LOCUS       NM_013087               1480 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Cd81 molecule (Cd81), mRNA.
ACCESSION   NM_013087 XM_346575
VERSION     NM_013087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Wang,P., Zhu,G., Wu,Q., Shen,L., Liu,D., Wang,Z., Wang,W., Ren,Z.,
            Jia,Y., Liu,M., Xue,Y., Ji,D., Hu,Y., Yu,Y. and Wang,X.
  TITLE     Renal CD81 interacts with sodium potassium 2 chloride cotransporter
            and sodium chloride cotransporter in rats with
            lipopolysaccharide-induced preeclampsia
  JOURNAL   FASEB J 37 (4), e22834 (2023)
   PUBMED   36961378
  REMARK    GeneRIF: Renal CD81 interacts with sodium potassium 2 chloride
            cotransporter and sodium chloride cotransporter in rats with
            lipopolysaccharide-induced preeclampsia.
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Horiguchi,K., Yoshida,S., Tsukada,T., Nakakura,T., Fujiwara,K.,
            Hasegawa,R., Takigami,S. and Ohsako,S.
  TITLE     Expression and functions of cluster of differentiation 9 and 81 in
            rat mammary epithelial cells
  JOURNAL   J Reprod Dev 66 (6), 515-522 (2020)
   PUBMED   32830152
  REMARK    GeneRIF: Expression and functions of cluster of differentiation 9
            and 81 in rat mammary epithelial cells.
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Ramanathan,S., Douglas,S.R., Alexander,G.M., Shenoda,B.B.,
            Barrett,J.E., Aradillas,E., Sacan,A. and Ajit,S.K.
  TITLE     Exosome microRNA signatures in patients with complex regional pain
            syndrome undergoing plasma exchange
  JOURNAL   J Transl Med 17 (1), 81 (2019)
   PUBMED   30871575
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Rocha-Perugini,V., Suarez,H., Alvarez,S., Lopez-Martin,S.,
            Lenzi,G.M., Vences-Catalan,F., Levy,S., Kim,B.,
            Munoz-Fernandez,M.A., Sanchez-Madrid,F. and Yanez-Mo,M.
  TITLE     CD81 association with SAMHD1 enhances HIV-1 reverse transcription
            by increasing dNTP levels
  JOURNAL   Nat Microbiol 2 (11), 1513-1522 (2017)
   PUBMED   28871089
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Shen,L., Diao,Z., Sun,H.X., Yan,G.J., Wang,Z., Li,R.T., Dai,Y.,
            Wang,J., Li,J., Ding,H., Zhao,G., Zheng,M., Xue,P., Liu,M., Zhou,Y.
            and Hu,Y.
  TITLE     Up-regulation of CD81 inhibits cytotrophoblast invasion and
            mediates maternal endothelial cell dysfunction in preeclampsia
  JOURNAL   Proc Natl Acad Sci U S A 114 (8), 1940-1945 (2017)
   PUBMED   28167787
  REMARK    GeneRIF: Overexpression of CD81 in pregnant rats triggers
            preeclampsia-like manifestations in vivo.
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Geisert,E.E. Jr., Yang,L. and Irwin,M.H.
  TITLE     Astrocyte growth, reactivity, and the target of the
            antiproliferative antibody, TAPA
  JOURNAL   J Neurosci 16 (17), 5478-5487 (1996)
   PUBMED   8757260
REFERENCE   7  (bases 1 to 1480)
  AUTHORS   Secrist,H., Levy,S., DeKruyff,R.H. and Umetsu,D.T.
  TITLE     Ligation of TAPA-1 (CD81) or major histocompatibility complex class
            II in co-cultures of human B and T lymphocytes enhances
            interleukin-4 synthesis by antigen-specific CD4+ T cells
  JOURNAL   Eur J Immunol 26 (7), 1435-1442 (1996)
   PUBMED   8766544
REFERENCE   8  (bases 1 to 1480)
  AUTHORS   Schick,M.R. and Levy,S.
  TITLE     The TAPA-1 molecule is associated on the surface of B cells with
            HLA-DR molecules
  JOURNAL   J Immunol 151 (8), 4090-4097 (1993)
   PUBMED   8409388
REFERENCE   9  (bases 1 to 1480)
  AUTHORS   Irwin,M.H. and Geisert,E.E. Jr.
  TITLE     The upregulation of a glial cell surface antigen at the astrocytic
            scar in the rat
  JOURNAL   Neurosci Lett 154 (1-2), 57-60 (1993)
   PUBMED   8361649
REFERENCE   10 (bases 1 to 1480)
  AUTHORS   Geisert,E.E. Jr., Murphy,T.P., Irwin,M.H. and Larjava,H.
  TITLE     A novel cell adhesion molecule, G-CAM, found on cultured rat glia
  JOURNAL   Neurosci Lett 133 (2), 262-266 (1991)
   PUBMED   1816505
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM032840.1, FN799324.1, FM090203.1 and CR476007.1.
            
            On Apr 28, 2015 this sequence version replaced NM_013087.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ215739.1, FQ214006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                FM032840.1         1-80
            81-738              FN799324.1         1-658
            739-1447            FM090203.1         17-725
            1448-1480           CR476007.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41-q42"
     gene            1..1480
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /note="Cd81 molecule"
                     /db_xref="GeneID:25621"
                     /db_xref="RGD:2315"
     exon            1..314
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..959
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /note="target of the antiproliferative antibody 1; CD81
                     antigen (target of antiproliferative antibody 1); CD 81
                     antigen"
                     /codon_start=1
                     /product="CD81 antigen"
                     /protein_id="NP_037219.2"
                     /db_xref="GeneID:25621"
                     /db_xref="RGD:2315"
                     /translation="MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTSL
                     LYLELGDKPAPSTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILF
                     ACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSN
                     TLTTLTTTVLRNSLCPSSSNSFTQLLKEDCHQKIDELFSGKLYLIGIAAIVVAVIMIF
                     EMILSMVLCCGIRNSSVY"
     exon            315..429
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..527
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..602
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..707
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..809
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..896
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1477
                     /gene="Cd81"
                     /gene_synonym="Tapa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggtctataa agagtgaaga gctcggcgcg cgcccggtct gagcgagcgc gcccttgctt
       61 caaagcggta gcgactctag cgcctccggc taggcctcca acccttctct accctacgtc
      121 tcaatagccg caccgcagtt ctccggccct caagcgaccc aggctatctt ccagtcccgg
      181 actccggtac tgcgtcccca gaccgcccgc tccaggacca acccaagctc cgcaggccgc
      241 gcgccgccat gggggtggaa ggctgcacca aatgcatcaa atacctgctc ttcgtcttca
      301 atttcgtctt ctggctggct ggaggtgtga tcctaggtgt agctctgtgg ttgcgccatg
      361 atccacaaac caccagcctt ctctacctgg aactgggaga caaaccagca cctagcacct
      421 tctatgtggg catctacatt ctcattgctg tgggagctgt gatgatgttt gtaggcttcc
      481 tggggtgcta tggggccatc caggagtccc agtgcctgct ggggacgttc ttcacttgcc
      541 ttgtgatcct gtttgcctgt gaggtagctg cgggcatctg gggctttgta aacaaagacc
      601 agatcgccaa ggatgtgaag cagttctacg accaggccct tcagcaggct gtgatggatg
      661 atgatgccaa caatgccaag gcagtggtga agaccttcca tgagacgctc aactgttgtg
      721 gctccaatac gctgaccaca ctgaccacca ccgtgctgag gaacagcctg tgtccctcaa
      781 gcagcaactc attcactcag cttctgaagg aagactgcca tcagaaaatc gatgagctct
      841 tttctgggaa gctgtacctc attggaattg cagccattgt ggtagctgtc attatgatct
      901 tcgagatgat tctgagcatg gtgctgtgct gtggcatccg gaacagctcc gtgtactaag
      961 gcccttcgct tcgcaccaga gggtccctgg aatgaccaga ggccaccttg ggggccatgg
     1021 cctgtgtata tactatttct gtattactct gctacactta gcctttttac ttttgagtct
     1081 tttttgttct gaacttttcc tgtcaccttt tggagccgac accacacata ggtggcgtat
     1141 gtggggacgt agaggtggag ctggccctag ctggcagggc cctgtacttc tgggacccct
     1201 ggagagttct gcctgctgag ccaaacctcc tccatagcta cttgtccaga ggccacatag
     1261 ccaagctaga aggccatgtc cacccactct gcccactgtg ggtcacatcg ctcccatctt
     1321 tttaatcctt gtccctttcc tgcctccatt tcaagagctg ggtttgtaag cactcttatg
     1381 ccttcaatgc acttattctt tctaacgtgt caccttcaac tgtaattaaa tcttgaaaca
     1441 gtcatttaat aaaggaggaa aaaatcaggc atgctaaaaa
//
