LOCUS       NM_019190               1192 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus CD46 molecule (Cd46), mRNA.
ACCESSION   NM_019190
VERSION     NM_019190.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1192)
  AUTHORS   Lewis,D.A., Suchindran,S., Beckman,M.G., Hooper,W.C., Grant,A.M.,
            Heit,J.A., Manco-Johnson,M., Moll,S., Philipp,C.S., Kenney,K., De
            Staercke,C., Pyle,M.E., Chi,J.T. and Ortel,T.L.
  TITLE     Whole blood gene expression profiles distinguish clinical
            phenotypes of venous thromboembolism
  JOURNAL   Thromb Res 135 (4), 659-665 (2015)
   PUBMED   25684211
REFERENCE   2  (bases 1 to 1192)
  AUTHORS   Lokki,A.I., Aalto-Viljakainen,T., Meri,S. and Laivuori,H.
  CONSRTM   FINNPEC
  TITLE     Genetic analysis of membrane cofactor protein (CD46) of the
            complement system in women with and without preeclamptic
            pregnancies
  JOURNAL   PLoS One 10 (2), e0117840 (2015)
   PUBMED   25710174
  REMARK    Erratum:[PLoS One. 2015 Apr 10;10(4):e0125449. doi:
            10.1371/journal.pone.0125449.. PMID: 25860883]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1192)
  AUTHORS   Nuutila,J., Jalava-Karvinen,P., Hohenthal,U., Kotilainen,P.,
            Pelliniemi,T.T., Nikoskelainen,J. and Lilius,E.M.
  TITLE     Use of complement regulators, CD35, CD46, CD55, and CD59, on
            leukocytes as markers for diagnosis of viral and bacterial
            infections
  JOURNAL   Hum Immunol 74 (5), 522-530 (2013)
   PUBMED   23376460
REFERENCE   4  (bases 1 to 1192)
  AUTHORS   Le Friec,G., Sheppard,D., Whiteman,P., Karsten,C.M., Shamoun,S.A.,
            Laing,A., Bugeon,L., Dallman,M.J., Melchionna,T., Chillakuri,C.,
            Smith,R.A., Drouet,C., Couzi,L., Fremeaux-Bacchi,V., Kohl,J.,
            Waddington,S.N., McDonnell,J.M., Baker,A., Handford,P.A., Lea,S.M.
            and Kemper,C.
  TITLE     The CD46-Jagged1 interaction is critical for human TH1 immunity
  JOURNAL   Nat Immunol 13 (12), 1213-1221 (2012)
   PUBMED   23086448
REFERENCE   5  (bases 1 to 1192)
  AUTHORS   Wirstlein,P.K., Jasinski,P., Rajewski,M., Gozdziewicz,T. and
            Skrzypczak,J.
  TITLE     Complement inhibitory proteins expression in placentas of
            thrombophilic women
  JOURNAL   Folia Histochem Cytobiol 50 (3), 460-467 (2012)
   PUBMED   23042280
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1192)
  AUTHORS   Miwa,T., Nonaka,M., Okada,N., Wakana,S., Shiroishi,T. and Okada,H.
  TITLE     Molecular cloning of rat and mouse membrane cofactor protein (MCP,
            CD46): preferential expression in testis and close linkage between
            the mouse Mcp and Cr2 genes on distal chromosome 1
  JOURNAL   Immunogenetics 48 (6), 363-371 (1998)
   PUBMED   9799332
REFERENCE   7  (bases 1 to 1192)
  AUTHORS   Simpson,K.L., Jones,A., Norman,S. and Holmes,C.H.
  TITLE     Expression of the complement regulatory proteins decay accelerating
            factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and CD59
            in the normal human uterine cervix and in premalignant and
            malignant cervical disease
  JOURNAL   Am J Pathol 151 (5), 1455-1467 (1997)
   PUBMED   9358772
REFERENCE   8  (bases 1 to 1192)
  AUTHORS   van den Berg,C.W., Perez de la Lastra,J.M., Llanes,D. and
            Morgan,B.P.
  TITLE     Purification and characterization of the pig analogue of human
            membrane cofactor protein (CD46/MCP)
  JOURNAL   J Immunol 158 (4), 1703-1709 (1997)
   PUBMED   9029106
REFERENCE   9  (bases 1 to 1192)
  AUTHORS   Hofman,P., Hsi,B.L., Manie,S., Fenichel,P., Thyss,A. and Rossi,B.
  TITLE     High expression of the antigen recognized by the monoclonal
            antibody GB24 on human breast carcinomas: a preventive mechanism of
            malignant tumor cells against complement attack?
  JOURNAL   Breast Cancer Res Treat 32 (2), 213-219 (1994)
   PUBMED   7532466
REFERENCE   10 (bases 1 to 1192)
  AUTHORS   Yang,C., Jones,J.L. and Barnum,S.R.
  TITLE     Expression of decay-accelerating factor (CD55), membrane cofactor
            protein (CD46) and CD59 in the human astroglioma cell line, D54-MG,
            and primary rat astrocytes
  JOURNAL   J Neuroimmunol 47 (2), 123-132 (1993)
   PUBMED   7690370
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB010920.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010920.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132274 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..1192
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /note="CD46 molecule"
                     /db_xref="GeneID:29333"
                     /db_xref="RGD:3061"
     exon            1..132
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1079
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /note="membrane cofactor protein; CD46 antigen, complement
                     regulatory protein; CD46 molecule, complement regulatory
                     protein"
                     /codon_start=1
                     /product="membrane cofactor protein precursor"
                     /protein_id="NP_062063.1"
                     /db_xref="GeneID:29333"
                     /db_xref="RGD:3061"
                     /translation="MTAAPLTPDPTHPRRRRKSYTFFSLGIYAEALLFLLSSLSDACE
                     PPPPFEAMELKDKPKPHYAIGEIIEYTCKKGYLYLSPYPMTAICQPNHTWVPISDHGC
                     IKVQCTMLQDPSFGKVHYIDGRFSWGARVKYTCMNGYYMVGMSVLQCELNGNGDAFWN
                     GHPPSCKKVYCLPPPKIKNGTHTFTDIKVFKYHEAVIYSCDPNPGPDKFSLVGPSMLF
                     CAGHNTWSSDPPECKVVKCPFPVLQNGRQISRTEKKFSYQALVLFQCLEGFYMEGSSM
                     VVCGAKSSWEPSIPQCLKGPKPHSTKPPVYSESGYPSPREGIFGQEFDAWIIALIVVT
                     SVVGVIVICLIILRCSEYRKK"
     exon            133..321
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            322..424
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            425..513
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            514..711
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            712..894
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            895..939
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            940..981
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1017
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1078
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1192
                     /gene="Cd46"
                     /gene_synonym="Mcp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctggtaa catgacagcg gcgcctctca cgccagaccc aacgcatccc cgtcgcagaa
       61 ggaagagcta cactttcttc tccctgggca tttacgctga ggcccttctg tttctgctgt
      121 ctagtttatc tgatgcctgt gaaccaccac caccatttga agctatggaa ctcaaggata
      181 agcctaaacc ccattatgcg attggagaga taatagaata tacgtgtaaa aaaggatacc
      241 tatatctgtc tccataccca atgactgcta tctgtcagcc aaatcacaca tgggtcccta
      301 tttcagatca tggttgtatt aaagttcaat gtactatgtt acaggaccct tcgtttggca
      361 aagtacacta catagatggt agattttcat ggggtgctcg agttaaatat acttgtatga
      421 atggttatta catggttggt atgtcagttc tacagtgtga gcttaatggc aacggtgatg
      481 cattctggaa tggccatccc ccaagttgta aaaaagtcta ttgtttacca cctccaaaaa
      541 taaaaaatgg aacacacacc tttactgata taaaagtatt caaataccat gaagcagtaa
      601 tttacagttg tgatcctaac ccagggccag ataagttttc ccttgttgga ccgagcatgc
      661 tattctgtgc tggccataac acctggagta gcgaccctcc ggagtgtaaa gtggtaaaat
      721 gtccatttcc agtgctacaa aatggaagac agatatcaag aactgaaaaa aaattttcct
      781 accaagcact agtgctgttt cagtgtttgg agggatttta catggagggc agtagcatgg
      841 tggtctgtgg tgctaagagc tcttgggagc cctctatccc acaatgtctt aaaggtccta
      901 agcctcattc taccaagcct ccagtttaca gtgaatcagg atatcctagt ccccgtgaag
      961 gaatatttgg ccaagaattc gatgcatgga tcattgcttt gattgttgtt acttcagttg
     1021 ttggagttat tgtaatttgt ctcatcatac tcaggtgttc tgagtacagg aagaaatgaa
     1081 atgtatctgc agcaagatga aaaatcccac gtgtggaagt cattactgtt ccatttttga
     1141 aaactggttc ttcaagtctg caaaagcaaa attatatatt tgcaggagct tc
//
