LOCUS       NM_012523               1710 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus Cd53 molecule (Cd53), mRNA.
ACCESSION   NM_012523
VERSION     NM_012523.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1710)
  AUTHORS   Todros-Dawda,I., Kveberg,L., Vaage,J.T. and Inngjerdingen,M.
  TITLE     The tetraspanin CD53 modulates responses from activating NK cell
            receptors, promoting LFA-1 activation and dampening NK cell
            effector functions
  JOURNAL   PLoS One 9 (5), e97844 (2014)
   PUBMED   24832104
  REMARK    GeneRIF: CD53 may shift natural killer cell responses from effector
            functions towards a proliferation phase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1710)
  AUTHORS   Liu,Q.C., Zha,X.H., Faralli,H., Yin,H., Louis-Jeune,C.,
            Perdiguero,E., Pranckeviciene,E., Munoz-Canoves,P., Rudnicki,M.A.,
            Brand,M., Perez-Iratxeta,C. and Dilworth,F.J.
  TITLE     Comparative expression profiling identifies differential roles for
            Myogenin and p38alpha MAPK signaling in myogenesis
  JOURNAL   J Mol Cell Biol 4 (6), 386-397 (2012)
   PUBMED   22847234
REFERENCE   3  (bases 1 to 1710)
  AUTHORS   Draber,P., Vonkova,I., Stepanek,O., Hrdinka,M., Kucova,M.,
            Skopcova,T., Otahal,P., Angelisova,P., Horejsi,V., Yeung,M.,
            Weiss,A. and Brdicka,T.
  TITLE     SCIMP, a transmembrane adaptor protein involved in major
            histocompatibility complex class II signaling
  JOURNAL   Mol Cell Biol 31 (22), 4550-4562 (2011)
   PUBMED   21930792
REFERENCE   4  (bases 1 to 1710)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 1710)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   6  (bases 1 to 1710)
  AUTHORS   Griffiths,M.M., Encinas,J.A., Remmers,E.F., Kuchroo,V.K. and
            Wilder,R.L.
  TITLE     Mapping autoimmunity genes
  JOURNAL   Curr Opin Immunol 11 (6), 689-700 (1999)
   PUBMED   10631556
  REMARK    Review article
REFERENCE   7  (bases 1 to 1710)
  AUTHORS   Wilder,R.L., Griffiths,M.M., Remmers,E.F., Cannon,G.W., Caspi,R.R.,
            Kawahito,Y., Gulko,P.S., Longman,R.E., Dracheva,S.V., Du,Y.,
            Sun,S.H., Wang,J., Shepard,J.S., Joe,B., Ge,L., Chen,S., Chang,L.,
            Hoffman,J., Silver,P.B. and Reese,V.R.
  TITLE     Localization in rats of genetic loci regulating susceptibility to
            experimental erosive arthritis and related autoimmune diseases
  JOURNAL   Transplant Proc 31 (3), 1585-1588 (1999)
   PUBMED   10331011
REFERENCE   8  (bases 1 to 1710)
  AUTHORS   Gulko,P.S., Kawahito,Y., Remmers,E.F., Reese,V.R., Wang,J.,
            Dracheva,S.V., Ge,L., Longman,R.E., Shepard,J.S., Cannon,G.W.,
            Sawitzke,A.D., Wilder,R.L. and Griffiths,M.M.
  TITLE     Identification of a new non-major histocompatibility complex
            genetic locus on chromosome 2 that controls disease severity in
            collagen-induced arthritis in rats
  JOURNAL   Arthritis Rheum 41 (12), 2122-2131 (1998)
   PUBMED   9870869
REFERENCE   9  (bases 1 to 1710)
  AUTHORS   Bellacosa,A., Lazo,P.A., Bear,S.E. and Tsichlis,P.N.
  TITLE     The rat leukocyte antigen MRC OX-44 is a member of a new family of
            cell surface proteins which appear to be involved in growth
            regulation
  JOURNAL   Mol Cell Biol 11 (5), 2864-2872 (1991)
   PUBMED   2017181
REFERENCE   10 (bases 1 to 1710)
  AUTHORS   Classon,B.J., Williams,A.F., Willis,A.C., Seed,B. and
            Stamenkovic,I.
  TITLE     The primary structure of the human leukocyte antigen CD37, a
            species homologue of the rat MRC OX-44 antigen
  JOURNAL   J Exp Med 169 (4), 1497-1502 (1989)
   PUBMED   2466944
  REMARK    Erratum:[J Exp Med. 1990 Sep 1;172(3):1007. doi:
            10.1084/jem.172.3.1007.. PMID: 2388030]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and BC078900.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012523.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57276.1, BC078900.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN06680430 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000002.1  197087848-197087896 c
            50-1677             BC078900.1         1-1628
            1678-1710           JAXUCZ010000002.1  197040369-197040401 c
FEATURES             Location/Qualifiers
     source          1..1710
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1710
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /note="Cd53 molecule"
                     /db_xref="GeneID:24251"
                     /db_xref="RGD:2310"
     exon            1..131
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
     exon            132..210
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..807
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /note="leukocyte antigen MRC OX-44; cell surface
                     glycoprotein CD53; CD53 antigen"
                     /codon_start=1
                     /product="leukocyte surface antigen CD53"
                     /protein_id="NP_036655.1"
                     /db_xref="GeneID:24251"
                     /db_xref="RGD:2310"
                     /translation="MGMSSLKLLKYVLFFFNFLFWVCGCCILGFGIHLLVQNTYGILF
                     RNLPFLTLGNVLVIVGSIIMVVAFLGCMGSIKENKCLLMSFFVLLLLILLAEVTLAIL
                     LFVYEKKINTLVAEGLNDSIQHYHSDNSTRMAWDFIQSQLQCCGVNGSSDWISGPPSS
                     CPSGADVQGCYKKGQAWFHSNFLYIGIVTICVCVIQVLGMSFALTLNCQIDKTSQALG
                     L"
     exon            211..399
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
     exon            400..474
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
     exon            475..570
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
     exon            571..651
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
     exon            652..735
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
     exon            736..1710
                     /gene="Cd53"
                     /gene_synonym="Ox-44; OX44"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtattttttc tctcttcact tctcctttta cacaaataga catagacttc tgggttacca
       61 gactgtgctc gccactttaa agataataag caaattctac ctgaagtact gagggacact
      121 gccttctaaa gggcatacta tcccagcatg ggcatgagca gcctgaaatt gctgaaatat
      181 gttctgtttt tctttaactt tcttttttgg gtctgtggct gttgcatttt gggctttggg
      241 atccacctcc tggtccagaa tacctatgga atactcttcc gtaatctccc cttcctgaca
      301 cttggcaatg ttctggtcat tgtgggctcc attatcatgg tagttgcctt cttgggctgc
      361 atgggatcaa tcaaggagaa taagtgcctg cttatgtcgt tctttgttct gctgctgctt
      421 attctccttg ctgaggtgac cttagccatc ctgctctttg tgtatgaaaa aaagatcaac
      481 acgttagtgg cagagggcct gaatgacagc atccaacatt atcactctga caacagcacc
      541 aggatggcat gggacttcat ccagtcacaa ctgcagtgtt gtggtgtaaa tggctcaagt
      601 gattggatca gtggtccacc atcttcctgc ccatcaggtg cagatgttca gggttgttat
      661 aaaaaagggc aggcgtggtt tcactccaat ttcttgtata ttggaattgt taccatctgc
      721 gtatgtgtga tacaggtgct ggggatgtcc tttgctctga cactgaactg ccagattgac
      781 aaaaccagcc aggctttagg gctgtgattt acacctacct tctgcttaag tgatttattt
      841 ctctctagaa agtcaaagca cccattccat aaggagttaa acaattacgt gcctcactgg
      901 cattttgact ttctcttatt ccttctttga ctggacctct gtcttataca catccaggga
      961 agagaacatt tgtcatggac ttcccacatc aagcagaaga caaacattaa ccaactgata
     1021 gcagtaacca tatcccttaa agatgatgaa acatacctgg gtaatttttt aaaagagaca
     1081 ctgtagcact gtaatttgat atccactgct agctgcaggt gtggatatat ctcagaatac
     1141 tggcctacca catgtaatcc attgagttta gccccaaatc caataaaaag aggtccaagt
     1201 ttaaatgtta gactcttaac aattgtaaaa tcaatctcta ccttctaaat cttgctgctg
     1261 tcactctaca aagtcacata ggagacaagc tgaaggaaaa tttggagtcc cattcattag
     1321 ataattgaca tgtccagttc ccttttgaac acagtccttg ggaataggaa tcatacagag
     1381 atcttttatc actggaaaaa cattctgatt tctttgttaa aatgtattat tgattttgtt
     1441 acatcatcca cacatccatc catccatcca tccatccatc catccatcca tccatccata
     1501 aaagactaat tattctcatc ctaccatcag ccagtttgca gctttgaatt acattgccaa
     1561 agaacaactc agaagaatta atatctccag tgtgttagct gataatcata tccatgttga
     1621 tgttgttgtt atttctctat taaataaggt tctgttaatg taccatttta acctgtcaat
     1681 aaacaaaagt ttatatcact attcatcaaa
//
