LOCUS       NM_031539               1258 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus CD8 subunit beta (Cd8b), mRNA.
ACCESSION   NM_031539
VERSION     NM_031539.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1258)
  AUTHORS   Liu,Y., Chen,N., Chen,G. and You,P.
  TITLE     The protective effect of CD8+CD28- T suppressor cells on the acute
            rejection responses in rat liver transplantation
  JOURNAL   Transplant Proc 39 (10), 3396-3403 (2007)
   PUBMED   18089392
  REMARK    GeneRIF: CD8 positive T suppressor cells protect allogenic
            recipients from acute rejection in rats liver transplantation.
REFERENCE   2  (bases 1 to 1258)
  AUTHORS   Kang,J., DiBenedetto,B., Narayan,K., Zhao,H., Der,S.D. and
            Chambers,C.A.
  TITLE     STAT5 is required for thymopoiesis in a development stage-specific
            manner
  JOURNAL   J Immunol 173 (4), 2307-2314 (2004)
   PUBMED   15294943
REFERENCE   3  (bases 1 to 1258)
  AUTHORS   Kerry,S.E., Buslepp,J., Cramer,L.A., Maile,R., Hensley,L.L.,
            Nielsen,A.I., Kavathas,P., Vilen,B.J., Collins,E.J. and
            Frelinger,J.A.
  TITLE     Interplay between TCR affinity and necessity of coreceptor
            ligation: high-affinity peptide-MHC/TCR interaction overcomes lack
            of CD8 engagement
  JOURNAL   J Immunol 171 (9), 4493-4503 (2003)
   PUBMED   14568922
REFERENCE   4  (bases 1 to 1258)
  AUTHORS   Allam,A. and Illges,H.
  TITLE     Calyculin A inhibits expression of CD8alpha but not CD4 in human
            peripheral blood T cells
  JOURNAL   Immunobiology 202 (4), 353-362 (2000)
   PUBMED   11131152
REFERENCE   5  (bases 1 to 1258)
  AUTHORS   Kennedy,M.K., Glaccum,M., Brown,S.N., Butz,E.A., Viney,J.L.,
            Embers,M., Matsuki,N., Charrier,K., Sedger,L., Willis,C.R.,
            Brasel,K., Morrissey,P.J., Stocking,K., Schuh,J.C., Joyce,S. and
            Peschon,J.J.
  TITLE     Reversible defects in natural killer and memory CD8 T cell lineages
            in interleukin 15-deficient mice
  JOURNAL   J Exp Med 191 (5), 771-780 (2000)
   PUBMED   10704459
REFERENCE   6  (bases 1 to 1258)
  AUTHORS   Lin,R.S., Rodriguez,C., Veillette,A. and Lodish,H.F.
  TITLE     Zinc is essential for binding of p56(lck) to CD4 and CD8alpha
  JOURNAL   J Biol Chem 273 (49), 32878-32882 (1998)
   PUBMED   9830036
REFERENCE   7  (bases 1 to 1258)
  AUTHORS   Simpson,S.J., Mizoguchi,E., Allen,D., Bhan,A.K. and Terhorst,C.
  TITLE     Evidence that CD4+, but not CD8+ T cells are responsible for murine
            interleukin-2-deficient colitis
  JOURNAL   Eur J Immunol 25 (9), 2618-2625 (1995)
   PUBMED   7589135
REFERENCE   8  (bases 1 to 1258)
  AUTHORS   Fung-Leung,W.P., Schilham,M.W., Rahemtulla,A., Kundig,T.M.,
            Vollenweider,M., Potter,J., van Ewijk,W. and Mak,T.W.
  TITLE     CD8 is needed for development of cytotoxic T cells but not helper T
            cells
  JOURNAL   Cell 65 (3), 443-449 (1991)
   PUBMED   1673361
REFERENCE   9  (bases 1 to 1258)
  AUTHORS   Parnes,J.R.
  TITLE     Molecular biology and function of CD4 and CD8
  JOURNAL   Adv Immunol 44, 265-311 (1989)
   PUBMED   2493728
  REMARK    Review article
REFERENCE   10 (bases 1 to 1258)
  AUTHORS   Johnson,P. and Williams,A.F.
  TITLE     Striking similarities between antigen receptor J pieces and
            sequence in the second chain of the murine CD8 antigen
  JOURNAL   Nature 323 (6083), 74-76 (1986)
   PUBMED   3092111
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031539.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X04310.1, CO556924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                JAXUCZ010000004.1  104870911-104870992
            83-439              JAXUCZ010000004.1  104873900-104874256
            440-526             JAXUCZ010000004.1  104876958-104877044
            527-616             JAXUCZ010000004.1  104881979-104882068
            617-653             JAXUCZ010000004.1  104883602-104883638
            654-1258            JAXUCZ010000004.1  104886234-104886838
FEATURES             Location/Qualifiers
     source          1..1258
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..1258
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /note="CD8 subunit beta"
                     /db_xref="GeneID:24931"
                     /db_xref="RGD:2317"
     exon            1..82
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..666
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /note="T-cell surface glycoprotein CD8 beta chain; OX-8
                     membrane antigen; CD8 antigen 37 kDa chain; CD8 antigen
                     beta-chain; CD8b molecule"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD8 beta chain
                     precursor"
                     /protein_id="NP_113727.2"
                     /db_xref="GeneID:24931"
                     /db_xref="RGD:2317"
                     /translation="MQPWLWLVFSVKLSALWGSSALLQTPSSLLVQTNQTAKMSCEAK
                     TFPKGTTIYWLRELQDSNKNKHFEFLASRTSTKGIKYGERVKKNMTLSFNSTLPFLKI
                     MDVKPEDSGFYFCAMVGSPMVVFGTGTKLTVVDVLPTTAPTKKTTLKKKQCPTPHPKT
                     QKGLTCGLITLSLLVACILVLLVSLSVAIHFHCTRRRARIRFMKQFHK"
     exon            83..439
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..526
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..616
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..653
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..1258
                     /gene="Cd8b"
                     /gene_synonym="Cd8b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccctga ggagaacagg tgtctcaaag agcgccaaga tgcagccatg gctctggctg
       61 gtcttcagtg tgaagctatc agctctctgg ggcagctctg ccctccttca gactccttca
      121 tccctgctgg ttcaaaccaa ccaaacagca aaaatgtcct gtgaggctaa aaccttccct
      181 aaaggaacaa ccatctactg gctgagagag ctccaggatt ccaacaagaa caagcacttt
      241 gagttcctgg cgtcccggac ttcaaccaaa ggaatcaaat atggtgaaag ggtgaagaag
      301 aatatgactc tgtctttcaa ttcaaccctg ccctttctca agatcatgga tgtgaaacca
      361 gaggacagtg gcttctactt ctgcgcgatg gttgggagtc ccatggtagt ctttgggaca
      421 gggacaaagc tgactgtggt tgatgtcctt cctacaactg ctccaaccaa aaagactaca
      481 ctgaagaaga aacaatgtcc aaccccccac ccaaagaccc agaaaggctt gacatgtggc
      541 ctcattaccc tcagcctgct ggtggcctgc atcctggttc tgctggtatc cctcagtgtg
      601 gccatccact ttcactgcac gcggaggaga gcccggattc gcttcatgaa acagtttcac
      661 aaatgatccg cgcccacgac actgacagcc tgctacaaag gactcaatat aaagcaagac
      721 ctggaccaac gagagacgac gcatttagct caagctgtct gcctgaactg ctgcaagtcc
      781 tgtgaatggt caggcacgtt acctggagtc tcacagagaa ggccccagaa tccaggctca
      841 ctcacggagt gtgctgaaga accaagaact cccaccatga cacccctgtg gcttttgtac
      901 ccttcttgga ctggaccttg gatggcagcc ttgcagccac catctttgta agttgcttgg
      961 tagggcagca tgactggctt tttggcgtct catgggagag agctaggtgg gcagccctgc
     1021 agaagactgc acatcctcac acagagaggc cacctcatga ataaggtttc ctgcaaacat
     1081 cttctgggcc cttggcagcc atcttgctct ctcaggcctt gctgtggttt tgggaagctg
     1141 ttggctcaga agacagactt ctacttcatc tcctagtagg aaatttctta agcttcttct
     1201 ccctcgtggc ttatatattt cttccctcac tctctgtcct ttttatgaaa atgtcttg
//
