LOCUS       NM_175577               2947 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Cd6 molecule (Cd6), mRNA.
ACCESSION   NM_175577 XM_219581
VERSION     NM_175577.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2947)
  AUTHORS   Chappell,P.E., Garner,L.I., Yan,J., Metcalfe,C., Hatherley,D.,
            Johnson,S., Robinson,C.V., Lea,S.M. and Brown,M.H.
  TITLE     Structures of CD6 and Its Ligand CD166 Give Insight into Their
            Interaction
  JOURNAL   Structure 23 (8), 1426-1436 (2015)
   PUBMED   26146185
REFERENCE   2  (bases 1 to 2947)
  AUTHORS   Oliveira,M.I., Goncalves,C.M., Pinto,M., Fabre,S., Santos,A.M.,
            Lee,S.F., Castro,M.A., Nunes,R.J., Barbosa,R.R., Parnes,J.R.,
            Yu,C., Davis,S.J., Moreira,A., Bismuth,G. and Carmo,A.M.
  TITLE     CD6 attenuates early and late signaling events, setting thresholds
            for T-cell activation
  JOURNAL   Eur J Immunol 42 (1), 195-205 (2012)
   PUBMED   21956609
  REMARK    GeneRIF: CD6 is a signaling attenuator whose expression alone, i.e.
            in the absence of ligand engagement, is sufficient to restrain
            signaling in T cells.
REFERENCE   3  (bases 1 to 2947)
  AUTHORS   Sarrias,M.R., Farnos,M., Mota,R., Sanchez-Barbero,F., Ibanez,A.,
            Gimferrer,I., Vera,J., Fenutria,R., Casals,C., Yelamos,J. and
            Lozano,F.
  TITLE     CD6 binds to pathogen-associated molecular patterns and protects
            from LPS-induced septic shock
  JOURNAL   Proc Natl Acad Sci U S A 104 (28), 11724-11729 (2007)
   PUBMED   17601777
REFERENCE   4  (bases 1 to 2947)
  AUTHORS   Castro,M.A., Oliveira,M.I., Nunes,R.J., Fabre,S., Barbosa,R.,
            Peixoto,A., Brown,M.H., Parnes,J.R., Bismuth,G., Moreira,A.,
            Rocha,B. and Carmo,A.M.
  TITLE     Extracellular isoforms of CD6 generated by alternative splicing
            regulate targeting of CD6 to the immunological synapse
  JOURNAL   J Immunol 178 (7), 4351-4361 (2007)
   PUBMED   17371992
REFERENCE   5  (bases 1 to 2947)
  AUTHORS   Zimmerman,A.W., Joosten,B., Torensma,R., Parnes,J.R., van
            Leeuwen,F.N. and Figdor,C.G.
  TITLE     Long-term engagement of CD6 and ALCAM is essential for T-cell
            proliferation induced by dendritic cells
  JOURNAL   Blood 107 (8), 3212-3220 (2006)
   PUBMED   16352806
REFERENCE   6  (bases 1 to 2947)
  AUTHORS   Gimferrer,I., Calvo,M., Mittelbrunn,M., Farnos,M., Sarrias,M.R.,
            Enrich,C., Vives,J., Sanchez-Madrid,F. and Lozano,F.
  TITLE     Relevance of CD6-mediated interactions in T cell activation and
            proliferation
  JOURNAL   J Immunol 173 (4), 2262-2270 (2004)
   PUBMED   15294938
REFERENCE   7  (bases 1 to 2947)
  AUTHORS   Castro,M.A., Nunes,R.J., Oliveira,M.I., Tavares,P.A., Simoes,C.,
            Parnes,J.R., Moreira,A. and Carmo,A.M.
  TITLE     OX52 is the rat homologue of CD6: evidence for an effector function
            in the regulation of CD5 phosphorylation
  JOURNAL   J Leukoc Biol 73 (1), 183-190 (2003)
   PUBMED   12525577
  REMARK    GeneRIF: CD6 has an important role in the regulation of CD5
            tyrosine phosphorylation, probably as a result of its unique
            feature of associating with kinases of different families.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089767.1, AF488727.1 and CO559874.1.
            
            On Oct 11, 2005 this sequence version replaced NM_175577.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1039              BC089767.1         1-1039
            1040-1913           AF488727.1         979-1852
            1914-2427           CO559874.1         151-664
            2428-2947           BC089767.1         2932-3451
FEATURES             Location/Qualifiers
     source          1..2947
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LEW"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2947
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /note="Cd6 molecule"
                     /db_xref="GeneID:25752"
                     /db_xref="RGD:2312"
     exon            1..127
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2076
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /note="CD6 antigen, Tp120; T-cell differentiation antigen
                     CD6; T-cell differentiation antigen CD6-like"
                     /codon_start=1
                     /product="T-cell differentiation antigen CD6 precursor"
                     /protein_id="NP_783167.2"
                     /db_xref="GeneID:25752"
                     /db_xref="RGD:2312"
                     /translation="MWLFLGIAGLLTAVLSGLPPPAPSDQHRNGSIPNMSSDPEEQLG
                     IRLVNGSSRCSGFVQVLLESWEPVCAGHWNRAATEAACNALGCGDLGNFTHLAPPTSE
                     RPPGATSRNTSSSRNTTWAGAPTVRCHGANWQLCKVEDYECSSDRRLVWVTCAENQAV
                     RLVDGGSRCAGRVEMLQHGEWGTVCDDTWDLDDANVVCKQLKCGWAVKALAGLHFTPG
                     QGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGVDSCEGQ
                     VEVYFRGVWSTVCDSEWYPSEAKVLCQSLGCGSEVDRPKGLPHSLAGRMYYSCKGEEL
                     TLSTCSWRFNNSNLCSQSLAARVVCSGSQRHPNLSTSEVPSRVPVTIESSVPVSVKDK
                     DSQNLTLLIPCIVLGILLLVSLIFIVFLLLKAKGQYALPTSVNHQQLSTANPAGINNY
                     HPVPITIAKEAPMLFIKPRVPEDSDSSSESDYEHYDFSSQPPVALTTFYNSQRHRVTE
                     EEAQQNRFRMPPLEEGLEELHVSNIPAADPRPCVVDAPSLGSQYHTRNNSDSSTSSEE
                     GYCNDPSSKPPPWNSQVFSEKSPLTEQPPNLELAGSQAMFSAGASADDSSSTSSGEWY
                     QNFQPPPQHPPVEQFECPGPPDLQADSIDDDEEDYDDIGAA"
     exon            128..196
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            197..544
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            545..856
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1159
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1222
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1363
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1459
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1576
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1648
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1900
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2005
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2926
                     /gene="Cd6"
                     /gene_synonym="OX52"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggcacaac tgcctcaccg aatcaggatg gcacttccta caggcaggcg tgggtagcag
       61 ttggagccgg caacagacat gtggctcttc cttgggatcg ctggattgct gacagcagtt
      121 ctctcaggtc tcccacctcc agccccctct gaccagcaca gaaatggcag catcccaaat
      181 atgtcctcgg acccagagga gcagctgggg attcgcctgg tgaacgggag cagtcgctgc
      241 agtggatttg tgcaggttct tctagagtcc tgggagcctg tgtgtgcagg gcactggaat
      301 cgggctgcta cagaggctgc atgcaacgca ctgggctgtg gcgatttggg aaactttacc
      361 cacctggcgc cacccacctc tgagcgtcca ccaggagcca cttcccggaa cactagcagc
      421 tccaggaata cgacatgggc gggggcacca actgtgagat gccacggagc caattggcaa
      481 ctctgcaagg tggaggacta cgagtgcagc agcgacaggc ggctggtgtg ggtcacctgt
      541 gcagagaacc aggctgtgcg gttagtggat ggtggcagtc gctgcgctgg ccgcgtggag
      601 atgctgcagc atggtgaatg gggaacagtg tgcgatgaca cgtgggacct ggatgatgca
      661 aacgtagtgt gtaagcagct gaagtgtggc tgggcagtga aggcactggc cggcttgcac
      721 ttcaccccag gccaaggacc catccaccgt gaccaagtga actgctctgg gaccgaggcc
      781 tatctgtggg actgcccggg gcggccagga gaccagtact gcggtcacaa ggaggatgca
      841 ggagtggtgt gctcagagca ccagtcctgg cgcctgactg gaggtgttga ctcctgcgaa
      901 gggcaagtgg aagtgtactt ccggggtgtc tggagcaccg tgtgtgacag cgaatggtac
      961 ccatccgagg ccaaagtgct ctgtcagtcc ttgggttgtg gatcagaagt ggaccggccc
     1021 aaggggctgc cacactccct ggcaggcaga atgtactact cctgtaaagg ggaggagctc
     1081 accctcagca cctgctcctg gcggttcaac aattccaact tgtgcagcca gtcgctggcc
     1141 gcaagggttg tctgctcagg ctcccagaga catcccaatc tgtcgacttc tgaagtgcct
     1201 tccagagttc cggtcaccat agaatcttct gtgcctgtga gcgtgaagga taaggactct
     1261 caaaatttga cacttctcat tccctgcatt gtcctgggaa ttctccttct tgtctccctc
     1321 atcttcatag tttttcttct cttgaaagcc aaaggacaat atgccctccc tacttcagtg
     1381 aaccaccagc aactgtccac tgccaatcca gcagggatca acaactacca tcctgtccct
     1441 atcaccattg ccaaagaagc tcctatgttg ttcatcaagc cccgggtccc cgaggactcg
     1501 gactccagtt ctgaatccga ctatgagcat tatgacttca gctcccagcc gcctgtggcc
     1561 ctgaccacct tctacaattc ccagaggcac cgggtcacag aggaagaagc ccaacagaac
     1621 aggttccgga tgccaccctt ggaggaagga cttgaagagt tgcacgtttc taacatccca
     1681 gctgctgacc ccagaccctg tgtggtggat gccccctctc tgggctctca gtaccacacg
     1741 aggaacaaca gtgactccag cacatcctct gaggagggtt actgcaatga tcccagcagc
     1801 aagccacctc catggaactc ccaggtgttt tccgagaaga gtcccctcac agagcagccc
     1861 cccaacttgg aactggctgg ctctcaggca atgttttcag caggggcctc ggccgatgac
     1921 agctccagta cctcgtctgg ggagtggtac cagaacttcc agccaccacc ccagcatcct
     1981 ccagtggaac agtttgaatg tccaggaccg cctgacctcc aagcagactc cattgatgat
     2041 gatgaggaag actacgatga cattggagca gcctagcctg ggtcgccgag gctcctgggt
     2101 gacccctccc tctgctctcc tgttctacca cccatcaact tctcagaggc tgaggcccct
     2161 ggcagagatg gaagggtggg cattctccca gccccgcatc ctccacccat tgattaacct
     2221 gcaggagcct ggaacagaaa gcagggccaa tggtgtgagt gctgggttga acgaacagag
     2281 tctggccact tcttggtggt ggttgagggc catgctgggt aaccctgagg cctcatctca
     2341 ctccatgtca tgtgctttga tcccaagtct caggaagctg ctgagggact gagcagctca
     2401 cccgctgctg aaatacaggc ccgaggccag aggctgccat tatcactcag cctcaataca
     2461 acccggggct ttgcatgggc atggctccct gggcactgtc agctaagagt aatcaagaca
     2521 agcacatgct tccttccaga gtcaggccaa ggccagtcct gccaaccaga ggcctctgag
     2581 tccaccacag gcaccggctg gactcctctc tctatccctg gataactaag cagtattcta
     2641 attccttggg ctttatagag ggtccctgcc ctgcctgagt caggagatgg gcagcccagt
     2701 tgggacaaga atgcagggat ctgtcctgga gggctagagg gcacggacag cttcgagtcc
     2761 ccacagatcc ccttgggttg acaggaacac tcacccaagt gagtgtggtt attgccggca
     2821 agaccttaaa cgggtcctcc ccacagcctc agagaactgg agggtcccag ccaggctaca
     2881 gagagctgtc ctgagttcca gagattaaac gattactgag tgaaaaaaaa aaaaaaaaaa
     2941 aaaaaaa
//
