LOCUS       NM_020081               1608 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus CD86 molecule (Cd86), mRNA.
ACCESSION   NM_020081
VERSION     NM_020081.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1608)
  AUTHORS   Ebaid H, Abdel-Salam B, Hassan I, Al-Tamimi J, Metwalli A, Rady A
            and Alhazza IM.
  TITLE     Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and
            CD86 on Neutrophils after Delayed Wound Healing in Male Rats
  JOURNAL   Biomed Res Int 2020, 3592425 (2020)
   PUBMED   32733939
  REMARK    GeneRIF: Diabetes-Mediated Toxicity Resulted in the Expression of
            CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male
            Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1608)
  AUTHORS   Hu X, Tai J, Qu Z, Zhao S, Zhang L, Li M, Sun X and Jiang Y.
  TITLE     A Lower Proportion of Regulatory B Cells in Patients with
            Henoch-Schoenlein Purpura Nephritis
  JOURNAL   PLoS One 11 (3), e0152368 (2016)
   PUBMED   27030970
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1608)
  AUTHORS   Wagner M, Sobczynski M, Karabon L, Bilinska M, Pokryszko-Dragan A,
            Pawlak-Adamska E, Cyrul M, Kusnierczyk P and Jasek M.
  TITLE     Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence
            the risk of multiple sclerosis and its age of onset
  JOURNAL   J Neuroimmunol 288, 79-86 (2015)
   PUBMED   26531698
REFERENCE   4  (bases 1 to 1608)
  AUTHORS   Huemer M, Rebhandl S, Zaborsky N, Gassner FJ, Hainzl S, Weiss L,
            Hebenstreit D, Greil R and Geisberger R.
  TITLE     AID induces intraclonal diversity and genomic damage in CD86(+)
            chronic lymphocytic leukemia cells
  JOURNAL   Eur J Immunol 44 (12), 3747-3757 (2014)
   PUBMED   25179679
REFERENCE   5  (bases 1 to 1608)
  AUTHORS   Asai-Tajiri Y, Matsumoto K, Fukuyama S, Kan-O K, Nakano T, Tonai K,
            Ohno T, Azuma M, Inoue H and Nakanishi Y.
  TITLE     Small interfering RNA against CD86 during allergen challenge blocks
            experimental allergic asthma
  JOURNAL   Respir Res 15 (1), 132 (2014)
   PUBMED   25344652
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1608)
  AUTHORS   Hofer MF, Jirapongsananuruk O, Trumble AE and Leung DY.
  TITLE     Upregulation of B7.2, but not B7.1, on B cells from patients with
            allergic asthma
  JOURNAL   J Allergy Clin Immunol 101 (1 Pt 1), 96-102 (1998)
   PUBMED   9449507
REFERENCE   7  (bases 1 to 1608)
  AUTHORS   Maeda K, Sato T, Azuma M, Yagita H and Okumura K.
  TITLE     Characterization of rat CD80 and CD86 by molecular cloning and mAb
  JOURNAL   Int Immunol 9 (7), 993-1000 (1997)
   PUBMED   9237108
REFERENCE   8  (bases 1 to 1608)
  AUTHORS   Herold KC, Vezys V, Koons A, Lenschow D, Thompson C and Bluestone
            JA.
  TITLE     CD28/B7 costimulation regulates autoimmune diabetes induced with
            multiple low doses of streptozotocin
  JOURNAL   J Immunol 158 (2), 984-991 (1997)
   PUBMED   8993020
REFERENCE   9  (bases 1 to 1608)
  AUTHORS   Sainio-Pollanen S, Rulli M, Pollanen P and Simell O.
  TITLE     Appearance of cells expressing CD80 and CD86 costimulatory antigens
            in the pancreas of nonobese diabetic mice
  JOURNAL   Pancreas 13 (4), 388-394 (1996)
   PUBMED   8899799
REFERENCE   10 (bases 1 to 1608)
  AUTHORS   Imagawa A, Hanafusa T, Itoh N, Miyagawa J, Nakajima H, Namba M,
            Kuwajima M, Tamura S, Kawata S, Matsuzawa Y and Harlan DM.
  TITLE     Islet-infiltrating t lymphocytes in insulin-dependent diabetic
            patients express CD80 (B7-1) and CD86 (B7-2)
  JOURNAL   J Autoimmun 9 (3), 391-396 (1996)
   PUBMED   8816976
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000222.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_020081.3.
            
            On Oct 4, 2022 this sequence version replaced NM_020081.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D50558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JACYVU010000222.1  43473676-43473867
            193-242             JACYVU010000222.1  43486429-43486478
            243-578             JACYVU010000222.1  43493905-43494240
            579-875             JACYVU010000222.1  43496285-43496581
            876-1011            JACYVU010000222.1  43499612-43499747
            1012-1608           JACYVU010000222.1  43509993-43510589
FEATURES             Location/Qualifiers
     source          1..1608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..1608
                     /gene="Cd86"
                     /gene_synonym="B7-2"
                     /note="CD86 molecule"
                     /db_xref="GeneID:56822"
                     /db_xref="RGD:628714"
     exon            1..192
                     /gene="Cd86"
                     /gene_synonym="B7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            193..242
                     /gene="Cd86"
                     /gene_synonym="B7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..578
                     /gene="Cd86"
                     /gene_synonym="B7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..875
                     /gene="Cd86"
                     /gene_synonym="B7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1011
                     /gene="Cd86"
                     /gene_synonym="B7-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1608
                     /gene="Cd86"
                     /gene_synonym="B7-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taggaggcct ggggagcgga caaggctcct tttacttttt cttcttcttc ttcttctatt
       61 ttttaccttc cacctttttc cttcaagttc ctgtgatctt cgggaatgct actgtgcttg
      121 tgtgtggggt ccctgagcgc tgcggtggag aggcactggt gacatgtatg tcgtcaagac
      181 atgtgtaacc tgcaccatgt acttgggaat ccttttctcg gtgttggcct atctgctctc
      241 agatgctgtt cctgtgaaga ggcaagctta cttcaatagc actgcatacc tgccgtgccc
      301 gttcacaaag gctcaaaaca taagcccgag tgagctcgta gtattttggc aggaccggaa
      361 aaagtcggtt ctgtacgaac actatttggg cgcagagaaa cttgataacg tgaatgccaa
      421 gtacctgggc cgcacaagct ttgataggga taaccaggct ctacgacttc acaatgttca
      481 gatcaaggac acgggcttgt atgattgttt tatacagcaa aagacaccca cgggatcaat
      541 tatcctccag cagtgggaaa cagagctctc agtgatcgcc aacttcagtg aacctgaaat
      601 agaggaggct cagaatgaaa caagaaacac tggcataaat ttgacctgct catctaagca
      661 aggatacccg aaacctacaa agatgtattt tttgataact aattcaacta atgagtatgg
      721 cgacaacatg cagatatcac aagacaatgt cacaaagctg ttcagtgtct ccatcagcct
      781 atctcttcca ttcccggatg gggtgtacaa tatgaccatt gtgtgtattc tggaaacgga
      841 gtcaatgaat atttcctcca aacctcacaa tatggttttt tcgcagcccc agtttgatcg
      901 aaagacttgg atccagattg caggtcccag ttcacttctg tgctgtctct ttctgctggt
      961 cgtctacaaa gcagtcaaaa agtgtttgaa gatgcagaac cagcccggca gacccagcag
     1021 aaagacttgt gagtccaagc aggacagtgg tgttgacgag tcgatcaacc tggaggaagt
     1081 tgaaccccaa ttgcatcagc agtaagttca ttcaaagagc aactcggcct cctagccacc
     1141 tcagtactca acagatggtt catgatctcc gtgtagagca gctacattga tgaaatgcaa
     1201 gaaggaaggc tggaattctt tcagctcatg actgcatgaa aagaggaaaa gcagcaatcg
     1261 caaaactctg aggctacctt agttctgcag ataccccagt gggcatggct tggccctttc
     1321 aaagaaggac aaagaccaac tgatgctgaa aagcacgtgg tgtgtctgta aggcatggag
     1381 tagtcaccac ccacacttac agacttcggc gggtctgagc agcaaaacat tgctctttac
     1441 agtttgcaca aaggtccctg gaggcctgaa gcctgttttg ctagcagggt tcatgctcat
     1501 aatgtttcag tgaatacatc ttgacccagc ctgtgcagac tcagggttta gctacttgct
     1561 aacgtgttct gtacagagtg gatttcaata aagttttctt gaaatttt
//
