LOCUS       NM_053353               1316 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus CD40 ligand (Cd40lg), mRNA.
ACCESSION   NM_053353
VERSION     NM_053353.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1316)
  AUTHORS   Kong,D., Tan,R., Gao,Y., Gao,S., Feng,Z., Qi,H., Shen,B., Yang,L.,
            Shen,X., Jing,X. and Zhao,X.
  TITLE     Arterial Baroreflex Dysfunction Promotes Neuroinflammation by
            Activating the Platelet CD40L/Nuclear Factor Kappa B Signaling
            Pathway in Microglia and Astrocytes
  JOURNAL   Neurochem Res 48 (6), 1691-1706 (2023)
   PUBMED   36592325
  REMARK    GeneRIF: Arterial Baroreflex Dysfunction Promotes Neuroinflammation
            by Activating the Platelet CD40L/Nuclear Factor Kappa B Signaling
            Pathway in Microglia and Astrocytes.
REFERENCE   2  (bases 1 to 1316)
  AUTHORS   Hashem,A.M., Algaissi,A., Agrawal,A.S., Al-Amri,S.S.,
            Alhabbab,R.Y., Sohrab,S.S., S Almasoud,A., Alharbi,N.K., Peng,B.H.,
            Russell,M., Li,X. and Tseng,C.K.
  TITLE     A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine
            Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L
            Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse
            Model
  JOURNAL   J Infect Dis 220 (10), 1558-1567 (2019)
   PUBMED   30911758
REFERENCE   3  (bases 1 to 1316)
  AUTHORS   Takada,Y.K., Yu,J., Shimoda,M. and Takada,Y.
  TITLE     Integrin Binding to the Trimeric Interface of CD40L Plays a
            Critical Role in CD40/CD40L Signaling
  JOURNAL   J Immunol 203 (5), 1383-1391 (2019)
   PUBMED   31331973
REFERENCE   4  (bases 1 to 1316)
  AUTHORS   Grosdidier,C., Blanz,K.D., Deharo,P., Bernot,D., Poggi,M.,
            Bastelica,D., Wolf,D., Duerschmied,D., Grino,M., Cuisset,T.,
            Alessi,M.C. and Canault,M.
  TITLE     Platelet CD40 ligand and bleeding during P2Y12 inhibitor treatment
            in acute coronary syndrome
  JOURNAL   Res Pract Thromb Haemost 3 (4), 684-694 (2019)
   PUBMED   31624788
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1316)
  AUTHORS   Jiang,R.H., Xu,X.Q., Wu,C.J., Lu,S.S., Zu,Q.Q., Zhao,L.B., Liu,S.
            and Shi,H.B.
  TITLE     The CD40/CD40L system regulates rat cerebral microvasculature after
            focal ischemia/reperfusion via the mTOR/S6K signaling pathway
  JOURNAL   Neurol Res 40 (9), 717-723 (2018)
   PUBMED   29843579
  REMARK    GeneRIF: Transient middle cerebral artery occlusion (MCAO) rats
            yielded an acceleration of thrombus formation that was accompanied
            by increased CD40 levels in serum. The brain infarction was
            significantly decreased in CD40 antagonist treatment group compared
            to MCAO model group. The mTOR/S6K signaling was activated in MACO
            model than that of CD40 antagonist treatment group.
            Erratum:[Neurol Res. 2019 Jan;41(1):98. doi:
            10.1080/01616412.2018.1526508.. PMID: 30311854]
REFERENCE   6  (bases 1 to 1316)
  AUTHORS   Pietravalle,F., Lecoanet-Henchoz,S., Aubry,J.P., Elson,G.,
            Bonnefoy,J.Y. and Gauchat,J.F.
  TITLE     Cleavage of membrane-bound CD40 ligand is not required for inducing
            B cell proliferation and differentiation
  JOURNAL   Eur J Immunol 26 (3), 725-728 (1996)
   PUBMED   8605945
REFERENCE   7  (bases 1 to 1316)
  AUTHORS   Biancone,L., Andres,G., Ahn,H., DeMartino,C. and Stamenkovic,I.
  TITLE     Inhibition of the CD40-CD40ligand pathway prevents murine
            membranous glomerulonephritis
  JOURNAL   Kidney Int 48 (2), 458-468 (1995)
   PUBMED   7564113
REFERENCE   8  (bases 1 to 1316)
  AUTHORS   Snapper,C.M., Kehry,M.R., Castle,B.E. and Mond,J.J.
  TITLE     Multivalent, but not divalent, antigen receptor cross-linkers
            synergize with CD40 ligand for induction of Ig synthesis and class
            switching in normal murine B cells. A redefinition of the TI-2 vs T
            cell-dependent antigen dichotomy
  JOURNAL   J Immunol 154 (3), 1177-1187 (1995)
   PUBMED   7529792
REFERENCE   9  (bases 1 to 1316)
  AUTHORS   Durie,F.H., Fava,R.A., Foy,T.M., Aruffo,A., Ledbetter,J.A. and
            Noelle,R.J.
  TITLE     Prevention of collagen-induced arthritis with an antibody to gp39,
            the ligand for CD40
  JOURNAL   Science 261 (5126), 1328-1330 (1993)
   PUBMED   7689748
REFERENCE   10 (bases 1 to 1316)
  AUTHORS   Aruffo,A., Farrington,M., Hollenbaugh,D., Li,X., Milatovich,A.,
            Nonoyama,S., Bajorath,J., Grosmaire,L.S., Stenkamp,R., Neubauer,M.
            et al.
  TITLE     The CD40 ligand, gp39, is defective in activated T cells from
            patients with X-linked hyper-IgM syndrome
  JOURNAL   Cell 72 (2), 291-300 (1993)
   PUBMED   7678782
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Sep 6, 2022 this sequence version replaced NM_053353.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF013985.1, EF066490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680422
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               JAXUCZ010000021.1  140164341-140164563
            224-355             JAXUCZ010000021.1  140166447-140166578
            356-410             JAXUCZ010000021.1  140170008-140170062
            411-473             JAXUCZ010000021.1  140171647-140171709
            474-1316            JAXUCZ010000021.1  140175215-140176057
FEATURES             Location/Qualifiers
     source          1..1316
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..1316
                     /gene="Cd40lg"
                     /gene_synonym="Cd40l; Tnfsf5"
                     /note="CD40 ligand"
                     /db_xref="GeneID:84349"
                     /db_xref="RGD:708418"
     exon            1..223
                     /gene="Cd40lg"
                     /gene_synonym="Cd40l; Tnfsf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..850
                     /gene="Cd40lg"
                     /gene_synonym="Cd40l; Tnfsf5"
                     /note="CD40 ligand CD154; CD40-L; tumor necrosis factor
                     ligand superfamily member 5"
                     /codon_start=1
                     /product="CD40 ligand"
                     /protein_id="NP_445805.2"
                     /db_xref="GeneID:84349"
                     /db_xref="RGD:708418"
                     /translation="MIETYSQPSPRSVATGLPASMKIFMYLLTVFLITQMIGSVLFAV
                     YLHRRLDKVEEEASLHEDFVFVKKLKRCNKGEGSLSLLNCEEMRRQFEDLVKDISLNK
                     EEKKEKSFEMQRGDEDPQIAAHVVSEANSNAASVLQWAKKGYYTMKSNLVVLENGRQL
                     TVKREGLYYVYTQVTFCSNREPLSQRPFIVSLWLKPSSGSERILLRAANTHSSSKLCE
                     QQSIHLGGVFELQAGASVFVNVTEASQVIHGIGFSSFGLLKL"
     exon            224..355
                     /gene="Cd40lg"
                     /gene_synonym="Cd40l; Tnfsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            356..410
                     /gene="Cd40lg"
                     /gene_synonym="Cd40l; Tnfsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            411..473
                     /gene="Cd40lg"
                     /gene_synonym="Cd40l; Tnfsf5"
                     /inference="alignment:Splign:2.1.0"
     exon            474..1316
                     /gene="Cd40lg"
                     /gene_synonym="Cd40l; Tnfsf5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagtcttc tcatgctgcc tctgccacct tcttggtcag aagacaccat ttcagctttc
       61 agccagcatg atagaaacat acagccaacc ttctcccaga tctgtggcta ctgggcttcc
      121 agcgagcatg aagattttta tgtatttact tactgttttt cttatcaccc agatgattgg
      181 gtcggtgctt tttgctgtgt atcttcatag aagattggat aaggtagagg aggaagcaag
      241 ccttcacgag gattttgtat tcgtaaaaaa gctaaagagg tgcaacaaag gagaagggtc
      301 cttatccttg ctcaactgtg aggagatgag aaggcaattt gaagaccttg tcaaggatat
      361 atcgttaaac aaagaagaga aaaaagaaaa gagctttgaa atgcaaagag gtgatgagga
      421 tcctcaaatt gcagcacatg ttgtaagtga ggccaacagt aatgcagcat ctgttcttca
      481 gtgggcgaag aaaggatatt ataccatgaa aagcaacttg gtagtgctgg aaaatgggag
      541 acagctgacg gttaaaagag aaggactcta ttatgtctac acccaagtca ccttctgctc
      601 taatcgggaa cctttgagtc aacgtccatt catcgtcagc ctctggctga agcccagcag
      661 tgggtcagag agaatcttac tcagggcagc gaatacccac agttcctcca agctttgtga
      721 gcaacagtcc attcacttgg gcggagtatt tgaattacaa gcaggtgctt ctgtgtttgt
      781 caacgtgact gaagcaagcc aagtgatcca cggaattggc ttctcatctt ttggcttact
      841 caaactctga acagtatgct gtcctaggct gcagcagggc tgatgctggc agtcttccag
      901 atacagtaca tcagttagga cctgccctgt gttaaaccgc ctatttataa ccctaggacc
      961 ctcctcatgg aaaactattt attatgtacc cccaaggcac atagagctgg aataacagaa
     1021 ttacaggaca ggcaaactcc taatggaccc tgctccctaa caacttacaa tctgaaacag
     1081 caagcccact gattcagact accagagagc cctaggcaaa gacaaagcca taatgcacag
     1141 atgacagagc tctgatgaaa cagcggataa ctaacggagc tcagttttgt tgttttatgg
     1201 gtgtgttgtt caatggacag tgtacttgac ttaccaggaa agatgcagaa gggcaactgt
     1261 gagccttagc tcacaatctg ttatggttga cttggggtcc ctgtggccct agtagg
//
