LOCUS       NM_013069               1220 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CD74 molecule (Cd74), mRNA.
ACCESSION   NM_013069
VERSION     NM_013069.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Song,H., Zhu,Z., Zhou,Y., Du,N., Song,T., Liang,H., Chen,X.,
            Wang,Y., Wang,Y. and Hu,Y.
  TITLE     MIF/CD74 axis participates in inflammatory activation of Schwann
            cells following sciatic nerve injury
  JOURNAL   J Mol Histol 50 (4), 355-367 (2019)
   PUBMED   31197516
  REMARK    GeneRIF: macrophage migration inhibitory factor (MIF) was
            identified as a core regulator of inflammatory response following
            sciatic nerve injury through interaction with CD74 membrane
            receptor.
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Su,Y., Wang,Y., Zhou,Y., Zhu,Z., Zhang,Q., Zhang,X., Wang,W.,
            Gu,X., Guo,A. and Wang,Y.
  TITLE     Macrophage migration inhibitory factor activates inflammatory
            responses of astrocytes through interaction with CD74 receptor
  JOURNAL   Oncotarget 8 (2), 2719-2730 (2017)
   PUBMED   27926507
  REMARK    GeneRIF: cytokine MIF was able to elicit inflammatory response of
            astrocytes through interaction with CD74 receptor, and activation
            of ERK was necessary for the intracellular signal transduction.
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Wang,J., Lin,J., Schlotterer,A., Wu,L., Fleming,T., Busch,S.,
            Dietrich,N. and Hammes,H.P.
  TITLE     CD74 indicates microglial activation in experimental diabetic
            retinopathy and exogenous methylglyoxal mimics the response in
            normoglycemic retina
  JOURNAL   Acta Diabetol 51 (5), 813-821 (2014)
   PUBMED   24974304
  REMARK    GeneRIF: Methylglyoxal induced gene expression of CD74 in the in
            the diabetic retina.
REFERENCE   4  (bases 1 to 1220)
  AUTHORS   Zhen,A., Krutzik,S.R., Levin,B.R., Kasparian,S., Zack,J.A. and
            Kitchen,S.G.
  TITLE     CD4 ligation on human blood monocytes triggers macrophage
            differentiation and enhances HIV infection
  JOURNAL   J Virol 88 (17), 9934-9946 (2014)
   PUBMED   24942581
REFERENCE   5  (bases 1 to 1220)
  AUTHORS   Xiong,C., Huang,B., Cun,Y., Aghdasi,B.G. and Zhou,Y.
  TITLE     Migration inhibitory factor enhances inflammation via CD74 in
            cartilage end plates with Modic type 1 changes on MRI
  JOURNAL   Clin Orthop Relat Res 472 (6), 1943-1954 (2014)
   PUBMED   24569872
REFERENCE   6  (bases 1 to 1220)
  AUTHORS   Ghosh,P., Amaya,M., Mellins,E. and Wiley,D.C.
  TITLE     The structure of an intermediate in class II MHC maturation: CLIP
            bound to HLA-DR3
  JOURNAL   Nature 378 (6556), 457-462 (1995)
   PUBMED   7477400
REFERENCE   7  (bases 1 to 1220)
  AUTHORS   Riberdy,J.M., Newcomb,J.R., Surman,M.J., Barbosa,J.A. and
            Cresswell,P.
  TITLE     HLA-DR molecules from an antigen-processing mutant cell line are
            associated with invariant chain peptides
  JOURNAL   Nature 360 (6403), 474-477 (1992)
   PUBMED   1448172
REFERENCE   8  (bases 1 to 1220)
  AUTHORS   McKnight,A.J., Mason,D.W. and Barclay,A.N.
  TITLE     Sequence of a rat MHC class II-associated invariant chain cDNA
            clone containing a 64 amino acid thyroglobulin-like domain
  JOURNAL   Nucleic Acids Res 17 (10), 3983-3984 (1989)
   PUBMED   2499873
REFERENCE   9  (bases 1 to 1220)
  AUTHORS   Henkes,W., Syha,J. and Reske,K.
  TITLE     Nucleotide sequence of rat invariant gamma chain cDNA clone pLR
            gamma 34.3
  JOURNAL   Nucleic Acids Res 16 (24), 11822 (1988)
   PUBMED   3264906
REFERENCE   10 (bases 1 to 1220)
  AUTHORS   Sant,A.J., Cullen,S.E., Giacoletto,K.S. and Schwartz,B.D.
  TITLE     Invariant chain is the core protein of the Ia-associated
            chondroitin sulfate proteoglycan
  JOURNAL   J Exp Med 162 (6), 1916-1934 (1985)
   PUBMED   3864916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB696567.1, BC059152.1 and CB611598.1.
            
            On Oct 26, 2005 this sequence version replaced NM_013069.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231756.1, FQ232412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CB696567.1         11-33
            24-1197             BC059152.1         5-1178
            1198-1220           CB611598.1         524-546
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1220
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /note="CD74 molecule"
                     /db_xref="GeneID:25599"
                     /db_xref="RGD:2313"
     exon            1..173
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..747
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /note="ii; ia antigen-associated invariant chain; MHC
                     class II-associated invariant chain; Cd74 molecule, major
                     histocompatibility complex, class II invariant chain"
                     /codon_start=1
                     /product="H-2 class II histocompatibility antigen gamma
                     chain"
                     /protein_id="NP_037201.1"
                     /db_xref="GeneID:25599"
                     /db_xref="RGD:2313"
                     /translation="MDDQRDLISNHEQLPILGQRARAPESNCNRGVLYTSVSVLVALL
                     LAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKSAKPVSPMRMATPLLMRPL
                     SMDNMLQAPVKNVTKYGNMTQDHVMHLLTKSGPVNYPQLKGSFPENLKHLKNSMNGLD
                     WKVFESWMKQWLLFEMSKNSLEEKQPTQTPPKEPLDMEDPSSGLGVTKQDMGQMFL"
     exon            174..346
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
     exon            347..426
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
     exon            427..489
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
     exon            490..582
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
     exon            583..673
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
     exon            674..736
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1201
                     /gene="Cd74"
                     /gene_synonym="INVG34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggctcaa gggtcccaga tacacagcag cagcagcagc agcagcagca gcagcagcac
       61 cagcagcact tgggggaaaa gctagaggct agagtcatgg atgaccagcg cgacctcatc
      121 tctaaccatg agcagctgcc catcctgggc cagcgtgcta gagccccaga aagcaattgc
      181 aaccgtggag tcctgtacac cagtgtctct gtcctggtgg ctctgctctt ggctgggcag
      241 gccaccactg cttacttcct gtaccagcag cagggccgcc tggacaagct gaccgtcacc
      301 tcccagaacc tgcaactgga gaaccttcgc atgaagcttc cgaaatctgc caaacctgtg
      361 agcccgatgc gcatggctac tcccttgctg atgcgcccac tgtccatgga taacatgctc
      421 caagcgcccg tgaagaatgt taccaagtat ggcaacatga cccaggacca cgtgatgcac
      481 ctgcttacga agtctggacc cgtgaactac ccacagctga aggggagctt cccggagaat
      541 ctgaagcacc ttaagaactc tatgaatggt ctggactgga aggtctttga gagctggatg
      601 aaacagtggc tgttgtttga aatgagcaag aactccctgg aggagaagca gcccacccag
      661 actccaccta aagagccact ggacatggaa gacccatctt ctggcctggg agtgaccaag
      721 caggatatgg gccaaatgtt cttgtgaaga cagaagccag ctctgcacgg cggcagctcc
      781 cctgctcctc agcccttctt acactcccta acatcacacc ccatttcccg tcttcctgca
      841 ccctggggct tgagactggt atctgcttca ccgtccctgg acacaacaaa tgaaaccgga
      901 acagaatgag aacactggag ggagggcctt gctgcctacc cccatctaag ggacccccat
      961 ttctgaccca ttagcagtct ttaatgtggg gctctgagat ctaggcccac tgacagggat
     1021 aggggatgcc ctacccttaa tctaggctgg atacatttgc tgtcttctca aggaagaggc
     1081 caagccctcc cagcaaccct tcctcatgtc ctgccgacgc ccctgggatc cctgctcagc
     1141 caagcttgtc agcagcctgt aggaccatgg ttcacgtgac aataaaaggt agaaggtaga
     1201 aaaaaaaaaa aaaaaaaaaa
//
