LOCUS       NM_012925               1517 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus CD59b molecule (Cd59b), mRNA.
ACCESSION   NM_012925 XM_346664
VERSION     NM_012925.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1517)
  AUTHORS   Sahni,S., Krisp,C., Molloy,M.P., Nahm,C., Maloney,S., Gillson,J.,
            Gill,A.J., Samra,J. and Mittal,A.
  TITLE     PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer
            progression
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (11), 129682 (2020)
   PUBMED   32663515
REFERENCE   2  (bases 1 to 1517)
  AUTHORS   Abdel-Latif,M., Saidan,S. and Morsy,B.M.
  TITLE     Coenzyme Q10 attenuates rat hepatocarcinogenesis via the reduction
            of CD59 expression and phospholipase D activity
  JOURNAL   Cell Biochem Funct 38 (4), 490-499 (2020)
   PUBMED   31989689
  REMARK    GeneRIF: Coenzyme Q10 attenuates rat hepatocarcinogenesis via the
            reduction of CD59 expression and phospholipase D activity.
REFERENCE   3  (bases 1 to 1517)
  AUTHORS   Golec,E., Rosberg,R., Zhang,E., Renstrom,E., Blom,A.M. and
            King,B.C.
  TITLE     A cryptic non-GPI-anchored cytosolic isoform of CD59 controls
            insulin exocytosis in pancreatic beta-cells by interaction with
            SNARE proteins
  JOURNAL   FASEB J 33 (11), 12425-12434 (2019)
   PUBMED   31412214
  REMARK    GeneRIF: study thus proposes the previously undescribed existence
            of non-GPI-anchored cytosolic CD59, which is required for insulin
            secretion.
REFERENCE   4  (bases 1 to 1517)
  AUTHORS   Yao,X. and Verkman,A.S.
  TITLE     Complement regulator CD59 prevents peripheral organ injury in rats
            made seropositive for neuromyelitis optica immunoglobulin G
  JOURNAL   Acta Neuropathol Commun 5 (1), 57 (2017)
   PUBMED   28750658
  REMARK    GeneRIF: Organ injury in neuromyelitis optica (NMO) seropositive
            CD59(-/-) rats was prevented by a complement inhibitor. Significant
            pathological changes in seropositive CD59(-/-) rats were not seen
            in optic nerve, spinal cord or brain, including circumventricular
            tissue. Results implicate a major protective role of CD59 outside
            of the central nervous system in seropositive NMO.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1517)
  AUTHORS   Yao,X. and Verkman,A.S.
  TITLE     Marked central nervous system pathology in CD59 knockout rats
            following passive transfer of Neuromyelitis optica immunoglobulin G
  JOURNAL   Acta Neuropathol Commun 5 (1), 15 (2017)
   PUBMED   28212662
  REMARK    GeneRIF: Study generated CD59(-/-) rats to investigate the role of
            CD59 in neuromyelitis optica spectrum disorders (NMO) and to create
            NMO pathology by passive transfer of AQP4-IgG. Results implicate an
            important role of CD59 in modulating NMO pathology in rats and
            demonstrate amplification of AQP4-IgG-induced NMO disease with CD59
            knockout.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1517)
  AUTHORS   Liversidge,J., Dawson,R., Hoey,S., McKay,D., Grabowski,P. and
            Forrester,J.V.
  TITLE     CD59 and CD48 expressed by rat retinal pigment epithelial cells are
            major ligands for the CD2-mediated alternative pathway of T cell
            activation
  JOURNAL   J Immunol 156 (10), 3696-3703 (1996)
   PUBMED   8621904
REFERENCE   7  (bases 1 to 1517)
  AUTHORS   Rushmere,N.K., Harrison,R.A., van den Berg,C.W. and Morgan,B.P.
  TITLE     Molecular cloning of the rat analogue of human CD59: structural
            comparison with human CD59 and identification of a putative active
            site
  JOURNAL   Biochem J 304 (Pt 2) (Pt 2), 595-601 (1994)
   PUBMED   7528012
REFERENCE   8  (bases 1 to 1517)
  AUTHORS   Matsuo,S., Nishikage,H., Yoshida,F., Nomura,A., Piddlesden,S.J. and
            Morgan,B.P.
  TITLE     Role of CD59 in experimental glomerulonephritis in rats
  JOURNAL   Kidney Int 46 (1), 191-200 (1994)
   PUBMED   7523753
REFERENCE   9  (bases 1 to 1517)
  AUTHORS   Vakeva,A., Morgan,B.P., Tikkanen,I., Helin,K., Laurila,P. and
            Meri,S.
  TITLE     Time course of complement activation and inhibitor expression after
            ischemic injury of rat myocardium
  JOURNAL   Am J Pathol 144 (6), 1357-1368 (1994)
   PUBMED   7515561
REFERENCE   10 (bases 1 to 1517)
  AUTHORS   Hughes,T.R., Piddlesden,S.J., Williams,J.D., Harrison,R.A. and
            Morgan,B.P.
  TITLE     Isolation and characterization of a membrane protein from rat
            erythrocytes which inhibits lysis by the membrane attack complex of
            rat complement
  JOURNAL   Biochem J 284 (Pt 1) (Pt 1), 169-176 (1992)
   PUBMED   1376109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012925.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U48255.1, BC063176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000003.1  110914097-110914163
            68-143              JAXUCZ010000003.1  110922158-110922233
            144-245             JAXUCZ010000003.1  110928895-110928996
            246-1517            JAXUCZ010000003.1  110931010-110932281
FEATURES             Location/Qualifiers
     source          1..1517
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..1517
                     /gene="Cd59b"
                     /gene_synonym="Cd59; Cd59a; MAC-IP; MACIF; MACIP"
                     /note="CD59b molecule"
                     /db_xref="GeneID:25407"
                     /db_xref="RGD:2311"
     exon            1..67
                     /gene="Cd59b"
                     /gene_synonym="Cd59; Cd59a; MAC-IP; MACIF; MACIP"
                     /inference="alignment:Splign:2.1.0"
     exon            68..143
                     /gene="Cd59b"
                     /gene_synonym="Cd59; Cd59a; MAC-IP; MACIF; MACIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..466
                     /gene="Cd59b"
                     /gene_synonym="Cd59; Cd59a; MAC-IP; MACIF; MACIP"
                     /note="CD59 glycoprotein; protectin; MAC-inhibitory
                     protein; membrane attack complex inhibition factor; CD59
                     antigen; Cb59b molecule; CD59b moleucle, complement
                     regulatory protein; CD59 molecule, complement regulatory
                     protein"
                     /codon_start=1
                     /product="CD59 glycoprotein precursor"
                     /protein_id="NP_037057.1"
                     /db_xref="GeneID:25407"
                     /db_xref="RGD:2311"
                     /translation="MRARRGFILLLLLAVLCSTGVSLRCYNCLDPVSSCKTNSTCSPN
                     LDACLVAVSGKQVYQQCWRFSDCNAKFILSRLEIANVQYRCCQADLCNKSFEDKPNNG
                     AISLLGKTALLVTSVLAAILKPCF"
     exon            144..245
                     /gene="Cd59b"
                     /gene_synonym="Cd59; Cd59a; MAC-IP; MACIF; MACIP"
                     /inference="alignment:Splign:2.1.0"
     exon            246..1517
                     /gene="Cd59b"
                     /gene_synonym="Cd59; Cd59a; MAC-IP; MACIF; MACIP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagcccgaa agctggcgca ggcaagaaga acctctagca cagatctagc tgactgcgag
       61 gttgcagatt tggtggacca gcacaatgag agctcggagg ggattcatct tactcctgct
      121 tctggctgtc ctctgttcca caggtgttag cctcagatgc tacaactgtt tagacccggt
      181 ttcttcatgc aaaacaaaca gcacttgctc tcctaacctg gatgcttgtc ttgttgctgt
      241 atccggaaag caagtctatc aacagtgttg gagattttcg gattgtaatg ccaagttcat
      301 tttgagccga ctagaaatcg caaacgtaca atacagatgc tgccaggcgg acttgtgtaa
      361 caaaagcttc gaagacaagc caaacaatgg ggcaatctcc ctattgggga agacagcgtt
      421 gctggtgacc tcggttctgg cggccatttt gaagccttgt ttctaaatca tctctaagct
      481 cccgatgcct cctttctttt ttccttcttt ttcttcttct tcagcactct aaagccttta
      541 ttattttcca acttatattc gtttaggaaa caatatagtt cacttgaaat cttggataag
      601 agggagggtt gtaagcagca cggaagagca ccgaagagca ccgtgcacat agggaaggcc
      661 cacctgcagg tacagagtga agtgcgtggg taaaacacta acaggttatg taatcttcct
      721 ttgtcacttc ggagggctgg ctttcagttt cagcttaagt gggtttccgg caaccctcag
      781 ggatatctct ttggttcccg gaatgtagct gaggagtgag gtcagaaagt acctttaagt
      841 gagtggacca ggaggattct cttcattact ctgacacact caaaacgctt tcataacttt
      901 tacaggtcct gagctggtgt gcaaatgttc catatgtgag ctgtcagtca ggggcgctga
      961 ttgttcattt gctttaaaac aacaaaaaca aaaacaacaa caaaacagtt ctgggaatga
     1021 aacccagtgc attgagcatg taggcaagtg ctttacccat aagccccagc tccagctcca
     1081 gcagcgaatg aagcagctgc attttcagct agaaaacata gggatttgac ctacatttca
     1141 acaagacctc tgaaccagat gtgatgatgc ttgcttagta tgtttagcat ctcagtgctc
     1201 tggaggcaga gacaggagga gggccataag ttgaaggcca gcctgacctt cacagtggtc
     1261 tccaagtcac ctaaaactat atagtaagac cttgcctcaa atgaaaaaca aaatggcgag
     1321 tggtggtgca tgcctttaat accagcactt gggagtagaa gcaggtgcat ctccgtgagg
     1381 tcaaagccag ccagttcccg gacagccaag gctatacaga gaaagcctgt ctatacatac
     1441 atacatacat acatacatac atacatacat acatacatag aaaagaaaaa cctcaaaaca
     1501 acaataacaa caaaaca
//
