LOCUS       NM_001108410            2119 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus CD83 molecule (Cd83), mRNA.
ACCESSION   NM_001108410 XM_001057071 XM_341509
VERSION     NM_001108410.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Xiong L, Wang D, Lin S, Wang Y, Luo M and Gao L.
  TITLE     Soluble CD83 inhibits acute rejection by up regulating TGF-beta and
            IDO secretion in rat liver transplantation
  JOURNAL   Transpl Immunol 64, 101351 (2021)
   PUBMED   33171217
  REMARK    GeneRIF: Soluble CD83 inhibits acute rejection by up regulating
            TGF-beta and IDO secretion in rat liver transplantation.
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Lan Z, Lian D, Liu W, Arp J, Charlton B, Ge W, Brand S, Healey D,
            DeBenedette M, Nicolette C, Garcia B and Wang H.
  TITLE     Prevention of chronic renal allograft rejection by soluble CD83
  JOURNAL   Transplantation 90 (12), 1278-1285 (2010)
   PUBMED   21079552
  REMARK    GeneRIF: Peritransplant treatment with recombinant soluble CD83
            attenuates both innate and adaptive immune responses and leads to
            prevention of chronic rejection in a rat renal transplant model.
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Garcia-Martinez LF, Appleby MW, Staehling-Hampton K, Andrews DM,
            Chen Y, McEuen M, Tang P, Rhinehart RL, Proll S, Paeper B, Brunkow
            ME, Grandea AG 3rd, Howard ED, Walker DE, Charmley P, Jonas M, Shaw
            S, Latham JA and Ramsdell F.
  TITLE     A novel mutation in CD83 results in the development of a unique
            population of CD4+ T cells
  JOURNAL   J Immunol 173 (5), 2995-3001 (2004)
   PUBMED   15322158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341509.3, XM_001057071.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166582.1, CV073499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2119
                     /gene="Cd83"
                     /note="CD83 molecule"
                     /db_xref="GeneID:361226"
                     /db_xref="RGD:1309677"
     exon            1..139
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..693
                     /gene="Cd83"
                     /note="CD83 antigen"
                     /codon_start=1
                     /product="CD83 antigen precursor"
                     /protein_id="NP_001101880.1"
                     /db_xref="GeneID:361226"
                     /db_xref="RGD:1309677"
                     /translation="MSQGLQLLLLGCACSLAPALAMREVTVACSETADLPCTAPWDPQ
                     LSYTVSWAKVSESGNERLELPESKQNSSVEAPKKRPYSLTIQNTTICSAGTYRCALQE
                     LGGQRNFSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQ
                     SIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV"
     exon            140..261
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     exon            262..457
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     exon            458..564
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     exon            565..2119
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagtcccc ggggccggcg cgcggggaag tcccaagcgc gggtacaaga gcagggcgcg
       61 cgcccaggag ggcggcccgg acagtggcgc agcgctccag tcatgtcgca aggcctccag
      121 ctcctgcttc taggctgcgc ctgcagcctg gcgcccgcgt tggcgatgcg ggaggtgacg
      181 gtggcttgct ccgaaacggc cgacttgccg tgcacagcgc cctgggaccc gcagctctcc
      241 tacacagtgt cctgggccaa ggtctcagag agtggcaacg agaggctgga gctccctgag
      301 agcaagcaaa acagctccgt cgaggccccc aagaaaaggc cttattcctt gacaatccaa
      361 aacactacga tctgcagcgc tggcacctac aggtgtgcct tgcaggagct tggagggcaa
      421 cgtaacttca gtggcacagt ggttctgaag gtgacaggat gtcccaagga agctacagag
      481 tcaaccttca ggaagtacag ggcggaagct gtgttgctct tctctctggt cgttttctac
      541 ctgacactca tcattttcac atgtaagttt gcacgactac agagtatttt tccagatatt
      601 tctaaacctg gtacagaaca agcttttctt ccagtcacct ccccaagcaa acatttgggg
      661 ccagtgaccc ttcccaagac agaaacagta tgagtaaggt ctccactggt ttttacgacg
      721 ccaagggcac atcagatcaa tgtgcctgaa taccacctgg acaagagaag aatgagtccc
      781 accctcagat ggcaaccttt ctttgaagtc cttcacctga cagtgggttc cacactactc
      841 cctgccacag ggtcttgagc actatcatat gatcacgaag catggaacat cactgcttct
      901 ctgtggctgt cagcttcatg tttcatgcgg ctatctggtc aacctcgtga atacttttca
      961 gtcatataaa agctatggtg agatgatggt ggagcagggt catgggaaat ttgaacactc
     1021 cgagctggcc ctatgacaga ctcctgagga cagctgtcct cttctacatc tgggaggcat
     1081 ctctttgaat ttgtcctgtt tcgttgcacc agtccagatg tctcacatct ggcagaaatt
     1141 gacaggccaa gttgtgagcc agtgggaaat atttagcaaa taatttccca gtgagaaggt
     1201 ccagctatta gtaaggagta ttatgtgtac atagaaatga gaggtcagtg aactgttcct
     1261 cagcagggcc ttttcatctg gaaaaggcat ttataaagcg gcagtacaga ggaatgccac
     1321 atttattttt ttaatcttca tgtacttgtc aaagaagaat tttcatgttt ttcaaagaaa
     1381 tgtgtttctt ttctttttta aaaaaatatg aatgtctagt ctagctgaca agcagcctga
     1441 gtgaatatgg agagtgttcc tcagaatagg gatagcaagc tcgaagcact ctacagtagt
     1501 ctgctgggaa gggcaggcca tggactgagc aaccgaaact ctggtcacag gactgcctgt
     1561 gtgatcctgg gtgggtcact tgtgatttcc actctctggc ttgtaaccag tccgggttga
     1621 ctaaactgga tgtgaagatg cttggggata gctgaacgta atggatatag tggcaattct
     1681 actgggctgt tcctttgttg atattctaga gttctggagc tgagcaaatg cctgtcatag
     1741 ctcagctttc ccgtcattcc aaacaaacaa aggaggcctc gaaatggaca ttcgcatggt
     1801 cttctgtgtg aactcccaag aaacgtcgag actggcgcag tgttttgctc ttgaaggact
     1861 aatcacaagt tcttgaagat atggacctat gggagctatt gtgccatgac aagaggaact
     1921 tctcagatgc tgcactgata tgacattgtt gcatttcttt aatgtactgg accccttcct
     1981 catttgcttc ccaaagagat tttgtcctac cgatggtgtg tccgtcaccc acactatgag
     2041 agtgaacggg atgctgagcg gataccgtgt gcttgcctct cagtcactac tttcatgcta
     2101 ttaaaagtat gcatgtgag
//
