LOCUS       NM_022269               1836 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus CD55 molecule (Cromer blood group) (Cd55), mRNA.
ACCESSION   NM_022269
VERSION     NM_022269.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E and
            Lianos EA.
  TITLE     Generation of a novel decay accelerating factor (DAF) knock-out rat
            model using clustered regularly-interspaced short palindromic
            repeats, (CRISPR)/associated protein 9 (Cas9), genome editing
  JOURNAL   Transgenic Res 30 (1), 11-21 (2021)
   PUBMED   33387103
  REMARK    GeneRIF: Generation of a novel decay accelerating factor (DAF)
            knock-out rat model using clustered regularly-interspaced short
            palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome
            editing.
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Ramlall V, Thangaraj PM, Meydan C, Foox J, Butler D, Kim J, May B,
            De Freitas JK, Glicksberg BS, Mason CE, Tatonetti NP and Shapira
            SD.
  TITLE     Immune complement and coagulation dysfunction in adverse outcomes
            of SARS-CoV-2 infection
  JOURNAL   Nat Med 26 (10), 1609-1615 (2020)
   PUBMED   32747830
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Huang Y, Li Y, Wei B, Wu W and Gao X.
  TITLE     CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus
            B3-Induced Acute Myocarditis
  JOURNAL   Inflammation 41 (1), 232-239 (2018)
   PUBMED   29039143
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Ozen A, Comrie WA, Ardy RC, Dominguez Conde C, Dalgic B, Beser OF,
            Morawski AR, Karakoc-Aydiner E, Tutar E, Baris S, Ozcay F, Serwas
            NK, Zhang Y, Matthews HF, Pittaluga S, Folio LR, Unlusoy Aksu A,
            McElwee JJ, Krolo A, Kiykim A, Baris Z, Gulsan M, Ogulur I, Snapper
            SB, Houwen RHJ, Leavis HL, Ertem D, Kain R, Sari S, Erkan T, Su HC,
            Boztug K and Lenardo MJ.
  TITLE     CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and
            Thrombosis
  JOURNAL   N Engl J Med 377 (1), 52-61 (2017)
   PUBMED   28657829
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Detsika MG, Duann P, Atsaves V, Papalois A and Lianos EA.
  TITLE     Heme Oxygenase 1 Up-Regulates Glomerular Decay Accelerating Factor
            Expression and Minimizes Complement Deposition and Injury
  JOURNAL   Am J Pathol 186 (11), 2833-2845 (2016)
   PUBMED   27662796
  REMARK    GeneRIF: HO-1 is a physiologic regulator of glomerular decay
            accelerating factor (DAF) and identify hemin analogues as inducers
            of functional glomerular DAF able to minimize complement component
            C3 fragment b (C3b) deposition.
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Hinchliffe SJ, Spiller OB, Rushmere NK and Morgan BP.
  TITLE     Molecular cloning and functional characterization of the rat
            analogue of human decay-accelerating factor (CD55)
  JOURNAL   J Immunol 161 (10), 5695-5703 (1998)
   PUBMED   9820551
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Simpson KL, Jones A, Norman S and Holmes CH.
  TITLE     Expression of the complement regulatory proteins decay accelerating
            factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59
            in the normal human uterine cervix and in premalignant and
            malignant cervical disease
  JOURNAL   Am J Pathol 151 (5), 1455-1467 (1997)
   PUBMED   9358772
REFERENCE   8  (bases 1 to 1836)
  AUTHORS   Ward T, Pipkin PA, Clarkson NA, Stone DM, Minor PD and Almond JW.
  TITLE     Decay-accelerating factor CD55 is identified as the receptor for
            echovirus 7 using CELICS, a rapid immuno-focal cloning method
  JOURNAL   EMBO J 13 (21), 5070-5074 (1994)
   PUBMED   7525274
REFERENCE   9  (bases 1 to 1836)
  AUTHORS   Lund-Johansen F, Olweus J, Symington FW, Arli A, Thompson JS,
            Vilella R, Skubitz K and Horejsi V.
  TITLE     Activation of human monocytes and granulocytes by monoclonal
            antibodies to glycosylphosphatidylinositol-anchored antigens
  JOURNAL   Eur J Immunol 23 (11), 2782-2791 (1993)
   PUBMED   8223854
REFERENCE   10 (bases 1 to 1836)
  AUTHORS   Nicholson-Weller,A., Burge,J., Fearon,D.T., Weller,P.F. and
            Austen,K.F.
  TITLE     Isolation of a human erythrocyte membrane glycoprotein with
            decay-accelerating activity for C3 convertases of the complement
            system
  JOURNAL   J Immunol 129 (1), 184-189 (1982)
   PUBMED   6211481
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB610207.1 and BC061869.1.
            
            On Oct 5, 2005 this sequence version replaced NM_022269.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039583.1, AB026901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CB610207.1         1-36
            37-1836             BC061869.1         1-1800
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1836
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /note="CD55 molecule (Cromer blood group)"
                     /db_xref="GeneID:64036"
                     /db_xref="RGD:620651"
     exon            1..159
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1259
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /note="decay accelerating factor GPI-form;
                     glycosylphophatidylinositol-anchored form; decay
                     accelerating factor 1; CD55 molecule, decay accelerating
                     factor for complement; complement decay-accelerating
                     factor; CD55 antigen; decay accelarating factor 1;
                     decay-accelarating factor"
                     /codon_start=1
                     /product="complement decay-accelerating factor precursor"
                     /protein_id="NP_071605.2"
                     /db_xref="GeneID:64036"
                     /db_xref="RGD:620651"
                     /translation="MIRTRAPGTRAPPPPPLLLSLSLLLLLLSPTVSGDCGPPPDIPN
                     ATPNSGKHTKFAHQSQVTYSCNKGFKQIPDKPNTVVCLENDQWSNYETFCNKTCSAPL
                     RLNYASLKKEYRNMNFFPIGTTVEFECRPGFQKVTSRTGKSTCLEELVWSPVVEFCKK
                     RACPNPRELKNGHINIPTDILFGSEIIFSCDKGYKLVGVTSTFCSITGNAVDWDDVFP
                     VCTTIFCPDPPKINNGRIREESDSYAYRQSVTYSCDQGFILVGNSSVHCTLNGEVGEW
                     SSAPPKCIERHKVPTKTPPEVDIPSTMPHESTLINFPSTRAPLSHKPTTVKVPGTRVK
                     PTSHKPTEVKVPATQHVPVSKTTVRHPTRTSKDRGESNSGGDHFIYGHTCLITMTILH
                     VMLLLTG"
     exon            160..345
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..537
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..637
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..723
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..912
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1098
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1179
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1200
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1836
                     /gene="Cd55"
                     /gene_synonym="Daf; Daf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taaccctggc tcaaaacagc tccagccgca gccgggcacc gtctcttcta cctggggcta
       61 tgatccgcac gcgggcgccg gggactcggg caccgccgcc gccgccgctg ctgctgtcgc
      121 tgtcgctgct gctgctgctg ctgtccccga ctgtaagcgg agactgcggc ccacctccag
      181 acattcctaa tgccacgcca aactcgggta aacacaccaa gtttgcccac caaagccaag
      241 tgacatattc gtgtaataag ggcttcaaac aaattccaga caagccaaac acagtggtct
      301 gccttgaaaa tgaccaatgg tctaactacg aaactttctg taataaaacc tgtagtgctc
      361 cactgagact gaattatgca tccctcaaaa aggagtatcg taacatgaat tttttcccaa
      421 ttggcaccac tgtggaattt gagtgtcggc caggatttca aaaagtaact tcacgcacag
      481 gaaaatcaac ttgccttgag gaattagtat ggtctccagt tgttgaattt tgtaaaaaaa
      541 gagcatgccc taatcctaga gaactgaaaa atggtcacat caacatacca actgacatat
      601 tattcggatc agaaataatc ttctcatgcg acaaagggta caagctggtc ggtgtaactt
      661 ctacattctg ttctattacg gggaatgctg tggactggga tgacgtattt ccagtgtgca
      721 caacaatttt ttgtccagac ccaccaaaaa tcaataatgg aagaattcga gaggaaagcg
      781 actcctacgc atatagacag tcggtgacct attcctgtga ccaaggcttc attctggttg
      841 gaaattcttc cgttcattgt actctgaacg gtgaagtagg agaatggagt agtgcaccac
      901 ccaagtgcat agagagacac aaggtcccaa ctaagacccc accagaagtt gatattccaa
      961 gtacaatgcc tcatgaatcc accttaatta attttccaag tacaagagcc ccactgtctc
     1021 ataaacccac tacagttaaa gttccaggta caagagtcaa accaacgtct cacaagccca
     1081 ctgaagttaa agttccagca acacagcatg tacctgtttc caagacaacg gtacgtcatc
     1141 caacgagaac atctaaagac agaggagagt ctaattcagg tggtgaccat tttatatatg
     1201 gacatacatg tttaataacc atgacaattt tgcatgtgat gctcttactc actggctagt
     1261 tgacgtagcc aacgaagagt taagaagaaa gtatatacaa ccactgagaa tacttctagt
     1321 ttgttagaat gtccaggaag aatggataca ataaatttaa tagtgttgtt ggttctgtat
     1381 gctgtcatcg tcttgaaggt gtgctagaaa tgataacaaa gcaagaagaa aggaggttgt
     1441 ctggaatggt cttttcaatg catataagtc tcttgaaaat atttcaaaac tagacaaatt
     1501 cacaatgttg tgtagtatct tttctaaaaa aaagtgtggg aaagtgtaga aaattttcag
     1561 gggagaggga aatcatgatt tcttaggcta gatctatcct gttattctag cttacaataa
     1621 aaaataggaa gctaaaaata ctgatgagat tgcaaaagta aaagacccca aacgaaattt
     1681 ccttccttgt aaaccgaatt gctagagctg ggacattctt atttaaccct tgacctgaag
     1741 gcattttcct ttctactctg tattggcaaa ctgttataaa ggaagagcat gctaacaaac
     1801 cagtagtagg acaggaaaag agctcacttg gtgcag
//
