LOCUS       NM_019195               1952 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus Cd47 molecule (Cd47), mRNA.
ACCESSION   NM_019195
VERSION     NM_019195.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Zhang,Y. and Hao,J.
  TITLE     Anti-tumor effect of PTEN and its effect on inhibition of the bone
            tumor through the CD47-SIRPalpha signaling pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 40-44 (2023)
   PUBMED   38279488
  REMARK    GeneRIF: Anti-tumor effect of PTEN and its effect on inhibition of
            the bone tumor through the CD47-SIRPalpha signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Takayasu,H.
  TITLE     Upregulated TSP1 and CD47 expression in the lung in
            nitrofen-induced congenital diaphragmatic hernia
  JOURNAL   Pediatr Int 65 (1), e15447 (2023)
   PUBMED   36528876
  REMARK    GeneRIF: Upregulated TSP1 and CD47 expression in the lung in
            nitrofen-induced congenital diaphragmatic hernia.
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Ye,F., Hua,Y., Keep,R.F., Xi,G. and Garton,H.J.L.
  TITLE     CD47 blocking antibody accelerates hematoma clearance and
            alleviates hydrocephalus after experimental intraventricular
            hemorrhage
  JOURNAL   Neurobiol Dis 155, 105384 (2021)
   PUBMED   33945877
  REMARK    GeneRIF: CD47 blocking antibody accelerates hematoma clearance and
            alleviates hydrocephalus after experimental intraventricular
            hemorrhage.
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Gao,Y., Zhang,D., Yang,C., Duan,X., Li,X. and Zhong,D.
  TITLE     Two validated liquid chromatography-mass spectrometry methods with
            different pretreatments for the quantification of an anti-CD47
            monoclonal antibody in rat and cynomolgus monkey serum compared
            with an electrochemiluminescence method
  JOURNAL   J Pharm Biomed Anal 175, 112792 (2019)
   PUBMED   31377653
  REMARK    GeneRIF: For the quantification of an anti-CD47 monoclonal
            antibody.
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Li,Y., Zhao,K., Zong,P., Fu,H., Zheng,Y., Bao,D., Yin,Y., Chen,Q.,
            Lu,L., Dai,Y., Hou,D. and Kong,X.
  TITLE     CD47 deficiency protects cardiomyocytes against
            hypoxia/reoxygenation injury by rescuing autophagic clearance
  JOURNAL   Mol Med Rep 19 (6), 5453-5463 (2019)
   PUBMED   31059044
  REMARK    GeneRIF: The CD47 antibody or SiCD47 can protect cardiomyocytes
            against H/R injury through increasing autophagic flux and
            autophagic clearance. CD47 deficiency may offer a potential
            therapeutic approach for preventing myocardial I/R injury.
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   de Vries,H.E., Hendriks,J.J., Honing,H., De Lavalette,C.R., van der
            Pol,S.M., Hooijberg,E., Dijkstra,C.D. and van den Berg,T.K.
  TITLE     Signal-regulatory protein alpha-CD47 interactions are required for
            the transmigration of monocytes across cerebral endothelium
  JOURNAL   J Immunol 168 (11), 5832-5839 (2002)
   PUBMED   12023387
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Latour,S., Tanaka,H., Demeure,C., Mateo,V., Rubio,M., Brown,E.J.,
            Maliszewski,C., Lindberg,F.P., Oldenborg,A., Ullrich,A.,
            Delespesse,G. and Sarfati,M.
  TITLE     Bidirectional negative regulation of human T and dendritic cells by
            CD47 and its cognate receptor signal-regulator protein-alpha:
            down-regulation of IL-12 responsiveness and inhibition of dendritic
            cell activation
  JOURNAL   J Immunol 167 (5), 2547-2554 (2001)
   PUBMED   11509594
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Verdrengh,M., Lindberg,F.P., Ryden,C. and Tarkowski,A.
  TITLE     Integrin-associated protein (IAP)-deficient mice are less
            susceptible to developing Staphylococcus aureus-induced arthritis
  JOURNAL   Microbes Infect 1 (10), 745-751 (1999)
   PUBMED   10816079
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Huang,A.M., Wang,H.L., Tang,Y.P. and Lee,E.H.
  TITLE     Expression of integrin-associated protein gene associated with
            memory formation in rats
  JOURNAL   J Neurosci 18 (11), 4305-4313 (1998)
   PUBMED   9592107
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Nishiyama,Y., Tanaka,T., Naitoh,H., Mori,C., Fukumoto,M., Hiai,H.
            and Toyokuni,S.
  TITLE     Overexpression of integrin-associated protein (CD47) in rat kidney
            treated with a renal carcinogen, ferric nitrilotriacetate
  JOURNAL   Jpn J Cancer Res 88 (2), 120-128 (1997)
   PUBMED   9119739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085740.1.
            
            On Nov 15, 2004 this sequence version replaced NM_019195.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085740.1, D87659.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..1952
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /note="Cd47 molecule"
                     /db_xref="GeneID:29364"
                     /db_xref="RGD:2308"
     exon            1..161
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1027
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /note="leukocyte surface antigen CD47; IAP;
                     integrin-associated protein; CD47 antigen (Rh-related
                     antigen, integrin-associated signal transducer)"
                     /codon_start=1
                     /product="leukocyte surface antigen CD47 precursor"
                     /protein_id="NP_062068.1"
                     /db_xref="GeneID:29364"
                     /db_xref="RGD:2308"
                     /translation="MWPLAAALLLGSCCCGSAQLLLSKVKSVEFTSCNDTVVIPCKVL
                     NVEAQSTDEMFVKWKLNKSYIFIYDGNKNSTTREQNFTSAKISVSDLLKGIASLTMDT
                     HEAVVGNYTCEVTELSREGKTVIELKNRPVSWFSTNEKILIVIFPILAILLFWGKFGI
                     LTLKYKSSHTNKRIILLLVAGLALTLIVVVGAILFIPGEKPVKNASGLGLIVISTGIL
                     ILLQYNVFMTAFGMTSFTIAILITQVLGYVLAVVGMCLCIMACEPVHGPLLISGLGII
                     ALAELLGLVYMKFVASNQRTIQPPRNN"
     exon            162..509
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            510..599
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            600..707
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            708..800
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            801..893
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            894..986
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1018
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1942
                     /gene="Cd47"
                     /gene_synonym="Itgp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggcggcc gttcctgcct atcacggctg cggcgctgct ggtcgttctc ttgaaggcag
       61 cggaggcggc ggctgctcca gacacctgcg gcggcgaccc cccggcggcg cggagatgtg
      121 gcccttggcg gcggcgctgt tgctgggctc ctgctgctgc ggttcagctc aactcctgct
      181 tagtaaagtc aaatctgtag agttcacgtc atgcaatgac actgtggtca tcccttgcaa
      241 agtccttaat gtggaagccc aaagcaccga tgaaatgttt gtgaagtgga agttgaacaa
      301 atcgtatatt ttcatctatg atggaaataa aaatagcact actagagaac aaaactttac
      361 cagtgcaaaa atctcggtct cagacttgct caaaggcatt gcctctttga caatggatac
      421 ccatgaggct gtggtgggaa actacacctg tgaagtgact gagctttcca gagaaggcaa
      481 aacagttata gagctgaaaa accgcccagt ttcgtggttt tctacaaatg aaaagatcct
      541 cattgttatt ttcccaattt tggctatact cctgttctgg ggaaagtttg gtatattaac
      601 actcaaatac aagtccagcc atacgaataa gagaatcatt ctgctgctgg ttgccgggct
      661 ggcgctcaca ctcatcgtgg ttgttggcgc catccttttc atcccgggag agaagcccgt
      721 gaagaacgct tctggtcttg gcctcattgt aatctccaca ggaatattaa tactgcttca
      781 gtacaatgtg tttatgacag cttttggaat gacctctttc accattgcca tattgatcac
      841 tcaagtgctg ggctatgtcc ttgctgtggt cgggatgtgt ctctgcatca tggcttgtga
      901 accagtgcac ggcccccttt tgatttcagg tttgggaatc atagctctag cagaattact
      961 tggactagtt tatatgaagt ttgtcgcttc caaccagcgg actatacaac ctcctaggaa
     1021 taactgaagg gaagtgatgg actgtaactt gaaagtcaga agtggaagaa ttcagttgtc
     1081 tgagcaccat ggccttcaca actcacagct ggaaggaaca cacaacagtg actgactttc
     1141 atctctgaaa aaagtcattg aaccataaat gaatattaca gttaagttta tattaaagca
     1201 gctgtaattt acgtaataaa aaatatatga tgtgctgtgt aaccaatcga aatccatttt
     1261 tctattgttt ctactcaact aggggcaaaa gtttcagggg caacttccaa gaatgatgct
     1321 tgttagatcc ttgagtctct gaacactgag tttaaatcga ttcccagaga gactcgccaa
     1381 gcactaacct tcgggttagt tacctagaga tacctacgag aaacaggggt atccagcaag
     1441 ccttagtaaa ctcaggttcc cagcagcttt gccactcatg ctgctagctg aataacaaga
     1501 ctgccacttc tgggtcttag tgacagagac tgaagtacaa aaatgaatgt ggttgggcaa
     1561 accccgtgtg gcccctctgt gtgctatgat gttgatggcc ctgttgtctt cattcttggg
     1621 cgttgccatc gttcacacac accccctttg acatacagcg cacccaggtt ttgaatactt
     1681 ttttttttac agatgtggtt ttcctttttg cacacaaccc tttgcaccct gtcccgtcct
     1741 gctactttga tttgtgtttc aagatacagt acctttcctc ccctttaaac atgatcctgt
     1801 gacacaattt tgtcagttgc agaaaggagc cagacttatt ctcaaagcac tgtgctcaaa
     1861 ctcttcaaaa aaaaaataaa atagctatgg ttgtaacata tgtattccag acctctggtt
     1921 taaaggcaaa aaaaaaaaaa aaaaaaaaaa aa
//
