LOCUS       NM_001402547            1000 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CD79a molecule (Cd79a), mRNA.
ACCESSION   NM_001402547 XM_006228537
VERSION     NM_001402547.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1000)
  AUTHORS   Patterson,H.C., Kraus,M., Kim,Y.M., Ploegh,H. and Rajewsky,K.
  TITLE     The B cell receptor promotes B cell activation and proliferation
            through a non-ITAM tyrosine in the Igalpha cytoplasmic domain
  JOURNAL   Immunity 25 (1), 55-65 (2006)
   PUBMED   16860757
REFERENCE   2  (bases 1 to 1000)
  AUTHORS   Sigalov,A., Aivazian,D. and Stern,L.
  TITLE     Homooligomerization of the cytoplasmic domain of the T cell
            receptor zeta chain and of other proteins containing the
            immunoreceptor tyrosine-based activation motif
  JOURNAL   Biochemistry 43 (7), 2049-2061 (2004)
   PUBMED   14967045
REFERENCE   3  (bases 1 to 1000)
  AUTHORS   Pelanda,R., Braun,U., Hobeika,E., Nussenzweig,M.C. and Reth,M.
  TITLE     B cell progenitors are arrested in maturation but have intact VDJ
            recombination in the absence of Ig-alpha and Ig-beta
  JOURNAL   J Immunol 169 (2), 865-872 (2002)
   PUBMED   12097390
REFERENCE   4  (bases 1 to 1000)
  AUTHORS   Lankar,D., Vincent-Schneider,H., Briken,V., Yokozeki,T., Raposo,G.
            and Bonnerot,C.
  TITLE     Dynamics of major histocompatibility complex class II compartments
            during B cell receptor-mediated cell activation
  JOURNAL   J Exp Med 195 (4), 461-472 (2002)
   PUBMED   11854359
REFERENCE   5  (bases 1 to 1000)
  AUTHORS   Kraus,M., Pao,L.I., Reichlin,A., Hu,Y., Canono,B., Cambier,J.C.,
            Nussenzweig,M.C. and Rajewsky,K.
  TITLE     Interference with immunoglobulin (Ig)alpha immunoreceptor
            tyrosine-based activation motif (ITAM) phosphorylation modulates or
            blocks B cell development, depending on the availability of an
            Igbeta cytoplasmic tail
  JOURNAL   J Exp Med 194 (4), 455-469 (2001)
   PUBMED   11514602
REFERENCE   6  (bases 1 to 1000)
  AUTHORS   Cheng,P.C., Brown,B.K., Song,W. and Pierce,S.K.
  TITLE     Translocation of the B cell antigen receptor into lipid rafts
            reveals a novel step in signaling
  JOURNAL   J Immunol 166 (6), 3693-3701 (2001)
   PUBMED   11238609
REFERENCE   7  (bases 1 to 1000)
  AUTHORS   Cheng,P.C., Dykstra,M.L., Mitchell,R.N. and Pierce,S.K.
  TITLE     A role for lipid rafts in B cell antigen receptor signaling and
            antigen targeting
  JOURNAL   J Exp Med 190 (11), 1549-1560 (1999)
   PUBMED   10587346
REFERENCE   8  (bases 1 to 1000)
  AUTHORS   Richards,J.D., Gold,M.R., Hourihane,S.L., DeFranco,A.L. and
            Matsuuchi,L.
  TITLE     Reconstitution of B cell antigen receptor-induced signaling events
            in a nonlymphoid cell line by expressing the Syk protein-tyrosine
            kinase
  JOURNAL   J Biol Chem 271 (11), 6458-6466 (1996)
   PUBMED   8626447
REFERENCE   9  (bases 1 to 1000)
  AUTHORS   Matsuuchi,L., Gold,M.R., Travis,A., Grosschedl,R., DeFranco,A.L.
            and Kelly,R.B.
  TITLE     The membrane IgM-associated proteins MB-1 and Ig-beta are
            sufficient to promote surface expression of a partially functional
            B-cell antigen receptor in a nonlymphoid cell line
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3404-3408 (1992)
   PUBMED   1373499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 17, 2022 this sequence version replaced XM_006228537.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231092.1, FQ225076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000001.1  89621460-89621554
            96-389              JAXUCZ010000001.1  89623143-89623436
            390-508             JAXUCZ010000001.1  89623650-89623768
            509-577             JAXUCZ010000001.1  89625191-89625259
            578-1000            JAXUCZ010000001.1  89625391-89625813
FEATURES             Location/Qualifiers
     source          1..1000
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1000
                     /gene="Cd79a"
                     /gene_synonym="Cd79al"
                     /note="CD79a molecule"
                     /db_xref="GeneID:100913063"
                     /db_xref="RGD:6484896"
     exon            1..95
                     /gene="Cd79a"
                     /gene_synonym="Cd79al"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..691
                     /gene="Cd79a"
                     /gene_synonym="Cd79al"
                     /note="B-cell antigen receptor complex-associated protein
                     alpha chain-like; Cd79a molecule,
                     immunoglobulin-associated alpha; Cd79a molecule-like;
                     CD79A antigen (immunoglobulin-associated alpha); -cell
                     antigen receptor complex-associated protein alpha
                     chain-like"
                     /codon_start=1
                     /product="B-cell antigen receptor complex-associated
                     protein alpha chain precursor"
                     /protein_id="NP_001389476.1"
                     /db_xref="GeneID:100913063"
                     /db_xref="RGD:6484896"
                     /translation="MLGGLGVLRTLPLLLLFLSEACLGPGCQALMLERDPPSLTVNLG
                     EEAVLTCKNDGKNPNITWWFSLQSNSTWPPMPLGPGLGPMGKLIFPEVNKSHRGLYWC
                     QVIESKEVKRSCGTYLRVRKQVPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLF
                     RKRWQNEKFGVDMPDDYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLHIGDVQL
                     EKP"
     exon            96..389
                     /gene="Cd79a"
                     /gene_synonym="Cd79al"
                     /inference="alignment:Splign:2.1.0"
     exon            390..508
                     /gene="Cd79a"
                     /gene_synonym="Cd79al"
                     /inference="alignment:Splign:2.1.0"
     exon            509..577
                     /gene="Cd79a"
                     /gene_synonym="Cd79al"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1000
                     /gene="Cd79a"
                     /gene_synonym="Cd79al"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactaaccg gctccctggg agacgatgct agggggtcta ggagtcctcc gaaccctgcc
       61 tctcctcctc ctcttcctgt ccgaagcctg cctgggtcct ggatgccagg ccctgatgtt
      121 agaaagggat ccaccatccc tgacggtgaa cttgggtgag gaggccgtcc tcacctgtaa
      181 gaacgacggc aagaacccta atatcacatg gtggttcagt ctccagtcca acagcacatg
      241 gcccccaatg ccactgggtc ctggcctggg tcccatgggc aagctgatct tccccgaagt
      301 taacaagagc cacaggggct tgtactggtg ccaagtgata gagagcaaag aagtaaagcg
      361 ttcctgtggc acttacctcc gagtgcgcaa gcaagtcccg aggcccttcc tggacatggg
      421 ggaaggcacc aagaaccgca tcatcacggc agaagggatc atcttgctgt tctgtgcagt
      481 ggtgccaggg acgctgctgc tcttcaggaa gcggtggcaa aatgagaagt ttggagtgga
      541 catgccagat gactacgaag atgaaaatct ctatgagggc ctgaatcttg atgactgctc
      601 tatgtatgag gacatctcca ggggactcca gggcacctac caggacgtgg gcagcctcca
      661 cattggagat gtccagctgg aaaaaccatg actgacatcc ccccaccctc cccactcccc
      721 atcctgctgt gctgtctgcc cctgcctgcc ctatgcccaa ctccagaatc cctgcccctg
      781 ctgctcttcc gctgtgcttg tccctctgaa gtgtcccacc cttgcctcca ggctgcccca
      841 ccctattctt gtccttcccc ctggggttcc ctccctagtg ggtaatgagc ccttaatcgc
      901 tgcctctagg ggagctgatt acagcaggct cgttagtgtc acccccctcc tcccagatct
      961 gtcatggcca cttaagtgat aataaatcct tcccaaagca
//
