LOCUS       NM_053877               1648 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cell division cycle 123 (Cdc123), mRNA.
ACCESSION   NM_053877
VERSION     NM_053877.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1648)
  AUTHORS   Okuda,A., Ohtsu,M. and Kimura,G.
  TITLE     Reversion of temperature-sensitive mutation by inhibition of
            proteasome-mediated degradation of mutated D123 protein
  JOURNAL   Cell Struct Funct 26 (4), 205-214 (2001)
   PUBMED   11699637
  REMARK    GeneRIF: The D123 protein is unstable in the temperature-sensitive
            cell-cycle mutant of the rat 3Y1 fibroblast cell line.
REFERENCE   2  (bases 1 to 1648)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   3  (bases 1 to 1648)
  AUTHORS   Okuda,A., Ohtsu,M. and Kimura,G.
  TITLE     Extensive degradation of mutant-type D123 protein is responsible
            for temperature-sensitive proliferation inhibition in 3Y1tsD123
            cells
  JOURNAL   Cell Struct Funct 24 (6), 443-449 (1999)
   PUBMED   10698258
REFERENCE   4  (bases 1 to 1648)
  AUTHORS   Onisto,M., Zeilante,P., Scannapieco,P., Pellati,D., Pozza,M.,
            Caenazzo,C., Negro,A. and Garbisa,S.
  TITLE     Expression study on D123 gene product: evidence for high positivity
            in testis
  JOURNAL   Exp Cell Res 242 (2), 451-459 (1998)
   PUBMED   9683532
REFERENCE   5  (bases 1 to 1648)
  AUTHORS   Okuda,A. and Kimura,G.
  TITLE     An amino acid change in novel protein D123 is responsible for
            temperature-sensitive G1-phase arrest in a mutant of rat fibroblast
            line 3Y1
  JOURNAL   Exp Cell Res 223 (2), 242-249 (1996)
   PUBMED   8601400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On May 26, 2021 this sequence version replaced NM_053877.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U34843.2, BC061527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000017.1  77368617-77368757
            142-213             JAXUCZ010000017.1  77371683-77371754
            214-271             JAXUCZ010000017.1  77379582-77379639
            272-304             JAXUCZ010000017.1  77380178-77380210
            305-400             JAXUCZ010000017.1  77386537-77386632
            401-507             JAXUCZ010000017.1  77389428-77389534
            508-556             JAXUCZ010000017.1  77396892-77396940
            557-632             JAXUCZ010000017.1  77400187-77400262
            633-755             JAXUCZ010000017.1  77401887-77402009
            756-784             JAXUCZ010000017.1  77402889-77402917
            785-913             JAXUCZ010000017.1  77409296-77409424
            914-1051            JAXUCZ010000017.1  77411450-77411587
            1052-1648           JAXUCZ010000017.1  77412063-77412659
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..1648
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /note="cell division cycle 123"
                     /db_xref="GeneID:116656"
                     /db_xref="RGD:619766"
     exon            1..141
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1078
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /note="cell division cycle protein 123 homolog; D123 gene
                     product; cell division cycle 123 homolog"
                     /codon_start=1
                     /product="translation initiation factor eIF2 assembly
                     protein"
                     /protein_id="NP_446329.1"
                     /db_xref="GeneID:116656"
                     /db_xref="RGD:619766"
                     /translation="MKKEHVSHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTL
                     VVSGREDPPTCSQPDSGDEAEETQWSDDESTATLTAPEFPEFNTQVQEAINSLGGSVF
                     PKLNWSAPRDAYWIAMNSSLKCKSLSDIFLLFKSSDFITHDFTQPFIHCNDDSPDPCI
                     EYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFK
                     EHLQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELTSENNLRGDVSE
                     ADALEQDSPAFRCTNSEVTVQPSPYLSYGLPKDFVDLSTGEDAHKLIDFLKLKRNQQE
                     DD"
     exon            142..213
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            214..271
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            272..304
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            305..400
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            401..507
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            508..556
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            557..632
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            633..755
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            756..784
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            785..913
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1051
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1648
                     /gene="Cdc123"
                     /gene_synonym="D123"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagggtt ccgggagagt gctggcggga gaggggacag ggcagcgatt gacgcggcag
       61 ctggaggatg aagaaggagc atgttagtca ctgtcagttc tccgcgtggt acccactctt
      121 ccgaagcctt accatcaaga gtgtcatcct cccgcttcct cagaatgtga aagactattt
      181 acttgacgac gggactctgg tggtctcagg aagggaagac ccaccaacat gctctcagcc
      241 agacagtggt gacgaagcag aggaaacaca gtggtccgat gatgagagca cagccacact
      301 tacggcaccc gagtttcctg agttcaatac tcaagtccaa gaagctatca attcgctggg
      361 gggcagtgtc ttccctaagc ttaactggag tgccccaagg gatgcatact ggatagcaat
      421 gaacagttct ctgaagtgta aaagcctcag tgacatcttc ctgcttttca agagttcgga
      481 cttcatcact catgacttca cacagccgtt tattcattgt aatgatgatt ctccagatcc
      541 ttgtatagag tacgagcttg ttctccgaaa atggtgtgaa ttaatccctg gggctgagtt
      601 ccgatgtttt gtcaaggaaa acaagcttat tggtatttct cagagggact acacgcagta
      661 ctatgatcat atctctaagc aaaaagaaga aatttgcaga tgcattcaag actttttcaa
      721 ggaacacctg cagtacaaat tcttagatga agactttgtg tttgatatat acagagacag
      781 taggggcaag gtgtggctga tcgactttaa cccatttggg gaggtcacag actctctgct
      841 gtttacttgg gaagagctga catcggagaa caatctgcga ggcgacgtca gtgaggcgga
      901 cgctctggag caggattctc cagccttccg ttgtacgaac agtgaagtca cggtccagcc
      961 cagcccctat ctgagctacg gcctgcccaa ggacttcgta gacctttcca ccggggaaga
     1021 tgctcacaag ctcatagatt ttcttaagct gaaaagaaat cagcaagagg acgactgagc
     1081 gctgcttgga gaataagtca agagggaaac agcttttcag aagcctcata tagaacacaa
     1141 cttcccagtg acccaaacta ggtgcagatg ggtgggcagt atgcaaaatc atcagctttt
     1201 atattcgtgt atatttacct ggagaaagat ggaggacctt tggtacttgt aaaagaaata
     1261 acaatataat aaatagatct taaacacaag gaagcacact gtgatggttt gtatatgctt
     1321 gggccaggga gtggcactat gaggaggtgt ggcctggttg gagtaggggg tgtcactatg
     1381 ggtgtgggct ttaagaccct agtcctaact gcctggaagt cagttttttc ctagctacct
     1441 tcagctaagt tcctcctgca ccatgcctgc ctgggtgccg ccatactccc accttgatga
     1501 taatggactg aaactctgac cctctgaacc tgtaagccag ccccagtgaa atgttgttct
     1561 tataagagtt gtcttggtca tggcgtctgc tcacagcaac tatgctaaga cacacactgt
     1621 tctgaaaata aaataacttt ctacgaaa
//
