaac tgtccatgtg ctacattctg ctggctcctc ttcaagtaaa tgccgagttt
     2581 caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
