LOCUS       NM_001031638            1224 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus Cd68 molecule (Cd68), mRNA.
ACCESSION   NM_001031638 XM_213372
VERSION     NM_001031638.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1224)
  AUTHORS   de Oliveira,F.L., Panera,N., De Stefanis,C., Mosca,A., D'Oria,V.,
            Crudele,A., De Vito,R., Nobili,V. and Alisi,A.
  TITLE     The Number of Liver Galectin-3 Positive Cells Is Dually Correlated
            with NAFLD Severity in Children
  JOURNAL   Int J Mol Sci 20 (14), 3460 (2019)
   PUBMED   31337151
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1224)
  AUTHORS   Mortazavi-Jahromi,S.S., Alizadeh,S., Javanbakht,M.H. and
            Mirshafiey,A.
  TITLE     Cardioprotective effect of beta-d-mannuronic acid (M2000) as a
            novel NSAID on gene expression of oxLDL scavenger receptors in the
            experimental diabetic model
  JOURNAL   Immunopharmacol Immunotoxicol 40 (4), 284-289 (2018)
   PUBMED   29619884
  REMARK    GeneRIF: The M2000, as a novel NSAID is able to modify by lowering
            the gene expression levels of SR-A, LOX-1, CD36, and CD68 in
            treated rats compared to the untreated diabetic group, which may
            play an important role in preventing the complications that could
            lead to a cardioprotective efficacy.
REFERENCE   3  (bases 1 to 1224)
  AUTHORS   Zhou,J., Zhang,J., Wang,C., Qu,S., Zhu,Y., Yang,Z. and Wang,L.
  TITLE     Acai (Euterpe oleracea Mart.) attenuates alcohol-induced liver
            injury in rats by alleviating oxidative stress and inflammatory
            response
  JOURNAL   Exp Ther Med 15 (1), 166-172 (2018)
   PUBMED   29399060
REFERENCE   4  (bases 1 to 1224)
  AUTHORS   Zhou,X., Han,D., Yang,X., Wang,X. and Qiao,A.
  TITLE     Glucose regulated protein 78 is potentially an important player in
            the development of nonalcoholic steatohepatitis
  JOURNAL   Gene 637, 138-144 (2017)
   PUBMED   28951310
REFERENCE   5  (bases 1 to 1224)
  AUTHORS   Ren,C.X., Leng,R.X., Fan,Y.G., Pan,H.F., Li,B.Z., Wu,C.H., Wu,Q.,
            Wang,N.N., Xiong,Q.R., Geng,X.P. and Ye,D.Q.
  TITLE     Intratumoral and peritumoral expression of CD68 and CD206 in
            hepatocellular carcinoma and their prognostic value
  JOURNAL   Oncol Rep 38 (2), 886-898 (2017)
   PUBMED   28656201
REFERENCE   6  (bases 1 to 1224)
  AUTHORS   Xu,J., Qi,L., Chi,X., Yang,J., Wei,X., Gong,E., Peh,S. and Gu,J.
  TITLE     Orchitis: a complication of severe acute respiratory syndrome
            (SARS)
  JOURNAL   Biol Reprod 74 (2), 410-416 (2006)
   PUBMED   16237152
REFERENCE   7  (bases 1 to 1224)
  AUTHORS   Wong,A.M., Patel,N.V., Patel,N.K., Wei,M., Morgan,T.E., de
            Beer,M.C., de Villiers,W.J. and Finch,C.E.
  TITLE     Macrosialin increases during normal brain aging are attenuated by
            caloric restriction
  JOURNAL   Neurosci Lett 390 (2), 76-80 (2005)
   PUBMED   16157452
REFERENCE   8  (bases 1 to 1224)
  AUTHORS   Cosenza,M.A., Zhao,M.L. and Lee,S.C.
  TITLE     HIV-1 expression protects macrophages and microglia from apoptotic
            death
  JOURNAL   Neuropathol Appl Neurobiol 30 (5), 478-490 (2004)
   PUBMED   15488024
REFERENCE   9  (bases 1 to 1224)
  AUTHORS   Sakai,S., Mantani,N., Kogure,T., Ochiai,H., Shimada,Y. and
            Terasawa,K.
  TITLE     Gene expression of cell surface antigens in the early phase of
            murine influenza pneumonia determined by a cDNA expression array
            technique
  JOURNAL   Mediators Inflamm 11 (6), 359-361 (2002)
   PUBMED   12581500
REFERENCE   10 (bases 1 to 1224)
  AUTHORS   Baldus,S.E., Zirbes,T.K., Weidner,I.C., Flucke,U., Dittmar,E.,
            Thiele,J. and Dienes,H.P.
  TITLE     Comparative quantitative analysis of macrophage populations defined
            by CD68 and carbohydrate antigens in normal and pathologically
            altered human liver tissue
  JOURNAL   Anal Cell Pathol 16 (3), 141-150 (1998)
   PUBMED   9699943
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098931.1.
            
            On Aug 12, 2005 this sequence version replaced XM_213372.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680427, SAMN06680435
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1224
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1224
                     /gene="Cd68"
                     /note="Cd68 molecule"
                     /db_xref="GeneID:287435"
                     /db_xref="RGD:1305970"
     exon            1..91
                     /gene="Cd68"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1041
                     /gene="Cd68"
                     /note="CD68 antigen; macrosialin"
                     /codon_start=1
                     /product="macrosialin precursor"
                     /protein_id="NP_001026808.1"
                     /db_xref="GeneID:287435"
                     /db_xref="RGD:1305970"
                     /translation="MRFPVCLTLLVLLVAQGTGKDCPHKKAATLLPSFTETPTTTGST
                     ASPTTTHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHRPTTTSHGNATVSPTT
                     NSPGFSTVGPHPGPPPPSPSPSPSSTGALGNYTWTNGSQPCVQLQAQIQIRILYLTQG
                     GKKAWGLSVLNPNKTKVQGGCDSAHPHLALSFPYGQLTFGFKQDRHQSHSTVYLNYMA
                     VEYNVSFPQAAQWTFSAQNSSLQELQAPLGQSFCCGNTSIVLSPAIHLDLLSLRLQAA
                     QLPDKGHFGPCFSCASDQSLLLPLIIGLVLLGLLTLVLIAFCVTRRRQSTYQPL"
     exon            92..537
                     /gene="Cd68"
                     /inference="alignment:Splign:2.1.0"
     exon            538..657
                     /gene="Cd68"
                     /inference="alignment:Splign:2.1.0"
     exon            658..736
                     /gene="Cd68"
                     /inference="alignment:Splign:2.1.0"
     exon            737..907
                     /gene="Cd68"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1200
                     /gene="Cd68"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgaggaa ggagctgtta cagcctagct ggactcagca gctctaccat gaggttccct
       61 gtgtgtctga ccttgctggt actgcttgta gcccaaggaa cagggaaaga ctgtcctcac
      121 aaaaaggctg ccactcttct gccatccttc acggagacac ctacaaccac cggaagcaca
      181 gcaagcccta cgaccaccca caggcccacc acaaccagcc acaggcccac cacaaccagc
      241 cacaggccca ccaccaccag ccacaggccc accaccacca gccacaggcc caccaccacc
      301 agccacaggc ccaccaccac cagtcatggg aatgccacag tttctcccac cacaaacagt
      361 ccaggcttct ccactgttgg ccctcaccct ggaccacctc cgccctcacc aagtcctagt
      421 ccaagctcta ctggggctct tggaaactac acatggacta atggttccca gccatgtgtt
      481 cagctccaag cccaaattca aattcgcatc ttgtacctga cccagggtgg aaaaaaggcc
      541 tggggcctct ctgtattgaa cccgaacaaa accaaggtcc aggggggctg tgacagtgcc
      601 catccccact tggctctctc attcccttac ggacagctta cctttggatt caaacaggac
      661 cgacatcaga gccacagtac agtctacctt aactacatgg cagtggaata caatgtgtcc
      721 ttcccacaag cagcacagtg gacattctca gcgcagaatt catctcttca agagctccaa
      781 gctcccctgg gccaaagctt ctgttgcgga aatacaagca tagttctttc tccagcaatt
      841 cacctggacc tgctctccct gaggctgcag gctgctcagt tgccggacaa gggacacttc
      901 gggccatgct tctcttgcgc cagtgaccaa tctctcttgc tgcctctcat cattggcctg
      961 gtcctcctgg gcctcctcac cctggtgctc attgccttct gcgttacccg gagacgacaa
     1021 tcaacctacc agcccctctg agcatttgct ccagtccact ctgtaggcca ccaaggagca
     1081 tcctcatttc ttcagcatgc aattgactca acagagttat ctcccttctc tgtctttaag
     1141 aacaaaatta agagattttt ataatagggg tggggaatta ataaacatgc atggtacgca
     1201 aaaaaaaaaa aaaaaaaaaa aaaa
//
