LOCUS       NM_001108688             944 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus cytidine deaminase (Cda), mRNA.
ACCESSION   NM_001108688 XM_001070553 XM_342955
VERSION     NM_001108688.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 944)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 944)
  AUTHORS   Pellicer M, Garcia-Gonzalez X, Garcia MI, Robles L, Gravalos C,
            Garcia-Alfonso P, Pachon V, Longo F, Martinez V, Blanco C, Iglesias
            I, Sanjurjo M and Lopez-Fernandez LA.
  TITLE     Identification of new SNPs associated with severe toxicity to
            capecitabine
  JOURNAL   Pharmacol Res 120, 133-137 (2017)
   PUBMED   28347776
REFERENCE   3  (bases 1 to 944)
  AUTHORS   Tibaldi C, Giovannetti E, Vasile E, Mey V, Laan AC, Nannizzi S, Di
            Marsico R, Antonuzzo A, Orlandini C, Ricciardi S, Del Tacca M,
            Peters GJ, Falcone A and Danesi R.
  TITLE     Correlation of CDA, ERCC1, and XPD polymorphisms with response and
            survival in gemcitabine/cisplatin-treated advanced non-small cell
            lung cancer patients
  JOURNAL   Clin Cancer Res 14 (6), 1797-1803 (2008)
   PUBMED   18347182
REFERENCE   4  (bases 1 to 944)
  AUTHORS   Sugiyama E, Kaniwa N, Kim SR, Kikura-Hanajiri R, Hasegawa R,
            Maekawa K, Saito Y, Ozawa S, Sawada J, Kamatani N, Furuse J, Ishii
            H, Yoshida T, Ueno H, Okusaka T and Saijo N.
  TITLE     Pharmacokinetics of gemcitabine in Japanese cancer patients: the
            impact of a cytidine deaminase polymorphism
  JOURNAL   J Clin Oncol 25 (1), 32-42 (2007)
   PUBMED   17194903
REFERENCE   5  (bases 1 to 944)
  AUTHORS   Nakamura Y, Sato H and Motokura T.
  TITLE     Development of multidrug resistance due to multiple factors
            including P-glycoprotein overexpression under K-selection after MYC
            and HRAS oncogene activation
  JOURNAL   Int J Cancer 118 (10), 2448-2454 (2006)
   PUBMED   16353156
REFERENCE   6  (bases 1 to 944)
  AUTHORS   Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S,
            Bono H, Okazaki Y and Hayashizaki Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   7  (bases 1 to 944)
  AUTHORS   Gran C, Boyum A, Johansen RF, Lovhaug D and Seeberg EC.
  TITLE     Growth inhibition of granulocyte-macrophage colony-forming cells by
            human cytidine deaminase requires the catalytic function of the
            protein
  JOURNAL   Blood 91 (11), 4127-4135 (1998)
   PUBMED   9596658
REFERENCE   8  (bases 1 to 944)
  AUTHORS   Laliberte J and Momparler RL.
  TITLE     Human cytidine deaminase: purification of enzyme, cloning, and
            expression of its complementary DNA
  JOURNAL   Cancer Res 54 (20), 5401-5407 (1994)
   PUBMED   7923172
REFERENCE   9  (bases 1 to 944)
  AUTHORS   Durak I, Cetin R, Canbolat O, Cetin D, Yurtarslani Z and Unal A.
  TITLE     Adenosine deaminase, 5'-nucleotidase, guanase and cytidine
            deaminase activities in gastric tissues from patients with gastric
            cancer
  JOURNAL   Cancer Lett 84 (2), 199-202 (1994)
   PUBMED   8076377
REFERENCE   10 (bases 1 to 944)
  AUTHORS   Seifert,J. and Vacha,J.
  TITLE     Pyrimidine nucleotide synthesis in rat liver after the
            administration of cycloheximide
  JOURNAL   Toxicology 10 (1), 29-38 (1978)
   PUBMED   675715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342955.3, XM_001070553.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..944
                     /gene="Cda"
                     /note="cytidine deaminase"
                     /db_xref="GeneID:362638"
                     /db_xref="RGD:1311101"
     exon            1..191
                     /gene="Cda"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..478
                     /gene="Cda"
                     /EC_number="3.5.4.5"
                     /codon_start=1
                     /product="cytidine deaminase"
                     /protein_id="NP_001102158.1"
                     /db_xref="GeneID:362638"
                     /db_xref="RGD:1311101"
                     /translation="MAQERPSCAVEPEHVQRLLLSSREAKKSAYCPYSRFPVGAALLT
                     GDGRIFSGCNVENACYPLGVCAERTAIQKAISEGYKDFRAIAIASDLQEEFISPCGAC
                     RQVMREFGTNWAVYMTKPDGTFVVRTVQELLPASFGPEDLQKIH"
     exon            192..303
                     /gene="Cda"
                     /inference="alignment:Splign:2.1.0"
     exon            304..361
                     /gene="Cda"
                     /inference="alignment:Splign:2.1.0"
     exon            362..944
                     /gene="Cda"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagtctgcag ctgctagctc actctcctcg gaccgacatg gcccaggaac gcccctcctg
       61 tgccgtggag cctgagcacg tccagcggct gctgctgtcc tctcgtgaag ccaagaagtc
      121 agcctactgc ccctacagcc gcttccctgt tggggctgcc ctgctcaccg gggacgggag
      181 gatcttctct gggtgcaacg tagaaaacgc ctgctaccca cttggtgtgt gtgccgagcg
      241 gaccgccatc cagaaggcca tctctgaagg ctacaaggat ttcagggcta ttgccattgc
      301 cagtgacttg caagaagagt tcatctctcc ctgcggagcc tgccgacaag tcatgagaga
      361 gtttggcacc aactgggctg tgtacatgac caagcccgat ggcacattcg tagtgaggac
      421 ggtccaggag ctgctgccgg cctcgtttgg gcctgaagac ttgcagaaga ttcactgaag
      481 gttagagaag agaatgtccg ctgaatgtgc gagtccaggt gccctaccta aggaacagct
      541 cttggaagac ttcataatga agacaccatg acgatgctgt ctctgcctgg gccctgggga
      601 cacttaccac atgggtccca aatggctagg caagggagac cttgtttcac actccacagc
      661 ttcccctaga gtgatgatgg aaggtgccac ttacctgggc caaagccctc accctcctgg
      721 ggtctcagaa caccccattc cttcttctcc cgaaggccct ggcattccag gcttggtctg
      781 ccttccacgg ctccgtcgtg tgagtcttca gattataaac accacagcat gtcctgatga
      841 cgaagaacgt gtttttgttc ttagtccgtg tgtacagctc tcaggggcgg ttcgtctcac
      901 ggggcagaat tagctgcgtc cttctggagg atgtggatgc ttcc
//
