LOCUS       NM_001106878             827 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus Cd70 molecule (Cd70), mRNA.
ACCESSION   NM_001106878 XM_001059337 XM_217320
VERSION     NM_001106878.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 827)
  AUTHORS   Abolhassani H, Edwards ES, Ikinciogullari A, Jing H, Borte S,
            Buggert M, Du L, Matsuda-Lennikov M, Romano R, Caridha R, Bade S,
            Zhang Y, Frederiksen J, Fang M, Bal SK, Haskologlu S, Dogu F,
            Tacyildiz N, Matthews HF, McElwee JJ, Gostick E, Price DA,
            Palendira U, Aghamohammadi A, Boisson B, Rezaei N, Karlsson AC,
            Lenardo MJ, Casanova JL, Hammarstrom L, Tangye SG, Su HC and
            Pan-Hammarstrom Q.
  TITLE     Combined immunodeficiency and Epstein-Barr virus-induced B cell
            malignancy in humans with inherited CD70 deficiency
  JOURNAL   J Exp Med 214 (1), 91-106 (2017)
   PUBMED   28011864
REFERENCE   2  (bases 1 to 827)
  AUTHORS   Izawa K, Martin E, Soudais C, Bruneau J, Boutboul D, Rodriguez R,
            Lenoir C, Hislop AD, Besson C, Touzot F, Picard C, Callebaut I, de
            Villartay JP, Moshous D, Fischer A and Latour S.
  TITLE     Inherited CD70 deficiency in humans reveals a critical role for the
            CD70-CD27 pathway in immunity to Epstein-Barr virus infection
  JOURNAL   J Exp Med 214 (1), 73-89 (2017)
   PUBMED   28011863
REFERENCE   3  (bases 1 to 827)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 827)
  AUTHORS   Fourie AM, Coles F, Moreno V and Karlsson L.
  TITLE     Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on
            synthetic peptide substrates and in ectodomain cleavage of CD23
  JOURNAL   J Biol Chem 278 (33), 30469-30477 (2003)
   PUBMED   12777399
REFERENCE   5  (bases 1 to 827)
  AUTHORS   Held-Feindt J and Mentlein R.
  TITLE     CD70/CD27 ligand, a member of the TNF family, is expressed in human
            brain tumors
  JOURNAL   Int J Cancer 98 (3), 352-356 (2002)
   PUBMED   11920585
REFERENCE   6  (bases 1 to 827)
  AUTHORS   Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S and Schlossman
            SF.
  TITLE     CD27, a member of the tumor necrosis factor receptor family,
            induces apoptosis and binds to Siva, a proapoptotic protein
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6346-6351 (1997)
   PUBMED   9177220
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474092.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217320.2, XM_001059337.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF568029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132294, SAMD00155337
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..827
                     /gene="Cd70"
                     /note="Cd70 molecule"
                     /db_xref="GeneID:301132"
                     /db_xref="RGD:1588573"
     exon            1..315
                     /gene="Cd70"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..741
                     /gene="Cd70"
                     /codon_start=1
                     /product="CD70 antigen"
                     /protein_id="NP_001100348.1"
                     /db_xref="GeneID:301132"
                     /db_xref="RGD:1588573"
                     /translation="MPEEGRPYPWVRWSWSAFQRLLPWLLMVIIAICWWLLCGGHLSK
                     PQHVLLEPPELHVAELQLNLTDPQKDLTLRWGAGPALGRSFTHGPGLEKGNLRIHQDG
                     IYRLHIQVTLANCSSSGSALQHRASLVVGICSPAVHIISLLRRRFGQDCTVSLQRLTP
                     LARGDVLCSNLTQPLLPSRNADETFFGVQRVYPWP"
     exon            316..349
                     /gene="Cd70"
                     /inference="alignment:Splign:2.1.0"
     exon            350..827
                     /gene="Cd70"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaggtgcca caagctccag gggatttccc tgccccctga gtcggacatc ccccgggttc
       61 taagggcagg tcaaggaagg cagaagcttc agaagttcgg ctgaggaagc taccgcttcc
      121 cgctgccttc tggccgccgc tattcgtgca gagatgcccg aggaaggtcg cccttacccc
      181 tgggtgcgct ggagctggtc cgcgttccag cgcctgctgc cgtggctgct gatggtgatt
      241 attgcgattt gctggtggct cctctgcggc gggcacctca gtaagcctca gcacgtgctg
      301 ctggagccac ctgagttgca cgtagctgag ttacagctga atctcacaga ccctcaaaag
      361 gacctcacac tgcgctgggg agcaggccca gccctgggaa gatccttcac gcacggacca
      421 gggctggaga agggcaatct gcgtatccat caagacggca tctacaggct gcatatccag
      481 gtgacactgg ccaactgctc ctcctcaggt agcgccctgc agcacagggc cagcctggtt
      541 gtgggcatct gctcccccgc tgtgcacatt atcagcttgc tgcgtcggcg cttcggacag
      601 gactgtacag tgtctttaca gcgccttacg ccgcttgccc gtggagatgt cctctgctcc
      661 aacctcaccc agcctctgct gccgtcccgc aatgctgacg agactttctt tggagttcag
      721 agggtatacc cttggccata actccaggat ggcttgtgaa taattttttt tcttttcgag
      781 ttctacatat ttataaatat gtatatttat aactgtatag ttcacat
//
