LOCUS       NM_017125                860 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus Cd63 molecule (Cd63), mRNA.
ACCESSION   NM_017125
VERSION     NM_017125.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 860)
  AUTHORS   Nicaise,A.M., Johnson,K.M., Willis,C.M., Guzzo,R.M. and
            Crocker,S.J.
  TITLE     TIMP-1 Promotes Oligodendrocyte Differentiation Through
            Receptor-Mediated Signaling
  JOURNAL   Mol Neurobiol 56 (5), 3380-3392 (2019)
   PUBMED   30121936
  REMARK    GeneRIF: These data provide a previously uncharacterized trophic
            action of TIMP-1 to regulate oligodendrocyte maturation via a
            CD63/beta1-integrin/Akt pathway mechanism.
REFERENCE   2  (bases 1 to 860)
  AUTHORS   Ramanathan,S., Douglas,S.R., Alexander,G.M., Shenoda,B.B.,
            Barrett,J.E., Aradillas,E., Sacan,A. and Ajit,S.K.
  TITLE     Exosome microRNA signatures in patients with complex regional pain
            syndrome undergoing plasma exchange
  JOURNAL   J Transl Med 17 (1), 81 (2019)
   PUBMED   30871575
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 860)
  AUTHORS   Gomes de Andrade,G., Reck Cechinel,L., Bertoldi,K., Galvao,F.,
            Valdeci Worm,P. and Rodrigues Siqueira,I.
  TITLE     The Aging Process Alters IL-1beta and CD63 Levels Differently in
            Extracellular Vesicles Obtained from the Plasma and Cerebrospinal
            Fluid
  JOURNAL   Neuroimmunomodulation 25 (1), 18-22 (2018)
   PUBMED   30021215
  REMARK    GeneRIF: A disruption of cerebrospinal fluid exosomes in aged rats,
            evaluated by CD63 levels, can be related to susceptibility to
            neurodegenerative disorders.
REFERENCE   4  (bases 1 to 860)
  AUTHORS   Banushi,B., Forneris,F., Straatman-Iwanowska,A., Strange,A.,
            Lyne,A.M., Rogerson,C., Burden,J.J., Heywood,W.E., Hanley,J.,
            Doykov,I., Straatman,K.R., Smith,H., Bem,D., Kriston-Vizi,J.,
            Ariceta,G., Risteli,M., Wang,C., Ardill,R.E., Zaniew,M.,
            Latka-Grot,J., Waddington,S.N., Howe,S.J., Ferraro,F., Gjinovci,A.,
            Lawrence,S., Marsh,M., Girolami,M., Bozec,L., Mills,K. and
            Gissen,P.
  TITLE     Regulation of post-Golgi LH3 trafficking is essential for collagen
            homeostasis
  JOURNAL   Nat Commun 7, 12111 (2016)
   PUBMED   27435297
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 860)
  AUTHORS   Blom,T., Li,S., Dichlberger,A., Back,N., Kim,Y.A.,
            Loizides-Mangold,U., Riezman,H., Bittman,R. and Ikonen,E.
  TITLE     LAPTM4B facilitates late endosomal ceramide export to control cell
            death pathways
  JOURNAL   Nat Chem Biol 11 (10), 799-806 (2015)
   PUBMED   26280656
REFERENCE   6  (bases 1 to 860)
  AUTHORS   Rauch,U., Ziegler,D., Piolot,R., Schwippert,B., Benthake,H.,
            Schultheiss,H.P. and Tschoepe,D.
  TITLE     Platelet activation in diabetic cardiovascular autonomic neuropathy
  JOURNAL   Diabet Med 16 (10), 848-852 (1999)
   PUBMED   10547212
REFERENCE   7  (bases 1 to 860)
  AUTHORS   Hallden,G., Hadi,M., Hong,H.T. and Aponte,G.W.
  TITLE     Y receptor-mediated induction of CD63 transcripts, a tetraspanin
            determined to be necessary for differentiation of the intestinal
            epithelial cell line, hBRIE 380i cells
  JOURNAL   J Biol Chem 274 (39), 27914-27924 (1999)
   PUBMED   10488139
REFERENCE   8  (bases 1 to 860)
  AUTHORS   Nishikata,H., Oliver,C., Mergenhagen,S.E. and Siraganian,R.P.
  TITLE     The rat mast cell antigen AD1 (homologue to human CD63 or melanoma
            antigen ME491) is expressed in other cells in culture
  JOURNAL   J Immunol 149 (3), 862-870 (1992)
   PUBMED   1634775
REFERENCE   9  (bases 1 to 860)
  AUTHORS   Kolaskar,A.S. and Naik,P.S.
  TITLE     Computerization of virus data and its usefulness in virus
            classification
  JOURNAL   Intervirology 34 (3), 133-141 (1992)
   PUBMED   1302249
REFERENCE   10 (bases 1 to 860)
  AUTHORS   Kitani,S., Berenstein,E., Mergenhagen,S., Tempst,P. and
            Siraganian,R.P.
  TITLE     A cell surface glycoprotein of rat basophilic leukemia cells close
            to the high affinity IgE receptor (Fc epsilon RI). Similarity to
            human melanoma differentiation antigen ME491
  JOURNAL   J Biol Chem 266 (3), 1903-1909 (1991)
   PUBMED   1703158
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X61654.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017125.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X61654.1, BC063173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..860
                     /gene="Cd63"
                     /note="Cd63 molecule"
                     /db_xref="GeneID:29186"
                     /db_xref="RGD:62080"
     exon            1..49
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
     exon            50..126
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..777
                     /gene="Cd63"
                     /note="mast cell antigen AD1"
                     /codon_start=1
                     /product="CD63 antigen"
                     /protein_id="NP_058821.1"
                     /db_xref="GeneID:29186"
                     /db_xref="RGD:62080"
                     /translation="MAVEGGMKCVKFLLYVLLLAFCACAVGLIAIGVAVQVVLKQAIT
                     HETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAI
                     AGYVFRDQVKSEFSKSFQKQMQNYLTDNKTATILDKLQKENKCCGASNYTDWERIPGM
                     AKDRVPDSCCINITVGCGNDFKESTIHTQGCVETIAAWLRKNVLLVAGAALGIAFVEV
                     LGIIFSCCLVKSIRSGYEVM"
     exon            127..315
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
     exon            316..390
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
     exon            391..486
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
     exon            487..627
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
     exon            628..711
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
     exon            712..860
                     /gene="Cd63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgctgag ccgcggtagg agagcatcaa gaagcgtcgg ggagcgcagg cccagcagcc
       61 atggcggtgg aaggaggaat gaagtgtgtc aagtttttgc tctacgttct cctactggcc
      121 ttttgcgcct gcgcagtggg attgattgcc attggcgtag cagttcaggt tgtcttgaag
      181 caggccatta cccacgagac tactgctggc tcgctgttgc ctgtggtcat cattgcagtg
      241 ggtgccttcc tcttcctggt ggcctttgtg ggctgctgtg gggcctgcaa agagaactac
      301 tgtctcatga ttacatttgc catcttcctg tctcttatca tgctcgtgga ggtggcggtg
      361 gccattgctg gctatgtgtt tagagaccag gtgaagtcag agtttagtaa gagcttccag
      421 aagcagatgc agaattacct tacagacaac aaaacggcca ccattttgga caaattgcag
      481 aaggaaaata aatgctgtgg agcctctaac tacacagact gggagcgcat ccccggtatg
      541 gccaaggaca gggtccccga ttcttgctgc atcaacatca ctgtgggctg tggaaacgat
      601 ttcaaggaat ccaccatcca tacccagggc tgcgtggaaa ctatagcggc atggctgagg
      661 aagaacgtac tgctggtggc tggagcagcc ctgggcattg cttttgtgga ggtcctgggc
      721 attatcttct cctgctgtct ggtgaagagt atccggagtg gctacgaagt aatgtagggt
      781 gggggcgtgt ctgagctcgt ctgtcttttc atggagtgga ctctccaggt tttcaattaa
      841 acggattatt ttttcagacc
//
