LOCUS       NM_053383               6272 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus CD93 molecule (Cd93), mRNA.
ACCESSION   NM_053383
VERSION     NM_053383.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6272)
  AUTHORS   Qiao,N., Zhang,J., Zhang,Y. and Liu,X.
  TITLE     Synergistic regulation of microglia differentiation by CD93 and
            integrin beta1 in the rat pneumococcal meningitis model
  JOURNAL   Immunol Lett 251-252, 63-74 (2022)
   PUBMED   36336138
  REMARK    GeneRIF: Synergistic regulation of microglia differentiation by
            CD93 and integrin beta1 in the rat pneumococcal meningitis model.
REFERENCE   2  (bases 1 to 6272)
  AUTHORS   Qiao,N., Zhang,J., Zhang,Y. and Liu,X.
  TITLE     Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation
  JOURNAL   Ann Clin Lab Sci 52 (4), 634-641 (2022)
   PUBMED   36197773
  REMARK    GeneRIF: Crosstalk between CD93, C1q and GIPC in the Regulation of
            Pneumococcal Meningitis Inflammation.
REFERENCE   3  (bases 1 to 6272)
  AUTHORS   Shuwen,H., Xi,Y., Miao,D., Jiamin,X., Jing,Z. and Weili,G.
  TITLE     Nine Genes Mediate the Therapeutic Effects of Iodine-131
            Radiotherapy in Thyroid Carcinoma Patients
  JOURNAL   Dis Markers 2020, 9369341 (2020)
   PUBMED   32626543
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6272)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   5  (bases 1 to 6272)
  AUTHORS   Chen,Y.C., Pristera,A., Ayub,M., Swanwick,R.S., Karu,K., Hamada,Y.,
            Rice,A.S. and Okuse,K.
  TITLE     Identification of a receptor for neuropeptide VGF and its role in
            neuropathic pain
  JOURNAL   J Biol Chem 288 (48), 34638-34646 (2013)
   PUBMED   24106277
  REMARK    GeneRIF: These results indicate that gC1qR is the receptor for
            TLQP-21 and plays an important role in chronic pain through
            activation of macrophages
REFERENCE   6  (bases 1 to 6272)
  AUTHORS   Lovik,G., Vaage,J.T., Dissen,E., Szpirer,C., Ryan,J.C. and
            Rolstad,B.
  TITLE     Characterization and molecular cloning of rat C1qRp, a receptor on
            NK cells
  JOURNAL   Eur J Immunol 30 (12), 3355-3362 (2000)
   PUBMED   11093152
REFERENCE   7  (bases 1 to 6272)
  AUTHORS   Dean,Y.D., McGreal,E.P., Akatsu,H. and Gasque,P.
  TITLE     Molecular and cellular properties of the rat AA4 antigen, a C-type
            lectin-like receptor with structural homology to thrombomodulin
  JOURNAL   J Biol Chem 275 (44), 34382-34392 (2000)
   PUBMED   10934210
REFERENCE   8  (bases 1 to 6272)
  AUTHORS   Nepomuceno,R.R., Ruiz,S., Park,M. and Tenner,A.J.
  TITLE     C1qRP is a heavily O-glycosylated cell surface protein involved in
            the regulation of phagocytic activity
  JOURNAL   J Immunol 162 (6), 3583-3589 (1999)
   PUBMED   10092817
REFERENCE   9  (bases 1 to 6272)
  AUTHORS   Yoder,M.C., Hiatt,K., Dutt,P., Mukherjee,P., Bodine,D.M. and
            Orlic,D.
  TITLE     Characterization of definitive lymphohematopoietic stem cells in
            the day 9 murine yolk sac
  JOURNAL   Immunity 7 (3), 335-344 (1997)
   PUBMED   9324354
REFERENCE   10 (bases 1 to 6272)
  AUTHORS   Nepomuceno,R.R., Henschen-Edman,A.H., Burgess,W.H. and Tenner,A.J.
  TITLE     cDNA cloning and primary structure analysis of C1qR(P), the human
            C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro
  JOURNAL   Immunity 6 (2), 119-129 (1997)
   PUBMED   9047234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000119.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_053383.4.
            
            On Nov 27, 2020 this sequence version replaced NM_053383.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF160978.1, AF136537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2088              JACYVU010000119.1  9551406-9553493     c
            2089-6272           JACYVU010000119.1  9546974-9551157     c
FEATURES             Location/Qualifiers
     source          1..6272
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..6272
                     /gene="Cd93"
                     /gene_synonym="C1qr1; C1qRp; Ly68"
                     /note="CD93 molecule"
                     /db_xref="GeneID:84398"
                     /db_xref="RGD:621251"
     exon            1..2088
                     /gene="Cd93"
                     /gene_synonym="C1qr1; C1qRp; Ly68"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2113
                     /gene="Cd93"
                     /gene_synonym="C1qr1; C1qRp; Ly68"
                     /note="complement component C1q receptor; C1qR(p);
                     C1q/MBL/SPA receptor; cell surface antigen AA4; complement
                     component 1 q subcomponent receptor 1; lymphocyte antigen
                     68; CD93 antigen"
                     /codon_start=1
                     /product="complement component C1q receptor precursor"
                     /protein_id="NP_445835.2"
                     /db_xref="GeneID:84398"
                     /db_xref="RGD:621251"
                     /translation="MVTSTGLLLLLGLLGQLWAGAAADSEAVVCEGTACYTAHWGKLS
                     AAEAQHRCNENGGNLATVKSEEEARHVQEALAQLLKTKAPSETKIGKFWIGLQREKGK
                     CTYHDLPMKGFSWVGGGEDTTYSNWYKASKSSCISKRCVSLILDLSLKPHPSHLPKWH
                     ESPCGTPDAPGNSIEGFLCKFNFKGMCSPLALGGPGQLTYTTPFQATTSSLKAVPFAS
                     VANVVCGDEAESKTNYYLCKETTAGVFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGG
                     DGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCHCPRGYQLD
                     SSQVHCVDIDECEDSPCDQECINTPGGFHCECWVGYQSSGSKEEACEDVDECTAAYSP
                     CAQGCTNTDGSFYCSCKEGYIMSGEDSTQCEDIDECLGNPCDTLCINTDGSFRCGCPA
                     GFELAPNGVSCTRGSMFSELPARPPQKEDKGDGKESTVPLTEMPGSLNGSKDVSNRAQ
                     TTDLSIQSDSSTASVPLEIEVSSEASDVWLDLGTYLPTTSGHSQPTHEDSVPAHSDSD
                     TDGQKLLLFYILGTVVAISLLLALALGLLIYLKRKAKKEEIKEKKAQNAADSYSWIPE
                     RAESRAPENQYSPTPGTDC"
     exon            2089..6272
                     /gene="Cd93"
                     /gene_synonym="C1qr1; C1qRp; Ly68"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgtgaaaa gcctcgagtc tttgtaacct tctgtatgcc agagctgtgg tagtgtgaca
       61 gcggcagtgc agccctcagc tcctttcaga gcacagtctg gtgccaagct ccaaggttcc
      121 agtggctgct gctgtcactg tgggggagtc taacctctcc cagaaggaga catacagaag
      181 aatggtcacc tcaactggtt tgctcctgct gctggggctt ctcggccagc tctgggcagg
      241 ggctgctgct gattcagagg ctgtggtgtg cgagggaact gcctgctata cagcccactg
      301 gggcaagctg agtgccgcgg aagcccagca tcgctgtaat gagaatggag gcaatcttgc
      361 cactgtgaag agcgaggagg aggctcggca tgtccaggaa gctctggctc agcttctgaa
      421 gaccaaggca ccctcggaaa caaagatagg caaattctgg atcgggctcc agcgagagaa
      481 gggcaagtgt acgtatcatg atttgccaat gaagggcttc agctgggttg gtggtggaga
      541 ggacacaact tattcaaact ggtacaaagc gagcaagagc tcctgtatct ctaaacgctg
      601 tgtgtccctg atactggatc tgtccttgaa acctcacccc agccatctgc ctaaatggca
      661 tgagagtccc tgtgggactc ccgatgctcc aggcaacagc attgaaggct tcctgtgcaa
      721 gttcaacttc aaaggcatgt gcagtccact ggcgctgggt ggaccagggc agctgaccta
      781 taccacccct ttccaggcca ccacctcctc tctgaaggcc gtgccgtttg cctctgttgc
      841 caatgtagtt tgtggggatg aagctgagag taagaccaat tattacctat gcaaggaaac
      901 gactgcagga gtattccatt ggggcagctc aggccctctc tgtgtcagcc ccaagtttgg
      961 ttgcagtttc aacaatgggg gctgccagca ggattgcttc gaaggtgggg atggctcctt
     1021 ccgctgtggc tgccggcctg gattccggct gctggatgac ctagtaactt gtgcgtccag
     1081 gaacccctgc agttcaaacc catgcacagg aggcggcatg tgtcattctg tgccactaag
     1141 cgaaaactac acatgccatt gtcccagagg ctaccagctg gactctagcc aagtgcactg
     1201 tgtggatata gatgagtgtg aggactcccc ctgtgaccag gaatgtatca acactccagg
     1261 gggcttccat tgtgaatgtt gggtgggcta ccaatccagt ggttccaagg aggaggcctg
     1321 tgaggatgtg gatgagtgta ccgctgccta ctcaccctgt gcccagggct gcactaacac
     1381 tgatggctct ttttactgct cctgtaaaga gggatatatc atgtctgggg aagacagtac
     1441 ccagtgtgag gatatagatg agtgtttggg caatccatgt gataccctgt gtatcaacac
     1501 agatggttct ttcaggtgtg gctgcccagc aggttttgag ctggctccca atggggtctc
     1561 ttgtaccagg ggctctatgt tttcagagtt accagccagg cctccccaaa aggaagacaa
     1621 aggtgacgga aaggagagta ctgtgcctct tactgaaatg cctggttctc tcaatggctc
     1681 taaggatgtc tccaacagag cacagaccac agatctctcc attcaatcgg atagttccac
     1741 tgcctctgtt ccactagaaa tagaagtctc tagtgaggca tctgatgtct ggttagattt
     1801 gggcacatac ctccccacga cctctggcca cagccagccg actcatgaag attctgtgcc
     1861 tgcacacagt gacagtgaca ccgatgggca gaagctactt ctgttttaca tcctgggtac
     1921 agtggtggcc atctcactct tgctggctct ggcccttggg cttctcattt atcttaaacg
     1981 gaaagccaag aaagaggaga tcaaagagaa gaaggcccag aatgcagctg acagctattc
     2041 ctggattcca gagcgagcag agagccgagc cccagagaat cagtacagcc caacacctgg
     2101 gacggactgc tgaagacaac gtggctttag aaacatagtc agctgccact accttcagag
     2161 ttaccttctt agatgaggga gaagccacat cactctgaaa gactggactg gactctcagc
     2221 aataattggg caccttcccc tttaagaacc tggtgacttg ggttgggcag atattttcct
     2281 ggtgcctttg atatgcctgg ggagataaaa tgaccattgt ggggagtttt ggggatattg
     2341 acagacctca ctcacacacc cttttcaaat ccaaaagcaa ctggttcctc tggttgccaa
     2401 tcagggcgta ggaagtcaga gggggtgggg tagggtgggg gtagggggct tcaaagtctt
     2461 ttcttatgta ttgatttatc agagaaggag ctactggtgc taattacgat ggaaacaatt
     2521 cctttccttc acaggctaga aagcaaaacc aactaactaa taacctggta agactgctct
     2581 acccttccta cagggacttt ttcaggatgg ctgtctttgt gtacatttgc cttctggcat
     2641 ttcccctcca tcccgcttgc tcggtattgt tggaactgtc agaatgaaag gaagttcaac
     2701 caactgctca gggagcaagc aggcaggaag tttagacctt gtatcccctt gctctttctg
     2761 atagacttga gcttatgggc aaacaagttg gaaagttgct tcaagtgagt gaggtcttgg
     2821 taaaagcata gtctagaggg aggcaggcag gaattgattt aacagatatt tgaacaaaaa
     2881 aaaatctgaa ggaactgatg ctagcacaca ctcgactact gaggaacaat aacaaaaccc
     2941 caagatcaat ttgtctttga gcttgcacgg gtcctgactc cactgcaggg caccctctcc
     3001 ctttatacca tcccaaccag ggaagatggg acagcaggct cagaaagcct caggatgctt
     3061 tcattctgaa tgaaggaaag gatgtgtgag cctggtgatg ggctatttta aatactccca
     3121 tttaaatgaa gcttagcccc cttcatggtt aaaagtacat ctagaggact tgaaccctat
     3181 tttgtggatg tgacacagac tgaatcaagg attagtcatg aaggaggttc tctttttttt
     3241 tgtttttgct taaaaaagga gatacagggg agagggaaaa gggaagagag aacagctaaa
     3301 aaatttccaa ccgttaaaac ggcttagagc caccttatga ttgacatgtt tattttaaag
     3361 ggttcatatg caaaagtgtc ccttaaactt gctgcaggta atgctgttcc agctgcacag
     3421 gactgtctgg ggcctggaag gcagccctgg tgagtcactt cagtatctca ggaggcctgt
     3481 ctcagctgcc tttgctgttt gaaatactga gacaaggaat gtgtctccac cacgagattc
     3541 cgagtctttg ttctcagact agagtgtcct tttgttacta gtgtcaaaag caactatcct
     3601 tcaagttgat agccagaaag tgaagattaa taacaaccgg actcaaggcc tttgaaatat
     3661 cttagagaac tatattacag aagtgtcttt ttttttcttt gtcaatttaa aatggagata
     3721 ctttcattag tcagactttc tttctctctt tgaaaaccca tcgtggagag caatggggaa
     3781 ccgattgagc tcagtgggtg cctgaaatgt gtgcatttaa aagtcaactt actgtctggc
     3841 tttcagttga aatttgaaca tttggaacag gatctctggc aataactgag attggccact
     3901 agtccattac aaggagacca gttgaattta gatccatggc agtatctgca tatacggacg
     3961 tgaacctaaa tgcatcactt ttacctccag accttcaact gctcaccttt atggcttgag
     4021 atgaggaagg taactgagtc taggctcccc acagccttgc ttggtctata ctcaggctgc
     4081 tgtgtaggac ttaaagtgac caaagtaact tagaaggtag acatgaagct ccaactccaa
     4141 cactctctgg ggtacaggat cctctctgtg gaacccacaa cagagaaggg aatgatgagg
     4201 aacatatttt ctcaaagtgt gctttcagca tgagcccttc ccatggaggc cgggctctct
     4261 cgtctaatga cttgccaaag ccttcagcag gaccatacct catgtggcaa agccaatgga
     4321 gccagtcgct gttcctaaat gggtgcttta ttctccctat attcttgctg tcctcatgct
     4381 tgaacctggt aaattctggg ttagggtatc taagaggcca agcaataaat aatcgaactt
     4441 ccactggacc aagggtgtta ggctaggcct tctctaccca agaaaccagt gaacagagac
     4501 agaatactcc cctgcctctg atgagcatag cttcaggcct tcacccttct ccttactcaa
     4561 ttgcaggtgg ccatcattgc cttttgtatt ttatatggtt atggtgatgg aagccagcta
     4621 taagtatgtt agacacgagc tttccaggac ccctatacta ctagtacctc gcattatctt
     4681 tgttcattat taaagataaa tgaaacaata cacccccact aacttgagga gttaaaaaac
     4741 aaaaaccaaa aaaaaaaaaa aaaaaaaaac caaactactc aaaaagaaat gcctcaggag
     4801 ggagccctga acactatttg cagaggaagt ctagccccag ttttccctgg tatctagcat
     4861 gacttcgatg caatcccaaa tgtatgcatt ttctggcttt ggtgacccag tcatcattat
     4921 cattactacc accaccagca tcatcatcat cactgccatc accacctcat ggtgctgtgc
     4981 atcctcgtgg tgttttatta atggcagtaa ctggatgaat cctacctggc tctgactgag
     5041 ggcaaaaagg ccagaaagaa gaaaagcaga aagaaaaaaa atggggctgc tttccttcat
     5101 cttcttaccc atggaaaacc cagcaagctt ctgggaaggt ctatcctaat gccttcccca
     5161 gatcatggtg gaaggaaaca caaatacttc tgagttcacg ttcactgtgc agggcaagct
     5221 acctagggag aattctttat ctcctcatga agtttccctc ctcttttgag gtcctaacca
     5281 tgagcccttt cgtggactgt tatcaccaac caaactttca aaaggtagat gggatcatta
     5341 ggtcattttg ttccacccct cttttcccat aaatatttct ggcaaaacta aaggtttgca
     5401 gagatgtgat ttgaccaaaa aaggaaaaca aggttactcc attcaaaata acatactttg
     5461 aaagcaagta taggaaagcc ttttcctatt atttttcttc ttagcttccc cattgtctga
     5521 attgggaaaa caggaaagca ttgctttgta gcacctgcaa aatggtttaa tgcccctgca
     5581 tagttccata tctttcaaca atagatttag catgggaatc taaactagac accctgagaa
     5641 catctgtcct gtccccagct cctaaaccca ggctttgatt atgtgtggct tgtgaatcct
     5701 atcaaccaaa acagggggac agacatacct caccaactgt ataccctgat gactccttac
     5761 tcaagggctt tttgagtacc tgttcttgat agtacctgtc tatttcagat ggggaccctg
     5821 gagctttcat ccttcccatc ttacttgcag ggcggcaagt ggctcctctt tgcattttac
     5881 cgagcccccc tccaagctta agttcatttg cggatcaggg attaagcctg aattgtcttg
     5941 tccctgttgt caggggttat tgtaaatgtt agtaatctca ccccaagccc tcagtaagaa
     6001 cataaatatt taaaaaatat gtgcatttga aatctgtttc atggatcctg gaactgtggg
     6061 ctgttcaggc aggagtgact ttagtcttct agtgaatatt gcccagtttg tgggaaggga
     6121 aggctcccag gttatactcc tccttagagc gacaacatta acattctgaa gggaggcgca
     6181 ggattgcctt gaagaagtgg gaacttggtc atggtttgag cattctgtta tgcacctctc
     6241 ctaataaact ctgaaaaaat atttgctttg aa
//
