LOCUS       NM_012924               3993 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus CD44 molecule (Cd44), mRNA.
ACCESSION   NM_012924
VERSION     NM_012924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3993)
  AUTHORS   Matsushita,K., Toyoda,T., Akane,H., Morikawa,T. and Ogawa,K.
  TITLE     Role of CD44 expressed in renal tubules during maladaptive repair
            in renal fibrogenesis in an allopurinol-induced rat model of
            chronic kidney disease
  JOURNAL   J Appl Toxicol 44 (3), 455-469 (2024)
   PUBMED   37876353
  REMARK    GeneRIF: Role of CD44 expressed in renal tubules during maladaptive
            repair in renal fibrogenesis in an allopurinol-induced rat model of
            chronic kidney disease.
REFERENCE   2  (bases 1 to 3993)
  AUTHORS   Ye,H., He,S., Du,Y., Wang,Y., Hu,Y., Zhao,C., Jin,Y., Liu,F. and
            Guo,Y.
  TITLE     Involvement of CD44 and MAPK14-mediated ferroptosis in hemorrhagic
            shock
  JOURNAL   Apoptosis 29 (1-2), 154-168 (2024)
   PUBMED   37751106
  REMARK    GeneRIF: Involvement of CD44 and MAPK14-mediated ferroptosis in
            hemorrhagic shock.
REFERENCE   3  (bases 1 to 3993)
  AUTHORS   Wu,M., Wang,C., Gong,Y., Huang,Y., Jiang,L., Zhang,M., Gao,R. and
            Dang,B.
  TITLE     Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury
  JOURNAL   Int J Mol Med 52 (6) (2023)
   PUBMED   37888730
  REMARK    GeneRIF: Potential mechanism of TMEM2/CD44 in endoplasmic reticulum
            stress-induced neuronal apoptosis in a rat model of traumatic brain
            injury.
REFERENCE   4  (bases 1 to 3993)
  AUTHORS   Chang,C.J., Lai,Y.J., Tung,Y.C., Wu,L.S., Hsu,L.A., Tseng,C.N.,
            Chang,G.J., Yang,K.C. and Yeh,Y.H.
  TITLE     Osteopontin mediation of disturbed flow-induced endothelial
            mesenchymal transition through CD44 is a novel mechanism of
            neointimal hyperplasia in arteriovenous fistulae for hemodialysis
            access
  JOURNAL   Kidney Int 103 (4), 702-718 (2023)
   PUBMED   36646166
  REMARK    GeneRIF: Osteopontin mediation of disturbed flow-induced
            endothelial mesenchymal transition through CD44 is a novel
            mechanism of neointimal hyperplasia in arteriovenous fistulae for
            hemodialysis access.
REFERENCE   5  (bases 1 to 3993)
  AUTHORS   Alizadeh,A., Rezakhani,L., Anjom Shoa,M. and Ghasemi,S.
  TITLE     Frequency of CD44 positive cells in MKN45 cell line after treatment
            with docetaxel in two and three-dimensional cell cultures
  JOURNAL   Tissue Cell 63, 101324 (2020)
   PUBMED   32223952
  REMARK    GeneRIF: Frequency of CD44 positive cells in MKN45 cell line after
            treatment with docetaxel in two and three-dimensional cell
            cultures.
REFERENCE   6  (bases 1 to 3993)
  AUTHORS   Funaro,A., Spagnoli,G.C., Momo,M., Knapp,W. and Malavasi,F.
  TITLE     Stimulation of T cells via CD44 requires
            leukocyte-function-associated antigen interactions and
            interleukin-2 production
  JOURNAL   Hum Immunol 40 (4), 267-278 (1994)
   PUBMED   7528188
REFERENCE   7  (bases 1 to 3993)
  AUTHORS   He,Q., Lesley,J., Hyman,R., Ishihara,K. and Kincade,P.W.
  TITLE     Molecular isoforms of murine CD44 and evidence that the membrane
            proximal domain is not critical for hyaluronate recognition
  JOURNAL   J Cell Biol 119 (6), 1711-1719 (1992)
   PUBMED   1469058
REFERENCE   8  (bases 1 to 3993)
  AUTHORS   Arch,R., Wirth,K., Hofmann,M., Ponta,H., Matzku,S., Herrlich,P. and
            Zoller,M.
  TITLE     Participation in normal immune responses of a metastasis-inducing
            splice variant of CD44
  JOURNAL   Science 257 (5070), 682-685 (1992)
   PUBMED   1496383
REFERENCE   9  (bases 1 to 3993)
  AUTHORS   Gunthert,U., Hofmann,M., Rudy,W., Reber,S., Zoller,M.,
            Haussmann,I., Matzku,S., Wenzel,A., Ponta,H. and Herrlich,P.
  TITLE     A new variant of glycoprotein CD44 confers metastatic potential to
            rat carcinoma cells
  JOURNAL   Cell 65 (1), 13-24 (1991)
   PUBMED   1707342
REFERENCE   10 (bases 1 to 3993)
  AUTHORS   Arnaud,J.P., Gavioli,M., Adloff,M., Haegele,P. and Crob,J.G.
  TITLE     [Progress in the evaluation of lymphatic involvement in cancer of
            the rectum: endoscopic rectal lymphoscintigraphy]
  JOURNAL   Minerva Chir 45 (3-4), 137-140 (1990)
   PUBMED   2162503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 5, 2020 this sequence version replaced NM_012924.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96138.1, SRR26643295.14377.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000003.1  109699237-109699424 c
            189-354             JAXUCZ010000003.1  109664721-109664886 c
            355-491             JAXUCZ010000003.1  109660900-109661036 c
            492-560             JAXUCZ010000003.1  109655319-109655387 c
            561-782             JAXUCZ010000003.1  109652514-109652735 c
            783-908             JAXUCZ010000003.1  109648231-109648356 c
            909-1025            JAXUCZ010000003.1  109645968-109646084 c
            1026-1151           JAXUCZ010000003.1  109644493-109644618 c
            1152-1265           JAXUCZ010000003.1  109642102-109642215 c
            1266-1382           JAXUCZ010000003.1  109641528-109641644 c
            1383-1511           JAXUCZ010000003.1  109638863-109638991 c
            1512-1637           JAXUCZ010000003.1  109637319-109637444 c
            1638-1739           JAXUCZ010000003.1  109633569-109633670 c
            1740-1829           JAXUCZ010000003.1  109631822-109631911 c
            1830-2027           JAXUCZ010000003.1  109630713-109630910 c
            2028-2096           JAXUCZ010000003.1  109628105-109628173 c
            2097-2168           JAXUCZ010000003.1  109623779-109623850 c
            2169-2247           JAXUCZ010000003.1  109621721-109621799 c
            2248-3993           JAXUCZ010000003.1  109612033-109613778 c
FEATURES             Location/Qualifiers
     source          1..3993
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..3993
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /note="CD44 molecule"
                     /db_xref="GeneID:25406"
                     /db_xref="RGD:2307"
     exon            1..188
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2452
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /note="PGP-1; PGP-I; HUTCH-I; ECMR-III; hermes antigen;
                     hyaluronate receptor; phagocytic glycoprotein 1;
                     extracellular matrix receptor III; GP90 lymphocyte
                     homing/adhesion receptor; phagocytic glycoprotein I; Cell
                     surface glycoprotein CD44 (hyaluronate binding protein);
                     CD44 molecule (Indian blood group)"
                     /codon_start=1
                     /product="CD44 antigen precursor"
                     /protein_id="NP_037056.3"
                     /db_xref="GeneID:25406"
                     /db_xref="RGD:2307"
                     /translation="MDKVWWHTAWGLLCLLQLSLAQQQIDLNITCRYAGVFHVEKNGR
                     YSISRTEAADLCEAFNTTLPTMAQMELALSKGFETCRYGFIEGHVVIPRIHPNAICAA
                     NNTGVYILLASNTSHYDTYCFNASAPLEEDCTSVTDLPNSFDGPVTITIVNRDGTRYS
                     KKGEYRTHQEDIDASNIIDEDVSSGSTIEKSTPEGYILHTDLPTSQPTGDRDDAFFIG
                     STLATIASTVYSKSHATAQKQNNWIWSWFGNSQSTTQTQEPTTTATTALMTTPETPPK
                     RQEAQNWFSWFFQPSESKSHLHTTTKMPGTESNTNPTGWKPNEENEDETDKYPNFSGS
                     GIDDDEDFISSTIATTPWVSAHTKQNQERTQWNPIHSNPEVLLQTTTRMTDIDRNSTS
                     AHGENWTQEPQPPFNNHEYQDEEETPHATSTTWAAPNSTTEEAATQKEKWFENEWQGK
                     NPPTPSEDSHVTEGTTASGHNNHPSQRMTTQSQEDVSWTDFFDPISHPMGQGHQTESK
                     DTDSSHSTTLQPTAAPNTHLVEDLNRTGPLSVTTPQSHSQNFSTLPGELEEGEDHPTT
                     SVLPSSTKSGARRGGSLPRDTTTSLEGYTPQYPDTMENGTLFPVTPAKTEVFGETEGT
                     VATDSNFNVDGSLPGDGDSSMDPRGGFDTVTHGSELAGHSSGNQDSGVTTTSGPARRP
                     QIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGTVEDRKPSELNGEA
                     SKSQEMVHLVNKEPTETPDQFMTADETRNLQSVDMKIGV"
     exon            189..354
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            355..491
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            492..560
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            561..782
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            783..908
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1025
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1151
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1265
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1382
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1511
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1637
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1739
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1829
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2027
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2096
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2168
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2247
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..3993
                     /gene="Cd44"
                     /gene_synonym="CD44A; METAA; RHAMM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcattgccc agcagccccc agccagtgac aggttccatt caccctcttt gcccctttcc
       61 ccgcgaccct tttccagagg ctactagatc ctttggtttc atcctgcaca tcatggacaa
      121 ggtttggtgg cacacagctt ggggactact ttgcctctta cagttgagcc tggcacagca
      181 gcagatcgat ttgaatataa cctgccgtta cgcaggtgta ttccatgtgg agaaaaatgg
      241 ccgctacagt atctccagga ctgaagcagc tgacctctgc gaggctttca ataccacctt
      301 gcccaccatg gctcagatgg agttagccct gagcaagggg tttgaaacat gcaggtatgg
      361 gttcatagaa ggacacgtgg taatcccgag gatccacccc aacgctatct gtgcagccaa
      421 caacacagga gtgtatatcc tcctcgcatc caacacctcc cactatgaca catattgctt
      481 caatgcctca gctcctcttg aagaagactg tacatcagtc acagacctac ccaattcctt
      541 cgatggacca gttaccataa ctattgtcaa ccgtgatggc acccgctaca gcaagaaggg
      601 cgagtataga acacaccaag aagacatcga tgcctcaaac attatagatg aggatgtcag
      661 cagtggatcc accattgaga agagcacccc agaaggctac attttgcaca ccgaccttcc
      721 cacttcacag cctactggag accgggatga cgccttcttt attgggagca ccctggccac
      781 cattgcctca actgtgtact caaaaagcca tgcaacagct cagaaacaaa ataactggat
      841 atggtcttgg tttggtaatt cacaatccac aactcagact caggagccca caacaacagc
      901 aactacagcc ttgatgacta cccctgaaac accacccaag aggcaagaag cccagaactg
      961 gttttcatgg ttttttcaac catcagagtc caagagtcat cttcatacaa caacgaagat
     1021 gcctggtacg gagtcaaata ccaacccaac aggctggaag ccaaatgagg aaaatgaaga
     1081 tgaaacagac aaatacccca atttttctgg atcaggcatt gatgatgatg aagattttat
     1141 ctccagcacc attgcaacta ctccatgggt ttctgcccac acaaaacaga accaggaacg
     1201 gacccagtgg aacccgatcc attcaaaccc agaagtacta cttcagacaa ccaccaggat
     1261 gactgatata gacagaaaca gcaccagtgc tcatggagaa aactggaccc aggaaccaca
     1321 gcctcctttc aataaccatg agtatcagga tgaagaggag accccacatg ctacaagcac
     1381 aacctgggca gctcctaata gcacaacaga agaagcagct acccagaagg agaagtggtt
     1441 tgagaatgaa tggcagggga agaacccacc caccccaagt gaagactccc atgtgacaga
     1501 agggacaact gcctcaggcc acaacaacca tccaagtcaa agaatgacaa cacagagtca
     1561 agaggatgtt tcatggaccg atttcttcga cccaatctca catccaatgg gacaaggtca
     1621 tcaaacagaa agcaaggata cagactccag tcatagtaca acccttcagc ctactgcggc
     1681 tccaaatacc catttggtgg aagacttgaa caggacagga ccactttcag tgacaactcc
     1741 acagagtcat tctcagaact tctctacatt acctggagag ctggaagaag gcgaagacca
     1801 tccaacaact tctgttctgc catctagcac taagagtggt gcaagaagag gtggaagtct
     1861 tcccagagat acaactactt cactggaagg ctacacccct caatatccag acacaatgga
     1921 aaacgggact ctcttcccag tgacccctgc taagactgag gtctttggag aaactgaagg
     1981 gactgttgct actgactcca actttaatgt ggatggctcc ttaccaggtg atggagactc
     2041 atccatggac cccaggggtg gtttcgacac tgtgactcat ggatccgaat tagctggaca
     2101 ctcaagtggg aatcaagaca gtggagtgac cacaacttct ggtcctgcga ggagacctca
     2161 gattccagag tggcttatca tcttggcatc cctcctggcg ctggctctga ttcttgccgt
     2221 ctgcattgct gtcaacagta ggagaaggtg tgggcagaag aagaagctgg tgatcaacag
     2281 tggcaatgga acagtggaag acaggaaacc aagtgaactc aacggggagg ccagcaagtc
     2341 tcaggaaatg gtgcatttgg tgaacaagga accaacagag actccggacc agtttatgac
     2401 agctgatgag acccggaatc tgcagagtgt ggatatgaag attggggtgt agtgcctatg
     2461 ccactaactt gaaaagacac aacaattgga gacatgtcat tactgggagc tgggaccctt
     2521 aacagatgca atgtgctact gattattttt attggggatt attttgggca taaaatttcc
     2581 ctttttttgt tttttaaaag tttgttttcc aatttatgaa aatagcattg ctttctgaaa
     2641 tgagggtctc ttccagttcc tccttagagg ccttgcatta ccagggtatg ctaccatagg
     2701 cttctaccaa atgaatactc ttggtcccga ttgaacccaa agtcccaggt aacatccacc
     2761 agctaaggat ttccccagaa cttagagaga ttggtctctg ggaggaaatt tgaatgggtc
     2821 catattgcct cccagcagtc caatctgtag gcattgcttt gcagtggatg ggagatcagg
     2881 tgtactggtt acacactctc tttatagact cccttctgct ggaaaatttc cacatgcttc
     2941 tgagagattc cccaaagggt gacgctattt atctttagta agctatttat ctttgttttt
     3001 gaaatatcaa accctggagg tccttttttc agtatgactt tttttatttt gttttttttt
     3061 ttattttgtt ttttaggtta ctttgtcaga agcataacag ggtataagtt gattcataat
     3121 aaatacctgt ccatcttcca tcttgacctg ttgtgctgtg atccttcagt ttctaaatca
     3181 gcaaggtctg agtctttgta gcacatcaat gtgaccttag tatggtcctc tgaaactcat
     3241 gttagagcat ccgtgccctg cttgggttta cccagctgaa tctcagaaga tcaaggacag
     3301 gagcactgtt ttcattctag ggctatcaaa ggggtttctc tcctgttcaa gaatctgaat
     3361 tgggagtagg agagcttctg tcccttttat gtttcgataa ccacccattt ctctttctta
     3421 aagggcacat taagttttta tatcttacaa cattcgcggt cctgtttcat agacactgat
     3481 cttattggca ctttcacaaa acagtgtgga ggggacttct gacaccttat agtaaaagga
     3541 gaagccaaca gaaatgaaag tgtggacaga gagcagtaga ttggcatgag gaggcatgat
     3601 gtacaacccc cagaccactc tttccatcac cacatttgtt gatgctttcg caagccagtt
     3661 ggtacttaga atcagttccc cagggaatcc ttcaaaaagc cataagaatg cccacccctg
     3721 gaatcttacc accaccagat gagcaggttt atggtttagc aaaaggagaa tgctgtcacc
     3781 ctctgacctc atagttttca catactgggc aagtgttcat ctgccaggat gccccattgc
     3841 tcctaggtct tcccaggtac cttgtagaag aacttaaatc tataaaataa ggctttctct
     3901 aaaatggaac ttcctttcta aggctcccat ttttactgtt gactaaattt atatgtttaa
     3961 tagttttttt tcaaataaaa acaaacacaa aaa
//
