LOCUS       NM_031538               1413 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus CD8 subunit alpha (Cd8a), mRNA.
ACCESSION   NM_031538
VERSION     NM_031538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Han,K., Blair,R.V., Iwanaga,N., Liu,F., Russell-Lodrigue,K.E.,
            Qin,Z., Midkiff,C.C., Golden,N.A., Doyle-Meyers,L.A., Kabir,M.E.,
            Chandler,K.E., Cutrera,K.L., Ren,M., Monjure,C.J., Lehmicke,G.,
            Fischer,T., Beddingfield,B., Wanek,A.G., Birnbaum,A., Maness,N.J.,
            Roy,C.J., Datta,P.K., Rappaport,J., Kolls,J.K. and Qin,X.
  TITLE     Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes
            the Mouse to SARS-CoV-2 Infection
  JOURNAL   Am J Respir Cell Mol Biol 64 (1), 79-88 (2021)
   PUBMED   32991819
  REMARK    Erratum:[Am J Respir Cell Mol Biol. 2021 Jul;65(1):121. doi:
            10.1165/rcmb.v65erratum1.. PMID: 34241583]
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Lieberman,N.A.P., Peddu,V., Xie,H., Shrestha,L., Huang,M.L.,
            Mears,M.C., Cajimat,M.N., Bente,D.A., Shi,P.Y., Bovier,F.,
            Roychoudhury,P., Jerome,K.R., Moscona,A., Porotto,M. and
            Greninger,A.L.
  TITLE     In vivo antiviral host transcriptional response to SARS-CoV-2 by
            viral load, sex, and age
  JOURNAL   PLoS Biol 18 (9), e3000849 (2020)
   PUBMED   32898168
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Li,S., Jiang,L., Li,X., Lin,F., Wang,Y., Li,B., Jiang,T., An,W.,
            Liu,S., Liu,H., Xu,P., Zhao,L., Zhang,L., Mu,J., Wang,H., Kang,J.,
            Li,Y., Huang,L., Zhu,C., Zhao,S., Lu,J., Ji,J. and Zhao,J.
  TITLE     Clinical and pathological investigation of patients with severe
            COVID-19
  JOURNAL   JCI Insight 5 (12), 138070 (2020)
   PUBMED   32427582
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Saito,M., Ishii,T., Urakawa,I., Matsumoto,A., Masaki,A., Ito,A.,
            Kusumoto,S., Suzuki,S., Takahashi,T., Morita,A., Inagaki,H.,
            Iida,S. and Ishida,T.
  TITLE     Robust CD8+ T-cell proliferation and diversification after
            mogamulizumab in patients with adult T-cell leukemia-lymphoma
  JOURNAL   Blood Adv 4 (10), 2180-2191 (2020)
   PUBMED   32433748
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Verma,N.D., Robinson,C.M., Carter,N., Wilcox,P., Tran,G.T.,
            Wang,C., Sharland,A., Nomura,M., Plain,K.M., Bishop,G.A.,
            Hodgkinson,S.J. and Hall,B.M.
  TITLE     Alloactivation of Naive CD4+CD8-CD25+T Regulatory Cells: Expression
            of CD8alpha Identifies Potent Suppressor Cells That Can Promote
            Transplant Tolerance Induction
  JOURNAL   Front Immunol 10, 2397 (2019)
   PUBMED   31681288
  REMARK    GeneRIF: Alloactivation of Naive CD4(+)CD8(-)CD25(+)T Regulatory
            Cells: Expression of CD8alpha Identifies Potent Suppressor Cells
            That Can Promote Transplant Tolerance Induction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Beyers,A.D., Spruyt,L.L. and Williams,A.F.
  TITLE     Molecular associations between the T-lymphocyte antigen receptor
            complex and the surface antigens CD2, CD4, or CD8 and CD5
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2945-2949 (1992)
   PUBMED   1372996
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Gooley,A.A., Classon,B.J., Marschalek,R. and Williams,K.L.
  TITLE     Glycosylation sites identified by detection of glycosylated amino
            acids released from Edman degradation: the identification of
            Xaa-Pro-Xaa-Xaa as a motif for Thr-O-glycosylation
  JOURNAL   Biochem Biophys Res Commun 178 (3), 1194-1201 (1991)
   PUBMED   1908233
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Fung-Leung,W.P., Schilham,M.W., Rahemtulla,A., Kundig,T.M.,
            Vollenweider,M., Potter,J., van Ewijk,W. and Mak,T.W.
  TITLE     CD8 is needed for development of cytotoxic T cells but not helper T
            cells
  JOURNAL   Cell 65 (3), 443-449 (1991)
   PUBMED   1673361
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Czuprynski,C.J. and Brown,J.F.
  TITLE     Effects of purified anti-Lyt-2 mAb treatment on murine listeriosis:
            comparative roles of Lyt-2+ and L3T4+ cells in resistance to
            primary and secondary infection, delayed-type hypersensitivity and
            adoptive transfer of resistance
  JOURNAL   Immunology 71 (1), 107-112 (1990)
   PUBMED   2120126
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Parnes,J.R.
  TITLE     Molecular biology and function of CD4 and CD8
  JOURNAL   Adv Immunol 44, 265-311 (1989)
   PUBMED   2493728
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088126.1.
            
            On Jan 12, 2005 this sequence version replaced NM_031538.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088126.1, X03015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..1413
                     /gene="Cd8a"
                     /note="CD8 subunit alpha"
                     /db_xref="GeneID:24930"
                     /db_xref="RGD:2316"
     exon            1..55
                     /gene="Cd8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..717
                     /gene="Cd8a"
                     /note="T-cell surface glycoprotein CD8 alpha chain; OX-8
                     membrane antigen; CD8a molecule; CD8 antigen 32 kDa chain;
                     CD8 antigen, alpha-chain"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD8 alpha chain
                     precursor"
                     /protein_id="NP_113726.1"
                     /db_xref="GeneID:24930"
                     /db_xref="RGD:2316"
                     /translation="MASRVICFLSLNLLLLDVITRLQVSGQLQLSPKKVDAEIGQEVK
                     LTCEVLRDTSQGCSWLFRNSSSELLQPTFIIYVSSSRSKLNDILDPNLFSARKENNKY
                     ILTLSKFSTKNQGYYFCSITSNSVMYFSPLVPVFQKVNSIITKPVTRAPTPVPPPTGT
                     PRPLRPEACRPGASGSVEGMGLGFACDIYIWAPLAGICAVLLLSLVITLICCHRNRRR
                     VCKCPRPLVKPRPSEKFV"
     exon            56..421
                     /gene="Cd8a"
                     /inference="alignment:Splign:2.1.0"
     exon            422..535
                     /gene="Cd8a"
                     /inference="alignment:Splign:2.1.0"
     exon            536..646
                     /gene="Cd8a"
                     /inference="alignment:Splign:2.1.0"
     exon            647..677
                     /gene="Cd8a"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1389
                     /gene="Cd8a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacaccatgg cctcacgggt gatctgcttt ctgtcgctga acctgctact gctggatgtt
       61 atcactaggc tccaggtttc cggacagtta cagttgtcac caaagaaagt ggacgctgaa
      121 attggccagg aggtgaagct aacatgcgaa gtgctgcggg acacttcgca aggatgctct
      181 tggctcttcc ggaactccag ctccgaactc ctccagccca ccttcatcat ctatgtatct
      241 tcatcccgga gcaagctgaa cgatatactg gatccgaatc tgttctctgc ccggaaggaa
      301 aacaacaaat acatcctcac cctgagcaag ttcagcacta aaaaccaagg ctactatttc
      361 tgctcaatca ccagcaactc ggtgatgtac ttcagtcctc tggtgccggt gtttcagaaa
      421 gtgaactcta ttatcaccaa gccggtgacg cgagctccca caccagtgcc tcctcctaca
      481 gggacacccc ggcccctacg accagaagct tgccgacccg gggcgagtgg ctcagtggag
      541 ggaatgggat tgggcttcgc ctgcgatatt tacatctggg cacccttggc cggaatctgc
      601 gcggttcttc tgctgtccct ggtcatcact ctcatctgct gccacaggaa ccgaaggcgt
      661 gtttgcaaat gtcccaggcc ccttgtcaag cccagacctt cagagaaatt cgtgtaaaat
      721 ggcgccacta ggaagccaca actactacat gacttcagag atttctcaca agagaccggg
      781 ccctcctttt tcagagtttc ctgctggctt atatattgtc ctctgtattg ttttaggggt
      841 aggatgggga cagttccttt ttctttatga attctctttg atacaaaaca tacttgtatg
      901 cacacaatgg ggtaaagatc agactgtaac accagagata gtcccagttt cagggtcagc
      961 gtagctggtg gcctcggcac ccacttgata taaatctccg gtctgcccat catatagaag
     1021 aagctgaaga tcagagatgg gaacagcaag atctgtagac caggagagaa cccaagctga
     1081 aggacccctc actagctggt gcagggatct catccccctc ccctgagctc tctgtttagg
     1141 tgacacactt gtgcctcaaa ccacagggag caagtggtat gaacctgtga tctgctcagc
     1201 tctgcctgtg agcgtcagat gaaacaaatc caagacaaga gaactgccct tagcagtgca
     1261 actggacatc agagctcctt gtaaggaact gggaaattgc tggcagtcaa gggaaggggt
     1321 agagtaaatc tggaaaacag tcccctctgt cactgaagac taactcaatt aaagctattc
     1381 aaaccaccaa aaaaaaaaaa aaaaaaaaaa aaa
//
