LOCUS       NM_019295               2096 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus Cd5 molecule (Cd5), mRNA.
ACCESSION   NM_019295
VERSION     NM_019295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Lesourne,R., Zvezdova,E., Song,K.D., El-Khoury,D., Uehara,S.,
            Barr,V.A., Samelson,L.E. and Love,P.E.
  TITLE     Interchangeability of Themis1 and Themis2 in thymocyte development
            reveals two related proteins with conserved molecular function
  JOURNAL   J Immunol 189 (3), 1154-1161 (2012)
   PUBMED   22732588
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Diaz,D., Chara,L., Chevarria,J., Ubeda,M., Munoz,L., Barcenilla,H.,
            Sanchez,M.A., Moreno,Z., Monserrat,J., Albillos,A., Prieto,A. and
            Alvarez-Mon,M.
  TITLE     Loss of surface antigens is a conserved feature of apoptotic
            lymphocytes from several mammalian species
  JOURNAL   Cell Immunol 271 (1), 163-172 (2011)
   PUBMED   21745657
  REMARK    GeneRIF: Data show several homologies across human, rat and mouse
            in the kinetic of loss of several LAgs such as CD5, CD4 and CD28.
REFERENCE   3  (bases 1 to 2096)
  AUTHORS   Scaglione,B.J., Salerno,E., Balan,M., Coffman,F., Landgraf,P.,
            Abbasi,F., Kotenko,S., Marti,G.E. and Raveche,E.S.
  TITLE     Murine models of chronic lymphocytic leukaemia: role of microRNA-16
            in the New Zealand Black mouse model
  JOURNAL   Br J Haematol 139 (5), 645-657 (2007)
   PUBMED   17941951
  REMARK    Review article
REFERENCE   4  (bases 1 to 2096)
  AUTHORS   Ling,K.W., van Hamburg,J.P., de Bruijn,M.J., Kurek,D., Dingjan,G.M.
            and Hendriks,R.W.
  TITLE     GATA3 controls the expression of CD5 and the T cell receptor during
            CD4 T cell lineage development
  JOURNAL   Eur J Immunol 37 (4), 1043-1052 (2007)
   PUBMED   17357106
REFERENCE   5  (bases 1 to 2096)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   6  (bases 1 to 2096)
  AUTHORS   Wiest,D.L., Ashe,J.M., Howcroft,T.K., Lee,H.M., Kemper,D.M.,
            Negishi,I., Singer,D.S., Singer,A. and Abe,R.
  TITLE     A spontaneously arising mutation in the DLAARN motif of murine
            ZAP-70 abrogates kinase activity and arrests thymocyte development
  JOURNAL   Immunity 6 (6), 663-671 (1997)
   PUBMED   9208839
REFERENCE   7  (bases 1 to 2096)
  AUTHORS   Cheng,A.M., Rowley,B., Pao,W., Hayday,A., Bolen,J.B. and Pawson,T.
  TITLE     Syk tyrosine kinase required for mouse viability and B-cell
            development
  JOURNAL   Nature 378 (6554), 303-306 (1995)
   PUBMED   7477353
REFERENCE   8  (bases 1 to 2096)
  AUTHORS   Bendelac,A., Lantz,O., Quimby,M.E., Yewdell,J.W., Bennink,J.R. and
            Brutkiewicz,R.R.
  TITLE     CD1 recognition by mouse NK1+ T lymphocytes
  JOURNAL   Science 268 (5212), 863-865 (1995)
   PUBMED   7538697
REFERENCE   9  (bases 1 to 2096)
  AUTHORS   Vermeer,L.A., de Boer,N.K., Bucci,C., Bos,N.A., Kroese,F.G. and
            Alberti,S.
  TITLE     MRC OX19 recognizes the rat CD5 surface glycoprotein, but does not
            provide evidence for a population of CD5bright B cells
  JOURNAL   Eur J Immunol 24 (3), 585-592 (1994)
   PUBMED   7510236
REFERENCE   10 (bases 1 to 2096)
  AUTHORS   Davidson,W.F., Roths,J.B., Holmes,K.L., Rudikoff,E. and Morse,H.C.
            3rd.
  TITLE     Dissociation of severe lupus-like disease from polyclonal B cell
            activation and IL 2 deficiency in C3H-lpr/lpr mice
  JOURNAL   J Immunol 133 (2), 1048-1056 (1984)
   PUBMED   6610701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000046.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_019295.3.
            
            On Mar 10, 2021 this sequence version replaced NM_019295.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X78985.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JACYVU010000046.1  1213011-1213150     c
            141-215             JACYVU010000046.1  1204618-1204692     c
            216-518             JACYVU010000046.1  1200540-1200842     c
            519-581             JACYVU010000046.1  1200080-1200142     c
            582-923             JACYVU010000046.1  1199265-1199606     c
            924-1211            JACYVU010000046.1  1197308-1197595     c
            1212-1337           JACYVU010000046.1  1196151-1196276     c
            1338-1391           JACYVU010000046.1  1195330-1195383     c
            1392-1511           JACYVU010000046.1  1194312-1194431     c
            1512-1603           JACYVU010000046.1  1193637-1193728     c
            1604-2096           JACYVU010000046.1  1192174-1192666     c
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2096
                     /gene="Cd5"
                     /note="Cd5 molecule"
                     /db_xref="GeneID:54236"
                     /db_xref="RGD:2309"
     exon            1..140
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1600
                     /gene="Cd5"
                     /note="T-cell surface glycoprotein CD5; Lymphocyte antigen
                     CD5; CD5 antigen; T-cell surface glycoprotein CD5-like"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD5 precursor"
                     /protein_id="NP_062168.2"
                     /db_xref="GeneID:54236"
                     /db_xref="RGD:2309"
                     /translation="MDSHEVLLAATYLLGTLAAFCLGQSGRDGPGKKEHEKGRGFVGA
                     QVMLSGSNSKCQGLVEVQMNGMKTVCSSSWRLSQDLWKNANEASTVCQQLGCGNPLAL
                     GHLTLWNRPKNQILCQGPPWSFSNCSTSSLGQCLPLSLVCLEPQKTTPLPTTTLPTTM
                     PEPTAPPRLQLVPGHEGLRCTGVVEFYNGSRGGTILYKAKARPVDLGNLICKSLQCGS
                     FLTHLSRIETAGTPAPAELRDPRPLPIRWEAQNGSCTSLQQCFQKTTVQEGSQALAVV
                     CSDFQPKVQSRLVGGSSVCEGIAEVRQRSQWAALCDSSAARGPGRWEELCQEQQCGNL
                     ISFHVMDADRTSPGVLCTQEKLSQCYQLQKKTHCKRVFITCKDPNPVGLAPGTVASII
                     LTLVLLVVLMVMCGPLIYKKLVKKFRQKKQRQWIGPTGVNQSMSFHRSHTATVRSQVE
                     NPAASHVDNEYSQPPRNSRLSAYPALEGALHRSSTQPDNSSDSDYDLQVAQRL"
     exon            141..215
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            216..518
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            519..581
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            582..923
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1211
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1337
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1391
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1511
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1603
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..2096
                     /gene="Cd5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccaagaga gtaagacact gagccagaca cctttcctgg ctggccaact gaactcactg
       61 aggctgaggc agcagaaggc cattatccat ggactctcac gaagtgctgc tggctgccac
      121 atacctgctg ggaacactgg ctgctttctg ccttggacag tctggaaggg atggcccagg
      181 gaagaaggaa catgagaaag gaaggggctt cgtaggtgcc caggtgatgc taagtggctc
      241 caactccaag tgtcagggtc tagtggaggt ccagatgaat ggaatgaaaa cggtgtgcag
      301 ttccagttgg aggctgagcc aggatctctg gaaaaacgcc aatgaggcct ctacagtgtg
      361 ccagcagctg ggatgtggta accctctggc ccttggccat ttgaccttat ggaacagacc
      421 caagaaccag atcctctgcc aaggaccccc gtggtctttc tccaactgca gcacaagttc
      481 gctgggccag tgccttccgc tgagcctggt ctgcctagag ccccagaaga cgacacctct
      541 acccacaacc accctaccca ccaccatgcc ggagcccaca gcccctccca gattgcagct
      601 ggtgccagga cacgagggcc tgaggtgcac aggtgtggtg gaattctaca atggcagccg
      661 gggtggcacc atcctctata aggccaaggc caggcccgtg gacctgggga acctcatctg
      721 taagtctctg cagtgtggct ctttcctgac acatctgtcc cggatagaga cagcaggaac
      781 tccagctcct gcagagctga gggaccccag gcccttgcca attcgatggg aggcccagaa
      841 tgggagctgc acctcactac agcaatgctt ccagaaaaca acggtccagg agggcagcca
      901 ggcactcgca gtcgtctgct ctgatttcca gcccaaggtt cagagccgcc tggtgggggg
      961 cagcagcgtg tgtgagggca tcgctgaagt tcgccagagg tcacagtggg ctgccctgtg
     1021 tgacagttct gcagccaggg gtccaggacg gtgggaggag ctatgccaag agcagcagtg
     1081 tggcaacctc atctccttcc atgtgatgga tgctgacagg acctccccgg gggtcctctg
     1141 tacccaggag aagctgtctc agtgttacca gcttcagaaa aaaacccact gcaagagggt
     1201 attcatcaca tgcaaagacc caaacccagt gggcctggcc ccaggcactg tggcaagcat
     1261 catcctgacc ctggtactcc tggtggtgct gatggtcatg tgcggtcctc tgatctacaa
     1321 gaagctggtg aagaaatttc gtcagaagaa gcagcgtcag tggattggtc ccacaggagt
     1381 gaaccagagc atgtctttcc atcgaagcca cacggcaact gtgcggtccc aggttgagaa
     1441 cccggcagcc tctcacgtgg acaatgagta cagccagcct cccaggaact ctcgcctgtc
     1501 ggcttatcca gctctggaag gggccctaca ccgctcttcc acacaacctg acaattcctc
     1561 tgacagtgac tatgacctgc aagtggctca gagactgtaa aagaacttaa ggccagcaac
     1621 aaagaccaag cacatccctc tgtcctgagg aagcatttac cactctgagt actgcccact
     1681 tccacctcag ccagaacttg gacagaagcc aaggtccttt ggacaaggtc ctgggccctg
     1741 cagtggcagg ccagctccta tatcctgtgg ccatggtagc ctggctgctt cctccaaaag
     1801 ccaaaactca gcagacagag ccttcaagca accgatcctt gcaagcagag acccagtatc
     1861 cagaggagtc ccaatccttt ggggagcaat gaccagcgag gttgactttc tccttggact
     1921 cttgacgcca tgaacgaatg atgtgataca cccaagtggg atacgtacaa gaactccttt
     1981 ctcaagcata tttttaatat attctttgta aataatggtt tttctacttt ccaagaacat
     2041 gagtactccg gggctgctgt gttcagggcc ccatcctccc gaccttctaa tgagac
//
